Reaction

Product Distribution Issue reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,746 reports · 309 co-occurring drugs

As of the last recalculation, Product Distribution Issue appears in 8,746 FAERS reports alongside 309 co-occurring drug terms. The strongest observed disproportionality signal is TEDUGLUTIDE (PRR 27.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Teduglutide	155	27.9	28.2
Relugolix	246	25.5	25.8
Human Immunoglobulin G	214	25.3	25.5
Bimekizumab	214	24.5	24.7
Diphenhydramine Hydrochloride Capsule, Liquid Filled	195	22.2	22.4
Brivaracetam	61	16.2	16.4
Adrenalinum	254	15.0	15.1
Ruxolitinib	354	12.2	12.3
Pimavanserin Tartrate	251	11.1	11.1
Epinephrine	267	10.0	10.0
Rifaximin	86	9.9	9.9
Certolizumab Pegol	450	9.6	9.6
Cannabidiol	90	9.2	9.3
Lidocaine	217	9.1	9.1
Trifluridine And Tipiracil	40	8.9	8.9
Pomalidomide	367	8.8	8.9
Infliximab-Dyyb	103	8.5	8.5
Ofatumumab	114	8.3	8.3
Cyclobenzaprine Hydrochloride	31	8.2	8.3
Lidicaine	156	7.7	7.7
Burn Relief	156	7.7	7.7
Lidocaine Hydrochloride And Epinephrine	156	7.7	7.7
Voclosporin	28	7.7	7.7
Lidocaine, Menthol	156	7.6	7.6
Lenalidomide	1,183	7.5	7.6
Lidocaine Hydrochloride And Epinephrine Bitartrate	156	7.1	7.1
Lidocaine 4%	157	7.0	7.0
Diphenhydramine	181	6.9	7.0
Sodium Chloride Tablet	206	6.8	6.8
Sodium Chloride Tablets	206	6.8	6.8
Ozanimod Hydrochloride	23	6.6	6.6
Benralizumab	54	6.5	6.5
Lidocaine Hydrochloride	160	6.4	6.4
Sodium Chloride	207	6.4	6.4
Vedolizumab	219	6.2	6.2
Secukinumab	363	5.5	5.6
Hydroxyzine Hydrochloride	28	5.1	5.1
Hydroxyzine Hydrochloride Oral	28	5.1	5.1
Fluticasone Propionate Nasal	64	5.1	5.1
Azelastine	37	4.9	4.9
Buspirone Hydrochloride	21	4.5	4.5
Rosuvastatin Calcium	53	4.5	4.5
Amikacin	32	4.5	4.5
Doxyclycline Hyclate	31	4.3	4.4
Diphenhydramine Hydrochloride	290	4.3	4.3
Tizanidine Hydrochloride	32	4.2	4.2
Alpelisib	15	4.1	4.1
Canakinumab	18	4.0	4.0
Cetirizine Hcl	15	3.9	3.9
Zinc	40	3.9	3.9
Zinc Chloride	40	3.8	3.9
Tiotropium Bromide Inhalation Spray	18	3.8	3.8
Tapentadol Hydrochloride	52	3.7	3.7
Methocarbamol Tablets	26	3.7	3.7
Zinc Gluconate	40	3.7	3.7
Budesonide, Glycopyrrolate, And Formoterol Fumarate	16	3.6	3.7
Fexofenadine Hydrochloride	33	3.6	3.6
Ribociclib	47	3.6	3.6
Onabotulinumtoxina	114	3.5	3.6
Sitagliptin And Metformin Hydrochloride	32	3.5	3.5
Dicyclomine Hydrochloride	21	3.5	3.5
Siponimod	13	3.5	3.5
0Xygen	70	3.4	3.4
Oxygen	70	3.4	3.4
Fexofenadine Hcl	13	3.3	3.4
Promethazine Hydrochloride	26	3.3	3.3
Methocarbamol	31	3.3	3.3
Melatonin	74	3.3	3.3
