OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Metformin

1,153 flagged reaction(s) · 1,303,421 total co-reports · max PRR 67.6
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Lactic Acidosis 17,141 67.6 71.0 signal
2 Neurologic Neglect Syndrome 289 62.7 62.8 signal
3 Euglycaemic Diabetic Ketoacidosis 1,754 46.1 46.3 signal
4 Pulmonary Vasculitis 226 43.8 43.8 signal
5 Carotid Artery Thrombosis 296 31.0 31.0 signal
6 Diabetic Metabolic Decompensation 469 29.9 30.0 signal
7 Hyperlactacidaemia 804 25.6 25.7 signal
8 Adjustment Disorder 301 17.5 17.5 signal
9 Metabolic Acidosis 6,200 14.2 14.4 signal
10 Anion Gap Increased 243 12.9 12.9 signal
11 Glycosylated Haemoglobin Increased 4,539 12.8 13.0 signal
12 Ketoacidosis 1,347 12.8 12.8 signal
13 Glycosylated Haemoglobin Abnormal 210 12.6 12.6 signal
14 Hypoglycaemic Coma 508 12.4 12.4 signal
15 Gastrointestinal Hypomotility 384 12.1 12.1 signal
16 Diabetic Ketoacidosis 4,053 11.9 12.0 signal
17 Diabetes Mellitus Inadequate Control 2,895 11.4 11.5 signal
18 Vitamin B12 Deficiency 630 10.8 10.8 signal
19 Glycosylated Haemoglobin Decreased 243 10.5 10.5 signal
20 Hypoglycaemia 7,287 10.3 10.5 signal
21 Neuritis 227 10.1 10.1 signal
22 Blood Lactic Acid Increased 724 9.3 9.3 signal
23 Distributive Shock 305 9.3 9.3 signal
24 Impaired Gastric Emptying 1,751 9.3 9.3 signal
25 Diabetic Neuropathy 670 9.0 9.1 signal
26 Personality Disorder 345 8.8 8.8 signal
27 Blood Bicarbonate Decreased 245 8.6 8.6 signal
28 Suspected Suicide 578 8.0 8.0 signal
29 Hyperparathyroidism Secondary 295 7.7 7.7 signal
30 Blood Pressure Diastolic Abnormal 298 7.6 7.6 signal
31 Nephrogenic Anaemia 536 7.5 7.5 signal
32 Diabetic Retinopathy 389 7.5 7.5 signal
33 Blood Glucose Fluctuation 1,248 7.5 7.5 signal
34 Acute Kidney Injury 17,231 7.4 7.7 signal
35 Hyperkalaemia 3,924 7.4 7.4 signal
36 Blood Glucose Abnormal 2,060 7.3 7.3 signal
37 Insulin Resistance 228 7.3 7.3 signal
38 Forced Expiratory Volume Decreased 294 6.7 6.7 signal
39 Pancreatic Carcinoma Metastatic 287 6.5 6.5 signal
40 Drug Level Above Therapeutic 452 6.4 6.4 signal
41 Blood Glucose Increased 18,631 6.4 6.7 signal
42 Hyperglycaemia 3,528 6.3 6.3 signal
43 Hypovolaemia 566 6.2 6.2 signal
44 Anuria 837 6.2 6.2 signal
45 Pemphigoid 714 6.2 6.2 signal
46 Blood Pressure Systolic Abnormal 238 6.1 6.1 signal
47 Injection Site Nodule 1,038 6.1 6.1 signal
48 Immune-mediated Myositis 245 6.0 6.0 signal
49 Blood Glucose Decreased 4,471 5.9 6.0 signal
50 Respiratory Symptom 249 5.7 5.7 signal
51 Rebound Acid Hypersecretion 271 5.6 5.6 signal
52 Potentiating Drug Interaction 288 5.6 5.6 signal
53 Hypomagnesaemia 1,186 5.4 5.5 signal
54 Acidosis 647 5.4 5.4 signal
55 Shock 1,920 5.3 5.4 signal
56 Peripheral Venous Disease 326 5.2 5.2 signal
57 Facet Joint Syndrome 257 5.2 5.2 signal
58 Normochromic Normocytic Anaemia 243 5.1 5.1 signal
59 Diabetic Foot 248 5.1 5.1 signal
60 Vitamin B12 Decreased 232 5.1 5.1 signal
61 Onychomadesis 320 4.9 4.9 signal
62 Onychomycosis 336 4.8 4.8 signal
63 Hypothermia 764 4.7 4.7 signal
64 Intentional Device Misuse 333 4.7 4.7 signal
65 Hypovolaemic Shock 353 4.7 4.7 signal
66 Rales 429 4.6 4.6 signal
67 Blood Pressure Systolic Increased 1,445 4.6 4.6 signal
68 Blood Pressure Diastolic Decreased 546 4.6 4.6 signal
69 Drug Level Increased 1,205 4.6 4.6 signal
70 Type 2 Diabetes Mellitus 2,389 4.4 4.4 signal
71 Pancreatitis Acute 1,576 4.4 4.4 signal
72 Gangrene 427 4.4 4.4 signal
73 Arteriosclerosis Coronary Artery 453 4.3 4.3 signal
74 Abnormal Loss Of Weight 463 4.3 4.3 signal
75 Wound Complication 232 4.2 4.2 signal
76 Hypopnoea 230 4.1 4.1 signal
77 Polyuria 542 4.1 4.1 signal
78 Diabetes Mellitus 4,994 4.1 4.1 signal
79 Dyslipidaemia 330 4.0 4.0 signal
80 Necrotising Fasciitis 225 4.0 4.0 signal
81 Hemiplegia 533 4.0 4.0 signal
82 Obstructive Airways Disorder 708 3.9 3.9 signal
83 Pulseless Electrical Activity 264 3.9 3.9 signal
84 Sensory Loss 507 3.9 3.9 signal
85 Bronchiectasis 415 3.9 3.9 signal
86 Renal Tubular Necrosis 609 3.8 3.8 signal
87 Polydipsia 244 3.8 3.8 signal
88 Hepatic Steatosis 1,144 3.8 3.8 signal
89 Body Temperature Decreased 610 3.8 3.8 signal
90 Haemodynamic Instability 460 3.8 3.8 signal
91 Glomerular Filtration Rate Decreased 731 3.7 3.7 signal
92 Neurological Symptom 334 3.6 3.6 signal
93 Obesity 933 3.6 3.6 signal
94 Red Cell Distribution Width Increased 242 3.6 3.6 signal
95 Psychological Trauma 508 3.6 3.6 signal
96 Toe Amputation 296 3.6 3.6 signal
97 Left Ventricular Hypertrophy 248 3.6 3.6 signal
98 Overweight 308 3.5 3.5 signal
99 Chronic Kidney Disease 4,357 3.5 3.5 signal
100 Injection Site Extravasation 703 3.5 3.5 signal
101 Hair Disorder 467 3.4 3.5 signal
102 Finger Deformity 270 3.4 3.4 signal
103 Arterial Occlusive Disease 439 3.4 3.4 signal
104 Oliguria 344 3.4 3.4 signal
105 Full Blood Count Abnormal 580 3.4 3.4 signal
106 Tubulointerstitial Nephritis 1,021 3.4 3.4 signal
107 Lipase Increased 413 3.3 3.3 signal
108 End Stage Renal Disease 989 3.3 3.3 signal
109 Left Ventricular Dysfunction 357 3.3 3.3 signal
110 C-reactive Protein Abnormal 337 3.2 3.2 signal
111 Glucose Tolerance Impaired 309 3.2 3.2 signal
112 Urosepsis 482 3.2 3.2 signal
113 Blood Magnesium Decreased 450 3.2 3.2 signal
114 Pancreatitis 2,749 3.2 3.2 signal
115 Eructation 986 3.2 3.2 signal
116 Cardiac Failure Chronic 219 3.2 3.2 signal
117 Myopathy 443 3.1 3.1 signal
118 Rheumatic Fever 223 3.1 3.1 signal
119 Blepharospasm 315 3.1 3.1 signal
120 Haemodialysis 427 3.1 3.1 signal
121 Arteriosclerosis 471 3.1 3.1 signal
122 Bundle Branch Block Left 212 3.0 3.0 signal
123 Medication Residue Present 238 3.0 3.0 signal
124 Injection Site Mass 1,811 3.0 3.0 signal
125 Haemorrhagic Anaemia 219 3.0 3.0 signal
126 Tachypnoea 654 2.9 3.0 signal
127 Pulmonary Alveolar Haemorrhage 270 2.9 2.9 signal
128 Atrioventricular Block First Degree 210 2.9 2.9 signal
129 Blood Cholesterol Abnormal 220 2.9 2.9 signal
130 Breath Sounds Abnormal 233 2.9 2.9 signal
131 Motor Dysfunction 470 2.8 2.8 signal
132 Hair Colour Changes 584 2.8 2.8 signal
133 Bursitis 560 2.8 2.8 signal
134 Acute Coronary Syndrome 385 2.8 2.8 signal
