Reaction

Blood Lactic Acid Increased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,173 reports · 280 co-occurring drugs

As of the last recalculation, Blood Lactic Acid Increased appears in 5,173 FAERS reports alongside 280 co-occurring drug terms. The strongest observed disproportionality signal is ZIDOVUDINE (PRR 87.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Zidovudine	276	87.7	89.5
Oseltamivir Phosphate	209	35.8	36.1
Lamivudine	220	29.9	30.1
Abacavir Sulfate	66	27.6	27.8
Ceftriaxone Sodium	246	27.0	27.2
Nevirapine	55	24.8	24.9
Lopinavir And Ritonavir	78	23.5	23.6
Lamivudine Oral	130	21.2	21.3
Pegaspargase	59	19.6	19.7
Magnesium Sulfate In Water For	55	17.5	17.6
Magnesium Sulfate Heptahydrate	56	17.5	17.5
Magnesium Sulfate	56	17.4	17.5
Mepolizumab	200	16.8	16.9
Azithromycin Monohydrate	165	16.4	16.5
Sevoflurane	33	16.1	16.1
Midazolam Hydrochloride	100	15.2	15.3
Atazanavir	53	15.0	15.0
Midazolam	92	14.9	15.0
Norepinephrine	38	14.4	14.5
Norepinephrine Bitartrate	50	14.1	14.1
Ritonavir	97	13.6	13.6
Propofol	119	13.4	13.4
Azithromycin	123	12.6	12.6
Efavirenz	34	12.3	12.4
Tenofovir Disoproxil Fumarate	98	12.1	12.2
Phenobarbital	43	12.0	12.1
Ritonavir 100 Mg	43	11.7	11.7
Linezolid	80	11.0	11.0
Omalizumab	210	10.3	10.3
Metformin Hydrochloride Tablets	138	9.9	9.9
Metformin Hydrochloride Extended-Release Tablets	138	9.9	9.9
Metformin Hydrochloride Tablet	138	9.9	9.9
Valproic Acid	76	9.8	9.9
Metformin Hydrochloride	141	9.8	9.8
Vincristine Sulfate	69	9.6	9.6
Budesonide	136	9.5	9.5
Metformin	724	9.3	9.3
Albuterol	260	9.1	9.1
Azithromycin Dihydrate	127	8.9	8.9
Metformin Er 500 Mg	587	8.7	8.7
Metformin Er 750 Mg	587	8.7	8.7
Leucovorin Calcium	40	8.5	8.5
Clobazam	50	8.3	8.3
Ceftriaxone	67	8.3	8.3
Adrenalinum	83	8.2	8.2
Phenytoin	42	8.2	8.2
Human Immunoglobulin G	41	8.1	8.1
Theophylline Anhydrous	24	7.8	7.8
Theophylline	22	7.7	7.7
Montelukast Sodium	220	7.5	7.6
Darunavir	28	7.5	7.5
Acetylcysteine	17	7.3	7.3
Rocuronium Bromide	21	7.2	7.2
Tenofovir Disoproxil Fumarate Tablets	15	7.0	7.0
Nebivolol	27	6.9	6.9
Amphetamine	14	6.8	6.8
Ethyl Alcohol	45	6.7	6.7
Valproate Sodium	34	6.7	6.7
Bleomycin Sulfate	17	6.6	6.6
Entecavir	19	6.6	6.6
Lacosamide	59	6.4	6.5
Dextrose Monohydrate	21	6.3	6.4
Indapamide	28	6.3	6.3
Quetiapine Fumarate	45	6.2	6.2
Dextrose	20	6.1	6.1
Raltegravir	25	6.1	6.1
Metformin Hcl	83	6.1	6.1
Mercaptopurine	26	6.1	6.1
Epinephrine	93	5.8	5.8
Doxazosin	40	5.8	5.8
Sodium Bicarbonate	33	5.7	5.7
Sodium Bicarbonate Injection,	33	5.7	5.7
Hydrocortisone Sodium Succinate	13	5.6	5.6
Alcohol	53	5.5	5.5
Isopropyl Alcohol	46	5.5	5.5
Dronabinol	11	5.5	5.5
Piperacillin And Tazobactam	17	5.4	5.4
Cytarabine	78	5.3	5.3
Dapagliflozin	41	5.3	5.3
Doxazosin Mesylate	46	5.2	5.2
Linagliptin	23	5.1	5.1
Cefepime	18	5.1	5.1
Methocarbamol Tablets	21	5.1	5.1
Cefepime Hydrochloride	20	5.0	5.0
Piperacillin Sodium,Tazobactam Sodium	32	4.9	4.9