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	28	3.2	3.2
Cabotegravir	11	3.2	3.2
Naproxen Sodium, Pseudoephedrine Hydrochloride	28	3.2	3.2
Lacosamide	50	3.2	3.2
Cholestyramine	16	3.2	3.2
Belimumab	41	3.1	3.1
Elexacaftor, Tezacaftor, And Ivacaftor	16	3.1	3.1
Metoprolol Succinate Er Tablets	79	3.0	3.0
Rimegepant Sulfate	16	3.0	3.0
Clobetasol Propionate Ointment Usp, 0.05%	13	3.0	3.0
Clobetasol Propionate	13	3.0	3.0
Oxybutynin Chloride	11	3.0	3.0
Magnesium	102	3.0	3.0
Rotigotine	18	3.0	3.0
Diphenoxylate Hydrochloride And Atropine Sulfate	17	3.0	3.0
Tolvaptan	18	3.0	3.0
Ursosiol	24	2.9	2.9
Clobazam	30	2.9	2.9
Adalimumab-Aaty	58	2.9	2.9
Cyanocobalamin	39	2.8	2.8
Pantoprazole Sodium In 0.9% Sodium Chloride	73	2.8	2.8
Pantoprazole Sodium Injection	73	2.8	2.8
Cyclobenzaprine	58	2.8	2.8
Pravastatin Sodium	23	2.8	2.8
Vitamin C	106	2.8	2.8
Mometasone Furoate And Formoterol Fumarate Dihydrate	18	2.8	2.8
Benzonatate	19	2.7	2.7
Amitriptyline Hydrochloride	20	2.7	2.7
Atorvastatin Calcium, Film Coated	79	2.7	2.7
Sucralfate Oral	16	2.7	2.7
Tranexamic Acid	10	2.7	2.7
Vibegron	9	2.7	2.7
Sucralfate Oral Suspension	16	2.7	2.7
Guaifenesin	34	2.7	2.7
Mupirocin	15	2.6	2.7
Meclizine	18	2.6	2.6
Ursodiol	24	2.6	2.6
Calcitriol Capsules 0.25 Mcg	22	2.6	2.6
Calcitriol Capsules 0.5 Mcg	22	2.6	2.6
Mupirocin Calcium	15	2.6	2.6
Oxycodone And Acetaminophen Tablets	13	2.6	2.6
Hyoscyamine Sulfate	10	2.6	2.6
Calcitriol	22	2.6	2.6
Acetaminophen Tablet Extended Release	271	2.6	2.6
Pain Reliever	271	2.6	2.6
Iron	72	2.6	2.6
Acetaminophen 500Mg	271	2.6	2.6
Duloxetine	75	2.6	2.6
Cenobamate	9	2.6	2.6
Meclizine Hydrochloride	21	2.6	2.6
Nystatin Ointment	28	2.5	2.5
Triamcinolone Acetonide Ointment Usp, 0.05%	25	2.5	2.5
Metformin Hydrochloride Tablets	61	2.5	2.5
Metformin Hydrochloride Extended-Release Tablets	61	2.5	2.5
Nystatin Cream	28	2.5	2.5
Metformin Hydrochloride Tablet	61	2.5	2.5
Clotrimazole	13	2.5	2.5
Drs. Clotrimazole	12	2.5	2.5
Family Wellness Clotrimazole	12	2.5	2.5
Clotrimazole Topical	12	2.5	2.5
Metformin Hydrochloride	61	2.5	2.5
Liothyronine Sodium	9	2.5	2.5
Anakinra	17	2.4	2.4
Nystatin	28	2.4	2.4
Ergocalciferol	383	2.4	2.4
Velpatasvir And Sofosbuvir	13	2.4	2.4
Ferrous Sulfate	50	2.4	2.4
Abatacept	137	2.4	2.4
Azithromycin	40	2.4	2.4
Biotin	31	2.4	2.4
Azithromycin Monohydrate	41	2.3	2.3
Metoprolol Succinate	85	2.3	2.3
Valacyclovir	41	2.3	2.3
Prochlorperazine Maleate	9	2.3	2.3
Treprostinil	121	2.3	2.3
Hydroxyzine	46	2.3	2.3
Thiamine Hydrochloride	12	2.3	2.3
Loperamide Hydrochloride	43	2.3	2.3
Montelukast	80	2.3	2.3