135 Renal Cyst 366 2.8 2.8 signal
136 Exercise Tolerance Decreased 262 2.8 2.8 signal
137 Multiple Organ Dysfunction Syndrome 1,280 2.8 2.8 signal
138 Anal Incontinence 408 2.8 2.8 signal
139 Parosmia 345 2.8 2.8 signal
140 Blood Iron Decreased 538 2.8 2.8 signal
141 Appetite Disorder 297 2.8 2.8 signal
142 Sleep Apnoea Syndrome 869 2.8 2.8 signal
143 Hypercholesterolaemia 432 2.7 2.7 signal
144 Affect Lability 434 2.7 2.7 signal
145 Blood Pressure Diastolic Increased 208 2.7 2.7 signal
146 Renal Failure 5,997 2.7 2.8 signal
147 Coronary Artery Stenosis 226 2.7 2.7 signal
148 Blood Triglycerides Increased 788 2.7 2.7 signal
149 Rhinitis 358 2.7 2.7 signal
150 Back Injury 480 2.7 2.7 signal
151 Sleep Disorder Due To A General Medical Condition 716 2.7 2.7 signal
152 Weight Decreased 12,317 2.7 2.7 signal
153 Leukocytosis 797 2.7 2.7 signal
154 Flank Pain 409 2.7 2.7 signal
155 Toxicity To Various Agents 7,322 2.7 2.7 signal
156 Toxic Encephalopathy 213 2.6 2.6 signal
157 Renal Failure Acute 1,853 2.6 2.6 signal
158 Cardiogenic Shock 614 2.6 2.6 signal
159 Synovitis 775 2.6 2.6 signal
160 Accidental Underdose 624 2.6 2.6 signal
161 Dehydration 5,708 2.6 2.6 signal
162 Acute Myocardial Infarction 1,265 2.6 2.6 signal
163 Blood Potassium Increased 693 2.6 2.6 signal
164 Atrioventricular Block Complete 285 2.6 2.6 signal
165 Cardiac Murmur 371 2.6 2.6 signal
166 Nephropathy 399 2.6 2.6 signal
167 Food Craving 210 2.6 2.6 signal
168 Eating Disorder 904 2.6 2.6 signal
169 Atrioventricular Block 327 2.6 2.6 signal
170 Electrolyte Imbalance 485 2.6 2.6 signal
171 Hyperlipidaemia 505 2.6 2.6 signal
172 Polyp 276 2.6 2.6 signal
173 Taste Disorder 844 2.6 2.6 signal
174 Cholelithiasis 1,375 2.5 2.5 signal
175 Thirst 746 2.5 2.5 signal
176 Product Odour Abnormal 433 2.5 2.5 signal
177 Electrocardiogram Abnormal 328 2.5 2.5 signal
178 Completed Suicide 3,455 2.5 2.5 signal
179 Osteoarthritis 1,743 2.5 2.5 signal
180 Pollakiuria 1,706 2.5 2.5 signal
181 Coronary Artery Occlusion 564 2.5 2.5 signal
182 Parkinsonism 399 2.5 2.5 signal
183 Blindness Transient 301 2.5 2.5 signal
184 Angina Pectoris 1,177 2.5 2.5 signal
185 Hypophagia 1,030 2.5 2.5 signal
186 Gastroenteritis 590 2.5 2.5 signal
187 Metabolic Disorder 235 2.5 2.5 signal
188 Hepatic Cirrhosis 756 2.4 2.5 signal
189 Hemiparesis 688 2.4 2.4 signal
190 Large Intestine Polyp 279 2.4 2.4 signal
191 Joint Range Of Motion Decreased 538 2.4 2.4 signal
192 Rhabdomyolysis 1,674 2.4 2.4 signal
193 Intestinal Ischaemia 220 2.4 2.4 signal
194 Circulatory Collapse 685 2.4 2.4 signal
195 Labelled Drug-drug Interaction Medication Error 357 2.4 2.4 signal
196 Hair Texture Abnormal 537 2.4 2.4 signal
197 Coronary Artery Disease 1,214 2.4 2.4 signal
198 Sputum Discoloured 376 2.4 2.4 signal
199 Mitral Valve Incompetence 448 2.4 2.4 signal
200 Gingival Pain 315 2.4 2.4 signal
201 Drug Interaction 6,245 2.4 2.4 signal
202 Renal Injury 1,181 2.4 2.4 signal
203 Decreased Appetite 9,098 2.4 2.4 signal
204 Hypertriglyceridaemia 229 2.4 2.4 signal
205 Nocturia 475 2.4 2.4 signal
206 Sinus Congestion 530 2.4 2.4 signal
207 Blood Creatinine Increased 2,554 2.4 2.4 signal
208 Vasculitis 455 2.4 2.4 signal
209 Contraindicated Product Administered 1,174 2.4 2.4 signal
210 C-reactive Protein Increased 1,410 2.3 2.3 signal
211 Hyponatraemia 2,166 2.3 2.3 signal
212 Madarosis 450 2.3 2.3 signal
213 Angina Unstable 252 2.3 2.3 signal
214 Hunger 516 2.3 2.3 signal
215 Iron Deficiency Anaemia 352 2.3 2.3 signal
216 Impaired Quality Of Life 551 2.3 2.3 signal
217 Sopor 511 2.3 2.3 signal
218 Pulmonary Fibrosis 730 2.3 2.3 signal
219 Exostosis 347 2.3 2.3 signal
220 Myocardial Ischaemia 436 2.3 2.3 signal
221 Nodule 495 2.3 2.3 signal
222 Troponin Increased 286 2.3 2.3 signal
223 Cataract 2,247 2.3 2.3 signal
224 Fungal Infection 1,259 2.3 2.3 signal
225 Hypokinesia 549 2.3 2.3 signal
226 Blood Pressure Inadequately Controlled 229 2.3 2.3 signal
227 Nail Disorder 328 2.3 2.3 signal
228 Dyspnoea Exertional 1,416 2.3 2.3 signal
229 Sciatica 598 2.3 2.3 signal
230 Folliculitis 389 2.3 2.3 signal
231 Hypocalcaemia 705 2.3 2.3 signal
232 Blood Cholesterol Increased 1,739 2.3 2.3 signal
233 Muscle Injury 306 2.2 2.3 signal
234 Intentional Overdose 2,369 2.2 2.3 signal
235 Gait Inability 1,230 2.2 2.2 signal
236 Body Height Decreased 400 2.2 2.2 signal
237 Blood Pressure Fluctuation 890 2.2 2.2 signal
238 Renal Impairment 3,085 2.2 2.2 signal
239 Neutrophilia 209 2.2 2.2 signal
240 Cholecystitis 437 2.2 2.2 signal
241 Coordination Abnormal 516 2.2 2.2 signal
242 Wound Infection 399 2.2 2.2 signal
243 Breast Cancer Stage Iii 236 2.2 2.2 signal
244 Neutrophil Count Increased 375 2.2 2.2 signal
245 Urine Output Decreased 319 2.2 2.2 signal
246 Sinus Disorder 722 2.2 2.2 signal
247 Wound 1,012 2.2 2.2 signal
248 Duodenal Ulcer 256 2.2 2.2 signal
249 Upper Gastrointestinal Haemorrhage 612 2.2 2.2 signal
250 Skin Haemorrhage 523 2.2 2.2 signal
251 Orthostatic Hypotension 632 2.2 2.2 signal
252 Injection Site Haemorrhage 2,870 2.2 2.2 signal
253 Blood Urine Present 686 2.2 2.2 signal
254 Faeces Soft 260 2.2 2.2 signal
255 Dysarthria 1,350 2.2 2.2 signal
256 Inappropriate Antidiuretic Hormone Secretion 365 2.2 2.2 signal
257 Respiratory Rate Increased 319 2.2 2.2 signal
258 Diarrhoea 22,969 2.2 2.2 signal
259 Bladder Cancer 2,116 2.1 2.1 signal
260 Dysuria 1,308 2.1 2.1 signal
261 Acute Respiratory Failure 679 2.1 2.1 signal
262 Haematuria 1,216 2.1 2.1 signal
263 Gastrooesophageal Reflux Disease 2,827 2.1 2.1 signal
264 Red Blood Cell Sedimentation Rate Increased 391 2.1 2.1 signal
265 Cystitis 1,126 2.1 2.1 signal
266 Skin Ulcer 909 2.1 2.1 signal
267 Anti-cyclic Citrullinated Peptide Antibody Positive 250 2.1 2.1 signal
268 Pyelonephritis 302 2.1 2.1 signal
269 Hypotension 7,020 2.1 2.1 signal
270 Drug-induced Liver Injury 1,081 2.1 2.1 signal
271 Tricuspid Valve Incompetence 277 2.1 2.1 signal
272 Bradycardia 1,857 2.1 2.1 signal
273 Hypokalaemia 1,603 2.1 2.1 signal
274 Meniscus Injury 215 2.1 2.1 signal
275 Pericarditis 581 2.1 2.1 signal
276 Respiratory Tract Congestion 553 2.1 2.1 signal
