OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Metformin Er 750 Mg

1,147 flagged reaction(s) · 1,082,486 total co-reports · max PRR 46.0
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Lactic Acidosis 12,763 46.0 48.0 signal
2 Neurologic Neglect Syndrome 211 42.1 42.1 signal
3 Euglycaemic Diabetic Ketoacidosis 1,378 36.8 36.9 signal
4 Diabetic Metabolic Decompensation 368 25.1 25.1 signal
5 Carotid Artery Thrombosis 213 23.1 23.1 signal
6 Hyperlactacidaemia 633 21.9 21.9 signal
7 Catarrh 167 16.0 16.0 signal
8 Adjustment Disorder 224 14.4 14.4 signal
9 Gastrointestinal Hypomotility 380 14.2 14.2 signal
10 Glycosylated Haemoglobin Abnormal 196 13.7 13.8 signal
11 Glycosylated Haemoglobin Increased 4,081 13.4 13.6 signal
12 Anion Gap Increased 212 13.0 13.0 signal
13 Ketoacidosis 1,158 12.7 12.7 signal
14 Metabolic Acidosis 4,822 12.4 12.6 signal
15 Diabetic Ketoacidosis 3,568 12.1 12.2 signal
16 Glycosylated Haemoglobin Decreased 223 11.3 11.3 signal
17 Diabetes Mellitus Inadequate Control 2,387 10.8 10.9 signal
18 Impaired Gastric Emptying 1,668 10.4 10.5 signal
19 Product Monitoring Error 178 9.8 9.8 signal
20 Bladder Transitional Cell Carcinoma 174 9.6 9.6 signal
21 Suspected Suicide 578 9.5 9.6 signal
22 Vitamin B12 Deficiency 482 9.4 9.4 signal
23 Hypoglycaemia 5,729 9.3 9.4 signal
24 Diabetic Neuropathy 575 9.0 9.1 signal
25 Blood Bicarbonate Decreased 216 8.8 8.8 signal
26 Blood Lactic Acid Increased 587 8.7 8.7 signal
27 Neuritis 172 8.7 8.7 signal
28 Blood Pressure Diastolic Abnormal 284 8.6 8.6 signal
29 Hyperparathyroidism Secondary 277 8.5 8.5 signal
30 Nephrogenic Anaemia 503 8.3 8.4 signal
31 Hypoglycaemic Coma 308 8.2 8.3 signal
32 Blood Glucose Abnormal 1,843 7.6 7.7 signal
33 Insulin Resistance 203 7.6 7.6 signal
34 Blood Glucose Fluctuation 1,078 7.5 7.5 signal
35 Distributive Shock 214 7.4 7.4 signal
36 Diabetic Retinopathy 327 7.4 7.4 signal
37 Personality Disorder 253 7.3 7.3 signal
38 Acute Kidney Injury 14,181 7.1 7.4 signal
39 Blood Pressure Systolic Abnormal 228 7.0 7.0 signal
40 Injection Site Nodule 1,001 6.9 7.0 signal
41 Forced Expiratory Volume Decreased 257 6.9 6.9 signal
42 Blood Glucose Increased 17,005 6.8 7.2 signal
43 Hyperkalaemia 3,133 6.8 6.9 signal
44 Immune-mediated Myositis 234 6.7 6.7 signal
45 Pancreatic Carcinoma Metastatic 247 6.5 6.6 signal
46 Blood Glucose Decreased 4,098 6.4 6.5 signal
47 Rebound Acid Hypersecretion 259 6.4 6.4 signal
48 Drug Level Above Therapeutic 381 6.3 6.3 signal
49 Hyperglycaemia 2,945 6.1 6.2 signal
50 Hypovolaemia 469 6.0 6.0 signal
51 Pemphigoid 594 6.0 6.0 signal
52 Anuria 652 5.6 5.6 signal
53 Red Blood Cell Sedimentation Rate Abnormal 172 5.5 5.5 signal
54 Diabetic Foot 221 5.4 5.4 signal
55 Intentional Device Misuse 321 5.4 5.4 signal
56 Potentiating Drug Interaction 235 5.3 5.3 signal
57 Hypomagnesaemia 972 5.2 5.2 signal
58 Respiratory Symptom 192 5.1 5.1 signal
59 Normochromic Normocytic Anaemia 203 5.0 5.0 signal
60 Acidosis 517 5.0 5.0 signal
61 Shock 1,445 4.7 4.7 signal
62 Blood Pressure Diastolic Decreased 469 4.7 4.7 signal
63 Abnormal Loss Of Weight 427 4.7 4.7 signal
64 Blood Pressure Systolic Increased 1,218 4.6 4.6 signal
65 Vitamin B12 Decreased 178 4.6 4.6 signal
66 Hypopnoea 208 4.4 4.4 signal
67 Hypovolaemic Shock 285 4.4 4.4 signal
68 Pancreatitis Acute 1,309 4.3 4.3 signal
69 Gangrene 352 4.3 4.3 signal
70 Drug Level Increased 940 4.2 4.2 signal
71 Necrotising Fasciitis 199 4.1 4.1 signal
72 Polyuria 462 4.1 4.1 signal
73 Type 2 Diabetes Mellitus 1,892 4.1 4.1 signal
74 Psychological Trauma 488 4.1 4.1 signal
75 Diabetes Mellitus 4,207 4.0 4.1 signal
76 Arteriosclerosis Coronary Artery 361 4.0 4.0 signal
77 Hair Disorder 455 4.0 4.0 signal
78 Hypothermia 552 4.0 4.0 signal
79 Injection Site Extravasation 678 4.0 4.0 signal
80 Dyslipidaemia 276 4.0 4.0 signal
81 Polydipsia 214 4.0 4.0 signal
82 Rales 312 3.9 3.9 signal
83 Body Temperature Decreased 527 3.9 3.9 signal
84 Chronic Kidney Disease 4,041 3.8 3.9 signal
85 Glomerular Filtration Rate Decreased 627 3.8 3.8 signal
86 Toe Amputation 263 3.8 3.8 signal
87 Renal Tubular Necrosis 505 3.7 3.7 signal
88 Sensory Loss 410 3.7 3.7 signal
89 End Stage Renal Disease 934 3.7 3.7 signal
90 Hepatic Steatosis 941 3.7 3.7 signal
91 Obstructive Airways Disorder 555 3.6 3.6 signal
92 Wound Complication 171 3.6 3.6 signal
93 Left Ventricular Hypertrophy 212 3.6 3.6 signal
94 Bronchiectasis 329 3.6 3.6 signal
95 Hemiplegia 408 3.6 3.6 signal
96 Red Cell Distribution Width Increased 202 3.5 3.5 signal
97 Haemodynamic Instability 362 3.5 3.5 signal
98 Eructation 916 3.5 3.5 signal
99 Pulseless Electrical Activity 201 3.5 3.5 signal
100 Overweight 258 3.5 3.5 signal
101 Lipase Increased 361 3.4 3.4 signal
102 Arterial Occlusive Disease 370 3.4 3.4 signal
103 Injection Site Mass 1,726 3.4 3.4 signal
104 Haemorrhagic Anaemia 207 3.4 3.4 signal
105 Oliguria 284 3.3 3.3 signal
106 Blood Magnesium Decreased 394 3.3 3.3 signal
107 Neurological Symptom 259 3.3 3.3 signal
108 Left Ventricular Dysfunction 304 3.3 3.3 signal
109 Cardiac Failure Chronic 194 3.3 3.3 signal
110 Pancreatitis 2,409 3.3 3.3 signal
111 Full Blood Count Abnormal 480 3.3 3.3 signal
112 Tubulointerstitial Nephritis 843 3.3 3.3 signal
113 Hair Colour Changes 563 3.2 3.2 signal
114 Urosepsis 410 3.2 3.2 signal
115 Bundle Branch Block Left 189 3.2 3.2 signal
116 Glucose Tolerance Impaired 252 3.1 3.1 signal
117 Blood Cholesterol Abnormal 196 3.1 3.1 signal
118 Accidental Underdose 617 3.1 3.1 signal
119 Arteriosclerosis 394 3.0 3.0 signal
120 Parosmia 314 3.0 3.0 signal
121 Obesity 663 3.0 3.0 signal
122 Rhinitis 335 3.0 3.0 signal
123 Blood Pressure Diastolic Increased 191 3.0 3.0 signal
124 Myopathy 357 3.0 3.0 signal
125 Atrioventricular Block First Degree 179 3.0 3.0 signal
126 Exercise Tolerance Decreased 234 3.0 3.0 signal
127 Tachypnoea 532 2.8 2.8 signal
128 Iron Deficiency 174 2.8 2.8 signal
129 Weight Decreased 10,909 2.8 2.9 signal
130 Breath Sounds Abnormal 191 2.8 2.8 signal
131 Hair Texture Abnormal 519 2.8 2.8 signal
132 Blood Triglycerides Increased 678 2.7 2.8 signal
133 Anal Incontinence 340 2.7 2.7 signal
134 Sleep Apnoea Syndrome 727 2.7 2.7 signal
135 Polyp 249 2.7 2.7 signal
136 Renal Failure 5,080 2.7 2.8 signal
137 Leukocytosis 686 2.7 2.7 signal
138 Food Craving 188 2.7 2.7 signal
139 Electrocardiogram Abnormal 298 2.7 2.7 signal
140 Acute Coronary Syndrome 315 2.7 2.7 signal
