OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Apremilast

1,170 flagged reaction(s) · 568,642 total co-reports · max PRR 265.2
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Anti-cyclic Citrullinated Peptide Antibody 430 265.2 266.0 signal
2 C-reactive Protein 497 175.9 176.5 signal
3 Hepatic Enzyme 75 168.1 168.2 signal
4 Lupus Vulgaris 602 148.4 149.0 signal
5 Deep Vein Thrombosis Postoperative 975 143.3 144.3 signal
6 Rheumatic Fever 2,152 140.7 142.8 signal
7 Swollen Joint Count Increased 1,531 139.7 141.2 signal
8 Grip Strength 111 132.9 133.0 signal
9 Swollen Joint Count 115 126.9 127.0 signal
10 Red Blood Cell Sedimentation Rate 130 124.1 124.2 signal
11 Facet Joint Syndrome 1,377 112.1 113.2 signal
12 Subcutaneous Drug Absorption Impaired 207 88.3 88.5 signal
13 Adjustment Disorder With Depressed Mood 765 88.2 88.7 signal
14 Retinitis 603 81.5 81.8 signal
15 Dislocation Of Vertebra 767 75.8 76.2 signal
16 X-ray Abnormal 599 72.7 73.0 signal
17 Hypocholesterolaemia 95 64.2 64.2 signal
18 Rheumatoid Factor Positive 1,750 62.7 63.4 signal
19 Anti-cyclic Citrullinated Peptide Antibody Positive 2,094 60.1 61.0 signal
20 Duodenal Ulcer Perforation 2,155 59.8 60.7 signal
21 Sleep Disorder Due To General Medical Condition, Hypersomnia Type 28 55.7 55.7 signal
22 Peripheral Venous Disease 1,015 49.0 49.3 signal
23 Seronegative Arthritis 283 48.4 48.5 signal
24 C-reactive Protein Abnormal 1,577 46.9 47.4 signal
25 Bone Erosion 854 45.6 45.9 signal
26 Enthesopathy 359 42.3 42.4 signal
27 Tender Joint Count 19 41.3 41.3 signal
28 Helicobacter Infection 2,129 37.9 38.5 signal
29 Psoriatic Arthropathy 8,175 36.6 38.8 signal
30 Folliculitis 2,075 36.1 36.6 signal
31 Muscle Injury 1,586 34.4 34.8 signal
32 Hand Deformity 2,406 32.3 32.9 signal
33 Sleep Disorder Due To General Medical Condition, Insomnia Type 1,166 31.7 32.0 signal
34 Pemphigus 2,213 31.1 31.5 signal
35 Granuloma Skin 143 29.9 29.9 signal
36 Breast Cancer Stage Iii 1,069 28.6 28.8 signal
37 Synovitis 2,981 28.4 29.0 signal
38 Onychomadesis 678 28.0 28.1 signal
39 Psoriasis 20,585 26.8 31.1 signal
40 Overlap Syndrome 108 26.6 26.6 signal
41 Rebound Psoriasis 89 25.6 25.6 signal
42 Grip Strength Decreased 1,272 24.4 24.6 signal
43 Hypercholesterolaemia 1,371 24.0 24.2 signal
44 Lip Dry 1,282 23.9 24.1 signal
45 Pericarditis 2,239 22.3 22.6 signal
46 Porphyria Acute 185 22.2 22.2 signal
47 Blepharospasm 799 21.2 21.3 signal
48 Wound Infection 1,389 21.0 21.2 signal
49 Joint Range Of Motion Decreased 1,633 20.0 20.2 signal
50 Tenosynovitis 335 19.8 19.8 signal
51 Bursitis 1,433 19.3 19.5 signal
52 Blood Parathyroid Hormone Decreased 168 18.2 18.2 signal
53 Palmoplantar Pustulosis 57 18.0 18.0 signal
54 Glossodynia 2,470 17.8 18.1 signal
55 Onychomycosis 475 17.4 17.5 signal
56 Autoimmune Disorder 1,004 16.8 16.9 signal
57 Body Tinea 59 16.7 16.7 signal
58 Live Birth 848 16.3 16.3 signal
59 Drug Tolerance Decreased 282 16.0 16.1 signal
60 Irritable Bowel Syndrome 2,052 15.2 15.4 signal
61 Death Neonatal 128 14.7 14.7 signal
62 Fibromyalgia 2,254 14.7 14.9 signal
63 Wound 2,514 14.2 14.5 signal
64 Exostosis 809 13.9 14.0 signal
65 Alanine Aminotransferase Abnormal 184 13.8 13.8 signal
66 Pustular Psoriasis 302 13.8 13.8 signal
67 Therapy Non-responder 3,874 13.6 14.0 signal
68 Dactylitis 84 13.4 13.4 signal
69 Tension Headache 366 13.3 13.4 signal
70 Nail Disorder 740 13.3 13.4 signal
71 Infusion Site Reaction 243 13.1 13.1 signal
72 Sciatica 1,282 12.6 12.7 signal
73 Red Blood Cell Sedimentation Rate Increased 870 12.2 12.3 signal
74 Finger Deformity 361 11.5 11.5 signal
75 Systemic Lupus Erythematosus 2,595 11.3 11.5 signal
76 Type 2 Diabetes Mellitus 2,451 11.2 11.4 signal
77 Liver Injury 1,728 11.0 11.1 signal
78 Panniculitis 171 10.9 10.9 signal
79 Generalised Pustular Psoriasis 18 10.7 10.7 signal
80 Product Dose Omission 4,594 10.7 11.0 signal
81 Joint Dislocation 713 10.4 10.5 signal
82 Lupus-like Syndrome 609 10.4 10.4 signal
83 Obesity 1,020 9.8 9.8 signal
84 Walking Aid User 419 9.7 9.7 signal
85 Joint Ankylosis 36 9.6 9.6 signal
86 Foot Deformity 687 9.5 9.5 signal
87 Laryngitis 669 9.4 9.4 signal
88 Rheumatoid Nodule 170 9.3 9.3 signal
89 Impaired Healing 1,979 9.2 9.3 signal
90 Back Injury 638 9.0 9.0 signal
91 Contraindicated Product Administered 1,776 9.0 9.1 signal
92 Therapeutic Product Effect Decreased 2,613 9.0 9.1 signal
93 Product Label Confusion 336 8.8 8.8 signal
94 Lower Limb Fracture 1,049 8.3 8.4 signal
95 Spondylitis 195 8.1 8.1 signal
96 Arthropathy 2,979 8.1 8.2 signal
97 Breast Cancer Stage Ii 448 8.1 8.1 signal
98 Abdominal Discomfort 8,234 7.4 7.8 signal
99 Rheumatoid Lung 47 7.3 7.3 signal
100 Hip Arthroplasty 736 7.3 7.3 signal
101 Blood Cholesterol Increased 2,255 7.3 7.4 signal
102 Gait Inability 1,578 7.2 7.2 signal
103 Pulmonary Fibrosis 907 7.1 7.2 signal
104 C-reactive Protein Increased 1,724 7.1 7.2 signal
105 Hepatic Cirrhosis 847 6.8 6.8 signal
106 Rash Vesicular 218 6.8 6.8 signal
107 Frequent Bowel Movements 1,196 6.7 6.7 signal
108 Osteoarthritis 1,860 6.6 6.6 signal
109 Maternal Exposure Timing Unspecified 162 6.5 6.5 signal
110 Adverse Reaction 573 6.5 6.5 signal
111 Faeces Soft 312 6.5 6.5 signal
112 Prescribed Overdose 818 6.3 6.3 signal
113 Product Administration Interrupted 322 6.3 6.3 signal
114 Liver Function Test Increased 878 6.1 6.2 signal
115 Coeliac Disease 392 6.0 6.0 signal
116 Product Supply Issue 281 5.9 5.9 signal
117 Infusion Related Reaction 2,622 5.9 6.0 signal
118 Discomfort 2,406 5.9 6.0 signal
119 Blister 2,184 5.8 5.9 signal
120 Gastric Disorder 1,352 5.8 5.8 signal
121 Hepatic Enzyme Increased 2,619 5.7 5.8 signal
122 Diarrhoea 24,624 5.7 6.7 signal
123 Night Sweats 1,232 5.7 5.7 signal
124 Taste Disorder 764 5.7 5.7 signal
125 Joint Stiffness 994 5.6 5.7 signal
126 Adverse Drug Reaction 3,342 5.6 5.7 signal
127 Red Blood Cell Sedimentation Rate Abnormal 86 5.5 5.5 signal
128 Inflammation 1,895 5.5 5.5 signal
129 Oral Lichen Planus 18 5.4 5.4 signal
130 Mobility Decreased 2,579 5.3 5.4 signal
131 Knee Arthroplasty 741 5.3 5.3 signal
132 Inhibitory Drug Interaction 56 5.2 5.2 signal
133 Bone Cyst 33 5.2 5.2 signal
134 Lower Respiratory Tract Infection 1,556 5.1 5.1 signal
135 Upper Respiratory Tract Infection 1,581 5.1 5.1 signal
136 Gastrointestinal Disorder 3,003 5.0 5.1 signal
137 Prescribed Underdose 674 5.0 5.0 signal
138 Tongue Disorder 246 5.0 5.0 signal