277 Carpal Tunnel Syndrome 488 2.1 2.1 signal
278 Weight Fluctuation 362 2.1 2.1 signal
279 Productive Cough 1,643 2.1 2.1 signal
280 Melaena 764 2.1 2.1 signal
281 Localised Infection 835 2.1 2.1 signal
282 Blood Urea Increased 580 2.1 2.1 signal
283 Dyspepsia 3,374 2.1 2.1 signal
284 Lower Gastrointestinal Haemorrhage 255 2.1 2.1 signal
285 Accidental Overdose 1,255 2.1 2.1 signal
286 Wheezing 2,031 2.1 2.1 signal
287 Nephrolithiasis 1,569 2.1 2.1 signal
288 Hypothyroidism 1,089 2.1 2.1 signal
289 Atrial Flutter 274 2.1 2.1 signal
290 Loss Of Personal Independence In Daily Activities 1,619 2.0 2.1 signal
291 Gout 611 2.0 2.0 signal
292 Myositis 304 2.0 2.0 signal
293 Eye Haemorrhage 453 2.0 2.0 signal
294 Nerve Compression 310 2.0 2.0 signal
295 Grip Strength Decreased 294 2.0 2.0 signal
296 Seasonal Allergy 472 2.0 2.0 signal
297 Hypertensive Crisis 373 2.0 2.0 signal
298 Limb Injury 901 2.0 2.0 no signal
299 Lower Respiratory Tract Infection 1,506 2.0 2.0 no signal
300 Sinus Tachycardia 471 2.0 2.0 no signal
301 Vomiting 15,555 2.0 2.0 no signal
302 Atrial Fibrillation 3,235 2.0 2.0 no signal
303 Pemphigus 411 2.0 2.0 no signal
304 Urinary Incontinence 977 2.0 2.0 no signal
305 Flatulence 1,867 2.0 2.0 no signal
306 Cellulitis 1,658 2.0 2.0 no signal
307 Duodenal Ulcer Perforation 241 2.0 2.0 no signal
308 Ejection Fraction Decreased 510 2.0 2.0 no signal
309 Blood Pressure Increased 5,009 2.0 2.0 no signal
310 Confusional State 5,288 2.0 2.0 no signal
311 Muscle Spasticity 405 2.0 2.0 no signal
312 Respiration Abnormal 223 2.0 2.0 no signal
313 Sinus Bradycardia 316 2.0 2.0 no signal
314 Vitamin D Deficiency 317 2.0 2.0 no signal
315 Covid-19 Pneumonia 386 1.9 2.0 no signal
316 Micturition Urgency 368 1.9 2.0 no signal
317 Hypophosphataemia 238 1.9 1.9 no signal
318 Fibromyalgia 783 1.9 1.9 no signal
319 Pulmonary Mass 478 1.9 1.9 no signal
320 Psoriatic Arthropathy 1,292 1.9 1.9 no signal
321 Decreased Activity 342 1.9 1.9 no signal
322 Dizziness Postural 305 1.9 1.9 no signal
323 Abdominal Discomfort 5,306 1.9 1.9 no signal
324 Blood Pressure Abnormal 628 1.9 1.9 no signal
325 Pharyngitis 394 1.9 1.9 no signal
326 Renal Pain 334 1.9 1.9 no signal
327 Peripheral Swelling 4,850 1.9 1.9 no signal
328 Blood Sodium Decreased 593 1.9 1.9 no signal
329 Glaucoma 607 1.9 1.9 no signal
330 Rotator Cuff Syndrome 404 1.9 1.9 no signal
331 Oxygen Saturation Decreased 1,748 1.9 1.9 no signal
332 Blood Potassium Decreased 940 1.9 1.9 no signal
333 Hypercalcaemia 385 1.9 1.9 no signal
334 Urinary Tract Infection 5,304 1.9 1.9 no signal
335 Irritable Bowel Syndrome 665 1.9 1.9 no signal
336 Live Birth 259 1.9 1.9 no signal
337 Hepatic Cytolysis 380 1.9 1.9 no signal
338 Unresponsive To Stimuli 799 1.9 1.9 no signal
339 Aphasia 936 1.9 1.9 no signal
340 Mental Status Changes 858 1.9 1.9 no signal
341 Abdominal Pain 7,150 1.8 1.9 no signal
342 Lip Dry 275 1.8 1.8 no signal
343 Diverticulum 221 1.8 1.8 no signal
344 Intervertebral Disc Degeneration 285 1.8 1.8 no signal
345 Transient Ischaemic Attack 1,037 1.8 1.8 no signal
346 Diverticulitis 843 1.8 1.8 no signal
347 Muscle Atrophy 383 1.8 1.8 no signal
348 Muscular Weakness 3,460 1.8 1.8 no signal
349 Arthritis 2,398 1.8 1.8 no signal
350 Intervertebral Disc Protrusion 667 1.8 1.8 no signal
351 Haemorrhagic Stroke 239 1.8 1.8 no signal
352 Joint Injury 650 1.8 1.8 no signal
353 Osteomyelitis 549 1.8 1.8 no signal
354 Abdominal Distension 3,154 1.8 1.8 no signal
355 Constipation 6,559 1.8 1.8 no signal
356 Spinal Osteoarthritis 267 1.8 1.8 no signal
357 Ligament Sprain 298 1.8 1.8 no signal
358 Ventricular Fibrillation 336 1.8 1.8 no signal
359 Basal Cell Carcinoma 471 1.8 1.8 no signal
360 Ischaemic Stroke 539 1.8 1.8 no signal
361 Product Prescribing Error 712 1.8 1.8 no signal
362 Encephalopathy 735 1.8 1.8 no signal
363 Cardiac Arrest 2,485 1.8 1.8 no signal
364 Product Administration Interrupted 230 1.8 1.8 no signal
365 Abdominal Pain Upper 6,145 1.8 1.8 no signal
366 Musculoskeletal Pain 1,575 1.8 1.8 no signal
367 Dysstasia 873 1.8 1.8 no signal
368 Gastrointestinal Disorder 2,633 1.8 1.8 no signal
369 Hand Deformity 388 1.8 1.8 no signal
370 Feeding Disorder 591 1.8 1.8 no signal
371 Gastritis 779 1.8 1.8 no signal
372 Frequent Bowel Movements 796 1.8 1.8 no signal
373 Syncope 2,954 1.8 1.8 no signal
374 Heart Rate Decreased 1,041 1.8 1.8 no signal
375 Swollen Tongue 922 1.8 1.8 no signal
376 Retching 627 1.8 1.8 no signal
377 Increased Appetite 554 1.8 1.8 no signal
378 Cardiomegaly 365 1.8 1.8 no signal
379 Musculoskeletal Chest Pain 455 1.8 1.8 no signal
380 Fall 9,720 1.7 1.8 no signal
381 Hypertension 6,198 1.7 1.8 no signal
382 Electrocardiogram Qt Prolonged 1,048 1.7 1.7 no signal
383 Nausea 22,945 1.7 1.8 no signal
384 Hiatus Hernia 376 1.7 1.7 no signal
385 Asthenia 10,878 1.7 1.8 no signal
386 Cardiac Failure 2,321 1.7 1.7 no signal
387 Tenderness 301 1.7 1.7 no signal
388 Low Density Lipoprotein Increased 221 1.7 1.7 no signal
389 Ventricular Tachycardia 475 1.7 1.7 no signal
390 Helicobacter Infection 292 1.7 1.7 no signal
391 Septic Shock 1,229 1.7 1.7 no signal
392 Shock Haemorrhagic 231 1.7 1.7 no signal
393 Rectal Haemorrhage 1,224 1.7 1.7 no signal
394 Hepatomegaly 280 1.7 1.7 no signal
395 Presyncope 685 1.7 1.7 no signal
396 Tooth Abscess 289 1.7 1.7 no signal
397 Cold Sweat 498 1.7 1.7 no signal
398 Lung Disorder 1,381 1.7 1.7 no signal
399 Multiple Allergies 221 1.7 1.7 no signal
400 Hydronephrosis 210 1.7 1.7 no signal
401 Supraventricular Tachycardia 269 1.7 1.7 no signal
402 Skin Laceration 303 1.7 1.7 no signal
403 Tooth Infection 370 1.7 1.7 no signal
404 Eosinophilia 490 1.7 1.7 no signal
405 Incontinence 297 1.7 1.7 no signal
406 Needle Issue 800 1.7 1.7 no signal
407 Blood Creatine Phosphokinase Increased 817 1.7 1.7 no signal
408 Haematemesis 710 1.7 1.7 no signal
409 Underdose 2,037 1.7 1.7 no signal
410 Internal Haemorrhage 319 1.7 1.7 no signal
411 Frustration Tolerance Decreased 224 1.7 1.7 no signal
412 Gastrointestinal Haemorrhage 2,341 1.7 1.7 no signal
413 Toothache 503 1.7 1.7 no signal
414 Sneezing 621 1.7 1.7 no signal