Montelukast Sodium	115	2.3	2.3
Fluticasone Propionate	122	2.3	2.3
Ondansetron Hydrochloride	115	2.2	2.3
Famotidine	110	2.2	2.2
Linaclotide	25	2.2	2.2
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	28	2.2	2.2
Polyethylene Glycol	10	2.2	2.2
Sucralfate	22	2.2	2.2
Psyllium Husk	9	2.2	2.2
Terazosin Hydrochloride	8	2.1	2.1
Umeclidinium	8	2.1	2.1
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	37	2.1	2.1
Tamsulosin Hydrochloride	18	2.1	2.1
Acetaminophen	386	2.1	2.1
Ketoconazole Foam	13	2.1	2.1
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	31	2.1	2.1
Diltiazem Hydrochloride Extended-Release Tablets	10	2.1	2.1
Losartan Potassium	69	2.1	2.1
Losartan	152	2.1	2.1
Memantine	12	2.1	2.1
Memantine Hydrochloride	12	2.1	2.1
Torsemide	29	2.1	2.1
Ketoconazole Cream, 2%	13	2.1	2.1
Azithromycin Dihydrate	51	2.1	2.1
Risankizumab-Rzaa	71	2.1	2.1
Eltrombopag Olamine	20	2.1	2.1
Mometasone Furoate	36	2.1	2.1
Tretinoin	7	2.1	2.1
Lactulose	33	2.1	2.1
Chlorthalidone	10	2.1	2.1
Magnesium Oxide	35	2.0	2.0
Loratadine Oral	41	2.0	2.0
Mepolizumab	41	2.0	2.0
Fluticasone Furoate	10	2.0	2.0
Acalabrutinib	10	2.0	2.0
Icosapent Ethyl	7	2.0	2.0
Estradiol Gel 0.1%	37	2.0	2.0
Estradiol Transdermal	37	2.0	2.0
Mometasone	15	1.9	1.9
Naltrexone	25	1.9	1.9
Triamcinolone Acetonide	25	1.9	1.9
Alendronate Sodium Tablet	15	1.9	1.9
Ketoconazole	14	1.9	1.9
Abiraterone	11	1.9	1.9
Fluticasone Furoate And Vilanterol Trifenatate	29	1.9	1.9
Cetirizine Hydrochloride	132	1.9	1.9
Mesalamine	45	1.9	1.9
Fluticasone Propionate And Salmeterol Xinafoate	48	1.9	1.9
Levocetirizine Dihydrochloride	19	1.9	1.9
Lisdexamfetamine Dimesylate	26	1.9	1.9
Progesterone	18	1.9	1.9
Fremanezumab-Vfrm	9	1.9	1.9
Albuterol Sulfate	229	1.9	1.9
Loperamide Hydrochloride And Dimethicone	25	1.9	1.9
Potassium Chloride, Dextrose Monohydrate	72	1.9	1.9
Potassium Chloride Oral	72	1.9	1.9
Potassium Chloride Extended-Release	72	1.9	1.9
Calcium	115	1.9	1.9
Meloxicam	45	1.8	1.8
Escitalopram Oxalate	56	1.8	1.8
Enzalutamide	45	1.8	1.8
Apalutamide	9	1.8	1.8
Potassium Chloride	86	1.8	1.8
Hydroxyurea	16	1.8	1.8
Tobramycin Solution	9	1.8	1.8
Budesonide And Formoterol Fumarate Dihydrate	72	1.8	1.8
Ondansetron	81	1.8	1.8
Ondansetron Tablets	81	1.8	1.8
Fish Oil	67	1.8	1.8
Valacyclovir Hydrochloride	52	1.8	1.8
Posaconazole	12	1.8	1.8
Acyclovir	84	1.8	1.8
Cetiirizine	31	1.7	1.7
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	116	1.7	1.7
Tobramycin Sulfate	9	1.7	1.7
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	36	1.7	1.7
Ropinirole	11	1.7	1.7