139 Stomatitis 2,013 4.9 5.0 signal
140 Normal Newborn 180 4.9 4.9 signal
141 Wheezing 1,951 4.9 4.9 signal
142 Cutaneous Symptom 22 4.9 4.9 signal
143 Musculoskeletal Stiffness 2,859 4.8 4.9 signal
144 Spinal Fusion Surgery 131 4.8 4.8 signal
145 Drug Intolerance 3,041 4.7 4.7 signal
146 Skin Necrosis 164 4.7 4.7 signal
147 Treatment Failure 2,580 4.6 4.7 signal
148 Road Traffic Accident 1,312 4.6 4.7 signal
149 Ulcer Haemorrhage 202 4.4 4.4 signal
150 Infection Susceptibility Increased 65 4.4 4.4 signal
151 Rheumatoid Arthritis 3,346 4.4 4.4 signal
152 Joint Destruction 46 4.3 4.3 signal
153 Ear Infection 777 4.3 4.3 signal
154 Nail Psoriasis 18 4.3 4.3 signal
155 Injury 2,051 4.3 4.3 signal
156 Drug Tolerance 147 4.3 4.3 signal
157 Therapeutic Product Effect Incomplete 2,024 4.2 4.3 signal
158 Headache 17,913 4.2 4.7 signal
159 Sleep Disorder 1,975 4.2 4.2 signal
160 Joint Swelling 3,392 4.1 4.2 signal
161 Nausea 22,177 4.1 4.7 signal
162 Cutaneous T-cell Lymphoma 33 4.1 4.1 signal
163 Swelling 2,585 4.1 4.1 signal
164 Drug-induced Liver Injury 819 3.9 3.9 signal
165 Migraine 2,501 3.9 3.9 signal
166 Lung Disorder 1,273 3.8 3.8 signal
167 Ill-defined Disorder 1,574 3.8 3.8 signal
168 Dyspepsia 2,501 3.7 3.8 signal
169 Pregnancy 511 3.7 3.7 signal
170 General Symptom 189 3.7 3.7 signal
171 Congenital Anomaly 195 3.7 3.7 signal
172 General Physical Health Deterioration 2,871 3.7 3.7 signal
173 Epilepsy 760 3.7 3.7 signal
174 Loss Of Personal Independence In Daily Activities 1,184 3.7 3.7 signal
175 Muscle Swelling 23 3.7 3.7 signal
176 Liver Disorder 1,097 3.6 3.7 signal
177 Lichen Planus 57 3.6 3.6 signal
178 Depression 5,572 3.6 3.7 signal
179 Sinusitis 2,496 3.6 3.6 signal
180 Musculoskeletal Pain 1,276 3.5 3.6 signal
181 Disability 477 3.5 3.5 signal
182 Mycobacterium Tuberculosis Complex Test Positive 57 3.5 3.5 signal
183 Myositis 214 3.5 3.5 signal
184 Abdominal Pain Upper 4,896 3.5 3.6 signal
185 Erythrodermic Psoriasis 19 3.4 3.4 signal
186 Sinus Headache 137 3.4 3.4 signal
187 Oedema 1,224 3.3 3.3 signal
188 Latent Tuberculosis 47 3.3 3.3 signal
189 Delirium 772 3.3 3.3 signal
190 Granuloma 76 3.2 3.2 signal
191 Eye Injury 66 3.2 3.2 signal
192 Back Disorder 357 3.2 3.2 signal
193 Incorrect Route Of Product Administration 367 3.2 3.2 signal
194 Dry Mouth 1,707 3.1 3.1 signal
195 Skin Plaque 176 3.1 3.1 signal
196 Therapeutic Response Decreased 1,250 3.0 3.0 signal
197 Maternal Exposure During Pregnancy 1,824 3.0 3.0 signal
198 Multiple Allergies 162 3.0 3.0 signal
199 Infection 2,970 3.0 3.1 signal
200 Macule 57 3.0 3.0 signal
201 Tendonitis 312 2.9 2.9 signal
202 Arthritis 1,569 2.9 2.9 signal
203 Ear Pain 385 2.9 2.9 signal
204 Sleep Disorder Due To A General Medical Condition 315 2.8 2.8 signal
205 Osteoporosis 791 2.8 2.8 signal
206 Gastrooesophageal Reflux Disease 1,514 2.8 2.8 signal
207 Hypoaesthesia 2,757 2.7 2.7 signal
208 Nasopharyngitis 3,353 2.6 2.7 signal
209 Respiratory Disorder 544 2.6 2.6 signal
210 Weight Decreased 5,046 2.6 2.7 signal
211 Peripheral Swelling 2,737 2.6 2.6 signal
212 Sacroiliitis 33 2.5 2.5 signal
213 Product Dose Omission Issue 4,885 2.5 2.6 signal
214 Intentional Product Use Issue 1,505 2.5 2.5 signal
215 Osteolysis 35 2.5 2.5 signal
216 Seborrhoeic Keratosis 25 2.5 2.5 signal
217 Decreased Appetite 3,896 2.4 2.5 signal
218 Alopecia 3,310 2.4 2.5 signal
219 Bowel Movement Irregularity 126 2.4 2.4 signal
220 Depression Suicidal 57 2.4 2.4 signal
221 Hepatic Fibrosis 56 2.4 2.4 signal
222 Pruritus Allergic 19 2.4 2.4 signal
223 Coccidioidomycosis 19 2.3 2.3 signal
224 Fear Of Injection 111 2.3 2.3 signal
225 Hypersensitivity 2,947 2.3 2.3 signal
226 Dandruff 35 2.3 2.3 signal
227 Skin Injury 52 2.3 2.3 signal
228 Adverse Event 1,450 2.3 2.3 signal
229 Rash 6,776 2.3 2.3 signal
230 Contusion 1,501 2.3 2.3 signal
231 Arthralgia 6,436 2.3 2.3 signal
232 Memory Impairment 2,132 2.3 2.3 signal
233 Neck Pain 862 2.2 2.2 signal
234 Exposure During Pregnancy 953 2.2 2.2 signal
235 Joint Arthroplasty 27 2.2 2.2 signal
236 Drug Dose Omission 2,500 2.2 2.2 signal
237 Ulcer 237 2.2 2.2 signal
238 Urticaria 2,473 2.2 2.2 signal
239 Hypercalcaemia 183 2.2 2.2 signal
240 Hypertension 3,141 2.2 2.2 signal
241 Mood Altered 402 2.1 2.2 signal
242 Neoplasm Skin 23 2.1 2.1 signal
243 Basal Cell Carcinoma 230 2.1 2.1 signal
244 Hepatitis 376 2.1 2.1 signal
245 Depressive Symptom 51 2.1 2.1 signal
246 Therapy Interrupted 1,000 2.1 2.1 signal
247 Vomiting 6,555 2.0 2.1 signal
248 Glucose Tolerance Impaired 82 2.0 2.0 signal
249 Drug Effect Decreased 760 2.0 2.0 signal
250 Therapy Partial Responder 209 2.0 2.0 signal
251 Epigastric Discomfort 54 2.0 2.0 no signal
252 Stress 983 2.0 2.0 no signal
253 Onycholysis 21 2.0 2.0 no signal
254 Sensitivity To Weather Change 70 1.9 1.9 no signal
255 Polyarthritis 70 1.9 1.9 no signal
256 Amnesia 862 1.9 1.9 no signal
257 Viral Upper Respiratory Tract Infection 63 1.9 1.9 no signal
258 Drug Hypersensitivity 2,530 1.9 1.9 no signal
259 Bronchitis 967 1.9 1.9 no signal
260 Skin Disorder 425 1.9 1.9 no signal
261 Defaecation Urgency 89 1.9 1.9 no signal
262 Condition Aggravated 3,843 1.8 1.9 no signal
263 Colonoscopy 28 1.8 1.8 no signal
264 Insomnia 3,363 1.8 1.8 no signal
265 Inflammatory Bowel Disease 124 1.8 1.8 no signal
266 Unevaluable Event 953 1.8 1.8 no signal
267 Skin Haemorrhage 180 1.8 1.8 no signal
268 Uterine Disorder 29 1.8 1.8 no signal
269 Muscle Spasms 2,261 1.8 1.8 no signal
270 Confusional State 1,982 1.8 1.8 no signal
271 Skin Fissures 231 1.8 1.8 no signal
272 Complex Regional Pain Syndrome 18 1.8 1.8 no signal
273 Gastroenteritis Viral 219 1.8 1.8 no signal
274 Papule 84 1.8 1.8 no signal
275 Drug Eruption 210 1.7 1.7 no signal
276 Hypertransaminasaemia 81 1.7 1.7 no signal
277 Drug Ineffective 15,565 1.7 1.8 no signal
278 Contraindication To Medical Treatment 18 1.7 1.7 no signal
279 No Therapeutic Response 145 1.7 1.7 no signal
280 Rash Pruritic 627 1.7 1.7 no signal
281 Infectious Mononucleosis 26 1.7 1.7 no signal
282 Asthma 1,290 1.7 1.7 no signal
283 Pruritus 4,331 1.7 1.7 no signal
284 Pharyngitis Streptococcal 123 1.6 1.6 no signal
285 Musculoskeletal Disorder 217 1.6 1.6 no signal
286 Skin Atrophy 65 1.6 1.6 no signal
287 Upper Respiratory Tract Congestion 33 1.6 1.6 no signal
288 Flatulence 639 1.6 1.6 no signal
289 Dermatitis Psoriasiform 23 1.6 1.6 no signal
290 Pain 6,927 1.6 1.7 no signal