415 Candida Infection 463 1.7 1.7 no signal
416 Urinary Retention 922 1.7 1.7 no signal
417 Altered State Of Consciousness 597 1.7 1.7 no signal
418 Ventricular Extrasystoles 288 1.7 1.7 no signal
419 Stress 1,988 1.7 1.7 no signal
420 Facial Paralysis 234 1.6 1.6 no signal
421 General Physical Health Deterioration 3,166 1.6 1.7 no signal
422 Haematocrit Decreased 548 1.6 1.6 no signal
423 Malnutrition 305 1.6 1.6 no signal
424 Liver Function Test Increased 585 1.6 1.6 no signal
425 Middle Insomnia 510 1.6 1.6 no signal
426 Medication Error 1,521 1.6 1.6 no signal
427 Head Injury 865 1.6 1.6 no signal
428 White Blood Cell Count Increased 1,054 1.6 1.6 no signal
429 Weight Increased 6,097 1.6 1.6 no signal
430 Inability To Afford Medication 269 1.6 1.6 no signal
431 Bronchitis 2,034 1.6 1.6 no signal
432 Salivary Hypersecretion 273 1.6 1.6 no signal
433 Renal Disorder 1,275 1.6 1.6 no signal
434 Coma 1,299 1.6 1.6 no signal
435 Vitamin D Decreased 233 1.6 1.6 no signal
436 Retinal Detachment 250 1.6 1.6 no signal
437 Faeces Discoloured 588 1.6 1.6 no signal
438 Feeling Cold 756 1.6 1.6 no signal
439 Hypoxia 950 1.6 1.6 no signal
440 Balance Disorder 2,345 1.6 1.6 no signal
441 Dry Mouth 2,192 1.6 1.6 no signal
442 Heart Rate Increased 2,680 1.6 1.6 no signal
443 Haematoma 704 1.6 1.6 no signal
444 Ear Pain 525 1.6 1.6 no signal
445 Gastric Ulcer 513 1.6 1.6 no signal
446 Hyperhidrosis 3,473 1.6 1.6 no signal
447 Myocarditis 305 1.6 1.6 no signal
448 Night Sweats 867 1.6 1.6 no signal
449 Rhinorrhoea 1,732 1.6 1.6 no signal
450 Influenza 3,005 1.6 1.6 no signal
451 Respiratory Failure 1,958 1.6 1.6 no signal
452 Impaired Healing 881 1.6 1.6 no signal
453 Atelectasis 259 1.6 1.6 no signal
454 Mass 374 1.6 1.6 no signal
455 Cyst 331 1.6 1.6 no signal
456 Ageusia 666 1.6 1.6 no signal
457 Liver Injury 644 1.6 1.6 no signal
458 Groin Pain 234 1.6 1.6 no signal
459 Asthma 2,974 1.6 1.6 no signal
460 Heart Rate Irregular 602 1.6 1.6 no signal
461 Pain In Extremity 7,818 1.6 1.6 no signal
462 Coagulopathy 440 1.6 1.6 no signal
463 Haemolytic Anaemia 238 1.6 1.6 no signal
464 Cough 7,396 1.6 1.6 no signal
465 Prostatic Specific Antigen Increased 366 1.6 1.6 no signal
466 Blister 1,480 1.6 1.6 no signal
467 Furuncle 209 1.6 1.6 no signal
468 Kidney Infection 518 1.6 1.6 no signal
469 Nerve Injury 294 1.6 1.6 no signal
470 Anaemia 5,031 1.6 1.6 no signal
471 Impaired Work Ability 565 1.6 1.6 no signal
472 Subarachnoid Haemorrhage 269 1.6 1.6 no signal
473 Visual Impairment 3,239 1.6 1.6 no signal
474 Sleep Disorder 1,841 1.6 1.6 no signal
475 Blood Count Abnormal 404 1.6 1.6 no signal
476 Hidradenitis 228 1.6 1.6 no signal
477 Sepsis 2,918 1.6 1.6 no signal
478 Glossodynia 584 1.6 1.6 no signal
479 Mobility Decreased 1,870 1.6 1.6 no signal
480 Cardiac Failure Congestive 2,114 1.6 1.6 no signal
481 Intentional Product Use Issue 2,291 1.6 1.6 no signal
482 Oedema Peripheral 3,186 1.6 1.6 no signal
483 Cardiomyopathy 385 1.6 1.6 no signal
484 Pulmonary Congestion 344 1.5 1.6 no signal
485 Haemoptysis 726 1.5 1.6 no signal
486 Red Blood Cell Count Decreased 743 1.5 1.5 no signal
487 Pulmonary Oedema 1,162 1.5 1.5 no signal
488 Blindness Unilateral 365 1.5 1.5 no signal
489 Blood Pressure Decreased 1,718 1.5 1.5 no signal
490 Exposure During Pregnancy 1,606 1.5 1.5 no signal
491 Sluggishness 262 1.5 1.5 no signal
492 Neck Pain 1,443 1.5 1.5 no signal
493 Chronic Obstructive Pulmonary Disease 1,343 1.5 1.5 no signal
494 Suicide Attempt 1,564 1.5 1.5 no signal
495 Intentional Product Misuse 2,235 1.5 1.5 no signal
496 Arthropathy 1,434 1.5 1.5 no signal
497 Poor Quality Sleep 550 1.5 1.5 no signal
498 Haemorrhoids 502 1.5 1.5 no signal
499 Lethargy 1,477 1.5 1.5 no signal
500 Tachycardia 2,276 1.5 1.5 no signal
501 Angioedema 1,128 1.5 1.5 no signal
502 Chest Pain 4,742 1.5 1.5 no signal
503 Hepatic Enzyme Increased 1,736 1.5 1.5 no signal
504 Pancreatic Carcinoma 742 1.5 1.5 no signal
505 Decubitus Ulcer 208 1.5 1.5 no signal
506 Metastases To Liver 446 1.5 1.5 no signal
507 Schizophrenia 309 1.5 1.5 no signal
508 Abscess 405 1.5 1.5 no signal
509 Neuropathy Peripheral 2,401 1.5 1.5 no signal
510 Dizziness 12,638 1.5 1.5 no signal
511 Gait Disturbance 4,871 1.5 1.5 no signal
512 Ankle Fracture 393 1.5 1.5 no signal
513 Rib Fracture 520 1.5 1.5 no signal
514 International Normalised Ratio Increased 727 1.5 1.5 no signal
515 Limb Discomfort 781 1.5 1.5 no signal
516 Hernia 485 1.5 1.5 no signal
517 Gastroenteritis Viral 456 1.5 1.5 no signal
518 Spinal Pain 294 1.5 1.5 no signal
519 Lip Swelling 834 1.5 1.5 no signal
520 Gamma-glutamyltransferase Increased 556 1.5 1.5 no signal
521 Peripheral Coldness 345 1.5 1.5 no signal
522 Spinal Disorder 237 1.5 1.5 no signal
523 Disorientation 991 1.5 1.5 no signal
524 Chest Discomfort 2,544 1.5 1.5 no signal
525 Back Pain 5,797 1.5 1.5 no signal
526 Joint Swelling 2,992 1.5 1.5 no signal
527 Dyspnoea 14,041 1.5 1.5 no signal
528 Neuralgia 602 1.5 1.5 no signal
529 Hyperthyroidism 359 1.5 1.5 no signal
530 Blood Thyroid Stimulating Hormone Increased 229 1.5 1.5 no signal
531 Tooth Fracture 273 1.5 1.5 no signal
532 Memory Impairment 3,404 1.5 1.5 no signal
533 Back Disorder 404 1.5 1.5 no signal
534 Premature Delivery 395 1.5 1.5 no signal
535 Oropharyngeal Pain 2,286 1.5 1.5 no signal
536 Delirium 853 1.5 1.5 no signal
537 Gastrointestinal Pain 270 1.5 1.5 no signal
538 Ileus 303 1.5 1.5 no signal
539 Poisoning Deliberate 229 1.5 1.5 no signal
540 Vertigo 1,495 1.5 1.5 no signal
541 Initial Insomnia 250 1.5 1.5 no signal
542 Poor Venous Access 253 1.5 1.5 no signal
543 Injection Site Discomfort 253 1.5 1.5 no signal
544 Upper Respiratory Tract Infection 1,130 1.5 1.5 no signal
545 Splenomegaly 286 1.5 1.5 no signal
546 Hepatitis 625 1.5 1.5 no signal
547 Ulcer 389 1.5 1.5 no signal
548 Malaise 10,728 1.5 1.5 no signal
549 Aspiration 264 1.5 1.5 no signal
550 Proteinuria 458 1.4 1.4 no signal
551 Dysgeusia 1,813 1.4 1.4 no signal
552 Skin Lesion 660 1.4 1.4 no signal
553 Haemoglobin Decreased 2,483 1.4 1.4 no signal
554 Depressed Level Of Consciousness 952 1.4 1.4 no signal
555 Facial Pain 215 1.4 1.4 no signal