141 Cardiac Murmur 325 2.7 2.7 signal
142 Madarosis 436 2.7 2.7 signal
143 Thirst 663 2.7 2.7 signal
144 Motor Dysfunction 372 2.6 2.6 signal
145 Flank Pain 343 2.6 2.6 signal
146 Coronary Artery Occlusion 505 2.6 2.6 signal
147 Coronary Artery Stenosis 184 2.6 2.6 signal
148 Dehydration 4,863 2.6 2.6 signal
149 Renal Cyst 290 2.6 2.6 signal
150 Pancreatic Disorder 178 2.6 2.6 signal
151 Acute Myocardial Infarction 1,071 2.6 2.6 signal
152 Renal Injury 1,081 2.6 2.6 signal
153 Hyperlipidaemia 431 2.6 2.6 signal
154 Pollakiuria 1,493 2.6 2.6 signal
155 Eating Disorder 765 2.6 2.6 signal
156 Labelled Drug-drug Interaction Medication Error 319 2.6 2.6 signal
157 Impaired Quality Of Life 514 2.6 2.6 signal
158 Cholelithiasis 1,168 2.6 2.6 signal
159 Nephropathy 333 2.5 2.5 signal
160 Atrioventricular Block 275 2.5 2.5 signal
161 Blood Potassium Increased 575 2.5 2.5 signal
162 Intestinal Ischaemia 194 2.5 2.5 signal
163 Appetite Disorder 230 2.5 2.5 signal
164 Toxicity To Various Agents 5,924 2.5 2.6 signal
165 Pulmonary Alveolar Haemorrhage 197 2.5 2.5 signal
166 Gingival Pain 280 2.5 2.5 signal
167 Cardiogenic Shock 501 2.5 2.5 signal
168 Blood Iron Decreased 413 2.5 2.5 signal
169 Coronary Artery Disease 1,068 2.5 2.5 signal
170 Injection Site Haemorrhage 2,759 2.5 2.5 signal
171 Atrioventricular Block Complete 232 2.5 2.5 signal
172 Multiple Organ Dysfunction Syndrome 965 2.5 2.5 signal
173 Nodule 451 2.5 2.5 signal
174 Fungal Infection 1,146 2.5 2.5 signal
175 Sputum Discoloured 325 2.5 2.5 signal
176 Hunger 461 2.5 2.5 signal
177 Rhabdomyolysis 1,423 2.4 2.5 signal
178 Angina Pectoris 978 2.4 2.4 signal
179 Bladder Cancer 2,013 2.4 2.4 signal
180 Hypophagia 855 2.4 2.4 signal
181 Circulatory Collapse 576 2.4 2.4 signal
182 Blood Pressure Fluctuation 807 2.4 2.4 signal
183 Large Intestine Polyp 232 2.4 2.4 signal
184 Body Height Decreased 359 2.4 2.4 signal
185 Affect Lability 321 2.4 2.4 signal
186 Neutrophil Count Increased 341 2.4 2.4 signal
187 Parkinsonism 323 2.4 2.4 signal
188 Electrolyte Imbalance 380 2.4 2.4 signal
189 Decreased Appetite 7,645 2.4 2.4 signal
190 Upper Gastrointestinal Haemorrhage 557 2.4 2.4 signal
191 Sinus Congestion 446 2.4 2.4 signal
192 Drug Interaction 5,226 2.4 2.4 signal
193 Hepatic Cirrhosis 615 2.4 2.4 signal
194 Injection Site Injury 180 2.3 2.3 signal
195 Iron Deficiency Anaemia 301 2.3 2.3 signal
196 Gastroenteritis 477 2.3 2.3 signal
197 Metabolic Disorder 190 2.3 2.3 signal
198 Angina Unstable 214 2.3 2.3 signal
199 Neutrophilia 184 2.3 2.3 signal
200 Blood Creatinine Increased 2,111 2.3 2.3 signal
201 Hyponatraemia 1,806 2.3 2.3 signal
202 Vasculitis 374 2.3 2.3 signal
203 Sleep Disorder Due To A General Medical Condition 518 2.3 2.3 signal
204 Meniscus Injury 197 2.3 2.3 signal
205 Cataract 1,894 2.3 2.3 signal
206 Lower Gastrointestinal Haemorrhage 237 2.3 2.3 signal
207 Completed Suicide 2,678 2.3 2.3 signal
208 Blood Pressure Inadequately Controlled 193 2.3 2.3 signal
209 Renal Failure Acute 1,368 2.3 2.3 signal
210 Hypertriglyceridaemia 185 2.3 2.3 signal
211 Mitral Valve Incompetence 358 2.3 2.3 signal
212 Blindness Transient 232 2.2 2.3 signal
213 Faeces Soft 228 2.2 2.2 signal
214 Nocturia 381 2.2 2.2 signal
215 Myocardial Ischaemia 360 2.2 2.2 signal
216 Osteoarthritis 1,330 2.2 2.2 signal
217 Hemiparesis 532 2.2 2.2 signal
218 Nerve Compression 286 2.2 2.2 signal
219 Orthostatic Hypotension 540 2.2 2.2 signal
220 Hyperkeratosis 171 2.2 2.2 signal
221 Duodenal Ulcer 215 2.2 2.2 signal
222 Skin Ulcer 781 2.2 2.2 signal
223 Acute Respiratory Failure 579 2.2 2.2 signal
224 Sciatica 479 2.2 2.2 signal
225 Renal Impairment 2,514 2.1 2.2 signal
226 Blood Urine Present 570 2.1 2.1 signal
227 Dyspnoea Exertional 1,121 2.1 2.1 signal
228 Cystitis 954 2.1 2.1 signal
229 Weight Fluctuation 311 2.1 2.1 signal
230 Eye Haemorrhage 399 2.1 2.1 signal
231 Urine Output Decreased 261 2.1 2.1 signal
232 Carpal Tunnel Syndrome 418 2.1 2.1 signal
233 Localised Infection 720 2.1 2.1 signal
234 Accidental Overdose 1,087 2.1 2.1 signal
235 Exostosis 271 2.1 2.1 signal
236 Dysuria 1,093 2.1 2.1 signal
237 Haematuria 1,017 2.1 2.1 signal
238 Pulmonary Fibrosis 566 2.1 2.1 signal
239 Coordination Abnormal 416 2.1 2.1 signal
240 Atrial Flutter 237 2.1 2.1 signal
241 Hypocalcaemia 557 2.1 2.1 signal
242 Tricuspid Valve Incompetence 233 2.1 2.1 signal
243 Gout 529 2.1 2.1 signal
244 Diarrhoea 18,902 2.1 2.2 signal
245 Hypokinesia 427 2.1 2.1 signal
246 Cholecystitis 349 2.1 2.1 signal
247 Sopor 388 2.1 2.1 signal
248 Dyspepsia 2,847 2.1 2.1 signal
249 Troponin Increased 219 2.1 2.1 signal
250 Gait Inability 957 2.1 2.1 signal
251 Inappropriate Antidiuretic Hormone Secretion 293 2.0 2.0 signal
252 Nephrolithiasis 1,314 2.0 2.0 signal
253 Red Blood Cell Sedimentation Rate Increased 318 2.0 2.0 signal
254 Blood Urea Increased 482 2.0 2.0 signal
255 Bradycardia 1,521 2.0 2.0 signal
256 Atrial Fibrillation 2,783 2.0 2.0 signal
257 Melaena 628 2.0 2.0 signal
258 Diverticulum 205 2.0 2.0 signal
259 Flatulence 1,610 2.0 2.0 signal
260 Respiratory Rate Increased 253 2.0 2.0 signal
261 C-reactive Protein Abnormal 182 2.0 2.0 signal
262 Hypotension 5,655 2.0 2.0 signal
263 Gastrooesophageal Reflux Disease 2,263 2.0 2.0 signal
264 Dysarthria 1,060 2.0 2.0 signal
265 Pharyngitis 350 2.0 2.0 no signal
266 Cellulitis 1,415 2.0 2.0 no signal
267 Rotator Cuff Syndrome 361 2.0 2.0 no signal
268 Hypothyroidism 890 2.0 2.0 no signal
269 Blood Pressure Increased 4,280 2.0 2.0 no signal
270 Renal Pain 295 2.0 2.0 no signal
271 Blood Cholesterol Increased 1,302 2.0 2.0 no signal
272 Decreased Activity 299 2.0 2.0 no signal
273 Vomiting 13,070 2.0 2.0 no signal
274 Pyelonephritis 240 2.0 2.0 no signal
275 Intentional Overdose 1,776 2.0 2.0 no signal
276 Hypokalaemia 1,278 2.0 2.0 no signal
277 Taste Disorder 557 2.0 2.0 no signal
278 Sinus Bradycardia 269 2.0 2.0 no signal
279 Productive Cough 1,313 2.0 2.0 no signal
280 Hypertensive Crisis 309 2.0 2.0 no signal
281 Contraindicated Product Administered 832 2.0 2.0 no signal
282 Intervertebral Disc Degeneration 256 2.0 2.0 no signal
283 C-reactive Protein Increased 995 1.9 1.9 no signal
284 Urinary Incontinence 805 1.9 1.9 no signal
285 Osteomyelitis 491 1.9 1.9 no signal
286 Ejection Fraction Decreased 421 1.9 1.9 no signal
287 Ligament Sprain 266 1.9 1.9 no signal
288 Loss Of Personal Independence In Daily Activities 1,280 1.9 1.9 no signal
289 Respiratory Tract Congestion 428 1.9 1.9 no signal