291 Weight Fluctuation 117 1.6 1.6 no signal
292 Muscular Weakness 1,268 1.6 1.6 no signal
293 Exposure To Sars-cov-2 19 1.6 1.6 no signal
294 Suspected Off Label Use 19 1.6 1.6 no signal
295 Paranasal Sinus Discomfort 41 1.6 1.6 no signal
296 Respiratory Tract Infection 281 1.6 1.6 no signal
297 Drug Effect Less Than Expected 150 1.5 1.5 no signal
298 Skin Ulcer 274 1.5 1.5 no signal
299 Malaise 4,645 1.5 1.5 no signal
300 Sinus Disorder 208 1.5 1.5 no signal
301 Immune System Disorder 137 1.5 1.5 no signal
302 Drug Effect Incomplete 381 1.5 1.5 no signal
303 Weight Increased 2,286 1.5 1.5 no signal
304 Abdominal Distension 1,066 1.5 1.5 no signal
305 Joint Lock 29 1.5 1.5 no signal
306 Squamous Cell Carcinoma Of Skin 61 1.5 1.5 no signal
307 Pain In Extremity 2,991 1.5 1.5 no signal
308 Respiratory Symptom 28 1.4 1.4 no signal
309 Affective Disorder 78 1.4 1.4 no signal
310 Motion Sickness 19 1.4 1.4 no signal
311 Joint Injury 211 1.4 1.4 no signal
312 Skin Discomfort 26 1.4 1.4 no signal
313 Shoulder Operation 41 1.4 1.4 no signal
314 Therapy Cessation 488 1.4 1.4 no signal
315 Seasonal Allergy 134 1.4 1.4 no signal
316 Skin Papilloma 38 1.4 1.4 no signal
317 Gastrointestinal Pain 103 1.4 1.4 no signal
318 Red Cell Distribution Width Increased 39 1.4 1.4 no signal
319 Onychoclasis 64 1.3 1.3 no signal
320 Ear Congestion 25 1.3 1.3 no signal
321 Product Use Issue 1,722 1.3 1.3 no signal
322 Gout 165 1.3 1.3 no signal
323 Negative Thoughts 27 1.3 1.3 no signal
324 Inflammatory Marker Increased 45 1.3 1.3 no signal
325 Rhinorrhoea 573 1.3 1.3 no signal
326 Actinic Keratosis 23 1.3 1.3 no signal
327 Vomiting Projectile 25 1.3 1.3 no signal
328 Spinal Disorder 83 1.3 1.3 no signal
329 Lyme Disease 29 1.3 1.3 no signal
330 Influenza 971 1.3 1.3 no signal
331 Vitiligo 20 1.3 1.3 no signal
332 Middle Ear Effusion 19 1.2 1.2 no signal
333 Pigmentation Disorder 53 1.2 1.2 no signal
334 Localised Infection 208 1.2 1.2 no signal
335 Spinal Operation 104 1.2 1.2 no signal
336 Skin Lesion 233 1.2 1.2 no signal
337 Mood Swings 271 1.2 1.2 no signal
338 Nasal Congestion 496 1.2 1.2 no signal
339 Diverticulitis 234 1.2 1.2 no signal
340 Food Poisoning 45 1.2 1.2 no signal
341 Therapeutic Product Effect Delayed 38 1.2 1.2 no signal
342 Gastrointestinal Infection 75 1.2 1.2 no signal
343 Intentional Product Misuse 729 1.2 1.2 no signal
344 Exfoliative Rash 22 1.2 1.2 no signal
345 Gastrointestinal Sounds Abnormal 41 1.2 1.2 no signal
346 Fine Motor Skill Dysfunction 24 1.2 1.2 no signal
347 Chest Pain 1,545 1.2 1.2 no signal
348 Immunosuppression 72 1.2 1.2 no signal
349 Pustule 19 1.2 1.2 no signal
350 Rash Macular 287 1.2 1.2 no signal
351 Paraesthesia 1,298 1.2 1.2 no signal
352 Gallbladder Disorder 147 1.2 1.2 no signal
353 Nephrolithiasis 373 1.2 1.2 no signal
354 Tooth Abscess 83 1.2 1.2 no signal
355 Hernia Repair 21 1.2 1.2 no signal
356 Meniscus Injury 50 1.2 1.2 no signal
357 Feeling Jittery 154 1.2 1.2 no signal
358 Pneumonia 2,605 1.2 1.2 no signal
359 Fatigue 6,225 1.2 1.2 no signal
360 Abdominal Pain 1,861 1.2 1.2 no signal
361 Depressed Mood 421 1.2 1.2 no signal
362 Poor Quality Sleep 171 1.2 1.2 no signal
363 Arthropod Bite 58 1.1 1.1 no signal
364 Sinus Congestion 106 1.1 1.1 no signal
365 Cellulitis 394 1.1 1.1 no signal
366 Joint Effusion 54 1.1 1.1 no signal
367 Purpura 68 1.1 1.1 no signal
368 Laboratory Test Abnormal 225 1.1 1.1 no signal
369 Arthritis Bacterial 31 1.1 1.1 no signal
370 Scab 86 1.1 1.1 no signal
371 Dermatitis Exfoliative Generalised 26 1.1 1.1 no signal
372 Foot Operation 37 1.1 1.1 no signal
373 Symptom Recurrence 44 1.1 1.1 no signal
374 Intracranial Aneurysm 30 1.1 1.1 no signal
375 Immunodeficiency 109 1.1 1.1 no signal
376 Malignant Melanoma 99 1.1 1.1 no signal
377 Streptococcal Infection 41 1.1 1.1 no signal
378 Oedema Peripheral 895 1.1 1.1 no signal
379 Gait Disturbance 1,395 1.0 1.0 no signal
380 Skin Infection 81 1.0 1.0 no signal
381 Anxiety 2,067 1.0 1.0 no signal
382 Suicidal Ideation 663 1.0 1.0 no signal
383 Upper-airway Cough Syndrome 59 1.0 1.0 no signal
384 Muscle Strain 62 1.0 1.0 no signal
385 Muscle Spasticity 89 1.0 1.0 no signal
386 Impaired Quality Of Life 103 1.0 1.0 no signal
387 Blood Pressure Systolic Increased 140 1.0 1.0 no signal
388 Skin Hypertrophy 20 1.0 1.0 no signal
389 Rosacea 33 1.0 1.0 no signal
390 Arthritis Infective 33 1.0 1.0 no signal
391 Oral Disorder 52 1.0 1.0 no signal
392 Injection Site Reaction 485 1.0 1.0 no signal
393 Tooth Infection 93 1.0 1.0 no signal
394 Respiratory Tract Congestion 112 1.0 1.0 no signal
395 B-cell Lymphoma 24 1.0 1.0 no signal
396 Tuberculosis 90 1.0 1.0 no signal
397 Varices Oesophageal 21 1.0 1.0 no signal
398 Product Use In Unapproved Indication 1,699 1.0 1.0 no signal
399 Dizziness 3,461 1.0 1.0 no signal
400 Functional Gastrointestinal Disorder 24 1.0 1.0 no signal
401 Rectal Haemorrhage 298 1.0 1.0 no signal
402 Intentional Dose Omission 189 1.0 1.0 no signal
403 Knee Operation 67 1.0 1.0 no signal
404 Synovial Cyst 32 1.0 1.0 no signal
405 Furuncle 54 1.0 1.0 no signal
406 Skin Exfoliation 567 1.0 1.0 no signal
407 Retching 145 1.0 1.0 no signal
408 Gastric Infection 26 1.0 1.0 no signal
409 Hepatic Steatosis 126 1.0 1.0 no signal
410 Visual Impairment 833 1.0 1.0 no signal
411 Intestinal Haemorrhage 38 1.0 1.0 no signal
412 Herpes Zoster 387 1.0 1.0 no signal
413 Sars-cov-2 Test Positive 88 0.9 0.9 no signal
414 Generalised Erythema 38 0.9 0.9 no signal
415 Tendon Disorder 43 0.9 0.9 no signal
416 Medication Error 365 0.9 0.9 no signal
417 Back Pain 1,516 0.9 0.9 no signal
418 White Blood Cell Count Increased 250 0.9 0.9 no signal
419 Rash Generalised 170 0.9 0.9 no signal
420 Neoplasm Malignant 429 0.9 0.9 no signal
421 Skin Discolouration 294 0.9 0.9 no signal
422 Skin Reaction 90 0.9 0.9 no signal
423 Melanocytic Naevus 28 0.9 0.9 no signal
424 Osteomyelitis 115 0.9 0.9 no signal
425 Pancreatitis 336 0.9 0.9 no signal
426 Skin Cancer 136 0.9 0.9 no signal
427 Decreased Interest 37 0.9 0.9 no signal
428 Squamous Cell Carcinoma 59 0.9 0.9 no signal
429 Foot Fracture 119 0.9 0.9 no signal
430 Ear Discomfort 64 0.9 0.9 no signal
431 Intervertebral Disc Degeneration 58 0.9 0.9 no signal
432 Tendon Pain 47 0.9 0.9 no signal
433 Covid-19 1,093 0.9 0.9 no signal
434 Oral Herpes 120 0.9 0.9 no signal
435 Varicose Vein 32 0.9 0.9 no signal
436 Spinal Pain 72 0.9 0.9 no signal