556 Muscle Spasms 4,421 1.4 1.4 no signal
557 Treatment Noncompliance 1,308 1.4 1.4 no signal
558 Liver Function Test Abnormal 704 1.4 1.4 no signal
559 Loss Of Consciousness 3,081 1.4 1.4 no signal
560 Subdural Haematoma 345 1.4 1.4 no signal
561 Incorrect Product Storage 320 1.4 1.4 no signal
562 Respiratory Distress 663 1.4 1.4 no signal
563 Platelet Count Increased 313 1.4 1.4 no signal
564 Secretion Discharge 296 1.4 1.4 no signal
565 Neoplasm 275 1.4 1.4 no signal
566 Nasopharyngitis 4,401 1.4 1.4 no signal
567 Myalgia 4,043 1.4 1.4 no signal
568 Foot Deformity 264 1.4 1.4 no signal
569 Cerebrovascular Accident 4,040 1.4 1.4 no signal
570 Pneumonia Aspiration 590 1.4 1.4 no signal
571 Gastrointestinal Infection 211 1.4 1.4 no signal
572 Vitreous Floaters 230 1.4 1.4 no signal
573 Pneumonia 7,633 1.4 1.4 no signal
574 Palpitations 2,760 1.4 1.4 no signal
575 Sinusitis 2,423 1.4 1.4 no signal
576 Haematochezia 1,299 1.4 1.4 no signal
577 Oral Candidiasis 306 1.4 1.4 no signal
578 Brain Injury 236 1.4 1.4 no signal
579 Foot Fracture 447 1.4 1.4 no signal
580 Arrhythmia 1,118 1.4 1.4 no signal
581 Fluid Retention 1,195 1.4 1.4 no signal
582 Pulmonary Hypertension 491 1.4 1.4 no signal
583 Hypersomnia 671 1.4 1.4 no signal
584 Inflammation 1,201 1.4 1.4 no signal
585 Nasal Congestion 1,369 1.4 1.4 no signal
586 Blindness 952 1.4 1.4 no signal
587 Injection Site Bruising 1,842 1.4 1.4 no signal
588 Small Intestinal Obstruction 286 1.4 1.4 no signal
589 Chromaturia 526 1.4 1.4 no signal
590 Pallor 635 1.4 1.4 no signal
591 Musculoskeletal Discomfort 400 1.4 1.4 no signal
592 Gallbladder Disorder 416 1.4 1.4 no signal
593 Psoriasis 3,036 1.4 1.4 no signal
594 Metastases To Lung 268 1.4 1.4 no signal
595 Ear Infection 615 1.4 1.4 no signal
596 Thyroid Disorder 357 1.4 1.4 no signal
597 Vision Blurred 3,163 1.4 1.4 no signal
598 Eye Disorder 758 1.4 1.4 no signal
599 Oedema 1,251 1.4 1.4 no signal
600 Depressed Mood 1,216 1.4 1.4 no signal
601 Jaundice 623 1.4 1.4 no signal
602 Fatigue 17,926 1.4 1.4 no signal
603 Oesophagitis 252 1.4 1.4 no signal
604 Hot Flush 1,736 1.4 1.4 no signal
605 Movement Disorder 743 1.4 1.4 no signal
606 Myocardial Infarction 4,049 1.4 1.4 no signal
607 Laryngitis 250 1.4 1.4 no signal
608 Oral Pain 517 1.4 1.4 no signal
609 Incorrect Dose Administered By Device 584 1.4 1.4 no signal
610 Erectile Dysfunction 590 1.4 1.4 no signal
611 Infusion Site Pain 291 1.4 1.4 no signal
612 Skin Infection 254 1.4 1.4 no signal
613 Product Dose Omission 1,507 1.4 1.4 no signal
614 Somnolence 4,567 1.4 1.4 no signal
615 Drug Dose Omission 3,807 1.3 1.4 no signal
616 Scratch 235 1.3 1.3 no signal
617 Restless Legs Syndrome 413 1.3 1.3 no signal
618 Hallucination, Auditory 361 1.3 1.3 no signal
619 Muscle Rigidity 271 1.3 1.3 no signal
620 Hallucination, Visual 475 1.3 1.3 no signal
621 Product Administration Error 451 1.3 1.3 no signal
622 Generalised Oedema 278 1.3 1.3 no signal
623 Dysphonia 1,317 1.3 1.3 no signal
624 Pulmonary Embolism 2,152 1.3 1.3 no signal
625 Sudden Death 241 1.3 1.3 no signal
626 Device Leakage 954 1.3 1.3 no signal
627 Therapeutic Product Effect Incomplete 1,593 1.3 1.3 no signal
628 Hepatic Encephalopathy 210 1.3 1.3 no signal
629 Adrenal Insufficiency 269 1.3 1.3 no signal
630 Tendonitis 349 1.3 1.3 no signal
631 Diarrhoea Haemorrhagic 210 1.3 1.3 no signal
632 Pericardial Effusion 516 1.3 1.3 no signal
633 Choking 435 1.3 1.3 no signal
634 Sars-cov-2 Test Positive 299 1.3 1.3 no signal
635 Polyneuropathy 266 1.3 1.3 no signal
636 Hypoaesthesia 3,342 1.3 1.3 no signal
637 Covid-19 3,945 1.3 1.3 no signal
638 Malignant Melanoma 299 1.3 1.3 no signal
639 Nephropathy Toxic 248 1.3 1.3 no signal
640 Arthralgia 9,223 1.3 1.3 no signal
641 Scab 252 1.3 1.3 no signal
642 Acute Hepatic Failure 302 1.3 1.3 no signal
643 Eye Pain 1,226 1.3 1.3 no signal
644 Discomfort 1,345 1.3 1.3 no signal
645 Feeling Hot 1,360 1.3 1.3 no signal
646 Diplopia 574 1.3 1.3 no signal
647 Pruritus Generalised 484 1.3 1.3 no signal
648 Emphysema 223 1.3 1.3 no signal
649 Rash Pruritic 1,188 1.3 1.3 no signal
650 Skin Discolouration 1,010 1.3 1.3 no signal
651 Injection Site Pain 6,647 1.3 1.3 no signal
652 Transfusion 230 1.3 1.3 no signal
653 Tremor 3,614 1.3 1.3 no signal
654 Cardio-respiratory Arrest 914 1.3 1.3 no signal
655 Contusion 2,087 1.3 1.3 no signal
656 Inappropriate Schedule Of Product Administration 3,833 1.3 1.3 no signal
657 Drug Intolerance 2,086 1.3 1.3 no signal
658 Cholecystectomy 246 1.3 1.3 no signal
659 Alanine Aminotransferase Increased 1,328 1.3 1.3 no signal
660 Coeliac Disease 212 1.3 1.3 no signal
661 Brain Fog 315 1.3 1.3 no signal
662 Mental Impairment 523 1.3 1.3 no signal
663 Feeling Jittery 411 1.3 1.3 no signal
664 Dysphagia 2,037 1.3 1.3 no signal
665 Pharyngeal Swelling 206 1.3 1.3 no signal
666 Depression 4,915 1.3 1.3 no signal
667 Local Swelling 380 1.3 1.3 no signal
668 Hepatic Failure 649 1.3 1.3 no signal
669 Injection Site Pruritus 1,422 1.3 1.3 no signal
670 Cardiac Disorder 2,005 1.3 1.3 no signal
671 Osteoporosis 878 1.3 1.3 no signal
672 Hypoacusis 915 1.3 1.3 no signal
673 Epistaxis 1,593 1.3 1.3 no signal
674 Swelling 1,984 1.3 1.3 no signal
675 Eye Infection 238 1.3 1.3 no signal
676 Respiratory Tract Infection 551 1.3 1.3 no signal
677 Musculoskeletal Stiffness 1,860 1.3 1.3 no signal
678 Nervousness 1,114 1.3 1.3 no signal
679 Insurance Issue 314 1.3 1.3 no signal
680 Abdominal Pain Lower 536 1.3 1.3 no signal
681 Prescribed Overdose 408 1.3 1.3 no signal
682 Gastric Disorder 734 1.3 1.3 no signal
683 Hypoaesthesia Oral 317 1.2 1.2 no signal
684 Condition Aggravated 6,341 1.2 1.3 no signal
685 Hepatotoxicity 465 1.2 1.2 no signal
686 Intestinal Obstruction 784 1.2 1.2 no signal
687 Paraesthesia 3,297 1.2 1.2 no signal
688 Dementia 580 1.2 1.2 no signal
689 Aphonia 290 1.2 1.2 no signal
690 Dry Throat 211 1.2 1.2 no signal
691 Extra Dose Administered 829 1.2 1.2 no signal
692 Alopecia 4,086 1.2 1.2 no signal
693 Product Taste Abnormal 279 1.2 1.2 no signal
694 Nightmare 721 1.2 1.2 no signal
695 Cardiovascular Disorder 530 1.2 1.2 no signal