290 Pulmonary Mass 399 1.9 1.9 no signal
291 Urinary Tract Infection 4,531 1.9 1.9 no signal
292 Muscle Atrophy 335 1.9 1.9 no signal
293 Blood Potassium Decreased 801 1.9 1.9 no signal
294 Increased Appetite 500 1.9 1.9 no signal
295 Back Injury 288 1.9 1.9 no signal
296 Vitamin D Deficiency 259 1.9 1.9 no signal
297 Intervertebral Disc Protrusion 582 1.9 1.9 no signal
298 Wheezing 1,567 1.9 1.9 no signal
299 Cardiac Failure Acute 176 1.9 1.9 no signal
300 Sinus Disorder 525 1.9 1.9 no signal
301 Transient Ischaemic Attack 897 1.9 1.9 no signal
302 Blood Pressure Abnormal 524 1.9 1.9 no signal
303 Blood Sodium Decreased 497 1.9 1.9 no signal
304 Swollen Tongue 822 1.9 1.9 no signal
305 Arthritis 2,070 1.9 1.9 no signal
306 Mental Status Changes 730 1.9 1.9 no signal
307 Hypercholesterolaemia 251 1.9 1.9 no signal
308 Glaucoma 505 1.9 1.9 no signal
309 Synovitis 473 1.9 1.9 no signal
310 Skin Haemorrhage 378 1.9 1.9 no signal
311 Myositis 235 1.9 1.9 no signal
312 Constipation 5,666 1.9 1.9 no signal
313 Limb Injury 709 1.9 1.9 no signal
314 Hypophosphataemia 192 1.9 1.9 no signal
315 Unresponsive To Stimuli 672 1.9 1.9 no signal
316 Extrasystoles 183 1.9 1.9 no signal
317 Confusional State 4,219 1.8 1.9 no signal
318 Abdominal Pain 6,057 1.8 1.9 no signal
319 Micturition Urgency 295 1.8 1.8 no signal
320 Frequent Bowel Movements 699 1.8 1.8 no signal
321 Peripheral Swelling 3,983 1.8 1.9 no signal
322 Heart Rate Decreased 916 1.8 1.8 no signal
323 Haemorrhagic Stroke 204 1.8 1.8 no signal
324 Covid-19 Pneumonia 308 1.8 1.8 no signal
325 Product Prescribing Error 612 1.8 1.8 no signal
326 Sinus Tachycardia 365 1.8 1.8 no signal
327 Abdominal Discomfort 4,296 1.8 1.8 no signal
328 Needle Issue 734 1.8 1.8 no signal
329 Feeding Disorder 511 1.8 1.8 no signal
330 Dizziness Postural 246 1.8 1.8 no signal
331 Dysstasia 749 1.8 1.8 no signal
332 Abdominal Pain Upper 5,240 1.8 1.8 no signal
333 Wound 708 1.8 1.8 no signal
334 Gastritis 669 1.8 1.8 no signal
335 Supraventricular Tachycardia 243 1.8 1.8 no signal
336 Diverticulitis 702 1.8 1.8 no signal
337 Electrocardiogram Qt Prolonged 913 1.8 1.8 no signal
338 Bursitis 306 1.8 1.8 no signal
339 Hypercalcaemia 311 1.8 1.8 no signal
340 Hiatus Hernia 327 1.8 1.8 no signal
341 Low Density Lipoprotein Increased 194 1.8 1.8 no signal
342 Drug-induced Liver Injury 777 1.8 1.8 no signal
343 Gastrointestinal Haemorrhage 2,117 1.8 1.8 no signal
344 Oxygen Saturation Decreased 1,403 1.8 1.8 no signal
345 Hepatomegaly 248 1.8 1.8 no signal
346 Spinal Osteoarthritis 221 1.8 1.8 no signal
347 Cardiomegaly 310 1.8 1.8 no signal
348 Ventricular Tachycardia 414 1.8 1.8 no signal
349 Rectal Haemorrhage 1,077 1.8 1.8 no signal
350 Product Odour Abnormal 259 1.8 1.8 no signal
351 Nausea 19,666 1.8 1.8 no signal
352 Inability To Afford Medication 245 1.8 1.8 no signal
353 Underdose 1,819 1.8 1.8 no signal
354 Ventricular Fibrillation 277 1.8 1.8 no signal
355 Abdominal Distension 2,585 1.8 1.8 no signal
356 Tooth Abscess 253 1.8 1.8 no signal
357 Muscle Spasticity 306 1.7 1.7 no signal
358 Musculoskeletal Chest Pain 381 1.7 1.7 no signal
359 Retching 523 1.7 1.7 no signal
360 Retinal Detachment 226 1.7 1.7 no signal
361 Toothache 444 1.7 1.7 no signal
362 Salivary Hypersecretion 245 1.7 1.7 no signal
363 Aphasia 740 1.7 1.7 no signal
364 Lower Respiratory Tract Infection 1,107 1.7 1.7 no signal
365 Tenderness 255 1.7 1.7 no signal
366 Facial Paralysis 207 1.7 1.7 no signal
367 Incontinence 258 1.7 1.7 no signal
368 Mass 341 1.7 1.7 no signal
369 Cardiac Arrest 2,012 1.7 1.7 no signal
370 Groin Pain 214 1.7 1.7 no signal
371 Urinary Retention 808 1.7 1.7 no signal
372 Atelectasis 235 1.7 1.7 no signal
373 Stress 1,742 1.7 1.7 no signal
374 Syncope 2,424 1.7 1.7 no signal
375 Basal Cell Carcinoma 378 1.7 1.7 no signal
376 Muscular Weakness 2,748 1.7 1.7 no signal
377 Blood Testosterone Decreased 167 1.7 1.7 no signal
378 Haemodialysis 205 1.7 1.7 no signal
379 Hydronephrosis 180 1.7 1.7 no signal
380 Hypertension 5,106 1.7 1.7 no signal
381 Joint Injury 514 1.7 1.7 no signal
382 Fall 7,988 1.7 1.7 no signal
383 Furuncle 190 1.7 1.7 no signal
384 Tooth Infection 316 1.7 1.7 no signal
385 Ischaemic Stroke 428 1.7 1.7 no signal
386 Musculoskeletal Pain 1,264 1.7 1.7 no signal
387 Cyst 296 1.7 1.7 no signal
388 Ventricular Extrasystoles 247 1.7 1.7 no signal
389 Asthenia 8,925 1.7 1.7 no signal
390 Candida Infection 396 1.7 1.7 no signal
391 Vitamin D Decreased 203 1.7 1.7 no signal
392 Prostatic Specific Antigen Increased 328 1.7 1.7 no signal
393 Haematemesis 601 1.7 1.7 no signal
394 Medication Error 1,311 1.7 1.7 no signal
395 Visual Impairment 2,899 1.7 1.7 no signal
396 Lip Swelling 783 1.7 1.7 no signal
397 Blindness Unilateral 331 1.7 1.7 no signal
398 Internal Haemorrhage 269 1.7 1.7 no signal
399 Renal Disorder 1,097 1.7 1.7 no signal
400 Malnutrition 261 1.7 1.7 no signal
401 Weight Increased 5,227 1.7 1.7 no signal
402 Incorrect Product Storage 312 1.7 1.7 no signal
403 Cold Sweat 413 1.7 1.7 no signal
404 Hidradenitis 203 1.7 1.7 no signal
405 Abscess 372 1.7 1.7 no signal
406 Haematoma 605 1.6 1.6 no signal
407 Coagulopathy 386 1.6 1.6 no signal
408 Septic Shock 1,004 1.6 1.6 no signal
409 Kidney Infection 455 1.6 1.6 no signal
410 Injection Site Discomfort 239 1.6 1.6 no signal
411 Heart Rate Irregular 526 1.6 1.6 no signal
412 Impaired Work Ability 496 1.6 1.6 no signal
413 Gastrointestinal Disorder 2,044 1.6 1.6 no signal
414 White Blood Cell Count Increased 889 1.6 1.6 no signal
415 Blood Count Abnormal 355 1.6 1.6 no signal
416 Psoriatic Arthropathy 927 1.6 1.6 no signal
417 Sluggishness 234 1.6 1.6 no signal
418 Faeces Discoloured 499 1.6 1.6 no signal
419 Cardiac Failure 1,848 1.6 1.6 no signal
420 Sneezing 514 1.6 1.6 no signal
421 Head Injury 724 1.6 1.6 no signal
422 Subarachnoid Haemorrhage 234 1.6 1.6 no signal
423 Heart Rate Increased 2,268 1.6 1.6 no signal
424 Presyncope 554 1.6 1.6 no signal
425 Pancreatic Carcinoma 664 1.6 1.6 no signal
426 Intentional Product Misuse 1,984 1.6 1.6 no signal
427 Blood Creatine Phosphokinase Increased 668 1.6 1.6 no signal
428 Hyperhidrosis 2,944 1.6 1.6 no signal
429 Encephalopathy 558 1.6 1.6 no signal
430 Nerve Injury 254 1.6 1.6 no signal
431 Spinal Disorder 215 1.6 1.6 no signal
432 General Physical Health Deterioration 2,600 1.6 1.6 no signal
433 Tooth Fracture 249 1.6 1.6 no signal
