Reaction

Product Formulation Issue reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,522 reports · 62 co-occurring drugs

As of the last recalculation, Product Formulation Issue appears in 6,522 FAERS reports alongside 62 co-occurring drug terms. The strongest observed disproportionality signal is MINOXIDIL (PRR 64.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Minoxidil	796	64.3	65.4
Thyroid, Porcine	32	9.6	9.7
Minoxidil Foam 5% (Womens)	69	6.7	6.7
Biotin	56	5.8	5.8
Loperamide Hydrochloride And Dimethicone	52	5.2	5.2
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	67	5.2	5.2
Lisdexamfetamine Dimesylate	52	5.1	5.1
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	55	5.0	5.0
Ibuprofen Tablets, Coated	54	4.1	4.1
Ibuprofen Sodium	54	4.0	4.1
Liothyronine Sodium	11	4.0	4.0
Dapsone	13	3.9	3.9
Oxycodone Hydrochloride	256	3.9	3.9
Methylphenidate Hydrochloride	71	3.9	3.9
Buprenorphine Hydrochloride, Naloxone Hydrochloride	27	3.6	3.6
Tretinoin	9	3.5	3.5
Progesterone	25	3.5	3.5
Latanoprost	54	3.4	3.4
Extended Phenytoin Sodium	18	3.4	3.4
Lubiprostone	10	3.4	3.4
Niacin	12	3.3	3.3
Estradiol Gel 0.1%	44	3.1	3.1
Estradiol Transdermal	44	3.1	3.1
Zinc	24	3.1	3.1
Clobetasol Propionate Ointment Usp, 0.05%	10	3.1	3.1
Zinc Chloride	24	3.1	3.1
Clobetasol Propionate	10	3.1	3.1
Amphetamine	8	3.1	3.1
Methylphenidate	27	3.0	3.0
Oxycodone And Acetaminophen Tablets	11	2.9	3.0
Multivitamin	46	2.9	2.9
Zinc Gluconate	24	2.9	2.9
Vitamin C	83	2.9	2.9
Estradiol	77	2.9	2.9
Testosterone Cypionate	8	2.9	2.9
Guanfacine	7	2.8	2.8
Carboxymethylcellulose Sodium	8	2.7	2.7
Fexofenadine Hydrochloride	18	2.6	2.6
Testosterone	19	2.6	2.6
Ketoconazole	14	2.6	2.6
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	23	2.4	2.4
Fish Oil	66	2.3	2.3
Oxycodone And Acetaminophen	16	2.2	2.2
Miconazole Nitrate	5	1.8	1.8
Bimatoprost	16	1.8	1.8
Loratadine And Pseudoephedrine Sulfate	4	1.6	1.6
Travoprost	4	1.5	1.5
Asenapine Maleate	4	1.5	1.5
Crisaborole	4	1.3	1.3
Vortioxetine	7	1.3	1.3
Desvenlafaxine Succinate	11	1.3	1.3
Buprenorphine	37	1.3	1.3
Rimegepant Sulfate	5	1.3	1.3
Diclofenac Potassium	4	1.2	1.2
Sevelamer Carbonate	4	1.1	1.1
Hydrocodone Bitartrate And Acetaminophen	17	1.0	1.0
Brexpiprazole	5	1.0	1.0
Paliperidone Palmitate	9	0.9	0.9
Oxymorphone Hydrochloride	3	0.8	0.8
Somatropin	15	0.7	0.7
Nirmatrelvir And Ritonavir	6	0.4	0.4
Salicylic Acid	4	0.2	0.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.