437 Incorrect Dosage Administered 30 0.9 0.9 no signal
438 Eructation 116 0.9 0.9 no signal
439 Off Label Use 5,291 0.9 0.9 no signal
440 Limb Operation 29 0.9 0.9 no signal
441 Concussion 47 0.9 0.9 no signal
442 Lymphoma 94 0.9 0.9 no signal
443 Faeces Discoloured 131 0.9 0.9 no signal
444 Asthenia 2,269 0.9 0.9 no signal
445 Concomitant Disease Aggravated 37 0.9 0.9 no signal
446 Overweight 32 0.9 0.9 no signal
447 Loss Of Therapeutic Response 18 0.9 0.9 no signal
448 Pyrexia 2,054 0.9 0.9 no signal
449 Feeling Hot 364 0.9 0.9 no signal
450 Cardiac Operation 50 0.8 0.8 no signal
451 Rash Pustular 43 0.8 0.8 no signal
452 Chronic Sinusitis 22 0.8 0.8 no signal
453 Uveitis 79 0.8 0.8 no signal
454 Parosmia 44 0.8 0.8 no signal
455 Hip Surgery 31 0.8 0.8 no signal
456 Kidney Infection 114 0.8 0.8 no signal
457 Fungal Infection 193 0.8 0.8 no signal
458 Urine Odour Abnormal 34 0.8 0.8 no signal
459 Colitis Microscopic 27 0.8 0.8 no signal
460 Breast Cancer Stage I 54 0.8 0.8 no signal
461 Paranasal Sinus Hypersecretion 22 0.8 0.8 no signal
462 Hordeolum 24 0.8 0.8 no signal
463 Ankylosing Spondylitis 74 0.8 0.8 no signal
464 Surgery 328 0.8 0.8 no signal
465 Illness 567 0.8 0.8 no signal
466 Ligament Rupture 25 0.8 0.8 no signal
467 Spinal Stenosis 23 0.8 0.8 no signal
468 Colitis Ulcerative 251 0.8 0.8 no signal
469 Head Discomfort 99 0.8 0.8 no signal
470 Feeding Disorder 112 0.8 0.8 no signal
471 Therapy Change 54 0.8 0.8 no signal
472 Hyperlipidaemia 67 0.8 0.8 no signal
473 Cushingoid 18 0.8 0.8 no signal
474 Coronavirus Infection 37 0.8 0.8 no signal
475 Pemphigoid 41 0.8 0.8 no signal
476 Decreased Immune Responsiveness 54 0.8 0.8 no signal
477 Antinuclear Antibody Positive 18 0.8 0.8 no signal
478 Fungal Skin Infection 22 0.8 0.8 no signal
479 Abnormal Faeces 45 0.8 0.8 no signal
480 Fluid Retention 277 0.8 0.8 no signal
481 Ear Disorder 25 0.8 0.8 no signal
482 Increased Tendency To Bruise 50 0.8 0.8 no signal
483 Trigger Finger 22 0.8 0.8 no signal
484 Carpal Tunnel Syndrome 76 0.8 0.8 no signal
485 Scratch 56 0.8 0.8 no signal
486 Chemotherapy 20 0.8 0.8 no signal
487 Underdose 393 0.8 0.8 no signal
488 Menstrual Disorder 44 0.8 0.8 no signal
489 Eye Infection 60 0.8 0.8 no signal
490 Upper Limb Fracture 107 0.8 0.8 no signal
491 Hernia 102 0.8 0.8 no signal
492 Impaired Work Ability 113 0.8 0.8 no signal
493 Cough 1,474 0.8 0.8 no signal
494 Tenderness 55 0.8 0.8 no signal
495 Irritability 316 0.8 0.8 no signal
496 Gallbladder Operation 21 0.8 0.8 no signal
497 Aspartate Aminotransferase Increased 278 0.8 0.8 no signal
498 Energy Increased 31 0.8 0.8 no signal
499 Quality Of Life Decreased 70 0.7 0.7 no signal
500 Cyst 64 0.7 0.7 no signal
501 Tooth Disorder 115 0.7 0.7 no signal
502 Mouth Ulceration 108 0.7 0.7 no signal
503 Nail Discolouration 20 0.7 0.7 no signal
504 Limb Injury 138 0.7 0.7 no signal
505 Cystitis 162 0.7 0.7 no signal
506 Musculoskeletal Discomfort 87 0.7 0.7 no signal
507 Tachycardia 447 0.7 0.7 no signal
508 Renal Pain 53 0.7 0.7 no signal
509 Thyroid Mass 19 0.7 0.7 no signal
510 Muscle Fatigue 21 0.7 0.7 no signal
511 Pain Of Skin 133 0.7 0.7 no signal
512 Rehabilitation Therapy 19 0.7 0.7 no signal
513 Major Depression 36 0.7 0.7 no signal
514 Cardiac Valve Disease 28 0.7 0.7 no signal
515 Mass 68 0.7 0.7 no signal
516 Ankle Fracture 75 0.7 0.7 no signal
517 Product Quality Issue 652 0.7 0.7 no signal
518 Crying 176 0.7 0.7 no signal
519 Photosensitivity Reaction 79 0.7 0.7 no signal
520 Feeling Abnormal 1,146 0.7 0.7 no signal
521 Colon Cancer 71 0.7 0.7 no signal
522 Alanine Aminotransferase Increased 290 0.7 0.7 no signal
523 Productive Cough 223 0.7 0.7 no signal
524 Diarrhoea Haemorrhagic 44 0.7 0.7 no signal
525 Abnormal Dreams 130 0.7 0.7 no signal
526 Sneezing 104 0.7 0.7 no signal
527 Skin Irritation 213 0.7 0.7 no signal
528 Influenza Like Illness 381 0.7 0.7 no signal
529 Appetite Disorder 30 0.7 0.7 no signal
530 Thyroid Disorder 71 0.7 0.7 no signal
531 Oropharyngeal Pain 425 0.7 0.7 no signal
532 Limb Discomfort 142 0.7 0.7 no signal
533 Brain Neoplasm 42 0.7 0.7 no signal
534 Ligament Sprain 45 0.7 0.7 no signal
535 Spinal Osteoarthritis 40 0.7 0.7 no signal
536 Renal Disorder 211 0.6 0.6 no signal
537 Palpitations 526 0.6 0.6 no signal
538 Neuralgia 109 0.6 0.6 no signal
539 Dermatitis 93 0.6 0.6 no signal
540 Secretion Discharge 55 0.6 0.6 no signal
541 Anger 151 0.6 0.6 no signal
542 Skin Laceration 48 0.6 0.6 no signal
543 Sluggishness 45 0.6 0.6 no signal
544 Sunburn 33 0.6 0.6 no signal
545 Rotator Cuff Syndrome 57 0.6 0.6 no signal
546 Burning Sensation 310 0.6 0.6 no signal
547 Hepatic Enzyme Abnormal 22 0.6 0.6 no signal
548 Staphylococcal Infection 144 0.6 0.6 no signal
549 Dyspnoea 2,458 0.6 0.6 no signal
550 Nerve Compression 40 0.6 0.6 no signal
551 Incorrect Product Administration Duration 88 0.6 0.6 no signal
552 Dermatitis Allergic 54 0.6 0.6 no signal
553 Rash Erythematous 202 0.6 0.6 no signal
554 Urinary Tract Infection 733 0.6 0.6 no signal
555 Oral Candidiasis 56 0.6 0.6 no signal
556 Erythema 877 0.6 0.6 no signal
557 Viral Infection 142 0.6 0.6 no signal
558 Drug Ineffective For Unapproved Indication 238 0.6 0.6 no signal
559 Panic Attack 154 0.6 0.6 no signal
560 Pollakiuria 175 0.6 0.6 no signal
561 Toothache 76 0.6 0.6 no signal
562 Accident 50 0.6 0.6 no signal
563 Myalgia 713 0.6 0.6 no signal
564 Adrenal Insufficiency 50 0.6 0.6 no signal
565 Nervousness 219 0.6 0.6 no signal
566 Dry Skin 546 0.6 0.6 no signal
567 Gastrointestinal Motility Disorder 22 0.6 0.6 no signal
568 Product Prescribing Error 98 0.6 0.6 no signal
569 Blood Test Abnormal 58 0.6 0.6 no signal
570 Covid-19 Pneumonia 49 0.6 0.6 no signal
571 Initial Insomnia 42 0.6 0.6 no signal
572 Pyelonephritis 35 0.6 0.6 no signal
573 Hospitalisation 617 0.6 0.6 no signal
574 Bipolar Disorder 44 0.6 0.6 no signal
575 Intervertebral Disc Protrusion 88 0.6 0.6 no signal
576 Hepatitis C 49 0.6 0.6 no signal
577 Pulmonary Congestion 53 0.6 0.6 no signal
578 Tremor 664 0.6 0.6 no signal
579 Hyperkeratosis 22 0.6 0.6 no signal
580 Hand Fracture 28 0.6 0.6 no signal
581 Gastric Ulcer 75 0.6 0.6 no signal
582 Myasthenia Gravis 31 0.6 0.6 no signal
583 Leukaemia 37 0.6 0.6 no signal
584 Wrist Fracture 47 0.6 0.6 no signal
585 Feeling Of Body Temperature Change 23 0.6 0.6 no signal
586 Pain In Jaw 111 0.6 0.6 no signal
587 Skin Mass 26 0.6 0.6 no signal
588 Facial Paralysis 33 0.6 0.6 no signal
