Reaction

Vitamin B12 Deficiency reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,966 reports · 186 co-occurring drugs

As of the last recalculation, Vitamin B12 Deficiency appears in 3,966 FAERS reports alongside 186 co-occurring drug terms. The strongest observed disproportionality signal is METHYLPREDNISOLONE ACETATE (PRR 22.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Methylprednisolone Acetate	34	22.5	22.6
Cyanocobalamin	128	21.0	21.1
Metformin Hydrochloride	158	14.6	14.6
Metformin Hydrochloride Tablets	152	14.4	14.5
Metformin Hydrochloride Extended-Release Tablets	152	14.4	14.5
Metformin Hydrochloride Tablet	152	14.4	14.5
Esomeprazole Magnesium Capsule, Delayed Release	39	14.2	14.3
Esomeprazole Magnesium Delayed Release Capsules	39	14.2	14.3
Esomeprazole Magnesium Dihydrate	39	14.2	14.2
Thiamine Hydrochloride	29	12.3	12.3
Diphenhydramine Hydrochloride Capsule, Liquid Filled	48	11.9	11.9
Phytonadione	19	11.8	11.8
Niacin	25	11.4	11.4
Cetirizine Hydrochloride Allergy	63	11.1	11.1
Cetirizine Hydrochloride Tablets	63	11.1	11.1
Metformin	630	10.8	10.8
Etonogestrel And Ethinyl Estradiol	44	10.5	10.5
Vitamin E	60	10.1	10.2
Esomeprazole	110	9.5	9.6
Metformin Er 500 Mg	482	9.4	9.4
Metformin Er 750 Mg	482	9.4	9.4
Rivastigmine	32	9.0	9.0
Nicotine Polacrilex Mini	25	8.8	8.8
Nicotine Polarilex	25	8.8	8.8
Captopril	15	8.2	8.2
Alendronate Sodium	151	8.1	8.1
Biotin	45	7.6	7.7
Linagliptin	26	7.5	7.5
Methocarbamol	32	7.4	7.5
Dicyclomine Hydrochloride	19	7.0	7.0
Meclizine Hcl 12.5Mg	18	7.0	7.0
Meclizine Hcl 25Mg	18	7.0	7.0
Meclizine Hcl 12.5 Mg	18	7.0	7.0
Meclizine Hcl 25 Mg	18	7.0	7.0
Buspirone Hydrochloride	14	6.7	6.7
Ascorbic Acid	29	6.6	6.6
Cholestyramine	15	6.5	6.5
Meclizine	20	6.5	6.5
Sitagliptin And Metformin Hydrochloride	26	6.4	6.4
Zidovudine	16	6.3	6.3
Teduglutide	16	6.3	6.3
Ropinirole	18	6.2	6.2
Metformin Hcl	64	6.2	6.2
Efavirenz	13	6.1	6.1
Cimetidine	11	6.0	6.0
Aprepitant	21	6.0	6.0
Meclizine Hydrochloride	22	5.9	5.9
Paroxetine Hydrochloride Hemihydrate	37	5.9	5.9
Paroxetine	37	5.8	5.8
Hyoscyamine Sulfate	10	5.7	5.7
Telmisartan	19	5.6	5.6
Indapamide	19	5.6	5.6
Esomeprazole Magnesium	236	5.6	5.6
Iron Sucrose	10	5.5	5.5
Duloxetine	71	5.4	5.4
Oxybutynin Chloride	9	5.4	5.4
Cetirizine	78	5.4	5.4
Insulin Glulisine	10	5.2	5.2
Promethazine Hydrochloride	18	5.1	5.1
Tizanidine	23	5.1	5.1
Modafinil	31	5.1	5.1
Ferrous Sulfate	48	5.1	5.1
Atenolol	125	5.1	5.1
Standardized Senna Concentrate	12	5.0	5.0
Glyburide	23	5.0	5.0
Desloratadine	10	4.9	4.9
Pantoprazole	224	4.9	4.9
Aripiprazole Oral	38	4.9	4.9
Aripiprazole Orally Disintegrating	38	4.9	4.9
Insulin Glargine-Yfgn	20	4.8	4.8
Psyllium Husk	9	4.8	4.8
Timolol Maleate	9	4.8	4.8
Docusate Sodium - Sennosides	29	4.7	4.8
Tolterodine Tartrate	8	4.7	4.7
Tizanidine Hydrochloride	16	4.7	4.7
Epinephrine	56	4.5	4.5
Losartan Potassium And Hydrochlorothiazide	10	4.5	4.5
Raltegravir	14	4.5	4.5
Rabeprazole Sodium	23	4.4	4.4
Lubiprostone	8	4.4	4.4
Famotidine	97	4.4	4.4
Tapentadol Hydrochloride	28	4.4	4.4
Lansoprazole	145	4.4	4.4
Levodopa	10	4.4	4.4
Clonazepam	128	4.3	4.3
