Reaction

Which drugs are most reported with Application site reaction?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,003 reports · 42 co-occurring drugs

As of the last recalculation, Application Site Reaction appears in 7,003 FAERS reports alongside 42 co-occurring drug terms. The strongest observed disproportionality signal is NICOTINE (PRR 76.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Nicotine	903	76.0	77.8
Rotigotine	221	46.9	47.6
Buprenorphine	882	32.3	32.6
Glycerin, Lidocaine	122	26.3	26.6
Docosanol	123	25.4	25.6
Nicotine Polacrilex	164	13.0	13.1
Estradiol	262	9.3	9.4
Minoxidil	113	7.6	7.6
Minoxidil Foam 5% (Womens)	81	7.4	7.4
Rivastigmine	44	7.0	7.0
Nicotine Polacrilex Mini	35	7.0	7.0
Nicotine Polarilex	35	7.0	7.0
Methylphenidate	50	5.2	5.2
Estradiol Gel 0.1%	72	4.8	4.8
Estradiol Transdermal	72	4.8	4.8
Fentanyl Citrate	27	4.5	4.5
Rasagiline Mesylate	15	4.0	4.0
Chlorhexidine Gluconate	12	3.9	3.9
Crisaborole	12	3.7	3.7
Oxybutynin	34	3.5	3.5
Miconazole Nitrate	10	3.4	3.4
Asenapine Maleate	9	3.1	3.1
Tretinoin	8	2.9	2.9
Carbidopa And Levodopa	39	2.5	2.5
Progesterone	18	2.3	2.3
Testosterone	18	2.3	2.3
Clonidine	39	2.3	2.3
Granisetron	8	2.3	2.3
Fentanyl	74	2.2	2.2
Instalax Polyethylene Glycol 3350	9	2.2	2.2
Polyethylene Glycol 400	9	2.1	2.1
Epoprostenol	9	2.0	2.0
Fluticasone Furoate	8	2.0	2.0
Rizatriptan Benzoate	6	1.8	1.8
Levodopa	5	1.2	1.2
Pegfilgrastim	37	1.1	1.1
Tapentadol Hydrochloride	11	1.0	1.0
Fremanezumab-Vfrm	3	0.8	0.8
Salicylic Acid	13	0.7	0.7
Guselkumab	7	0.6	0.6
Bimekizumab	4	0.6	0.6
Adapalene	5	0.1	0.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.