Reaction

Blood Pressure Systolic Abnormal reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,458 reports · 208 co-occurring drugs

As of the last recalculation, Blood Pressure Systolic Abnormal appears in 2,458 FAERS reports alongside 208 co-occurring drug terms. The strongest observed disproportionality signal is DIPHENHYDRAMINE HYDROCHLORIDE CAPSULE, LIQUID FILLED (PRR 295.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Diphenhydramine Hydrochloride Capsule, Liquid Filled	573	295.8	304.0
Methylprednisolone Sodium Succinate	826	226.4	230.5
Diphenhydramine Hydrochloride	1,571	220.6	222.7
Methylprednisolone	1,387	193.7	195.7
Rituximab	1,413	131.8	132.7
Acetaminophen	1,720	106.0	106.4
Risedronate Sodium	294	90.8	91.7
Tocilizumab	809	89.0	89.6
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	973	84.6	85.1
Acetaminophen Tablet Extended Release	1,191	75.8	76.1
Pain Reliever	1,191	75.7	76.1
Acetaminophen 500Mg	1,191	75.7	76.0
Dimenhydrinate	81	66.5	67.0
Diphenhydramine	359	56.2	56.5
Rabeprazole	125	50.3	50.6
Rosuvastatin Calcium	154	49.3	49.6
Hydroxychloroquine Sulfate	433	48.6	48.9
Prednisone	1,297	45.1	45.2
Pantoprazole Sodium In 0.9% Sodium Chloride	291	45.0	45.2
Pantoprazole Sodium Injection	291	44.9	45.2
Folic Acid	845	43.2	43.4
Diphenhydramine Hcl	53	41.2	41.3
Calcium	542	39.3	39.5
Sulfasalazine	278	33.8	33.9
Irbesartan	165	33.5	33.6
Leflunomide	342	32.0	32.1
Methotrexate	932	29.6	29.7
Telmisartan	58	28.2	28.2
Methotrexate Sodium	987	28.1	28.1
Desoximetasone	60	27.3	27.4
Naproxen	218	25.7	25.8
Pantoprazole	569	24.5	24.5
Nifedipine	129	24.4	24.4
Esomeprazole	165	24.1	24.1
Candesartan	91	22.4	22.4
Indapamide	45	21.6	21.7
Alendronate Sodium	216	19.8	19.8
Hydroxychloroquine	160	19.3	19.4
Dutasteride	18	18.9	18.9
Pantoprazole Sodium	292	18.8	18.8
Alendronate Sodium Tablet	37	17.1	17.2
Diltiazem Hydrochloride	67	16.8	16.9
Celecoxib	237	16.8	16.8
Sulfamethoxazole And Trimethoprim	154	16.4	16.5
Chlorthalidone	22	16.2	16.2
Dexlansoprazole	76	15.9	15.9
Quetiapine Fumarate	54	15.8	15.8
Naproxen Sodium	237	15.4	15.5
Loperamide Hydrochloride And Dimethicone	57	15.4	15.4
Tolterodine Tartrate	16	15.2	15.2
Standardized Senna Concentrate	22	14.9	15.0
Moxifloxacin Hydrochloride	35	14.8	14.8
Mycophenolate Mofetil	217	14.7	14.8
Mycophenolate Mofetil Hydrochloride	217	14.7	14.7
Dicyclomine Hydrochloride	24	14.4	14.4
Atorvastatin Calcium, Film Coated	113	14.2	14.3
Atovaquone	13	13.7	13.8
Ibuprofen Tablets, Coated	67	13.7	13.7
Ibuprofen Sodium	67	13.6	13.6
Cetirizine Hydrochloride Allergy	47	13.4	13.4
Cetirizine Hydrochloride Tablets	47	13.4	13.4
Ampicillin	13	13.4	13.4
Ampicillin Sodium	13	13.4	13.4
Fluticasone Propionate And Salmeterol Xinafoate	91	13.3	13.3
Levothyroxine Sodium	415	13.2	13.3
Daspone	15	13.1	13.1
Dapsone Gel, 5%	15	13.1	13.1
Instalax Polyethylene Glycol 3350	19	13.1	13.1
Polyethylene Glycol 400	19	12.8	12.8
Hydrochlorothiazide	202	12.7	12.8
Calcium Gluconate	18	12.7	12.8
Iron	96	12.6	12.6
Diclofenac	121	12.5	12.5
Glyburide	35	12.4	12.4
Tramadol Hydrochloride	54	12.4	12.4
Cyclobenzaprine Hydrochloride	13	12.3	12.3
Ramipril	165	12.0	12.0
Naproxen Sodium Tablet, Coated	19	12.0	12.0
Naproxen Sodium, Coated Tablets	19	12.0	12.0
Dapsone	15	12.0	12.0
Naproxen Sodium 220Mg	19	11.9	12.0
Amlodipine	333	11.9	12.0
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	42	11.9	11.9
Venlafaxine	96	11.8	11.8
Vitamin C	120	11.6	11.6
Ezetimibe	97	11.4	11.4
Magnesium	104	11.1	11.2
Azathioprine	111	11.1	11.1
Citalopram Hydrobromide	133	11.1	11.1
Loperamide Hydrochloride	57	11.0	11.0
Indomethacin	17	10.9	10.9
Bisoprolol Fumarate	161	10.7	10.7