Calcium, Magnesium, Potassium, And Sodium Oxybates	7	4.3	4.3
Folic Acid	195	4.3	4.3
Ergocalciferol	294	4.3	4.3
Sucralfate	19	4.2	4.2
Desoximetasone	15	4.1	4.1
Aspirin 325 Mg	373	4.1	4.1
Aspirin 81 Mg	373	4.1	4.1
Cetiirizine	33	4.1	4.1
Methocarbamol Tablets	13	4.1	4.1
Duloxetine Hydrochloride	141	4.0	4.0
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	27	4.0	4.0
Aspirin	383	4.0	4.0
Sodium Oxybate	50	4.0	4.0
Nicotine Polacrilex	29	4.0	4.0
Cetirizine Hydrochloride	122	4.0	4.0
Iron	50	4.0	4.0
Olmesartan Medoxomil	27	4.0	4.0
Ustekinumab	76	4.0	4.0
Thyroid, Porcine	8	3.9	3.9
Vedolizumab	64	3.9	3.9
Nicotine	30	3.9	3.9
Adalimumab-Fkjp	33	3.8	3.8
Loratadine Tablet	38	3.7	3.7
Omeprazole Magnesium	300	3.7	3.7
Escitslopram	41	3.7	3.7
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	35	3.7	3.7
Adalimumab-Aaty	33	3.7	3.7
Mercaptopurine	12	3.6	3.6
Adalimumab-Adaz	36	3.6	3.6
Ondansetron	74	3.6	3.6
Ondansetron Tablets	74	3.6	3.6
Clobetasol Propionate Ointment Usp, 0.05%	7	3.6	3.6
Omeprazole	225	3.6	3.6
Clobetasol Propionate	7	3.6	3.6
Topiramate	62	3.5	3.5
Oxycodone And Acetaminophen Tablets	8	3.5	3.5
Methylphenidate Hydrochloride	39	3.5	3.5
Ondansetron Hydrochloride	80	3.5	3.5
Pravastatin Sodium	13	3.5	3.5
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	27	3.4	3.4
Instalax Polyethylene Glycol 3350	8	3.4	3.4
Baclofen	55	3.4	3.4
Sitagliptin	46	3.4	3.4
Fingolimod Hcl	55	3.4	3.4
Linaclotide	17	3.4	3.4
Polyethylene Glycol 400	8	3.3	3.3
Metoclopramide	34	3.3	3.3
Hydromorphone Hydrochloride	56	3.2	3.2
Azelastine	11	3.2	3.2
Clopidogrel Bisulfate	62	3.2	3.2
Loratadine	65	3.2	3.2
Mesalamine	34	3.2	3.2
Dexlansoprazole	25	3.2	3.2
Alpelisib	5	3.0	3.0
Armodafinil	12	3.0	3.0
Ocrelizumab	35	3.0	3.0
Glimepiride	22	3.0	3.0
Clopidogrel	110	3.0	3.0
Lisdexamfetamine Dimesylate	18	2.9	2.9
Letrozole Tablets	26	2.8	2.8
Rasagiline Mesylate	6	2.8	2.8
Peginterferon Beta-1A	7	2.8	2.8
Aripiprazole	63	2.7	2.7
Buprenorphine Hydrochloride, Naloxone Hydrochloride	12	2.6	2.6
Apixaban	33	2.6	2.6
Darbepoetin Alfa	26	2.5	2.5
Omalizumab	41	2.5	2.5
Latanoprost	24	2.5	2.5
Dapagliflozin	15	2.5	2.5
Fesoterodine Fumarate	5	2.4	2.4
Fexofenadine Hydrochloride	10	2.4	2.4
Ixazomib	13	2.4	2.4
Eculizumab	24	2.3	2.3
Vilazodone Hydrochloride	4	2.3	2.3
Tafamidis	5	2.2	2.2
Brexpiprazole	7	2.2	2.2
Dalfampridine	30	2.2	2.2
Methylphenidate	12	2.2	2.2
Niraparib	9	2.1	2.1
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	4	2.1	2.1
Liraglutide	19	2.0	2.0
Mometasone Furoate And Formoterol Fumarate Dihydrate	6	2.0	2.0
Olaparib	8	2.0	2.0
Medroxyprogesterone Acetate	19	2.0	2.0
Interferon Beta-1A	72	2.0	2.0
Ravulizumab	5	1.9	1.9
Benralizumab	7	1.8	1.8
Ofatumumab	11	1.7	1.7
Avapritinib	4	1.7	1.7
Rimegepant Sulfate	4	1.7	1.7
Palbociclib	29	1.6	1.6
Lutetium Lu 177 Vipivotide Tetraxetan	4	1.6	1.6
Drospirenone And Ethinyl Estradiol	13	1.5	1.5
Natalizumab	53	1.5	1.5
Teriflunomide	13	1.5	1.5
Isotretinoin	14	1.5	1.5
Alirocumab	7	1.5	1.5
Etonogestrel	10	1.1	1.1
Guselkumab	6	0.9	0.9
Tirzepatide	25	0.8	0.8
Voxelotor	3	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.