589 Tendon Rupture 48 0.6 0.6 no signal
590 Eczema 195 0.6 0.6 no signal
591 Dermatitis Contact 44 0.6 0.6 no signal
592 Musculoskeletal Chest Pain 60 0.6 0.6 no signal
593 Cholecystectomy 44 0.6 0.6 no signal
594 Feeling Of Despair 18 0.6 0.6 no signal
595 Gastrointestinal Inflammation 30 0.6 0.6 no signal
596 Diabetes Mellitus 295 0.6 0.6 no signal
597 Blood Iron Decreased 45 0.5 0.5 no signal
598 Heart Rate Increased 375 0.5 0.5 no signal
599 Cardiac Disorder 354 0.5 0.5 no signal
600 Bacterial Infection 70 0.5 0.5 no signal
601 Fall 1,252 0.5 0.5 no signal
602 Autoimmune Hepatitis 26 0.5 0.5 no signal
603 Nodule 49 0.5 0.5 no signal
604 Oral Pain 84 0.5 0.5 no signal
605 Pelvic Fracture 29 0.5 0.5 no signal
606 Disease Recurrence 178 0.5 0.5 no signal
607 Lymphadenopathy 132 0.5 0.5 no signal
608 Rhinitis 30 0.5 0.5 no signal
609 Bladder Disorder 37 0.5 0.5 no signal
610 Treatment Noncompliance 202 0.5 0.5 no signal
611 Hyperchlorhydria 22 0.5 0.5 no signal
612 Post Procedural Infection 30 0.5 0.5 no signal
613 Pruritus Generalised 81 0.5 0.5 no signal
614 Nightmare 128 0.5 0.5 no signal
615 Hidradenitis 32 0.5 0.5 no signal
616 Haemorrhoidal Haemorrhage 18 0.5 0.5 no signal
617 Conjunctivitis 67 0.5 0.5 no signal
618 Deafness Unilateral 20 0.5 0.5 no signal
619 Cataract 215 0.5 0.5 no signal
620 Nephropathy 34 0.5 0.5 no signal
621 Frustration Tolerance Decreased 29 0.5 0.5 no signal
622 Blood Pressure Increased 551 0.5 0.5 no signal
623 Hysterectomy 31 0.5 0.5 no signal
624 Haemorrhoids 70 0.5 0.5 no signal
625 Gastritis 93 0.5 0.5 no signal
626 Nonspecific Reaction 19 0.5 0.5 no signal
627 Tinnitus 162 0.5 0.5 no signal
628 Aphthous Ulcer 27 0.5 0.5 no signal
629 Rash Papular 79 0.5 0.5 no signal
630 Respiration Abnormal 24 0.5 0.5 no signal
631 Polyp 23 0.5 0.5 no signal
632 Haematochezia 193 0.5 0.5 no signal
633 Dysstasia 102 0.5 0.5 no signal
634 Lymphoedema 24 0.5 0.5 no signal
635 Cold Sweat 61 0.5 0.5 no signal
636 Uterine Cancer 28 0.5 0.5 no signal
637 Appendicitis 32 0.5 0.5 no signal
638 Prostatic Disorder 19 0.5 0.5 no signal
639 Hypoacusis 147 0.5 0.5 no signal
640 Body Temperature Increased 70 0.5 0.5 no signal
641 Emotional Disorder 106 0.5 0.5 no signal
642 Lethargy 195 0.5 0.5 no signal
643 Vitamin D Deficiency 33 0.5 0.5 no signal
644 Vitamin D Decreased 29 0.5 0.5 no signal
645 Stent Placement 27 0.5 0.5 no signal
646 Dry Throat 34 0.5 0.5 no signal
647 Muscle Tightness 54 0.5 0.5 no signal
648 Muscle Disorder 27 0.5 0.5 no signal
649 Thinking Abnormal 62 0.5 0.5 no signal
650 Tension 20 0.5 0.5 no signal
651 Skin Hyperpigmentation 28 0.5 0.5 no signal
652 Low Density Lipoprotein Increased 25 0.5 0.5 no signal
653 Skin Burning Sensation 230 0.5 0.5 no signal
654 Sensation Of Foreign Body 27 0.5 0.5 no signal
655 Angiopathy 18 0.5 0.5 no signal
656 Cardiac Pacemaker Insertion 19 0.5 0.5 no signal
657 Breast Tenderness 24 0.5 0.5 no signal
658 Rib Fracture 65 0.5 0.5 no signal
659 Insurance Issue 47 0.5 0.5 no signal
660 Aphonia 44 0.5 0.5 no signal
661 Temperature Intolerance 32 0.4 0.4 no signal
662 Post-traumatic Stress Disorder 21 0.4 0.4 no signal
663 Herpes Virus Infection 18 0.4 0.4 no signal
664 Swelling Of Eyelid 19 0.4 0.4 no signal
665 Therapeutic Response Shortened 99 0.4 0.4 no signal
666 Photophobia 58 0.4 0.4 no signal
667 Bone Disorder 57 0.4 0.4 no signal
668 Apathy 45 0.4 0.4 no signal
669 Micturition Urgency 35 0.4 0.4 no signal
670 Hypersomnia 88 0.4 0.4 no signal
671 Bone Pain 180 0.4 0.4 no signal
672 Skin Swelling 26 0.4 0.4 no signal
673 Expired Product Administered 101 0.4 0.4 no signal
674 Blood Creatinine Increased 199 0.4 0.4 no signal
675 Cataract Operation 18 0.4 0.4 no signal
676 Vertigo 185 0.4 0.4 no signal
677 Hyperaesthesia 25 0.4 0.4 no signal
678 Middle Insomnia 56 0.4 0.4 no signal
679 Abdominal Pain Lower 76 0.4 0.4 no signal
680 Eating Disorder 64 0.4 0.4 no signal
681 Inappropriate Schedule Of Product Administration 529 0.4 0.4 no signal
682 Flank Pain 28 0.4 0.4 no signal
683 Sensory Loss 24 0.4 0.4 no signal
684 Hyperhidrosis 383 0.4 0.4 no signal
685 Hepatitis B 18 0.4 0.4 no signal
686 Spinal Fracture 59 0.4 0.4 no signal
687 Chronic Obstructive Pulmonary Disease 154 0.4 0.4 no signal
688 Lung Neoplasm Malignant 122 0.4 0.4 no signal
689 Mental Disorder 128 0.4 0.4 no signal
690 Laceration 28 0.4 0.4 no signal
691 Cardiac Flutter 19 0.4 0.4 no signal
692 Facial Pain 26 0.4 0.4 no signal
693 Breast Pain 31 0.4 0.4 no signal
694 Hair Growth Abnormal 20 0.4 0.4 no signal
695 Nasal Discomfort 23 0.4 0.4 no signal
696 Constipation 623 0.4 0.4 no signal
697 Dysuria 106 0.4 0.4 no signal
698 Drug Effective For Unapproved Indication 84 0.4 0.4 no signal
699 Thirst 51 0.4 0.4 no signal
700 Intercepted Product Administration Error 22 0.4 0.4 no signal
701 Iron Deficiency Anaemia 26 0.4 0.4 no signal
702 Retinal Detachment 26 0.4 0.4 no signal
703 Blood Pressure Abnormal 56 0.4 0.4 no signal
704 Dysgeusia 211 0.4 0.4 no signal
705 Breast Mass 19 0.4 0.4 no signal
706 Renal Impairment 236 0.4 0.4 no signal
707 Ovarian Cancer 26 0.4 0.4 no signal
708 Herpes Simplex 18 0.4 0.4 no signal
709 Atrial Fibrillation 269 0.4 0.4 no signal
710 Eye Disorder 90 0.4 0.4 no signal
711 Formication 19 0.4 0.4 no signal
712 Hot Flush 205 0.4 0.4 no signal
713 Dysphonia 158 0.4 0.4 no signal
714 Dry Eye 131 0.4 0.4 no signal
715 Abscess 43 0.4 0.4 no signal
716 Therapeutic Response Unexpected 121 0.4 0.4 no signal
717 Blood Urine Present 51 0.4 0.4 no signal
718 Aspiration 29 0.4 0.4 no signal
719 Abnormal Loss Of Weight 18 0.4 0.4 no signal
720 Pharyngitis 33 0.4 0.4 no signal
721 Sputum Discoloured 25 0.4 0.4 no signal
722 Dehydration 352 0.4 0.4 no signal
723 Clostridium Difficile Colitis 28 0.4 0.4 no signal
724 Angina Pectoris 76 0.4 0.4 no signal
725 Clostridium Difficile Infection 57 0.4 0.4 no signal
726 Chest Discomfort 268 0.4 0.4 no signal
727 Groin Pain 23 0.4 0.4 no signal
728 Haematemesis 66 0.4 0.4 no signal
729 Product Distribution Issue 23 0.4 0.4 no signal
730 Cerebral Disorder 19 0.4 0.4 no signal
731 Oropharyngeal Discomfort 23 0.4 0.4 no signal
732 Pulmonary Mass 38 0.4 0.4 no signal
733 Lung Infection 40 0.4 0.4 no signal
734 Fracture 48 0.4 0.4 no signal
735 Food Allergy 19 0.4 0.4 no signal
736 Gingival Pain 20 0.4 0.4 no signal
737 Increased Appetite 47 0.4 0.4 no signal
738 Chills 293 0.4 0.4 no signal