434 Cardiac Failure Congestive 1,831 1.6 1.6 no signal
435 Bowel Movement Irregularity 172 1.6 1.6 no signal
436 Sepsis 2,513 1.6 1.6 no signal
437 Ageusia 563 1.6 1.6 no signal
438 Poor Venous Access 232 1.6 1.6 no signal
439 Gastric Ulcer 426 1.6 1.6 no signal
440 Middle Insomnia 416 1.6 1.6 no signal
441 Influenza 2,500 1.6 1.6 no signal
442 Angioedema 986 1.6 1.6 no signal
443 Respiratory Failure 1,629 1.6 1.6 no signal
444 Rib Fracture 458 1.6 1.6 no signal
445 Pain In Extremity 6,577 1.6 1.6 no signal
446 Joint Range Of Motion Decreased 297 1.6 1.6 no signal
447 Stent Placement 179 1.6 1.6 no signal
448 Incorrect Dose Administered By Device 564 1.6 1.6 no signal
449 Haemorrhoids 434 1.6 1.6 no signal
450 Spinal Pain 260 1.6 1.6 no signal
451 Chronic Obstructive Pulmonary Disease 1,157 1.6 1.6 no signal
452 Aphthous Ulcer 170 1.6 1.6 no signal
453 Poor Quality Sleep 474 1.6 1.6 no signal
454 Pulmonary Oedema 992 1.6 1.6 no signal
455 Anaemia 4,223 1.6 1.6 no signal
456 Eosinophilia 386 1.6 1.6 no signal
457 Oedema Peripheral 2,696 1.6 1.6 no signal
458 Balance Disorder 1,900 1.6 1.6 no signal
459 Haematocrit Decreased 438 1.6 1.6 no signal
460 Tachycardia 1,948 1.5 1.6 no signal
461 Product Dose Omission 1,448 1.5 1.5 no signal
462 Pulmonary Congestion 289 1.5 1.5 no signal
463 Fibromyalgia 530 1.5 1.5 no signal
464 Hypoxia 765 1.5 1.5 no signal
465 Rhinorrhoea 1,402 1.5 1.5 no signal
466 Injection Site Bruising 1,715 1.5 1.5 no signal
467 Drug Dose Omission 3,642 1.5 1.5 no signal
468 Bronchitis 1,615 1.5 1.5 no signal
469 Gait Disturbance 4,154 1.5 1.5 no signal
470 Asthma 2,425 1.5 1.5 no signal
471 Peripheral Coldness 298 1.5 1.5 no signal
472 Metastases To Liver 378 1.5 1.5 no signal
473 Splenomegaly 252 1.5 1.5 no signal
474 Frustration Tolerance Decreased 173 1.5 1.5 no signal
475 Ulcer 342 1.5 1.5 no signal
476 Ileus 264 1.5 1.5 no signal
477 Hiccups 175 1.5 1.5 no signal
478 Disorientation 852 1.5 1.5 no signal
479 Device Leakage 908 1.5 1.5 no signal
480 Shock Haemorrhagic 174 1.5 1.5 no signal
481 Facial Pain 191 1.5 1.5 no signal
482 Chest Pain 3,970 1.5 1.5 no signal
483 Dizziness 10,647 1.5 1.5 no signal
484 Dry Mouth 1,729 1.5 1.5 no signal
485 Lethargy 1,226 1.5 1.5 no signal
486 Liver Function Test Abnormal 623 1.5 1.5 no signal
487 Gastrointestinal Pain 233 1.5 1.5 no signal
488 Back Pain 4,941 1.5 1.5 no signal
489 Neuropathy Peripheral 2,009 1.5 1.5 no signal
490 Back Disorder 347 1.5 1.5 no signal
491 Dysgeusia 1,586 1.5 1.5 no signal
492 Abnormal Faeces 174 1.5 1.5 no signal
493 Haemoptysis 593 1.5 1.5 no signal
494 Hernia 408 1.5 1.5 no signal
495 Skin Lesion 577 1.5 1.5 no signal
496 Intentional Product Use Issue 1,863 1.5 1.5 no signal
497 Cough 5,925 1.5 1.5 no signal
498 Feeling Cold 589 1.5 1.5 no signal
499 International Normalised Ratio Increased 607 1.5 1.5 no signal
500 Blood Pressure Decreased 1,398 1.5 1.5 no signal
501 Wound Infection 229 1.5 1.5 no signal
502 Gastroenteritis Viral 381 1.5 1.5 no signal
503 Coma 1,003 1.5 1.5 no signal
504 Seasonal Allergy 297 1.5 1.5 no signal
505 Haematochezia 1,158 1.5 1.5 no signal
506 Red Blood Cell Count Decreased 601 1.5 1.5 no signal
507 Sleep Disorder 1,464 1.5 1.5 no signal
508 Schizophrenia 254 1.5 1.5 no signal
509 Subdural Haematoma 300 1.5 1.5 no signal
510 Vertigo 1,272 1.5 1.5 no signal
511 Platelet Count Increased 272 1.5 1.5 no signal
512 Ear Pain 404 1.5 1.5 no signal
513 Chromaturia 468 1.5 1.5 no signal
514 Pericarditis 345 1.5 1.5 no signal
515 Malaise 9,058 1.5 1.5 no signal
516 Limb Discomfort 637 1.5 1.5 no signal
517 Oropharyngeal Pain 1,904 1.5 1.5 no signal
518 Psoriasis 2,687 1.5 1.5 no signal
519 Chest Discomfort 2,095 1.4 1.5 no signal
520 Dyspnoea 11,614 1.4 1.5 no signal
521 Altered State Of Consciousness 441 1.4 1.4 no signal
522 Skin Laceration 221 1.4 1.4 no signal
523 Cardiomyopathy 302 1.4 1.4 no signal
524 Local Swelling 361 1.4 1.4 no signal
525 Neuralgia 494 1.4 1.4 no signal
526 Neck Pain 1,139 1.4 1.4 no signal
527 Malignant Melanoma 273 1.4 1.4 no signal
528 Pallor 555 1.4 1.4 no signal
529 Mobility Decreased 1,456 1.4 1.4 no signal
530 Gallbladder Disorder 364 1.4 1.4 no signal
531 Cerebrovascular Accident 3,455 1.4 1.4 no signal
532 Thyroid Disorder 313 1.4 1.4 no signal
533 Hepatic Cytolysis 248 1.4 1.4 no signal
534 Memory Impairment 2,790 1.4 1.4 no signal
535 Joint Swelling 2,442 1.4 1.4 no signal
536 Proteinuria 382 1.4 1.4 no signal
537 Oral Pain 455 1.4 1.4 no signal
538 Vitreous Floaters 197 1.4 1.4 no signal
539 Respiratory Distress 558 1.4 1.4 no signal
540 Hepatic Enzyme Increased 1,369 1.4 1.4 no signal
541 Myocardial Infarction 3,530 1.4 1.4 no signal
542 Palpitations 2,347 1.4 1.4 no signal
543 Myalgia 3,408 1.4 1.4 no signal
544 Myocarditis 227 1.4 1.4 no signal
545 Haemoglobin Decreased 2,058 1.4 1.4 no signal
546 Ankle Fracture 310 1.4 1.4 no signal
547 Arrhythmia 951 1.4 1.4 no signal
548 Delirium 691 1.4 1.4 no signal
549 Blindness 813 1.4 1.4 no signal
550 Depressed Level Of Consciousness 788 1.4 1.4 no signal
551 Treatment Noncompliance 1,084 1.4 1.4 no signal
552 Injection Site Pain 6,049 1.4 1.4 no signal
553 Metastases To Lung 230 1.4 1.4 no signal
554 Oral Candidiasis 259 1.4 1.4 no signal
555 Jaundice 537 1.4 1.4 no signal
556 Eye Disorder 652 1.4 1.4 no signal
557 Vision Blurred 2,714 1.4 1.4 no signal
558 Irritable Bowel Syndrome 424 1.4 1.4 no signal
559 Injection Site Pruritus 1,315 1.4 1.4 no signal
560 Secretion Discharge 244 1.4 1.4 no signal
561 Loss Of Consciousness 2,531 1.4 1.4 no signal
562 Blood Thyroid Stimulating Hormone Increased 182 1.4 1.4 no signal
563 Lung Disorder 965 1.4 1.4 no signal
564 Gastrointestinal Infection 176 1.4 1.4 no signal
565 Musculoskeletal Discomfort 339 1.4 1.4 no signal
566 Arthropathy 1,099 1.4 1.4 no signal
567 Nephropathy Toxic 219 1.4 1.4 no signal
568 Aspiration 213 1.4 1.4 no signal
569 Gamma-glutamyltransferase Increased 436 1.4 1.4 no signal
570 Feeling Jittery 375 1.4 1.4 no signal
571 Pruritus Generalised 430 1.4 1.4 no signal
572 Oesophagitis 213 1.4 1.4 no signal
573 Suicide Attempt 1,183 1.4 1.4 no signal
574 Muscle Spasms 3,571 1.4 1.4 no signal
575 Muscle Strain 168 1.4 1.4 no signal
576 Skin Infection 217 1.4 1.4 no signal
577 Neoplasm 224 1.4 1.4 no signal
578 Pulmonary Embolism 1,855 1.4 1.4 no signal
579 Pneumonia 6,270 1.4 1.4 no signal
580 Fatigue 15,039 1.4 1.4 no signal
581 Hyperthyroidism 280 1.4 1.4 no signal
