Reaction

Social Problem reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,089 reports · 62 co-occurring drugs

As of the last recalculation, Social Problem appears in 4,089 FAERS reports alongside 62 co-occurring drug terms. The strongest observed disproportionality signal is DALFAMPRIDINE (PRR 58.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Dalfampridine	687	58.4	59.0
Divalproex Sodium	311	36.7	37.0
Vedolizumab	243	15.2	15.2
Mepolizumab	142	15.0	15.1
Belimumab	87	14.3	14.3
Niraparib	59	13.7	13.7
Testosterone Cypionate	19	10.9	10.9
Aripiprazole Oral	77	9.6	9.7
Aripiprazole Orally Disintegrating	77	9.6	9.7
Elexacaftor, Tezacaftor, And Ivacaftor	23	9.4	9.5
Dornase Alfa	36	9.4	9.4
Digoxin	113	8.2	8.2
Aripiprazole	183	7.9	7.9
Guanfacine	12	7.8	7.8
Valproate Sodium	30	7.4	7.4
Mesalamine	78	7.2	7.2
Testosterone	30	6.6	6.6
Tobramycin Solution	15	6.4	6.4
Tobramycin Sulfate	15	6.2	6.2
Lisdexamfetamine Dimesylate	37	5.7	5.8
Ciclesonide	15	5.6	5.6
Lubiprostone	10	5.4	5.4
Quinine	9	5.4	5.4
Dolutegravir Sodium	9	5.1	5.1
Cholestyramine	12	5.1	5.1
Cephalexin	21	5.0	5.0
Tobramycin	22	4.7	4.7
Fluticasone Furoate	11	4.6	4.6
Thiamine Hydrochloride	11	4.5	4.5
Drs. Clotrimazole	10	4.4	4.4
Family Wellness Clotrimazole	10	4.4	4.4
Clotrimazole Topical	10	4.4	4.4
Clotrimazole	10	4.2	4.2
Ciprofloxacin Hydrochloride And Hydrocortisone	16	3.9	3.9
Oxazepam	16	3.8	3.8
Clobazam	18	3.8	3.8
Finasteride	43	3.7	3.7
Tiotropium Bromide Inhalation Spray	8	3.6	3.6
Simvastatin	166	3.5	3.5
Methylphenidate Hydrochloride	38	3.3	3.3
Isopropyl Alcohol	21	3.2	3.2
Paliperidone	14	3.1	3.1
Ethyl Alcohol	16	3.0	3.0
Isotretinoin	29	3.0	3.0
Metoclopramide	32	3.0	3.0
Pancrelipase	22	2.9	2.9
Bupropion	25	2.9	2.9
Vilazodone Hydrochloride	5	2.8	2.8
Paliperidone Palmitate	17	2.7	2.7
Levodopa	6	2.5	2.5
Umeclidinium Bromide And Vilanterol Trifenatate	8	2.4	2.4
Fluticasone Furoate And Vilanterol Trifenatate	17	2.4	2.4
Upadacitinib	38	2.4	2.4
Cariprazine	4	2.2	2.2
Brexpiprazole	7	2.1	2.1
Alcohol	16	2.1	2.1
Lurasidone Hydrochloride	8	1.9	1.9
Risankizumab-Rzaa	30	1.9	1.9
Fremanezumab-Vfrm	4	1.8	1.8
Benralizumab	6	1.5	1.5
Hydrocodone Bitartrate And Acetaminophen	15	1.4	1.4
Varenicline Tartrate	21	1.3	1.3

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.