739 Hypophagia 63 0.4 0.4 no signal
740 Restless Legs Syndrome 45 0.4 0.4 no signal
741 Hiatus Hernia 32 0.4 0.4 no signal
742 Movement Disorder 79 0.4 0.4 no signal
743 Chromaturia 55 0.3 0.3 no signal
744 Eye Swelling 90 0.3 0.3 no signal
745 Breast Cancer 228 0.3 0.3 no signal
746 Nerve Injury 27 0.3 0.3 no signal
747 Transient Ischaemic Attack 82 0.3 0.3 no signal
748 Menorrhagia 48 0.3 0.3 no signal
749 Vasculitis 28 0.3 0.3 no signal
750 Candida Infection 40 0.3 0.3 no signal
751 Product Dispensing Error 52 0.3 0.3 no signal
752 Colitis 90 0.3 0.3 no signal
753 Glaucoma 46 0.3 0.3 no signal
754 Muscle Atrophy 30 0.3 0.3 no signal
755 Cholelithiasis 78 0.3 0.3 no signal
756 Blood Glucose Abnormal 44 0.3 0.3 no signal
757 Throat Irritation 106 0.3 0.3 no signal
758 Face Oedema 40 0.3 0.3 no signal
759 Internal Haemorrhage 27 0.3 0.3 no signal
760 Arteriosclerosis 22 0.3 0.3 no signal
761 Ageusia 58 0.3 0.3 no signal
762 Thyroid Cancer 28 0.3 0.3 no signal
763 Respiratory Syncytial Virus Infection 20 0.3 0.3 no signal
764 Incorrect Dose Administered 519 0.3 0.3 no signal
765 Leukopenia 115 0.3 0.3 no signal
766 Osteopenia 35 0.3 0.3 no signal
767 Foetal Exposure During Pregnancy 186 0.3 0.3 no signal
768 Heart Rate Irregular 52 0.3 0.3 no signal
769 Lip Swelling 76 0.3 0.3 no signal
770 Bedridden 30 0.3 0.3 no signal
771 Arterial Occlusive Disease 18 0.3 0.3 no signal
772 Swelling Face 148 0.3 0.3 no signal
773 Neoplasm 26 0.3 0.3 no signal
774 Hip Fracture 72 0.3 0.3 no signal
775 Circumstance Or Information Capable Of Leading To Medication Error 74 0.3 0.3 no signal
776 Salivary Hypersecretion 22 0.3 0.3 no signal
777 Impaired Gastric Emptying 28 0.3 0.3 no signal
778 Pneumonia Bacterial 20 0.3 0.3 no signal
779 Tooth Fracture 24 0.3 0.3 no signal
780 Sensory Disturbance 35 0.3 0.3 no signal
781 Bone Density Decreased 68 0.3 0.3 no signal
782 Dermatitis Atopic 107 0.3 0.3 no signal
783 Pharyngeal Oedema 33 0.3 0.3 no signal
784 Cerebrovascular Accident 359 0.3 0.3 no signal
785 Lacrimation Increased 63 0.3 0.3 no signal
786 Pulmonary Thrombosis 23 0.3 0.3 no signal
787 Acne 160 0.3 0.3 no signal
788 Eye Haemorrhage 28 0.3 0.3 no signal
789 Pharyngeal Swelling 20 0.3 0.3 no signal
790 Tooth Extraction 26 0.3 0.3 no signal
791 Myocardial Infarction 366 0.3 0.3 no signal
792 Gastroenteritis 30 0.3 0.3 no signal
793 Blood Pressure Decreased 135 0.3 0.3 no signal
794 Hepatomegaly 20 0.3 0.3 no signal
795 Sepsis 226 0.3 0.3 no signal
796 Hypoaesthesia Oral 30 0.3 0.3 no signal
797 Anaphylactic Shock 51 0.3 0.3 no signal
798 Epistaxis 148 0.3 0.3 no signal
799 Haemoptysis 55 0.3 0.3 no signal
800 Neutrophil Count Increased 20 0.3 0.3 no signal
801 Ocular Discomfort 21 0.3 0.3 no signal
802 Personality Change 18 0.3 0.3 no signal
803 Swollen Tongue 60 0.3 0.3 no signal
804 Blood Glucose Decreased 91 0.3 0.3 no signal
805 Deafness 49 0.3 0.3 no signal
806 Disturbance In Attention 101 0.3 0.3 no signal
807 Dementia 52 0.3 0.3 no signal
808 Blood Triglycerides Increased 33 0.3 0.3 no signal
809 Blood Potassium Decreased 56 0.3 0.3 no signal
810 Eye Discharge 19 0.3 0.3 no signal
811 Body Height Decreased 20 0.3 0.3 no signal
812 Cardiac Failure Congestive 150 0.3 0.3 no signal
813 Mucosal Inflammation 48 0.3 0.3 no signal
814 Head Injury 58 0.3 0.3 no signal
815 Death 1,577 0.3 0.3 no signal
816 Pneumothorax 29 0.3 0.3 no signal
817 Glycosylated Haemoglobin Increased 46 0.3 0.3 no signal
818 Somnolence 362 0.3 0.3 no signal
819 Angioedema 79 0.3 0.3 no signal
820 Brain Fog 26 0.3 0.3 no signal
821 Motor Dysfunction 18 0.3 0.3 no signal
822 Thrombosis 143 0.3 0.3 no signal
823 Cholecystitis 21 0.3 0.3 no signal
824 Feeling Cold 49 0.3 0.3 no signal
825 Gingival Bleeding 24 0.3 0.3 no signal
826 Neuropathy Peripheral 165 0.3 0.2 no signal
827 Dysphagia 165 0.2 0.2 no signal
828 Peripheral Coldness 24 0.2 0.2 no signal
829 Glomerular Filtration Rate Decreased 21 0.2 0.2 no signal
830 Multiple Sclerosis 83 0.2 0.2 no signal
831 Sleep Apnoea Syndrome 33 0.2 0.2 no signal
832 Transaminases Increased 38 0.2 0.2 no signal
833 Generalised Oedema 21 0.2 0.2 no signal
834 Scar 29 0.2 0.2 no signal
835 Emphysema 17 0.2 0.2 no signal
836 Thrombocytopenia 187 0.2 0.2 no signal
837 Hypothyroidism 53 0.2 0.2 no signal
838 Blood Pressure Fluctuation 40 0.2 0.2 no signal
839 Nocturia 20 0.2 0.2 no signal
840 Poor Venous Access 17 0.2 0.2 no signal
841 Hunger 22 0.2 0.2 no signal
842 Dental Caries 18 0.2 0.2 no signal
843 Arrhythmia 77 0.2 0.2 no signal
844 Presyncope 39 0.2 0.2 no signal
845 Erythema Multiforme 15 0.2 0.2 no signal
846 Brain Injury 16 0.2 0.2 no signal
847 Abortion Spontaneous 64 0.2 0.2 no signal
848 Eye Inflammation 15 0.2 0.2 no signal
849 Hyperthyroidism 23 0.2 0.2 no signal
850 Full Blood Count Decreased 32 0.2 0.2 no signal
851 Ocular Hyperaemia 74 0.2 0.2 no signal
852 Loss Of Consciousness 203 0.2 0.2 no signal
853 Oral Discomfort 22 0.2 0.2 no signal
854 Prostate Cancer 128 0.2 0.2 no signal
855 Agitation 116 0.2 0.2 no signal
856 Seizure 180 0.2 0.2 no signal
857 Dizziness Postural 15 0.2 0.2 no signal
858 Overdose 338 0.2 0.2 no signal
859 Post Procedural Complication 30 0.2 0.2 no signal
860 Intraocular Pressure Increased 20 0.2 0.2 no signal
861 Affect Lability 15 0.2 0.2 no signal
862 Libido Decreased 19 0.2 0.2 no signal
863 Accidental Overdose 56 0.2 0.2 no signal
864 Paralysis 22 0.2 0.2 no signal
865 Haemorrhage 160 0.2 0.2 no signal
866 Malnutrition 17 0.2 0.2 no signal
867 Bacteraemia 18 0.2 0.2 no signal
868 Product Dose Omission In Error 41 0.2 0.2 no signal
869 Inappropriate Schedule Of Drug Administration 110 0.2 0.2 no signal
870 Blindness 62 0.2 0.2 no signal
871 Cardiac Failure 122 0.2 0.2 no signal
872 Blood Glucose Increased 287 0.2 0.2 no signal
873 Psychomotor Hyperactivity 25 0.2 0.2 no signal
874 Blood Potassium Increased 24 0.2 0.2 no signal
875 Heart Rate Decreased 52 0.2 0.2 no signal
876 Menstruation Irregular 39 0.2 0.2 no signal
877 Supraventricular Tachycardia 14 0.2 0.2 no signal
878 Renal Failure 195 0.2 0.2 no signal
879 Injection Site Discomfort 15 0.2 0.2 no signal
880 Femur Fracture 45 0.2 0.2 no signal
881 Restlessness 53 0.2 0.2 no signal
882 Paranoia 25 0.2 0.2 no signal
883 Vitreous Floaters 14 0.2 0.2 no signal
884 Device Related Infection 22 0.2 0.2 no signal
885 Blindness Unilateral 20 0.2 0.2 no signal
886 Throat Tightness 38 0.2 0.2 no signal