696 Therapeutic Product Effect Decreased 918 1.2 1.2 no signal
697 Head Discomfort 364 1.2 1.2 no signal
698 Visual Acuity Reduced 690 1.2 1.2 no signal
699 Swelling Face 1,339 1.2 1.2 no signal
700 Cerebral Haemorrhage 736 1.2 1.2 no signal
701 Joint Stiffness 539 1.2 1.2 no signal
702 Dialysis 292 1.2 1.2 no signal
703 Cholestasis 392 1.2 1.2 no signal
704 Feeling Abnormal 4,934 1.2 1.2 no signal
705 Prescribed Underdose 408 1.2 1.2 no signal
706 Illness 2,055 1.2 1.2 no signal
707 Burning Sensation 1,432 1.2 1.2 no signal
708 Amnesia 1,332 1.2 1.2 no signal
709 Incorrect Dose Administered 4,582 1.2 1.2 no signal
710 Speech Disorder 1,066 1.2 1.2 no signal
711 Delusion 315 1.2 1.2 no signal
712 Insomnia 5,412 1.2 1.2 no signal
713 Rheumatoid Arthritis 2,292 1.2 1.2 no signal
714 Blood Test Abnormal 284 1.2 1.2 no signal
715 Muscle Tightness 327 1.2 1.2 no signal
716 Cognitive Disorder 939 1.2 1.2 no signal
717 Flushing 2,060 1.2 1.2 no signal
718 Sensory Disturbance 325 1.2 1.2 no signal
719 Poisoning 254 1.2 1.2 no signal
720 Hepatocellular Injury 286 1.2 1.2 no signal
721 Intentional Dose Omission 549 1.2 1.2 no signal
722 Acute Respiratory Distress Syndrome 355 1.2 1.2 no signal
723 Macular Degeneration 239 1.2 1.2 no signal
724 Tinnitus 921 1.2 1.2 no signal
725 Neuroleptic Malignant Syndrome 238 1.2 1.2 no signal
726 Disturbance In Attention 1,078 1.2 1.2 no signal
727 Headache 12,459 1.2 1.2 no signal
728 Osteopenia 303 1.2 1.2 no signal
729 Blood Alkaline Phosphatase Increased 494 1.2 1.2 no signal
730 Joint Dislocation 209 1.2 1.2 no signal
731 Body Temperature Increased 406 1.2 1.2 no signal
732 Immunodeficiency 291 1.2 1.2 no signal
733 Cerebral Infarction 483 1.2 1.2 no signal
734 Infusion Related Reaction 1,304 1.2 1.2 no signal
735 Squamous Cell Carcinoma 186 1.2 1.2 no signal
736 Bladder Disorder 196 1.2 1.2 no signal
737 Upper Limb Fracture 394 1.2 1.2 no signal
738 Pleural Effusion 1,197 1.2 1.2 no signal
739 Anxiety 5,603 1.2 1.2 no signal
740 Colon Cancer 293 1.2 1.2 no signal
741 Pain 12,051 1.2 1.2 no signal
742 Throat Irritation 875 1.2 1.2 no signal
743 Chills 2,298 1.2 1.2 no signal
744 Paraesthesia Oral 281 1.2 1.2 no signal
745 Lacrimation Increased 584 1.2 1.2 no signal
746 Photosensitivity Reaction 321 1.2 1.2 no signal
747 Adverse Reaction 258 1.2 1.2 no signal
748 Respiratory Disorder 583 1.2 1.2 no signal
749 Pancytopenia 1,082 1.2 1.2 no signal
750 Blood Calcium Decreased 219 1.1 1.1 no signal
751 Pulmonary Thrombosis 212 1.1 1.1 no signal
752 Therapy Change 187 1.1 1.1 no signal
753 Herpes Zoster 1,116 1.1 1.1 no signal
754 Colitis 730 1.1 1.1 no signal
755 Generalised Tonic-clonic Seizure 316 1.1 1.1 no signal
756 Pruritus 7,274 1.1 1.1 no signal
757 Aspartate Aminotransferase Increased 1,021 1.1 1.1 no signal
758 Dermatitis Contact 218 1.1 1.1 no signal
759 Deep Vein Thrombosis 1,251 1.1 1.1 no signal
760 Systemic Lupus Erythematosus 677 1.1 1.1 no signal
761 Hospice Care 188 1.1 1.1 no signal
762 Ocular Discomfort 206 1.1 1.1 no signal
763 Bedridden 249 1.1 1.1 no signal
764 Knee Operation 184 1.1 1.1 no signal
765 Premature Baby 570 1.1 1.1 no signal
766 Epilepsy 575 1.1 1.1 no signal
767 Liver Disorder 832 1.1 1.1 no signal
768 Decreased Immune Responsiveness 183 1.1 1.1 no signal
769 Eyelid Ptosis 190 1.1 1.1 no signal
770 Drug Eruption 329 1.1 1.1 no signal
771 Therapy Cessation 953 1.1 1.1 no signal
772 Thrombosis 1,500 1.1 1.1 no signal
773 Injection Site Discolouration 230 1.1 1.1 no signal
774 Anosmia 269 1.1 1.1 no signal
775 Procedural Pain 512 1.1 1.1 no signal
776 Transaminases Increased 411 1.1 1.1 no signal
777 Eye Swelling 684 1.1 1.1 no signal
778 Impaired Driving Ability 210 1.1 1.1 no signal
779 Lymphocyte Count Decreased 326 1.1 1.1 no signal
780 Skin Fissures 348 1.1 1.1 no signal
781 Tendon Rupture 228 1.1 1.1 no signal
782 Pharyngeal Oedema 287 1.1 1.1 no signal
783 Stomatitis 1,115 1.1 1.1 no signal
784 Ataxia 219 1.1 1.1 no signal
785 Scar 315 1.1 1.1 no signal
786 Ascites 539 1.1 1.1 no signal
787 Road Traffic Accident 767 1.1 1.1 no signal
788 Knee Arthroplasty 382 1.1 1.1 no signal
789 Skin Exfoliation 1,522 1.1 1.1 no signal
790 Hip Fracture 587 1.1 1.1 no signal
791 Clostridium Difficile Colitis 194 1.1 1.1 no signal
792 Petechiae 190 1.1 1.1 no signal
793 Rash Maculo-papular 404 1.1 1.1 no signal
794 Foetal Exposure During Pregnancy 1,480 1.1 1.1 no signal
795 Bacteraemia 214 1.1 1.1 no signal
796 Viral Infection 602 1.1 1.1 no signal
797 Pyrexia 6,254 1.1 1.1 no signal
798 Photophobia 337 1.1 1.1 no signal
799 Laceration 172 1.1 1.1 no signal
800 Agitation 1,327 1.1 1.1 no signal
801 Wrist Fracture 216 1.1 1.1 no signal
802 Incorrect Product Administration Duration 362 1.1 1.1 no signal
803 Hallucination 1,333 1.1 1.1 no signal
804 Maternal Exposure During Pregnancy 1,568 1.1 1.1 no signal
805 Full Blood Count Decreased 358 1.1 1.1 no signal
806 Product Quality Issue 2,393 1.0 1.1 no signal
807 Migraine 1,684 1.0 1.1 no signal
808 Increased Tendency To Bruise 163 1.0 1.0 no signal
809 Bacterial Infection 328 1.0 1.0 no signal
810 Drug Prescribing Error 344 1.0 1.0 no signal
811 Immune System Disorder 232 1.0 1.0 no signal
812 Paralysis 253 1.0 1.0 no signal
813 Lower Limb Fracture 336 1.0 1.0 no signal
814 Restlessness 643 1.0 1.0 no signal
815 Product Use Issue 3,278 1.0 1.0 no signal
816 Temperature Intolerance 179 1.0 1.0 no signal
817 Pain In Jaw 497 1.0 1.0 no signal
818 Gastric Haemorrhage 203 1.0 1.0 no signal
819 Bone Pain 1,025 1.0 1.0 no signal
820 Blood Bilirubin Increased 473 1.0 1.0 no signal
821 Tooth Disorder 390 1.0 1.0 no signal
822 Caesarean Section 205 1.0 1.0 no signal
823 Metastases To Bone 285 1.0 1.0 no signal
824 Product Dose Omission In Error 466 1.0 1.0 no signal
825 Skin Disorder 577 1.0 1.0 no signal
826 Urticaria 2,882 1.0 1.0 no signal
827 Platelet Count Decreased 1,842 1.0 1.0 no signal
828 Ear Discomfort 177 1.0 1.0 no signal
829 Drug Hypersensitivity 3,353 1.0 1.0 no signal
830 Haemorrhage Intracranial 259 1.0 1.0 no signal
831 Oral Discomfort 240 1.0 1.0 no signal
832 Skin Reaction 242 1.0 1.0 no signal
