Reaction

Product Packaging Difficult To Open reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,439 reports · 50 co-occurring drugs

As of the last recalculation, Product Packaging Difficult To Open appears in 2,439 FAERS reports alongside 50 co-occurring drug terms. The strongest observed disproportionality signal is VOCLOSPORIN (PRR 160.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Voclosporin	153	160.3	163.2
Levodopa	69	50.1	50.4
Loperamide Hydrochloride And Dimethicone	121	33.8	34.0
Amikacin	62	31.8	31.9
Cenobamate	29	30.0	30.1
Loperamide Hydrochloride	134	27.0	27.1
Dorzolamide Hydrochloride And Timolol Maleate	12	13.0	13.0
Lifitegrast	23	12.1	12.1
Suvorexant	18	11.9	11.9
Alendronate Sodium Tablet	22	10.2	10.2
Brimonidine Tartrate	21	10.1	10.1
Cholestyramine	14	9.9	9.9
Loperamide Hydrochloride Oral	11	9.2	9.2
Oral Semaglutide	75	9.0	9.0
Rimegepant Sulfate	13	8.8	8.8
Emtricitabine And Tenofovir Alafenamide	11	8.3	8.3
Estradiol Gel 0.1%	43	8.2	8.3
Estradiol Transdermal	43	8.2	8.3
Selinexor	8	7.9	7.9
Latanoprost	44	7.6	7.6
Loperamide Hcl	11	7.3	7.3
Moxifloxacin	12	7.3	7.3
Fexofenadine Hydrochloride	17	6.7	6.7
Carbidopa And Levodopa	36	6.6	6.6
Loratadine Tablet	40	6.5	6.5
Docosanol	11	6.4	6.4
Rasagiline Mesylate	8	6.2	6.2
Alpelisib	6	5.9	5.9
Brivaracetam	6	5.7	5.7
Polyethylene Glycol 3350	61	5.6	5.6
Amantadine	10	5.5	5.5
Palbociclib	59	5.4	5.4
Loratadine And Pseudoephedrine Sulfate	5	5.4	5.4
Ixazomib	18	5.4	5.4
Vibegron	5	5.3	5.3
Estradiol	53	5.3	5.3
Travoprost	5	4.9	4.9
Asenapine Maleate	5	4.9	4.9
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	10	4.7	4.7
Lenvatinib	18	4.7	4.7
Teduglutide	7	4.4	4.4
Naproxen Sodium Tablet	27	4.4	4.4
Rotigotine	7	4.1	4.1
Siponimod	4	3.8	3.8
Tafamidis	4	2.9	2.9
Buprenorphine	29	2.7	2.7
Glycerin, Lidocaine	4	2.4	2.4
Minoxidil	7	1.3	1.3
Nirmatrelvir And Ritonavir	7	1.1	1.1
Valbenazine	3	1.0	1.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.