582 Poisoning Deliberate 180 1.4 1.4 no signal
583 Extra Dose Administered 771 1.4 1.4 no signal
584 Initial Insomnia 197 1.4 1.4 no signal
585 Nasal Congestion 1,128 1.4 1.4 no signal
586 Pericardial Effusion 443 1.4 1.4 no signal
587 Tendonitis 299 1.4 1.4 no signal
588 Impaired Healing 631 1.4 1.4 no signal
589 Transfusion 202 1.4 1.4 no signal
590 Nasopharyngitis 3,542 1.4 1.4 no signal
591 Dysphonia 1,120 1.4 1.4 no signal
592 Hepatic Encephalopathy 179 1.4 1.4 no signal
593 Somnolence 3,852 1.4 1.4 no signal
594 Fluid Retention 974 1.3 1.4 no signal
595 Blister 1,073 1.3 1.4 no signal
596 Liver Function Test Increased 408 1.3 1.3 no signal
597 Hypersomnia 547 1.3 1.3 no signal
598 Foot Fracture 361 1.3 1.3 no signal
599 Rash Pruritic 1,023 1.3 1.3 no signal
600 Ear Infection 502 1.3 1.3 no signal
601 Hot Flush 1,425 1.3 1.3 no signal
602 Tremor 3,134 1.3 1.3 no signal
603 Skin Discolouration 866 1.3 1.3 no signal
604 Nightmare 655 1.3 1.3 no signal
605 Generalised Oedema 232 1.3 1.3 no signal
606 Laryngitis 204 1.3 1.3 no signal
607 Hallucination, Visual 394 1.3 1.3 no signal
608 Emphysema 190 1.3 1.3 no signal
609 Sinusitis 1,927 1.3 1.3 no signal
610 Diplopia 487 1.3 1.3 no signal
611 Erectile Dysfunction 482 1.3 1.3 no signal
612 Mental Impairment 454 1.3 1.3 no signal
613 Scab 212 1.3 1.3 no signal
614 Pulmonary Hypertension 391 1.3 1.3 no signal
615 Intestinal Obstruction 699 1.3 1.3 no signal
616 Scratch 193 1.3 1.3 no signal
617 Depressed Mood 981 1.3 1.3 no signal
618 Adrenal Insufficiency 223 1.3 1.3 no signal
619 Arthralgia 7,706 1.3 1.3 no signal
620 Choking 361 1.3 1.3 no signal
621 Nervousness 976 1.3 1.3 no signal
622 Night Sweats 598 1.3 1.3 no signal
623 Premature Delivery 297 1.3 1.3 no signal
624 Discomfort 1,120 1.3 1.3 no signal
625 Movement Disorder 596 1.3 1.3 no signal
626 Dysphagia 1,747 1.3 1.3 no signal
627 Incorrect Dose Administered 4,148 1.3 1.3 no signal
628 Aphonia 257 1.3 1.3 no signal
629 Dry Throat 187 1.3 1.3 no signal
630 Pneumonia Aspiration 459 1.3 1.3 no signal
631 Feeling Hot 1,127 1.3 1.3 no signal
632 Hallucination, Auditory 292 1.3 1.3 no signal
633 Small Intestinal Obstruction 225 1.3 1.3 no signal
634 Sudden Death 196 1.3 1.3 no signal
635 Polyneuropathy 218 1.3 1.3 no signal
636 Swelling Face 1,191 1.3 1.3 no signal
637 Contusion 1,759 1.3 1.3 no signal
638 Abdominal Pain Lower 464 1.3 1.3 no signal
639 Sars-cov-2 Test Positive 244 1.3 1.3 no signal
640 Diarrhoea Haemorrhagic 171 1.3 1.3 no signal
641 Brain Injury 183 1.3 1.3 no signal
642 Inappropriate Schedule Of Product Administration 3,223 1.3 1.3 no signal
643 Alanine Aminotransferase Increased 1,118 1.3 1.3 no signal
644 Eye Infection 204 1.3 1.3 no signal
645 Product Administration Error 363 1.3 1.3 no signal
646 Hypoaesthesia 2,725 1.3 1.3 no signal
647 Muscle Rigidity 217 1.3 1.3 no signal
648 Cholecystectomy 206 1.3 1.3 no signal
649 Restless Legs Syndrome 330 1.3 1.3 no signal
650 Head Discomfort 319 1.3 1.3 no signal
651 Sensory Disturbance 292 1.3 1.3 no signal
652 Cardiac Disorder 1,700 1.3 1.3 no signal
653 Acute Hepatic Failure 246 1.3 1.3 no signal
654 Tinnitus 831 1.3 1.3 no signal
655 Osteopenia 275 1.3 1.3 no signal
656 Visual Acuity Reduced 603 1.3 1.3 no signal
657 Hypoacusis 772 1.3 1.3 no signal
658 Therapy Change 173 1.3 1.3 no signal
659 Feeling Abnormal 4,307 1.3 1.3 no signal
660 Epistaxis 1,341 1.3 1.3 no signal
661 Upper Limb Fracture 358 1.3 1.3 no signal
662 Alopecia 3,519 1.3 1.3 no signal
663 Hepatotoxicity 396 1.3 1.3 no signal
664 Upper Respiratory Tract Infection 823 1.3 1.3 no signal
665 Hepatic Failure 538 1.3 1.3 no signal
666 Covid-19 3,135 1.2 1.2 no signal
667 Dementia 493 1.2 1.2 no signal
668 Bladder Disorder 176 1.2 1.2 no signal
669 Foot Deformity 196 1.2 1.2 no signal
670 Gastric Disorder 614 1.2 1.2 no signal
671 Therapeutic Product Effect Incomplete 1,243 1.2 1.2 no signal
672 Muscle Tightness 284 1.2 1.2 no signal
673 Depression 4,011 1.2 1.2 no signal
674 Hepatocellular Injury 249 1.2 1.2 no signal
675 Amnesia 1,141 1.2 1.2 no signal
676 Joint Stiffness 458 1.2 1.2 no signal
677 Oedema 944 1.2 1.2 no signal
678 Joint Dislocation 183 1.2 1.2 no signal
679 Osteoporosis 714 1.2 1.2 no signal
680 Cognitive Disorder 806 1.2 1.2 no signal
681 Therapy Cessation 884 1.2 1.2 no signal
682 Burning Sensation 1,211 1.2 1.2 no signal
683 Condition Aggravated 5,207 1.2 1.2 no signal
684 Blood Test Abnormal 241 1.2 1.2 no signal
685 Insomnia 4,572 1.2 1.2 no signal
686 Macular Degeneration 204 1.2 1.2 no signal
687 Immunodeficiency 252 1.2 1.2 no signal
688 Cerebral Haemorrhage 609 1.2 1.2 no signal
689 Pharyngeal Oedema 265 1.2 1.2 no signal
690 Laceration 162 1.2 1.2 no signal
691 Respiratory Tract Infection 441 1.2 1.2 no signal
692 Paraesthesia Oral 244 1.2 1.2 no signal
693 Disturbance In Attention 914 1.2 1.2 no signal
694 Anxiety 4,816 1.2 1.2 no signal
695 Musculoskeletal Stiffness 1,477 1.2 1.2 no signal
696 Blood Calcium Decreased 190 1.2 1.2 no signal
697 Deep Vein Thrombosis 1,098 1.2 1.2 no signal
698 Blood Alkaline Phosphatase Increased 418 1.2 1.2 no signal
699 Inflammation 862 1.2 1.2 no signal
700 Cardio-respiratory Arrest 706 1.2 1.2 no signal
701 Drug Prescribing Error 326 1.2 1.2 no signal
702 Bedridden 219 1.2 1.2 no signal
703 Squamous Cell Carcinoma 157 1.2 1.2 no signal
704 Cardiovascular Disorder 425 1.2 1.2 no signal
705 Pharyngeal Swelling 159 1.2 1.2 no signal
706 Impaired Driving Ability 189 1.2 1.2 no signal
707 Pleural Effusion 1,011 1.2 1.2 no signal
708 Prescribed Underdose 331 1.2 1.2 no signal
709 Pain 10,185 1.2 1.2 no signal
710 Headache 10,333 1.2 1.2 no signal
711 Paraesthesia 2,602 1.2 1.2 no signal
712 Swelling 1,539 1.2 1.2 no signal
713 Pulmonary Thrombosis 180 1.2 1.2 no signal
714 Hospice Care 162 1.2 1.2 no signal
715 Colitis 619 1.2 1.2 no signal
716 Colon Cancer 245 1.2 1.2 no signal
717 Prescribed Overdose 317 1.2 1.2 no signal
718 Herpes Zoster 941 1.1 1.1 no signal
719 Chills 1,918 1.1 1.1 no signal
720 Eyelid Ptosis 166 1.1 1.1 no signal
721 Generalised Tonic-clonic Seizure 267 1.1 1.1 no signal
722 Hepatitis 416 1.1 1.1 no signal
723 Drug Intolerance 1,562 1.1 1.1 no signal
724 Clostridium Difficile Colitis 172 1.1 1.1 no signal
725 Decreased Immune Responsiveness 158 1.1 1.1 no signal
726 Neuroleptic Malignant Syndrome 192 1.1 1.1 no signal
727 Liver Injury 390 1.1 1.1 no signal
728 Cholestasis 308 1.1 1.1 no signal
