Reaction

Infusion Site Irritation reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,227 reports · 56 co-occurring drugs

As of the last recalculation, Infusion Site Irritation appears in 1,227 FAERS reports alongside 56 co-occurring drug terms. The strongest observed disproportionality signal is TREPROSTINIL (PRR 150.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Treprostinil	585	150.2	150.9
Ketoprofen	98	137.6	138.7
Amitriptyline Hydrochloride	83	86.0	86.4
Human Immunoglobulin G	68	59.1	59.3
Bendamustine Hydrochloride	38	55.5	55.7
Macitentan	175	49.8	50.0
Lidocaine Hydrochloride	150	48.0	48.1
0Xygen	123	47.0	47.1
Oxygen	123	47.0	47.1
Sildenafil	141	46.5	46.6
Sildenafil Powder,	86	44.0	44.1
Diphenhydramine Hydrochloride Capsule, Liquid Filled	46	37.9	38.0
Tadalafil	186	37.0	37.0
Sodium Chloride Tablet	139	36.0	36.1
Sodium Chloride Tablets	139	36.0	36.1
Clonidine	100	36.0	36.0
Riociguat	65	35.7	35.7
Sodium Chloride	140	33.8	33.9
Adrenalinum	69	29.8	29.9
Sildenafil Citrate	189	29.6	29.6
Ambrisentan	174	27.4	27.4
Lidocaine	81	25.2	25.2
Cetirizine Hcl	13	24.3	24.3
Epinephrine	84	23.3	23.3
Butalbital, Acetaminophen, And Caffeine	14	22.5	22.5
Diphenhydramine	77	22.0	22.0
Selexipag	32	21.5	21.6
Lidocaine, Menthol	59	21.1	21.2
Lidicaine	57	20.7	20.7
Burn Relief	57	20.7	20.7
Lidocaine Hydrochloride And Epinephrine	57	20.6	20.7
Epoprostenol	15	19.7	19.7
Lidocaine Hydrochloride And Epinephrine Bitartrate	57	19.0	19.0
Lidocaine 4%	57	18.6	18.6
Fluticasone Propionate Nasal	31	17.8	17.8
Torsemide	33	17.3	17.4
Bosentan	49	17.1	17.2
Hydroxyzine Hydrochloride	13	16.9	17.0
Hydroxyzine Hydrochloride Oral	13	16.9	17.0
Bumetanide	23	15.0	15.0
Fexofenadine Hcl	8	14.8	14.8
Buspirone Hydrochloride	9	13.9	13.9
Metolazone	9	13.7	13.7
Azelastine	14	13.4	13.4
Cyclobenzaprine Hydrochloride	7	13.3	13.3
Fosaprepitant Dimeglumine	10	12.4	12.4
Methocarbamol Tablets	12	12.3	12.3
Fexofenadine Hydrochloride	14	11.0	11.0
Carboxymethylcellulose Sodium	6	10.9	10.9
Benzonatate	10	10.3	10.3
Umeclidinium	5	9.5	9.5
Carbidopa And Levodopa	22	8.0	8.0
Rimegepant Sulfate	5	6.7	6.7
Insulin Lispro	49	6.2	6.2
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	14	5.8	5.8
Fremanezumab-Vfrm	3	4.4	4.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.