Standardized Senna Concentrate	15	4.8	4.8
Venlafaxine	84	4.8	4.8
Prochlorperazine	32	4.7	4.7
Piperacillin Sodium And Tazobactam Sodium	22	4.5	4.5
Amlodipine	289	4.5	4.5
Vancomycin	63	4.4	4.4
Irinotecan Hydrochloride	14	4.4	4.4
Meperidine Hydrochloride	10	4.4	4.4
Ganciclovir	11	4.3	4.3
Sulfamethoxazole And Trimethoprim	89	4.3	4.3
Colchicine	28	4.3	4.3
Albuterol Sulfate	302	4.3	4.3
Meropenem	34	4.3	4.3
Glimepiride	41	4.3	4.3
Vancomycin Hydrochloride	68	4.2	4.2
Ganciclovir Sodium	11	4.2	4.2
Bupropion	46	4.2	4.2
Levetiracetam In Sodium Chloride	79	4.2	4.2
Levetiracetam Oral	79	4.2	4.2
Levetiracetam Injection	79	4.1	4.2
Acetaminophen Tablet Extended Release	253	4.1	4.1
Pain Reliever	253	4.1	4.1
Acetaminophen 500Mg	253	4.1	4.1
Bisacodyl Suppositories	13	4.1	4.1
Sennosides 8.6 Mg Tablets	21	4.0	4.0
Senna Leaf	23	4.0	4.0
Fluoxetine	66	4.0	4.0
Senna	21	4.0	4.0
Biscodyl	13	4.0	4.0
Enalapril	55	4.0	4.0
Rifampicin	10	4.0	4.0
Oxcarbazepine	32	4.0	4.0
Ramipril	119	3.9	3.9
Empagliflozin	65	3.9	3.9
Enalapril Maleate	24	3.9	3.9
Nebivolol Hydrochloride	32	3.8	3.8
Digoxin	67	3.8	3.8
Quetiapine	176	3.8	3.8
Paroxetine Hydrochloride Hemihydrate	31	3.8	3.8
Oxazepam	20	3.8	3.8
Sitagliptin And Metformin Hydrochloride	20	3.7	3.7
Ipratropium Bromide	33	3.7	3.7
Methocarbamol	21	3.7	3.7
Bisacodyl	13	3.7	3.7
Polyethylene Glycol	10	3.7	3.7
Propranolol Hydrochloride	66	3.7	3.7
Paroxetine	31	3.7	3.7
Filgrastim	34	3.7	3.7
Fluconazole	63	3.6	3.7
Anti-Itch	60	3.6	3.6
Anti-Pruritic	60	3.6	3.6
Antipruritic (Anti-Itch)	60	3.6	3.6
Cool Relief Gel With Aloe	60	3.6	3.6
Drs. Hydrocortisone	60	3.6	3.6
Hydrocortisone Continuous Spray	60	3.6	3.6
Hydrocortisone Spray	60	3.6	3.6
Anti-Itch Cream	60	3.6	3.6
Hydrocortisone Lotion	60	3.6	3.6
Hydrocortisone Cream 1%	60	3.6	3.6
Hydrocortisone Cream 1/2%	60	3.6	3.6
Hydrocortisone 1%	60	3.6	3.6
Diphenhydramine Hcl	10	3.6	3.6
Lorazepam	158	3.6	3.6
Hydrocortisone Cream	60	3.6	3.6
Mirtazapine	81	3.6	3.6
Amikacin	15	3.5	3.5
Diltiazem Hydrochloride Extended-Release Tablets	10	3.5	3.5
Derma Foam Excel Hand Sanitizer	7	3.5	3.5
Ethanol	7	3.5	3.5
Insulin Glargine-Yfgn	19	3.5	3.5
Lidocaine Hydrochloride	52	3.5	3.5
Losartan Potassium And Hydrochlorothiazide	10	3.5	3.5
Eplerenone	11	3.5	3.5
Ampicillin	7	3.4	3.4
Ampicillin Sodium	7	3.4	3.4
Ketoprofen	11	3.4	3.4
Sennosides	25	3.4	3.4
Bisoprolol Fumarate	112	3.4	3.4
Ondansetron	90	3.4	3.4
Ondansetron Tablets	90	3.4	3.4
Haloperidol	20	3.3	3.3
Daspone	8	3.3	3.3
Dapsone Gel, 5%	8	3.3	3.3
Fentanyl	80	3.3	3.3
Fluorouracil Cream, 0.5%	62	3.3	3.3
Haloperidol Lactate	20	3.3	3.3
Fluorouracil	62	3.3	3.3
Diphenoxylate Hydrochloride And Atropine Sulfate	11	3.2	3.2
Metolazone	9	3.2	3.2
Sitagliptin	57	3.2	3.2
Insulin	44	3.2	3.2
Levetiracetam	104	3.2	3.2
Ondansetron Hydrochloride	95	3.2	3.2
Olanzapine	82	3.1	3.1
Blinatumomab	8	3.1	3.1
Oseltamivir	6	3.0	3.0
Remdesivir	10	3.0	3.0
Labetalol	10	3.0	3.0
Dapsone	8	3.0	3.0
Oxaliplatin	55	3.0	3.0