833 Thinking Abnormal 322 1.0 1.0 no signal
834 Product Substitution Issue 989 1.0 1.0 no signal
835 Device Malfunction 1,152 1.0 1.0 no signal
836 Drug Dispensing Error 264 1.0 1.0 no signal
837 Throat Tightness 458 1.0 1.0 no signal
838 Muscle Twitching 391 1.0 1.0 no signal
839 Inappropriate Schedule Of Drug Administration 1,218 1.0 1.0 no signal
840 Eye Inflammation 159 1.0 1.0 no signal
841 Spinal Operation 204 1.0 1.0 no signal
842 Infection 2,427 1.0 1.0 no signal
843 Multi-organ Failure 295 1.0 1.0 no signal
844 Therapeutic Response Unexpected 756 1.0 1.0 no signal
845 Overdose 3,635 1.0 1.0 no signal
846 Dental Caries 185 1.0 1.0 no signal
847 Therapy Interrupted 1,154 1.0 1.0 no signal
848 Apathy 243 1.0 1.0 no signal
849 Toxic Skin Eruption 169 1.0 1.0 no signal
850 Eye Pruritus 551 1.0 1.0 no signal
851 Influenza Like Illness 1,381 1.0 1.0 no signal
852 Bone Disorder 307 1.0 1.0 no signal
853 Injury Associated With Device 336 1.0 1.0 no signal
854 Anaphylactic Reaction 917 1.0 1.0 no signal
855 Lymphadenopathy 591 1.0 1.0 no signal
856 Expired Product Administered 553 1.0 1.0 no signal
857 Rash 7,202 1.0 1.0 no signal
858 Rash Macular 577 1.0 1.0 no signal
859 Dyskinesia 672 1.0 1.0 no signal
860 Accident 197 1.0 1.0 no signal
861 Eye Discharge 169 1.0 1.0 no signal
862 Post Procedural Complication 318 1.0 1.0 no signal
863 Breast Pain 176 1.0 1.0 no signal
864 Hypotonia 165 1.0 1.0 no signal
865 Mood Altered 447 1.0 1.0 no signal
866 Anhedonia 435 1.0 1.0 no signal
867 Adverse Drug Reaction 1,468 1.0 1.0 no signal
868 Quality Of Life Decreased 220 1.0 1.0 no signal
869 Staphylococcal Infection 542 1.0 1.0 no signal
870 Product Dose Omission Issue 4,654 1.0 1.0 no signal
871 Mental Disorder 710 1.0 1.0 no signal
872 Off Label Use 14,124 1.0 1.0 no signal
873 Gingival Bleeding 222 1.0 1.0 no signal
874 Wrong Technique In Device Usage Process 741 1.0 1.0 no signal
875 Injection Site Urticaria 393 1.0 1.0 no signal
876 Injection Site Induration 210 1.0 1.0 no signal
877 Febrile Neutropenia 1,072 1.0 1.0 no signal
878 Musculoskeletal Disorder 309 1.0 1.0 no signal
879 Blood Lactate Dehydrogenase Increased 257 1.0 1.0 no signal
880 Deafness 422 1.0 1.0 no signal
881 Mucosal Inflammation 419 0.9 0.9 no signal
882 Disease Recurrence 767 0.9 0.9 no signal
883 Face Oedema 272 0.9 0.9 no signal
884 Intraocular Pressure Increased 206 0.9 0.9 no signal
885 Device Mechanical Issue 207 0.9 0.9 no signal
886 Pneumonitis 433 0.9 0.9 no signal
887 Rash Generalised 420 0.9 0.9 no signal
888 Interstitial Lung Disease 772 0.9 0.9 no signal
889 Treatment Failure 1,307 0.9 0.9 no signal
890 Brain Oedema 201 0.9 0.9 no signal
891 Abnormal Dreams 442 0.9 0.9 no signal
892 Serotonin Syndrome 304 0.9 0.9 no signal
893 Rash Papular 355 0.9 0.9 no signal
894 Product Physical Issue 315 0.9 0.9 no signal
895 Abasia 396 0.9 0.9 no signal
896 Bipolar Disorder 173 0.9 0.9 no signal
897 Panic Attack 574 0.9 0.9 no signal
898 Economic Problem 242 0.9 0.9 no signal
899 Device Issue 1,366 0.9 0.9 no signal
900 Drug Effect Incomplete 576 0.9 0.9 no signal
901 Lung Infection 246 0.9 0.9 no signal
902 Hypersensitivity 2,890 0.9 0.9 no signal
903 Ovarian Cyst 156 0.9 0.9 no signal
904 Psychotic Disorder 456 0.9 0.9 no signal
905 Fear 418 0.9 0.9 no signal
906 Thrombocytopenia 1,719 0.9 0.9 no signal
907 Hyperbilirubinaemia 158 0.9 0.9 no signal
908 Spinal Fracture 305 0.9 0.9 no signal
909 Agranulocytosis 281 0.9 0.9 no signal
910 Ill-defined Disorder 923 0.9 0.9 no signal
911 Erythema 3,111 0.9 0.9 no signal
912 Therapy Non-responder 675 0.9 0.9 no signal
913 Clostridium Difficile Infection 328 0.9 0.9 no signal
914 Product Dispensing Error 329 0.9 0.9 no signal
915 Laboratory Test Abnormal 445 0.9 0.9 no signal
916 Rash Erythematous 704 0.9 0.9 no signal
917 Eczema 751 0.9 0.9 no signal
918 Product Use Complaint 231 0.9 0.9 no signal
919 White Blood Cell Count Decreased 1,614 0.9 0.9 no signal
920 Product Use In Unapproved Indication 3,632 0.9 0.9 no signal
921 Drug Level Decreased 152 0.9 0.9 no signal
922 Anger 503 0.9 0.9 no signal
923 Uveitis 200 0.9 0.9 no signal
924 Colitis Ulcerative 660 0.9 0.9 no signal
925 Dry Eye 714 0.9 0.9 no signal
926 Mania 242 0.9 0.9 no signal
927 Paranoia 255 0.9 0.9 no signal
928 Injury 1,038 0.9 0.9 no signal
929 Brain Neoplasm 135 0.9 0.9 no signal
930 Incorrect Route Of Product Administration 246 0.9 0.9 no signal
931 Tooth Extraction 181 0.9 0.9 no signal
932 Product Availability Issue 325 0.9 0.9 no signal
933 Drug Administration Error 451 0.9 0.9 no signal
934 Hereditary Angioedema 152 0.9 0.9 no signal
935 Breast Cancer Metastatic 155 0.9 0.9 no signal
936 Myoclonus 172 0.9 0.9 no signal
937 Drug Ineffective 18,951 0.8 0.8 no signal
938 Pain Of Skin 388 0.8 0.8 no signal
939 Injection Site Rash 436 0.8 0.8 no signal
940 Cyanosis 226 0.8 0.8 no signal
941 Euphoric Mood 147 0.8 0.8 no signal
942 Seizure 1,633 0.8 0.8 no signal
943 Fistula 160 0.8 0.8 no signal
944 Multiple Fractures 235 0.8 0.8 no signal
945 Injection Site Swelling 1,073 0.8 0.8 no signal
946 Irritability 852 0.8 0.8 no signal
947 Neutrophil Count Decreased 573 0.8 0.8 no signal
948 Activities Of Daily Living Impaired 284 0.8 0.8 no signal
949 Thyroid Cancer 171 0.8 0.8 no signal
950 Device Failure 214 0.8 0.8 no signal
951 Hip Arthroplasty 214 0.8 0.8 no signal
952 Dermatitis Allergic 175 0.8 0.8 no signal
953 Sedation 365 0.8 0.8 no signal
954 Autoimmune Disorder 134 0.8 0.8 no signal
955 Femur Fracture 434 0.8 0.8 no signal
956 Respiratory Arrest 386 0.8 0.8 no signal
957 Mouth Ulceration 291 0.8 0.8 no signal
958 Product Packaging Quantity Issue 151 0.8 0.8 no signal
959 Ankylosing Spondylitis 180 0.8 0.8 no signal
960 Skin Cancer 297 0.8 0.8 no signal
961 Fluid Overload 203 0.8 0.8 no signal
962 Surgery 795 0.8 0.8 no signal
963 Therapeutic Response Shortened 436 0.8 0.8 no signal
964 Drug Effect Less Than Expected 193 0.8 0.8 no signal
965 Eye Irritation 762 0.8 0.8 no signal
966 Drug Effect Decreased 745 0.8 0.8 no signal
967 Therapeutic Response Decreased 822 0.8 0.8 no signal
968 Pneumothorax 216 0.8 0.8 no signal