Budesonide	42	1.7	1.7
Metoroprolol Tartrate	47	1.7	1.7
Cetirizine	55	1.7	1.7
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	29	1.7	1.7
Anastrozole Tablets	15	1.7	1.7
Ixazomib	20	1.7	1.7
Oral Semaglutide	50	1.6	1.6
Nilotinib	20	1.6	1.6
Brimonidine Tartrate	12	1.6	1.6
Gabapentin	241	1.6	1.6
Brexpiprazole	11	1.6	1.6
Thyroid, Porcine	7	1.6	1.6
Amantadine	10	1.5	1.5
Carboxymethylcellulose Sodium	6	1.5	1.5
Lanreotide Acetate	5	1.5	1.5
Lisinopril And Hydrochlorothiazide Tablets	5	1.5	1.5
Fulvestrant	21	1.5	1.5
Guanfacine	5	1.5	1.5
Ivacaftor	5	1.5	1.5
Polyethylene Glycol 3350	60	1.5	1.5
Donepezil Hydrochloride	23	1.5	1.5
Latanoprost	31	1.5	1.5
Umeclidinium Bromide And Vilanterol Trifenatate	10	1.4	1.4
Sitagliptin	43	1.4	1.4
Ixekizumab	22	1.4	1.4
Mirabegron	23	1.4	1.4
Diclofenac Potassium, Film Coated	5	1.4	1.4
Diclofenac Potassium Tablets	5	1.4	1.4
Macitentan	41	1.4	1.4
Riociguat	19	1.4	1.4
Abaloparatide	17	1.4	1.4
Dornase Alfa	11	1.3	1.3
Oxycodone And Acetaminophen	13	1.3	1.3
Diclofenac Potassium	6	1.3	1.3
Pancrelipase	21	1.3	1.3
Suvorexant	7	1.3	1.3
Loratadine	58	1.3	1.3
Guselkumab	19	1.3	1.3
Emtricitabine And Tenofovir Alafenamide	6	1.3	1.3
Vortioxetine	9	1.3	1.3
Olaparib	11	1.3	1.3
Tadalafil	51	1.2	1.2
Omalizumab	43	1.2	1.2
Tobramycin	12	1.2	1.2
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	5	1.2	1.2
Thalidomide	18	1.2	1.2
Empagliflozin	33	1.2	1.2
Lifitegrast	8	1.2	1.2
Desvenlafaxine Succinate	13	1.1	1.1
Vigabatrin	7	1.1	1.1
Ustekinumab	49	1.1	1.1
Daratumumab	19	1.1	1.1
Travoprost	4	1.1	1.1
Selinexor	4	1.1	1.1
Dasatinib	17	1.1	1.1
Somatropin	33	1.1	1.1
Voxelotor	10	1.1	1.1
Carbidopa And Levodopa	21	1.1	1.1
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	8	1.1	1.1
Vilazodone Hydrochloride	4	1.0	1.0
Cariprazine	4	1.0	1.0
Crisaborole	4	1.0	1.0
Abiraterone Acetate	16	0.9	0.9
Osimertinib	12	0.9	0.9
Trametinib	9	0.9	0.9
Ravulizumab	5	0.9	0.9
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	3	0.9	0.9
Glecaprevir And Pibrentasvir	4	0.9	0.9
Naltrexone Hydrochloride And Bupropion Hydrochloride	3	0.8	0.8
Lumacaftor And Ivacaftor	3	0.8	0.8
Ambrisentan	43	0.8	0.8
Rucaparib	3	0.8	0.8
Teriparatide	34	0.7	0.7
Sacubitril And Valsartan	35	0.7	0.7
Romosozumab-Aqqg	4	0.7	0.7
Alirocumab	7	0.7	0.7
Erenumab-Aooe	13	0.6	0.6
Patiromer	3	0.5	0.5
Dulaglutide	19	0.5	0.5
Palivizumab	3	0.5	0.5
Salicylic Acid	10	0.4	0.4
Esketamine Hydrochloride	3	0.4	0.4
Galcanezumab-Gnlm	5	0.4	0.4
Apremilast	23	0.4	0.4
Evolocumab	23	0.3	0.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.