Cannabidiol	29	10.6	10.6
Cyclobenzaprine	58	10.1	10.1
Cyanocobalamin	38	9.9	9.9
Moxifloxacin	16	9.7	9.7
Docusate Sodium 100Mg	27	9.7	9.7
Azithromycin	45	9.6	9.6
Rosuvastatin	213	9.6	9.6
Terazosin Hydrochloride	10	9.6	9.6
Esomeprazole Magnesium Capsule, Delayed Release	16	9.4	9.4
Esomeprazole Magnesium Delayed Release Capsules	16	9.4	9.4
Clindamycin	31	9.4	9.4
Esomeprazole Magnesium Dihydrate	16	9.4	9.4
Escitalopram Oxalate	78	9.3	9.3
Azithromycin Monohydrate	45	9.3	9.3
Anakinra	18	9.2	9.3
Amlodipine Besylate	151	9.2	9.2
Valacyclovir	44	9.1	9.1
Citalopram	139	9.1	9.1
Hydrocortisone Sodium Succinate	10	9.0	9.0
Morphine	77	9.0	9.0
Estradiol	87	8.8	8.8
Atorvastatin Calcium	232	8.7	8.7
Epoetin Alfa	12	8.6	8.6
Oxazepam	21	8.3	8.3
Ticagrelor	31	8.3	8.3
Lorazepam	166	8.3	8.3
Human Immunoglobulin G	20	8.3	8.3
Nitrofurantoin	16	8.3	8.3
Nitrofurantoin (Monohydrate/Macrocrystals)	16	8.2	8.2
Carboxymethylcellulose Sodium	9	8.1	8.1
Docusate Sodium	54	8.1	8.1
Doxazosin Mesylate	34	8.1	8.1
Valacyclovir Hydrochloride	65	8.0	8.0
Clindamycin Phosphate	31	7.9	8.0
Tamsulosin Hydrochloride	19	7.9	7.9
Mometasone	17	7.9	7.9
Diclofenac Sodium	133	7.9	7.9
Candesartan Cilexetil	24	7.8	7.8
Colchicine	24	7.8	7.8
Clopidogrel Bisulfate	90	7.7	7.7
Acetaminophen And Codeine	11	7.7	7.7
Triamcinolone Acetonide Ointment Usp, 0.05%	21	7.7	7.7
Valsartan Oral	48	7.6	7.6
Escitslopram	51	7.6	7.6
Diltiazem Hydrochloride Extended-Release Tablets	10	7.5	7.5
Meloxicam	50	7.4	7.4
Venlafaxine Hydrochloride	111	7.4	7.4
Esomeprazole Magnesium	190	7.4	7.4
Azithromycin Dihydrate	49	7.2	7.2
Progesterone	19	7.1	7.1
Baricitinib	8	7.0	7.1
Fluticasone Furoate	10	7.0	7.0
Metformin Er 500 Mg	228	7.0	7.0
Metformin Er 750 Mg	228	7.0	7.0
Abatacept	109	6.9	6.9
Fluticasone Furoate And Vilanterol Trifenatate	29	6.9	6.9
Pregabalin	205	6.9	6.9
Brinzolamide	7	6.8	6.8
Oxybutynin Chloride	7	6.8	6.8
Nitroglycerin	42	6.7	6.7
Felodipine Extended-Release Tablets	9	6.7	6.7
Felodipine	9	6.7	6.7
Pramipexole	12	6.7	6.7
Valsartan	80	6.6	6.6
Clonazepam	120	6.6	6.6
Ibuprofen And Diphenhydramine Citrate	18	6.6	6.6
Losartan Potassium And Hydrochlorothiazide	9	6.6	6.6
Sucralfate Oral	11	6.6	6.6
Mometasone Furoate	32	6.6	6.6
Sucralfate Oral Suspension	11	6.6	6.6
Ciprofloxacin Hydrochloride And Hydrocortisone	16	6.6	6.6
Entecavir	9	6.5	6.6
Cyclosporine	83	6.5	6.5
Cetirizine	57	6.3	6.3
Gemfibrozil	11	6.2	6.2
Metformin	238	6.1	6.1
Ado-Trastuzumab Emtansine	6	6.0	6.0
Fenofibrate	25	6.0	6.0
Biotin	22	6.0	6.0
Atenolol	90	5.9	5.9
Triamcinolone Acetonide	21	5.8	5.8
Sildenafil Powder,	23	5.5	5.5
Fesoterodine Fumarate	7	5.5	5.5
Olmesartan Medoxomil	23	5.5	5.5
Hydromorphone Hydrochloride	58	5.4	5.4
Duloxetine Hydrochloride	116	5.4	5.4
Tizanidine	15	5.3	5.4
Denosumab	122	5.3	5.3
Metoprolol Tartrate Injection	114	5.3	5.3
Zoledronic Acid	24	5.1	5.1
Pertuzumab	16	5.0	5.0
Sitagliptin	42	5.0	5.0
Oxybutynin	17	4.9	4.9
Tiotropium Bromide	77	4.9	4.9
Mirabegron	22	4.8	4.9
Rifampin	8	4.7	4.7
Oxycodone And Acetaminophen	12	4.4	4.4
Canagliflozin	15	4.3	4.3
Timolol	6	4.2	4.2
Irinotecan Hydrochloride	6	4.0	4.0
Ranitidine	90	3.9	3.9
Travoprost	4	3.9	3.9
Brimonidine Tartrate	8	3.8	3.8
Methylphenidate	12	3.5	3.5
Oseltamivir Phosphate	10	3.5	3.5
Linaclotide	10	3.2	3.2
Liraglutide	18	3.1	3.1
Diclofenac Potassium, Film Coated	3	3.0	3.0
Diclofenac Potassium Tablets	3	3.0	3.0
Tofacitinib	63	2.9	2.9
Cetuximab	10	2.7	2.7
Bimatoprost	9	2.7	2.7
Budesonide, Glycopyrrolate, And Formoterol Fumarate	3	2.4	2.4
Sarilumab	5	1.6	1.6
Droxidopa	3	1.2	1.2
Nirmatrelvir And Ritonavir	6	0.9	0.9

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.