887 Intestinal Obstruction 52 0.2 0.2 no signal
888 Disorientation 55 0.2 0.2 no signal
889 Anosmia 20 0.2 0.2 no signal
890 Extra Dose Administered 55 0.2 0.2 no signal
891 Syncope 138 0.2 0.2 no signal
892 Eye Pain 76 0.2 0.2 no signal
893 Product Prescribing Issue 28 0.2 0.2 no signal
894 Nervous System Disorder 43 0.2 0.2 no signal
895 Blood Glucose Fluctuation 15 0.2 0.2 no signal
896 Lymphopenia 19 0.2 0.2 no signal
897 Diplopia 35 0.2 0.2 no signal
898 Muscle Twitching 31 0.2 0.2 no signal
899 Eye Pruritus 44 0.2 0.2 no signal
900 Dyspnoea Exertional 50 0.2 0.2 no signal
901 Blood Sodium Decreased 25 0.2 0.2 no signal
902 Balance Disorder 115 0.2 0.2 no signal
903 Incontinence 14 0.2 0.2 no signal
904 Coronary Artery Occlusion 18 0.2 0.2 no signal
905 Urosepsis 12 0.2 0.2 no signal
906 Gastric Haemorrhage 15 0.2 0.2 no signal
907 Product Packaging Issue 12 0.2 0.2 no signal
908 Deformity 12 0.2 0.2 no signal
909 Liver Function Test Abnormal 37 0.2 0.2 no signal
910 Bronchospasm 18 0.2 0.2 no signal
911 Intestinal Perforation 14 0.2 0.2 no signal
912 Activities Of Daily Living Impaired 25 0.2 0.2 no signal
913 Vision Blurred 170 0.2 0.2 no signal
914 Interstitial Lung Disease 60 0.2 0.2 no signal
915 Hypokinesia 18 0.2 0.2 no signal
916 Rebound Effect 14 0.2 0.2 no signal
917 Prostatic Specific Antigen Increased 17 0.2 0.2 no signal
918 Gastrointestinal Haemorrhage 103 0.2 0.2 no signal
919 Dysmenorrhoea 16 0.2 0.2 no signal
920 Vaginal Haemorrhage 52 0.2 0.2 no signal
921 Hospice Care 12 0.2 0.2 no signal
922 Product Storage Error 103 0.2 0.2 no signal
923 Wrong Technique In Product Usage Process 236 0.2 0.2 no signal
924 Hypertensive Crisis 13 0.2 0.2 no signal
925 Fistula 13 0.2 0.2 no signal
926 Ileus 14 0.2 0.2 no signal
927 Suicide Attempt 69 0.2 0.2 no signal
928 Hypokalaemia 52 0.2 0.2 no signal
929 Anaphylactic Reaction 62 0.2 0.2 no signal
930 Cardiomegaly 14 0.2 0.2 no signal
931 Procedural Pain 31 0.2 0.2 no signal
932 Decreased Activity 12 0.2 0.2 no signal
933 Deep Vein Thrombosis 73 0.2 0.2 no signal
934 Breast Cancer Female 30 0.2 0.2 no signal
935 Paraesthesia Oral 16 0.2 0.2 no signal
936 Body Temperature Decreased 11 0.2 0.2 no signal
937 Bladder Cancer 66 0.2 0.2 no signal
938 Drug Administration Error 34 0.2 0.2 no signal
939 Acute Myeloid Leukaemia 17 0.2 0.2 no signal
940 Macular Degeneration 13 0.2 0.2 no signal
941 Hepatotoxicity 24 0.2 0.2 no signal
942 Coronary Artery Disease 33 0.2 0.2 no signal
943 Abasia 27 0.2 0.2 no signal
944 Pneumonitis 29 0.2 0.2 no signal
945 Hepatic Cancer 26 0.2 0.2 no signal
946 White Blood Cell Count Decreased 115 0.2 0.2 no signal
947 Ventricular Extrasystoles 11 0.2 0.2 no signal
948 Urinary Retention 35 0.2 0.2 no signal
949 Haematuria 36 0.2 0.2 no signal
950 Flushing 106 0.1 0.1 no signal
951 Hair Texture Abnormal 14 0.1 0.1 no signal
952 Product Use Complaint 16 0.1 0.1 no signal
953 Breast Cancer Metastatic 11 0.1 0.1 no signal
954 Eyelid Oedema 12 0.1 0.1 no signal
955 Madarosis 12 0.1 0.1 no signal
956 Septic Shock 44 0.1 0.1 no signal
957 Cardiovascular Disorder 26 0.1 0.1 no signal
958 Drug Resistance 26 0.1 0.1 no signal
959 Anaemia 193 0.1 0.1 no signal
960 Cerebral Haemorrhage 36 0.1 0.1 no signal
961 Oesophagitis 11 0.1 0.1 no signal
962 Hallucination 75 0.1 0.1 no signal
963 Pancreatic Carcinoma 29 0.1 0.1 no signal
964 Hepatic Failure 30 0.1 0.1 no signal
965 Speech Disorder 52 0.1 0.1 no signal
966 Toxic Skin Eruption 10 0.1 0.1 no signal
967 Mental Impairment 24 0.1 0.1 no signal
968 Choking 19 0.1 0.1 no signal
969 Red Blood Cell Count Decreased 28 0.1 0.1 no signal
970 Blood Calcium Decreased 11 0.1 0.1 no signal
971 Orthostatic Hypotension 17 0.1 0.1 no signal
972 Hepatic Function Abnormal 36 0.1 0.1 no signal
973 Erectile Dysfunction 25 0.1 0.1 no signal
974 Euphoric Mood 10 0.1 0.1 no signal
975 Pulmonary Oedema 43 0.1 0.1 no signal
976 Pulmonary Embolism 91 0.1 0.1 no signal
977 Poisoning 12 0.1 0.1 no signal
978 Rash Maculo-papular 21 0.1 0.1 no signal
979 Stevens-johnson Syndrome 21 0.1 0.1 no signal
980 Atelectasis 9 0.1 0.1 no signal
981 Disease Progression 109 0.1 0.1 no signal
982 Pallor 25 0.1 0.1 no signal
983 Dialysis 13 0.1 0.1 no signal
984 Injection Site Bruising 72 0.1 0.1 no signal
985 Acute Myocardial Infarction 27 0.1 0.1 no signal
986 Hypoglycaemia 44 0.1 0.1 no signal
987 Lymphocyte Count Decreased 16 0.1 0.1 no signal
988 Schizophrenia 11 0.1 0.1 no signal
989 Product Administration Error 18 0.1 0.1 no signal
990 Injection Site Extravasation 11 0.1 0.1 no signal
991 Psychotic Disorder 26 0.1 0.1 no signal
992 Eye Irritation 49 0.1 0.1 no signal
993 Aggression 44 0.1 0.1 no signal
994 Hair Colour Changes 11 0.1 0.1 no signal
995 Electrolyte Imbalance 10 0.1 0.1 no signal
996 Petechiae 9 0.1 0.1 no signal
997 Device Defective 14 0.1 0.1 no signal
998 Mental Status Changes 24 0.1 0.1 no signal
999 Sexual Dysfunction 10 0.1 0.1 no signal
1000 Tubulointerstitial Nephritis 16 0.1 0.1 no signal
1001 Haemoglobin Decreased 87 0.1 0.1 no signal
1002 Platelet Count Increased 11 0.1 0.1 no signal
1003 Cognitive Disorder 39 0.1 0.1 no signal
1004 Cytopenia 10 0.1 0.1 no signal
1005 Oesophageal Carcinoma 25 0.1 0.1 no signal
1006 Myelodysplastic Syndrome 12 0.1 0.1 no signal
1007 Withdrawal Syndrome 35 0.1 0.1 no signal
1008 Hypotension 166 0.1 0.1 no signal
1009 Injection Site Warmth 17 0.1 0.1 no signal
1010 Multiple Organ Dysfunction Syndrome 23 0.1 0.1 no signal
1011 Small Intestinal Obstruction 10 0.1 0.1 no signal
1012 Inability To Afford Medication 8 0.1 0.1 no signal
1013 Gamma-glutamyltransferase Increased 18 0.1 0.1 no signal
1014 Pancreatitis Acute 18 0.1 0.1 no signal
1015 Injection Site Discolouration 10 0.1 0.1 no signal
1016 Emotional Distress 97 0.1 0.1 no signal
1017 Ovarian Cyst 8 0.1 0.1 no signal
1018 Injection Site Irritation 10 0.1 0.1 no signal
1019 Pericardial Effusion 18 0.1 0.1 no signal
1020 Hyperglycaemia 28 0.1 0.1 no signal
1021 Haematoma 20 0.1 0.1 no signal
1022 Splenomegaly 9 0.1 0.1 no signal
1023 Tooth Loss 16 0.1 0.1 no signal
1024 Transfusion 8 0.1 0.1 no signal
1025 Full Blood Count Abnormal 8 0.1 0.1 no signal
1026 Product Availability Issue 17 0.1 0.1 no signal
1027 Polyneuropathy 9 0.1 0.1 no signal
1028 Complication Associated With Device 10 0.1 0.1 no signal
1029 No Adverse Event 133 0.1 0.1 no signal
1030 Sudden Death 8 0.1 0.1 no signal
1031 Injection Site Pain 226 0.1 0.1 no signal