729 Speech Disorder 845 1.1 1.1 no signal
730 Rheumatoid Arthritis 1,822 1.1 1.1 no signal
731 Brain Fog 235 1.1 1.1 no signal
732 Scar 276 1.1 1.1 no signal
733 Delusion 249 1.1 1.1 no signal
734 Anosmia 233 1.1 1.1 no signal
735 Injury Associated With Device 323 1.1 1.1 no signal
736 Device Malfunction 1,077 1.1 1.1 no signal
737 Inappropriate Schedule Of Drug Administration 1,156 1.1 1.1 no signal
738 Haemorrhage Intracranial 240 1.1 1.1 no signal
739 Flushing 1,632 1.1 1.1 no signal
740 Drug Dispensing Error 247 1.1 1.1 no signal
741 Tendon Rupture 197 1.1 1.1 no signal
742 Injection Site Discolouration 197 1.1 1.1 no signal
743 Hip Fracture 510 1.1 1.1 no signal
744 Immune System Disorder 209 1.1 1.1 no signal
745 Photosensitivity Reaction 261 1.1 1.1 no signal
746 Throat Irritation 708 1.1 1.1 no signal
747 Pancytopenia 880 1.1 1.1 no signal
748 Aspartate Aminotransferase Increased 836 1.1 1.1 no signal
749 Transaminases Increased 349 1.1 1.1 no signal
750 Ataxia 187 1.1 1.1 no signal
751 Muscle Twitching 362 1.1 1.1 no signal
752 Product Quality Issue 2,110 1.1 1.1 no signal
753 Road Traffic Accident 653 1.1 1.1 no signal
754 Pruritus 5,860 1.1 1.1 no signal
755 Agitation 1,142 1.1 1.1 no signal
756 Device Mechanical Issue 200 1.1 1.1 no signal
757 Acute Respiratory Distress Syndrome 274 1.1 1.1 no signal
758 Petechiae 161 1.1 1.1 no signal
759 Lacrimation Increased 462 1.1 1.1 no signal
760 Poisoning 195 1.1 1.1 no signal
761 Procedural Pain 427 1.1 1.1 no signal
762 Glossodynia 345 1.1 1.1 no signal
763 Ascites 453 1.1 1.1 no signal
764 Thinking Abnormal 288 1.1 1.1 no signal
765 Eye Swelling 568 1.1 1.1 no signal
766 Thrombosis 1,234 1.1 1.1 no signal
767 Bone Pain 895 1.1 1.1 no signal
768 Dialysis 217 1.1 1.1 no signal
769 Body Temperature Increased 312 1.1 1.1 no signal
770 Intentional Dose Omission 416 1.1 1.1 no signal
771 Hallucination 1,137 1.1 1.1 no signal
772 Serotonin Syndrome 290 1.1 1.1 no signal
773 Wrong Technique In Device Usage Process 693 1.1 1.1 no signal
774 Injection Site Urticaria 367 1.1 1.1 no signal
775 Bacteraemia 178 1.1 1.1 no signal
776 Viral Infection 502 1.1 1.1 no signal
777 Paralysis 217 1.1 1.1 no signal
778 Expired Product Administered 501 1.1 1.1 no signal
779 Drug Effect Incomplete 556 1.1 1.1 no signal
780 Tooth Disorder 337 1.1 1.1 no signal
781 Bone Disorder 277 1.1 1.1 no signal
782 Eye Pain 830 1.1 1.1 no signal
783 Pyrexia 5,197 1.1 1.1 no signal
784 Infusion Related Reaction 990 1.1 1.1 no signal
785 Therapeutic Product Effect Decreased 664 1.0 1.0 no signal
786 Hypoaesthesia Oral 225 1.0 1.0 no signal
787 Knee Operation 145 1.0 1.0 no signal
788 Blood Bilirubin Increased 404 1.0 1.0 no signal
789 Knee Arthroplasty 311 1.0 1.0 no signal
790 Breast Pain 159 1.0 1.0 no signal
791 Pemphigus 185 1.0 1.0 no signal
792 Insurance Issue 221 1.0 1.0 no signal
793 Illness 1,492 1.0 1.0 no signal
794 Dental Caries 164 1.0 1.0 no signal
795 Injection Site Induration 192 1.0 1.0 no signal
796 Product Use Issue 2,769 1.0 1.0 no signal
797 Anhedonia 391 1.0 1.0 no signal
798 Drug Eruption 260 1.0 1.0 no signal
799 Therapeutic Response Unexpected 664 1.0 1.0 no signal
800 Rash Maculo-papular 325 1.0 1.0 no signal
801 Liver Disorder 649 1.0 1.0 no signal
802 Disease Recurrence 699 1.0 1.0 no signal
803 Incorrect Product Administration Duration 297 1.0 1.0 no signal
804 Respiratory Disorder 439 1.0 1.0 no signal
805 Temperature Intolerance 149 1.0 1.0 no signal
806 Apathy 212 1.0 1.0 no signal
807 Staphylococcal Infection 482 1.0 1.0 no signal
808 Lower Limb Fracture 278 1.0 1.0 no signal
809 Full Blood Count Decreased 293 1.0 1.0 no signal
810 Folliculitis 150 1.0 1.0 no signal
811 Device Issue 1,266 1.0 1.0 no signal
812 Post Procedural Complication 279 1.0 1.0 no signal
813 Pain In Jaw 411 1.0 1.0 no signal
814 Throat Tightness 391 1.0 1.0 no signal
815 Wrist Fracture 173 1.0 1.0 no signal
816 Increased Tendency To Bruise 133 1.0 1.0 no signal
817 Metastases To Bone 236 1.0 1.0 no signal
818 Intraocular Pressure Increased 185 1.0 1.0 no signal
819 Lung Infection 227 1.0 1.0 no signal
820 Abasia 361 1.0 1.0 no signal
821 Oral Discomfort 200 1.0 1.0 no signal
822 Ear Discomfort 147 1.0 1.0 no signal
823 Skin Exfoliation 1,191 1.0 1.0 no signal
824 Rash Generalised 375 1.0 1.0 no signal
825 Rash Papular 320 1.0 1.0 no signal
826 Premature Baby 430 1.0 1.0 no signal
827 Cerebral Infarction 348 1.0 1.0 no signal
828 Abnormal Dreams 395 1.0 1.0 no signal
829 Product Taste Abnormal 191 1.0 1.0 no signal
830 Lymphadenopathy 503 1.0 1.0 no signal
831 Infection 2,044 1.0 1.0 no signal
832 Restlessness 519 1.0 1.0 no signal
833 Platelet Count Decreased 1,508 1.0 1.0 no signal
834 Dyskinesia 574 1.0 1.0 no signal
835 Rash Macular 491 1.0 1.0 no signal
836 Eye Inflammation 133 1.0 1.0 no signal
837 Mood Altered 383 1.0 1.0 no signal
838 Lymphocyte Count Decreased 249 1.0 1.0 no signal
839 Quality Of Life Decreased 189 1.0 1.0 no signal
840 Skin Disorder 468 1.0 1.0 no signal
841 Accident 167 1.0 1.0 no signal
842 Deafness 367 1.0 1.0 no signal
843 Musculoskeletal Disorder 267 1.0 1.0 no signal
844 Off Label Use 12,093 1.0 1.0 no signal
845 Product Substitution Issue 802 1.0 1.0 no signal
846 Eye Discharge 142 1.0 1.0 no signal
847 Hyperbilirubinaemia 143 1.0 1.0 no signal
848 Urticaria 2,309 1.0 1.0 no signal
849 Ovarian Cyst 139 1.0 1.0 no signal
850 Gastric Haemorrhage 160 1.0 1.0 no signal
851 Febrile Neutropenia 913 1.0 1.0 no signal
852 Bacterial Infection 256 1.0 1.0 no signal
853 Rash 5,965 1.0 1.0 no signal
854 Mucosal Inflammation 358 1.0 1.0 no signal
855 Photophobia 256 1.0 1.0 no signal
856 Clostridium Difficile Infection 297 1.0 1.0 no signal
857 Face Oedema 232 1.0 1.0 no signal
858 Pneumonitis 369 1.0 1.0 no signal
859 Product Physical Issue 272 1.0 1.0 no signal
860 Fear 369 1.0 1.0 no signal
861 Spinal Fracture 271 1.0 1.0 no signal
862 Brain Oedema 171 0.9 0.9 no signal
863 Colitis Ulcerative 603 0.9 0.9 no signal
864 Mental Disorder 588 0.9 0.9 no signal
865 Therapy Interrupted 927 0.9 0.9 no signal
866 Influenza Like Illness 1,109 0.9 0.9 no signal
867 Stomatitis 814 0.9 0.9 no signal
868 Drug Level Decreased 137 0.9 0.9 no signal
869 Drug Hypersensitivity 2,599 0.9 0.9 no signal
870 Product Packaging Quantity Issue 146 0.9 0.9 no signal
871 Economic Problem 206 0.9 0.9 no signal
872 Bipolar Disorder 145 0.9 0.9 no signal
873 Migraine 1,255 0.9 0.9 no signal
874 Spinal Operation 160 0.9 0.9 no signal