Atovaquone	6	3.0	3.0
Glyburide	18	3.0	3.0
Venlafaxine Hydrochloride	97	3.0	3.0
Hydroxyzine	35	3.0	3.0
Doxorubicin Hydrochloride	24	3.0	3.0
Diazepam Oral Solution (Concentrate)	64	2.9	2.9
Diazepam Oral	64	2.9	2.9
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	13	2.9	2.9
Topiramate	66	2.9	2.9
Emtricitabine And Tenofovir Alafenamide	8	2.8	2.8
Canagliflozin	21	2.8	2.8
Felodipine Extended-Release Tablets	8	2.8	2.8
Felodipine	8	2.8	2.8
Sevelamer Carbonate	8	2.8	2.8
Divalproex Sodium	32	2.8	2.8
Fluoxetine Hydrochloride	87	2.8	2.8
Loperamide Hydrochloride Oral	7	2.8	2.8
Itraconazole	8	2.8	2.8
Hydroxyzine Hydrochloride	9	2.8	2.8
Hydroxyzine Hydrochloride Oral	9	2.8	2.8
Pitavastatin Calcium	7	2.8	2.8
Isoniazid	11	2.7	2.7
Prednisolone Acetate	7	2.7	2.7
Aflibercept	21	2.7	2.7
Bendamustine Hydrochloride	8	2.7	2.7
Allopurinol	103	2.7	2.7
Carbamazepine	44	2.7	2.7
Sildenafil Powder,	23	2.6	2.6
Sodium Chloride Tablet	47	2.6	2.6
Sodium Chloride Tablets	47	2.6	2.6
Budesonide And Formoterol Fumarate Dihydrate	61	2.5	2.5
Lamotirigine	45	2.5	2.5
Lamotrigine Extended-Release	45	2.5	2.5
Lamotrigine Chewable Dispersible	45	2.5	2.5
Loperamide Hcl	8	2.5	2.5
Fondaparinux Sodium	5	2.5	2.5
Ezetimibe	46	2.5	2.5
Cetuximab	19	2.4	2.4
Iohexol	5	2.4	2.4
Dexamethasone 1.5 Mg	171	2.4	2.4
Micafungin Sodium	5	2.4	2.4
Brentuximab Vedotin	6	2.4	2.4
Dexamethasone	169	2.3	2.3
Doxorubicin	51	2.3	2.3
Instalax Polyethylene Glycol 3350	7	2.3	2.3
Dolutegravir Sodium	5	2.2	2.2
Polyethylene Glycol 400	7	2.2	2.2
Capecitabine	49	2.2	2.2
Dexlansoprazole	22	2.1	2.1
Acyclovir	59	2.1	2.1
Polatuzumab Vedotin	5	2.1	2.1
Insulin Degludec	12	2.1	2.1
Guanfacine	4	2.0	2.0
Cyclophosphamide Injection, Solution	89	2.0	2.0
Cyclophosphamide	89	2.0	2.0
Cyclophosphamide For Injection	89	2.0	2.0
Axicabtagene Ciloleucel	5	2.0	2.0
Acalabrutinib	6	2.0	2.0
Azacitidine For	9	2.0	2.0
Acetaminophen And Codeine	6	2.0	2.0
Gemcitabine Hydrochloride	26	2.0	2.0
Dronedarone	5	2.0	2.0
Macitentan	33	1.9	1.9
Rifaximin	10	1.9	1.9
Liraglutide	23	1.9	1.9
Gemcitabine	18	1.8	1.8
Abiraterone	6	1.8	1.8
Carboplatin	53	1.7	1.7
Bevacizumab	50	1.6	1.6
Azacitidine	12	1.6	1.6
Velpatasvir And Sofosbuvir	5	1.6	1.6
Dabigatran Etexilate	30	1.6	1.6
Mometasone Furoate And Formoterol Fumarate Dihydrate	6	1.5	1.5
Dabrafenib	8	1.5	1.5
Dulaglutide	33	1.5	1.5
Asenapine Maleate	3	1.4	1.4
Vigabatrin	5	1.4	1.4
Alteplase	5	1.3	1.3
Temozolomide	7	1.3	1.3
Daptomycin	3	1.3	1.3
Erlotinib Hydrochloride	4	1.3	1.3
Clozapine	40	1.3	1.3
Emtricitabine And Tenofovir Disoproxil Fumarate	14	1.2	1.2
Paliperidone	7	1.2	1.2
Trifluridine And Tipiracil	3	1.1	1.1
Paliperidone Palmitate	8	1.0	1.0
Durvalumab	5	1.0	1.0
Olaparib	5	1.0	1.0
Romosozumab-Aqqg	3	0.9	0.9
Sacubitril And Valsartan	25	0.9	0.9
Dornase Alfa	4	0.8	0.8
Ranitidine Hydrochloride	11	0.8	0.8
Relugolix	4	0.7	0.7
Nirmatrelvir And Ritonavir	8	0.6	0.6
Tirzepatide	18	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.