1032 Wrong Technique In Device Usage Process 34 0.1 0.1 no signal
1033 Cerebral Infarction 18 0.1 0.1 no signal
1034 Chronic Kidney Disease 56 0.1 0.1 no signal
1035 Device Malfunction 49 0.1 0.1 no signal
1036 Aphasia 22 0.1 0.1 no signal
1037 Drug Interaction 115 0.1 0.1 no signal
1038 Pelvic Pain 13 0.1 0.1 no signal
1039 Blood Urea Increased 12 0.1 0.1 no signal
1040 Disseminated Intravascular Coagulation 10 0.1 0.1 no signal
1041 Injection Site Pruritus 47 0.1 0.1 no signal
1042 Renal Cancer 34 0.1 0.1 no signal
1043 Infusion Site Pain 9 0.1 0.1 no signal
1044 Vaginal Discharge 7 0.1 0.1 no signal
1045 Metastases To Lung 8 0.1 0.1 no signal
1046 Injection Site Rash 21 0.1 0.1 no signal
1047 Hallucination, Auditory 11 0.1 0.1 no signal
1048 Blood Alkaline Phosphatase Increased 17 0.1 0.1 no signal
1049 Melaena 15 0.1 0.1 no signal
1050 Cardiomyopathy 10 0.1 0.1 no signal
1051 Urinary Incontinence 20 0.1 0.1 no signal
1052 Ischaemic Stroke 12 0.1 0.1 no signal
1053 Hereditary Angioedema 7 0.1 0.1 no signal
1054 Multiple Fractures 11 0.1 0.1 no signal
1055 Injection Site Urticaria 16 0.1 0.1 no signal
1056 Injection Site Haemorrhage 52 0.1 0.1 no signal
1057 Pancytopenia 36 0.1 0.1 no signal
1058 Metrorrhagia 11 0.1 0.1 no signal
1059 Respiratory Failure 46 0.1 0.1 no signal
1060 Jaundice 17 0.1 0.1 no signal
1061 Blood Bilirubin Increased 17 0.1 0.1 no signal
1062 Gastric Cancer 16 0.1 0.1 no signal
1063 Local Swelling 11 0.1 0.1 no signal
1064 Myocarditis 7 0.1 0.1 no signal
1065 Impaired Driving Ability 7 0.1 0.1 no signal
1066 Mania 10 0.1 0.1 no signal
1067 Leukocytosis 11 0.1 0.1 no signal
1068 Osteonecrosis 20 0.1 0.1 no signal
1069 Abnormal Behaviour 24 0.1 0.1 no signal
1070 Post Procedural Haemorrhage 7 0.1 0.1 no signal
1071 Bone Loss 9 0.1 0.1 no signal
1072 Poor Quality Product Administered 6 0.1 0.1 no signal
1073 Delusion 9 0.1 0.1 no signal
1074 Multiple Sclerosis Relapse 40 0.1 0.1 no signal
1075 Menstruation Delayed 6 0.1 0.1 no signal
1076 Device Issue 50 0.1 0.1 no signal
1077 Injection Site Swelling 43 0.1 0.1 no signal
1078 Dysarthria 21 0.1 0.1 no signal
1079 Brain Oedema 7 0.1 0.1 no signal
1080 Coma 26 0.1 0.1 no signal
1081 Pleural Effusion 33 0.1 0.1 no signal
1082 Coagulopathy 9 0.1 0.1 no signal
1083 Amenorrhoea 9 0.1 0.1 no signal
1084 Oxygen Saturation Decreased 30 0.1 0.1 no signal
1085 Platelet Count Decreased 57 0.1 0.1 no signal
1086 Abortion Induced 5 0.1 0.1 no signal
1087 Circulatory Collapse 9 0.1 0.1 no signal
1088 Incorrect Product Storage 7 0.1 0.1 no signal
1089 Blood Count Abnormal 8 0.1 0.1 no signal
1090 Fear 14 0.1 0.1 no signal
1091 Hypoxia 18 0.1 0.1 no signal
1092 Central Nervous System Lesion 7 0.1 0.1 no signal
1093 Device Occlusion 7 0.1 0.1 no signal
1094 Myoclonus 6 0.1 0.1 no signal
1095 Injection Site Erythema 62 0.1 0.1 no signal
1096 Lactic Acidosis 16 0.1 0.1 no signal
1097 Subarachnoid Haemorrhage 5 0.1 0.1 no signal
1098 Injection Site Mass 18 0.1 0.1 no signal
1099 Hyperkalaemia 17 0.1 0.1 no signal
1100 Skeletal Injury 5 0.1 0.1 no signal
1101 Hemiparesis 8 0.1 0.1 no signal
1102 Plasma Cell Myeloma 18 0.1 0.1 no signal
1103 Diabetic Ketoacidosis 11 0.1 0.1 no signal
1104 Product Packaging Quantity Issue 5 0.1 0.1 no signal
1105 Syringe Issue 8 0.1 0.1 no signal
1106 Injection Site Nodule 5 0.1 0.1 no signal
1107 Needle Issue 13 0.1 0.1 no signal
1108 Drug Dispensing Error 7 0.1 0.1 no signal
1109 Injury Associated With Device 9 0.1 0.1 no signal
1110 Accidental Exposure To Product 44 0.1 0.1 no signal
1111 Gastrointestinal Carcinoma 4 0.1 0.1 no signal
1112 Peritonitis 9 0.1 0.1 no signal
1113 Blood Thyroid Stimulating Hormone Increased 4 0.1 0.1 no signal
1114 Incorrect Dose Administered By Device 11 0.1 0.1 no signal
1115 Hepatic Encephalopathy 4 0.1 0.1 no signal
1116 Generalised Tonic-clonic Seizure 7 0.1 0.1 no signal
1117 Caesarean Section 5 0.1 0.1 no signal
1118 Hepatocellular Injury 6 0.1 0.1 no signal
1119 Cytomegalovirus Infection 7 0.1 0.1 no signal
1120 Cholestasis 8 0.1 0.1 no signal
1121 Meningioma 6 0.1 0.1 no signal
1122 Pneumocystis Jirovecii Pneumonia 4 0.1 0.1 no signal
1123 Exposure Via Skin Contact 9 0.1 0.1 no signal
1124 Acute Kidney Injury 60 0.1 0.1 no signal
1125 Eyelid Ptosis 4 0.1 0.1 no signal
1126 Drug Reaction With Eosinophilia And Systemic Symptoms 10 0.1 0.1 no signal
1127 Economic Problem 6 0.1 0.1 no signal
1128 Cardiac Arrest 32 0.1 0.1 no signal
1129 Injection Site Induration 5 0.1 0.1 no signal
1130 Hallucination, Visual 8 0.1 0.1 no signal
1131 Anhedonia 10 0.1 0.1 no signal
1132 Proteinuria 7 0.1 0.1 no signal
1133 Application Site Pain 8 0.1 0.1 no signal
1134 Completed Suicide 29 0.0 0.0 no signal
1135 Accidental Underdose 5 0.0 0.0 no signal
1136 Diabetes Mellitus Inadequate Control 6 0.0 0.0 no signal
1137 Bradycardia 18 0.0 0.0 no signal
1138 Haemorrhage Intracranial 5 0.0 0.0 no signal
1139 Hepatic Cytolysis 4 0.0 0.0 no signal
1140 Device Difficult To Use 21 0.0 0.0 no signal
1141 Application Site Erythema 8 0.0 0.0 no signal
1142 Visual Acuity Reduced 10 0.0 0.0 no signal
1143 Drug Level Decreased 3 0.0 0.0 no signal
1144 Bone Marrow Failure 6 0.0 0.0 no signal
1145 Product Complaint 7 0.0 0.0 no signal
1146 Application Site Pruritus 6 0.0 0.0 no signal
1147 Device Leakage 11 0.0 0.0 no signal
1148 Drug Prescribing Error 5 0.0 0.0 no signal
1149 Gynaecomastia 8 0.0 0.0 no signal
1150 Product Physical Issue 5 0.0 0.0 no signal
1151 Intentional Self-injury 5 0.0 0.0 no signal
1152 Application Site Irritation 3 0.0 0.0 no signal
1153 Toxicity To Various Agents 40 0.0 0.0 no signal
1154 Device Breakage 9 0.0 0.0 no signal
1155 Product Administered At Inappropriate Site 4 0.0 0.0 no signal
1156 Akathisia 3 0.0 0.0 no signal
1157 Application Site Rash 3 0.0 0.0 no signal
1158 Incorrect Drug Administration Duration 6 0.0 0.0 no signal
1159 Dystonia 4 0.0 0.0 no signal
1160 Osteonecrosis Of Jaw 5 0.0 0.0 no signal
1161 Neoplasm Progression 7 0.0 0.0 no signal
1162 Premature Delivery 3 0.0 0.0 no signal
1163 Colorectal Cancer 9 0.0 0.0 no signal
1164 Neutropenia 24 0.0 0.0 no signal
1165 Product Substitution Issue 10 0.0 0.0 no signal
1166 Device Dislocation 7 0.0 0.0 no signal
1167 Intentional Overdose 8 0.0 0.0 no signal
1168 Product Adhesion Issue 4 0.0 0.0 no signal
1169 Drug Dose Omission By Device 6 0.0 0.0 no signal
1170 Drug Dependence 8 0.0 0.0 no signal