875 Fluid Overload 195 0.9 0.9 no signal
876 Eye Pruritus 435 0.9 0.9 no signal
877 Hand Deformity 172 0.9 0.9 no signal
878 Overdose 2,836 0.9 0.9 no signal
879 Drug Effect Decreased 715 0.9 0.9 no signal
880 Foetal Exposure During Pregnancy 1,061 0.9 0.9 no signal
881 Injection Site Rash 396 0.9 0.9 no signal
882 Drug Administration Error 406 0.9 0.9 no signal
883 Activities Of Daily Living Impaired 262 0.9 0.9 no signal
884 Psychotic Disorder 384 0.9 0.9 no signal
885 Anaphylactic Reaction 712 0.9 0.9 no signal
886 Multi-organ Failure 227 0.9 0.9 no signal
887 Ocular Discomfort 140 0.9 0.9 no signal
888 Fistula 145 0.9 0.9 no signal
889 Hypotonia 129 0.9 0.9 no signal
890 Sedation 335 0.9 0.9 no signal
891 Treatment Failure 1,052 0.9 0.9 no signal
892 Adverse Drug Reaction 1,140 0.9 0.9 no signal
893 Anger 431 0.9 0.9 no signal
894 Skin Reaction 178 0.9 0.9 no signal
895 Brain Neoplasm 116 0.9 0.9 no signal
896 Dermatitis Contact 143 0.9 0.9 no signal
897 Paranoia 218 0.9 0.9 no signal
898 Erythema 2,583 0.9 0.9 no signal
899 Thrombocytopenia 1,403 0.9 0.9 no signal
900 Gingival Bleeding 172 0.9 0.9 no signal
901 Panic Attack 458 0.9 0.9 no signal
902 Injection Site Swelling 951 0.9 0.9 no signal
903 Hypersensitivity 2,319 0.9 0.9 no signal
904 Pain Of Skin 337 0.9 0.9 no signal
905 Mania 205 0.9 0.9 no signal
906 Irritability 751 0.9 0.9 no signal
907 Laboratory Test Abnormal 367 0.9 0.9 no signal
908 Multiple Fractures 206 0.9 0.9 no signal
909 Drug Ineffective 16,333 0.9 0.9 no signal
910 Uveitis 167 0.9 0.9 no signal
911 Mouth Ulceration 259 0.9 0.9 no signal
912 Systemic Lupus Erythematosus 435 0.9 0.9 no signal
913 White Blood Cell Count Decreased 1,327 0.9 0.9 no signal
914 Tooth Extraction 152 0.9 0.9 no signal
915 Ankylosing Spondylitis 159 0.9 0.9 no signal
916 Incorrect Drug Administration Duration 348 0.9 0.9 no signal
917 Product Dose Omission Issue 3,463 0.9 0.8 no signal
918 Seizure 1,393 0.8 0.8 no signal
919 Rash Erythematous 568 0.8 0.8 no signal
920 Injection Site Erythema 1,483 0.8 0.8 no signal
921 Femur Fracture 372 0.8 0.8 no signal
922 Skin Cancer 257 0.8 0.8 no signal
923 Skin Fissures 225 0.8 0.8 no signal
924 Dermatitis Allergic 148 0.8 0.8 no signal
925 Myoclonus 141 0.8 0.8 no signal
926 Respiratory Depression 144 0.8 0.8 no signal
927 Crying 428 0.8 0.8 no signal
928 Device Failure 178 0.8 0.8 no signal
929 Product Dispensing Error 255 0.8 0.8 no signal
930 Product Availability Issue 260 0.8 0.8 no signal
931 Infusion Site Pain 148 0.8 0.8 no signal
932 Intestinal Perforation 130 0.8 0.8 no signal
933 Leukaemia 109 0.8 0.8 no signal
934 Interstitial Lung Disease 558 0.8 0.8 no signal
935 Cyanosis 182 0.8 0.8 no signal
936 Incorrect Route Of Product Administration 194 0.8 0.8 no signal
937 Suicidal Ideation 1,055 0.8 0.8 no signal
938 Appendicitis 107 0.8 0.8 no signal
939 Drug Ineffective For Unapproved Indication 641 0.8 0.8 no signal
940 Breast Cancer Metastatic 123 0.8 0.8 no signal
941 Hereditary Angioedema 120 0.8 0.8 no signal
942 Blood Lactate Dehydrogenase Increased 182 0.8 0.8 no signal
943 Eczema 574 0.8 0.8 no signal
944 Dry Eye 549 0.8 0.8 no signal
945 Product Use In Unapproved Indication 2,760 0.8 0.8 no signal
946 Bronchospasm 161 0.8 0.8 no signal
947 Maternal Exposure During Pregnancy 991 0.8 0.8 no signal
948 Abnormal Behaviour 448 0.8 0.8 no signal
949 Post Procedural Haemorrhage 131 0.8 0.8 no signal
950 Disease Progression 1,323 0.8 0.8 no signal
951 Hip Arthroplasty 170 0.8 0.8 no signal
952 Therapy Non-responder 496 0.8 0.8 no signal
953 Withdrawal Syndrome 469 0.8 0.8 no signal
954 Psychomotor Hyperactivity 185 0.8 0.8 no signal
955 Device Delivery System Issue 290 0.8 0.8 no signal
956 Neutrophil Count Decreased 446 0.8 0.8 no signal
957 Toxic Skin Eruption 111 0.8 0.8 no signal
958 Caesarean Section 129 0.8 0.8 no signal
959 Dermatitis 227 0.8 0.8 no signal
960 Fracture 207 0.8 0.8 no signal
961 Aggression 548 0.8 0.8 no signal
962 Ill-defined Disorder 663 0.8 0.8 no signal
963 Therapeutic Response Shortened 347 0.8 0.8 no signal
964 Product Use Complaint 169 0.8 0.8 no signal
965 Exposure During Pregnancy 677 0.8 0.8 no signal
966 Therapeutic Response Decreased 656 0.8 0.8 no signal
967 Device Defective 176 0.8 0.8 no signal
968 Wrong Technique In Product Usage Process 2,196 0.8 0.8 no signal
969 Malignant Neoplasm Progression 1,106 0.8 0.8 no signal
970 Eye Irritation 603 0.8 0.8 no signal
971 Injury 762 0.8 0.8 no signal
972 Epilepsy 329 0.8 0.8 no signal
973 Product Packaging Issue 100 0.8 0.8 no signal
974 Lymphoma 167 0.8 0.8 no signal
975 Haemorrhage 1,121 0.7 0.7 no signal
976 Coeliac Disease 105 0.7 0.7 no signal
977 Device Related Infection 165 0.7 0.7 no signal
978 Injection Site Irritation 135 0.7 0.7 no signal
979 Agranulocytosis 197 0.7 0.7 no signal
980 Thyroid Cancer 129 0.7 0.7 no signal
981 Injection Site Warmth 219 0.7 0.7 no signal
982 Application Site Pain 233 0.7 0.7 no signal
983 Circumstance Or Information Capable Of Leading To Medication Error 355 0.7 0.7 no signal
984 Respiratory Arrest 293 0.7 0.7 no signal
985 Vaginal Haemorrhage 447 0.7 0.7 no signal
986 Pneumothorax 166 0.7 0.7 no signal
987 Oral Herpes 203 0.7 0.7 no signal
988 Hepatitis C 127 0.7 0.7 no signal
989 Helicobacter Infection 106 0.7 0.7 no signal
990 Pulmonary Arterial Hypertension 151 0.7 0.7 no signal
991 Surgery 600 0.7 0.7 no signal
992 Palmar-plantar Erythrodysaesthesia Syndrome 242 0.7 0.7 no signal
993 Tuberculosis 132 0.7 0.7 no signal
994 Wrong Technique In Drug Usage Process 377 0.7 0.7 no signal
995 Ocular Hyperaemia 476 0.7 0.7 no signal
996 Product Dose Omission In Error 273 0.7 0.7 no signal
997 Lymphopenia 143 0.7 0.7 no signal
998 Neutropenia 1,374 0.7 0.7 no signal
999 Dry Skin 1,331 0.7 0.7 no signal
1000 Anorexia 132 0.7 0.7 no signal
1001 Drug Reaction With Eosinophilia And Systemic Symptoms 258 0.7 0.7 no signal
1002 Pelvic Pain 183 0.7 0.7 no signal
1003 Euphoric Mood 103 0.7 0.7 no signal
1004 Nervous System Disorder 313 0.7 0.7 no signal
1005 Device Use Issue 172 0.7 0.7 no signal
1006 Status Epilepticus 112 0.7 0.7 no signal
1007 Neoplasm Progression 347 0.7 0.7 no signal
1008 Adverse Reaction 131 0.7 0.7 no signal
1009 Unevaluable Event 745 0.7 0.7 no signal
1010 Personality Change 91 0.7 0.7 no signal
1011 Autoimmune Disorder 93 0.7 0.7 no signal
1012 Mood Swings 308 0.7 0.7 no signal
1013 Erythema Multiforme 90 0.7 0.7 no signal
1014 Pharyngitis Streptococcal 104 0.7 0.7 no signal
1015 Disseminated Intravascular Coagulation 135 0.7 0.7 no signal
1016 Injection Site Reaction 656 0.7 0.7 no signal
1017 Myelodysplastic Syndrome 137 0.7 0.7 no signal
1018 Cytopenia 111 0.6 0.6 no signal
1019 Osteonecrosis Of Jaw 231 0.6 0.6 no signal
1020 Tooth Loss 193 0.6 0.6 no signal
1021 Sexual Dysfunction 107 0.6 0.6 no signal
1022 Intentional Self-injury 184 0.6 0.6 no signal
1023 Poor Quality Product Administered 93 0.6 0.6 no signal
1024 Emotional Distress 1,097 0.6 0.6 no signal
1025 Drug Effect Less Than Expected 127 0.6 0.6 no signal
1026 Leukopenia 448 0.6 0.6 no signal
1027 Plasma Cell Myeloma 350 0.6 0.6 no signal
1028 Posterior Reversible Encephalopathy Syndrome 85 0.6 0.6 no signal
1029 Therapy Partial Responder 134 0.6 0.6 no signal
1030 Lung Neoplasm Malignant 366 0.6 0.6 no signal
1031 Emotional Disorder 273 0.6 0.6 no signal
1032 Libido Decreased 109 0.6 0.6 no signal
1033 Anaphylactic Shock 225 0.6 0.6 no signal
1034 Product Storage Error 755 0.6 0.6 no signal
1035 Adverse Event 799 0.6 0.6 no signal
1036 Conjunctivitis 159 0.6 0.6 no signal
1037 Central Nervous System Lesion 119 0.6 0.6 no signal
1038 Disability 169 0.6 0.6 no signal
1039 Drug Administered At Inappropriate Site 91 0.6 0.6 no signal
1040 Application Site Pruritus 191 0.6 0.6 no signal
1041 Neoplasm Malignant 561 0.6 0.6 no signal
1042 Hospitalisation 1,276 0.6 0.6 no signal
1043 Complication Associated With Device 110 0.6 0.6 no signal
1044 Eyelid Oedema 97 0.6 0.6 no signal
1045 Device Occlusion 114 0.6 0.6 no signal
1046 Neurotoxicity 142 0.6 0.6 no signal
1047 Product Prescribing Issue 166 0.6 0.6 no signal
1048 Acute Myeloid Leukaemia 126 0.6 0.6 no signal
1049 Toxic Epidermal Necrolysis 121 0.6 0.6 no signal
1050 Metastases To Central Nervous System 101 0.5 0.5 no signal
1051 Intentional Drug Misuse 166 0.5 0.5 no signal
1052 Death 6,738 0.5 0.5 no signal
1053 Product Administered At Inappropriate Site 142 0.5 0.5 no signal
1054 Application Site Erythema 203 0.5 0.5 no signal
1055 Abortion Spontaneous 305 0.5 0.5 no signal
1056 Bone Density Decreased 237 0.5 0.5 no signal
1057 Drug Resistance 192 0.5 0.5 no signal
1058 Vaginal Discharge 75 0.5 0.5 no signal
1059 Gastrointestinal Carcinoma 68 0.5 0.5 no signal
1060 Tardive Dyskinesia 210 0.5 0.5 no signal
1061 Stevens-johnson Syndrome 164 0.5 0.5 no signal
1062 Mydriasis 94 0.5 0.5 no signal
1063 Product Adhesion Issue 253 0.5 0.5 no signal
1064 Hepatic Cancer 170 0.5 0.5 no signal
1065 Injection Site Haematoma 101 0.5 0.5 no signal
1066 Bone Marrow Failure 141 0.5 0.5 no signal
1067 Embedded Device 67 0.5 0.5 no signal
1068 Skin Irritation 312 0.5 0.5 no signal
1069 Cytokine Release Syndrome 129 0.5 0.5 no signal
1070 Complication Of Device Removal 114 0.5 0.5 no signal
1071 Application Site Rash 92 0.5 0.5 no signal
1072 Hepatic Function Abnormal 246 0.5 0.5 no signal
1073 Deformity 62 0.5 0.5 no signal
1074 Akathisia 89 0.5 0.5 no signal
1075 Peritonitis 133 0.4 0.4 no signal
1076 No Therapeutic Response 79 0.4 0.4 no signal
1077 Bone Loss 96 0.4 0.4 no signal
1078 Pneumocystis Jirovecii Pneumonia 63 0.4 0.4 no signal
1079 Drug Abuse 525 0.4 0.4 no signal
1080 Extrapyramidal Disorder 155 0.4 0.4 no signal
1081 Multiple Sclerosis 291 0.4 0.4 no signal
1082 Skin Burning Sensation 430 0.4 0.4 no signal
1083 Dystonia 117 0.4 0.4 no signal
1084 Amenorrhoea 98 0.4 0.4 no signal
1085 Acne 447 0.4 0.4 no signal
1086 Breast Cancer 551 0.4 0.4 no signal
1087 Multiple Sclerosis Relapse 397 0.4 0.4 no signal
1088 Syringe Issue 98 0.4 0.4 no signal
1089 Dysmenorrhoea 73 0.4 0.4 no signal
1090 Device Breakage 215 0.4 0.4 no signal
1091 Osteonecrosis 181 0.4 0.4 no signal
1092 Ovarian Cancer 50 0.4 0.4 no signal
1093 Application Site Irritation 65 0.4 0.4 no signal
1094 Prostate Cancer 424 0.4 0.4 no signal
1095 Device Dislocation 220 0.4 0.4 no signal
1096 Menorrhagia 99 0.3 0.3 no signal
1097 Abnormal Weight Gain 62 0.3 0.3 no signal
1098 Thrombotic Microangiopathy 48 0.3 0.3 no signal
1099 Convulsion 287 0.3 0.3 no signal
1100 Dermatitis Atopic 243 0.3 0.3 no signal
1101 Incorrect Route Of Drug Administration 176 0.3 0.3 no signal
1102 Accidental Exposure To Product 477 0.3 0.3 no signal
1103 Pregnancy 94 0.3 0.3 no signal
1104 Drug Withdrawal Syndrome 408 0.3 0.3 no signal
1105 Breast Cancer Female 119 0.3 0.3 no signal
1106 Product Preparation Error 91 0.3 0.3 no signal
1107 Inflammatory Bowel Disease 43 0.3 0.3 no signal
1108 Drug Dose Omission By Device 329 0.3 0.3 no signal
1109 No Adverse Event 760 0.3 0.3 no signal
1110 Device Use Error 145 0.3 0.3 no signal
1111 Meningioma 58 0.3 0.3 no signal
1112 Metrorrhagia 68 0.3 0.3 no signal
1113 Rebound Effect 44 0.3 0.3 no signal
1114 Renal Cancer 187 0.3 0.3 no signal
1115 Grand Mal Convulsion 35 0.3 0.3 no signal
1116 Product Complaint 93 0.3 0.3 no signal
1117 Cytomegalovirus Infection 60 0.3 0.2 no signal
1118 Gastric Cancer 92 0.2 0.2 no signal
1119 Drug Toxicity 48 0.2 0.2 no signal
1120 Skeletal Injury 36 0.2 0.2 no signal
1121 Menstruation Irregular 90 0.2 0.2 no signal
1122 Abortion Induced 31 0.2 0.2 no signal
1123 Gynaecomastia 102 0.2 0.2 no signal
1124 Drug Effective For Unapproved Indication 93 0.2 0.2 no signal
1125 Genital Haemorrhage 41 0.2 0.2 no signal
1126 Peritonitis Bacterial 31 0.2 0.2 no signal
1127 Complication Of Device Insertion 56 0.2 0.2 no signal
1128 Myelosuppression 102 0.2 0.2 no signal
1129 Menstruation Delayed 31 0.2 0.2 no signal
1130 Pharmaceutical Product Complaint 77 0.2 0.2 no signal
1131 Exposure Via Skin Contact 62 0.2 0.2 no signal
1132 Device Difficult To Use 176 0.2 0.2 no signal
1133 Unintended Pregnancy 27 0.2 0.2 no signal
1134 Haematotoxicity 23 0.2 0.2 no signal
1135 Device Expulsion 153 0.2 0.2 no signal
1136 Drug Dependence 352 0.1 0.1 no signal
1137 Oesophageal Carcinoma 62 0.1 0.1 no signal
1138 Drug Exposure During Pregnancy 71 0.1 0.1 no signal
1139 Device Deployment Issue 20 0.1 0.1 no signal
1140 Unintentional Medical Device Removal 11 0.1 0.1 no signal
1141 Colorectal Cancer 45 0.1 0.1 no signal
1142 Intercepted Product Preparation Error 7 0.0 0.0 no signal
1143 Sickle Cell Anaemia With Crisis 9 0.0 0.0 no signal
1144 Dependence 30 0.0 0.0 no signal
1145 Breast Cancer Stage I 5 0.0 0.0 no signal
1146 Device Adhesion Issue 8 0.0 0.0 no signal
1147 Drug Withdrawal Syndrome Neonatal 5 0.0 0.0 no signal