969 Bronchospasm 195 0.8 0.8 no signal
970 Appendicitis 126 0.8 0.8 no signal
971 Pulmonary Arterial Hypertension 197 0.8 0.8 no signal
972 Leukaemia 127 0.8 0.8 no signal
973 Dry Skin 1,771 0.8 0.8 no signal
974 Dermatitis 278 0.8 0.8 no signal
975 Erythema Multiforme 125 0.8 0.8 no signal
976 Crying 489 0.8 0.8 no signal
977 Injection Site Erythema 1,654 0.8 0.8 no signal
978 Suicidal Ideation 1,226 0.8 0.8 no signal
979 Ocular Hyperaemia 623 0.8 0.8 no signal
980 Respiratory Depression 163 0.8 0.8 no signal
981 Disseminated Intravascular Coagulation 185 0.8 0.8 no signal
982 Drug Reaction With Eosinophilia And Systemic Symptoms 334 0.8 0.8 no signal
983 Oral Herpes 254 0.8 0.8 no signal
984 Lymphopenia 183 0.8 0.8 no signal
985 Abnormal Behaviour 518 0.8 0.8 no signal
986 Product Packaging Issue 120 0.8 0.8 no signal
987 Disease Progression 1,521 0.8 0.8 no signal
988 Psychomotor Hyperactivity 215 0.8 0.8 no signal
989 Haemorrhage 1,342 0.8 0.8 no signal
990 Post Procedural Haemorrhage 149 0.8 0.8 no signal
991 Neutropenia 1,721 0.7 0.7 no signal
992 Incorrect Drug Administration Duration 361 0.7 0.7 no signal
993 Malignant Neoplasm Progression 1,288 0.7 0.7 no signal
994 Device Related Infection 195 0.7 0.7 no signal
995 Drug Ineffective For Unapproved Indication 703 0.7 0.7 no signal
996 Injection Site Irritation 159 0.7 0.7 no signal
997 Intestinal Perforation 141 0.7 0.7 no signal
998 Palmar-plantar Erythrodysaesthesia Syndrome 290 0.7 0.7 no signal
999 Nervous System Disorder 386 0.7 0.7 no signal
1000 Aggression 618 0.7 0.7 no signal
1001 Wrong Technique In Product Usage Process 2,485 0.7 0.7 no signal
1002 Personality Change 115 0.7 0.7 no signal
1003 Fracture 232 0.7 0.7 no signal
1004 Injection Site Reaction 840 0.7 0.7 no signal
1005 Withdrawal Syndrome 516 0.7 0.7 no signal
1006 Toxic Epidermal Necrolysis 183 0.7 0.7 no signal
1007 Tuberculosis 156 0.7 0.7 no signal
1008 Anorexia 158 0.7 0.7 no signal
1009 Lymphoma 187 0.7 0.7 no signal
1010 Intentional Self-injury 243 0.7 0.7 no signal
1011 Device Use Issue 208 0.7 0.7 no signal
1012 Therapy Partial Responder 179 0.7 0.7 no signal
1013 Status Epilepticus 134 0.7 0.7 no signal
1014 Pharyngitis Streptococcal 128 0.7 0.7 no signal
1015 Disability 232 0.7 0.7 no signal
1016 Injection Site Warmth 239 0.7 0.7 no signal
1017 Device Defective 187 0.7 0.7 no signal
1018 Cytopenia 138 0.7 0.7 no signal
1019 Circumstance Or Information Capable Of Leading To Medication Error 385 0.7 0.7 no signal
1020 Vaginal Haemorrhage 488 0.7 0.7 no signal
1021 Unevaluable Event 867 0.7 0.7 no signal
1022 Device Delivery System Issue 299 0.7 0.7 no signal
1023 Pelvic Pain 208 0.7 0.7 no signal
1024 Myelodysplastic Syndrome 165 0.7 0.7 no signal
1025 Adverse Event 1,047 0.7 0.7 no signal
1026 Neoplasm Progression 398 0.7 0.7 no signal
1027 Anaphylactic Shock 290 0.7 0.7 no signal
1028 Wrong Technique In Drug Usage Process 414 0.7 0.7 no signal
1029 Hepatitis C 137 0.7 0.7 no signal
1030 Application Site Pain 246 0.7 0.7 no signal
1031 Poor Quality Product Administered 114 0.7 0.7 no signal
1032 Cytokine Release Syndrome 212 0.7 0.7 no signal
1033 Leukopenia 552 0.6 0.6 no signal
1034 Mood Swings 349 0.6 0.6 no signal
1035 Eyelid Oedema 126 0.6 0.6 no signal
1036 Hepatic Function Abnormal 399 0.6 0.6 no signal
1037 Posterior Reversible Encephalopathy Syndrome 102 0.6 0.6 no signal
1038 Conjunctivitis 194 0.6 0.6 no signal
1039 Product Prescribing Issue 214 0.6 0.6 no signal
1040 Neoplasm Malignant 699 0.6 0.6 no signal
1041 Lung Neoplasm Malignant 431 0.6 0.6 no signal
1042 Hospitalisation 1,589 0.6 0.6 no signal
1043 Osteonecrosis Of Jaw 259 0.6 0.6 no signal
1044 Complication Associated With Device 137 0.6 0.6 no signal
1045 Tooth Loss 214 0.6 0.6 no signal
1046 Device Occlusion 141 0.6 0.6 no signal
1047 Central Nervous System Lesion 140 0.6 0.6 no signal
1048 Emotional Disorder 313 0.6 0.6 no signal
1049 Libido Decreased 125 0.6 0.6 no signal
1050 Emotional Distress 1,220 0.6 0.6 no signal
1051 Plasma Cell Myeloma 392 0.6 0.6 no signal
1052 Product Storage Error 852 0.6 0.6 no signal
1053 Metastases To Central Nervous System 125 0.6 0.6 no signal
1054 Sexual Dysfunction 111 0.6 0.6 no signal
1055 Abortion Spontaneous 371 0.5 0.5 no signal
1056 Neurotoxicity 160 0.5 0.5 no signal
1057 Mydriasis 118 0.5 0.5 no signal
1058 Death 7,899 0.5 0.5 no signal
1059 Acute Myeloid Leukaemia 141 0.5 0.5 no signal
1060 Intentional Drug Misuse 190 0.5 0.5 no signal
1061 Application Site Pruritus 202 0.5 0.5 no signal
1062 Stevens-johnson Syndrome 196 0.5 0.5 no signal
1063 Drug Administered At Inappropriate Site 94 0.5 0.5 no signal
1064 Vaginal Discharge 88 0.5 0.5 no signal
1065 Bone Marrow Failure 178 0.5 0.5 no signal
1066 Drug Resistance 223 0.5 0.5 no signal
1067 Product Administered At Inappropriate Site 155 0.5 0.5 no signal
1068 Tardive Dyskinesia 243 0.5 0.5 no signal
1069 Extrapyramidal Disorder 211 0.5 0.5 no signal
1070 Gastrointestinal Carcinoma 77 0.5 0.5 no signal
1071 Bone Density Decreased 263 0.5 0.5 no signal
1072 Hepatic Cancer 201 0.5 0.5 no signal
1073 Drug Abuse 690 0.5 0.5 no signal
1074 Application Site Erythema 216 0.5 0.5 no signal
1075 Multiple Sclerosis 381 0.5 0.5 no signal
1076 Injection Site Haematoma 116 0.5 0.5 no signal
1077 Pneumocystis Jirovecii Pneumonia 79 0.5 0.5 no signal
1078 Dermatitis Atopic 392 0.5 0.5 no signal
1079 Deformity 73 0.5 0.5 no signal
1080 Skin Burning Sensation 541 0.4 0.4 no signal
1081 No Therapeutic Response 94 0.4 0.4 no signal
1082 Skin Irritation 346 0.4 0.4 no signal
1083 Embedded Device 74 0.4 0.4 no signal
1084 Peritonitis 155 0.4 0.4 no signal
1085 Product Adhesion Issue 264 0.4 0.4 no signal
1086 Multiple Sclerosis Relapse 507 0.4 0.4 no signal
1087 Application Site Rash 101 0.4 0.4 no signal
1088 Akathisia 98 0.4 0.4 no signal
1089 Breast Cancer 650 0.4 0.4 no signal
1090 Complication Of Device Removal 117 0.4 0.4 no signal
1091 Pregnancy 139 0.4 0.4 no signal
1092 Amenorrhoea 114 0.4 0.4 no signal
1093 Inflammatory Bowel Disease 67 0.4 0.4 no signal
1094 Bone Loss 102 0.4 0.4 no signal
1095 Acne 509 0.4 0.4 no signal
1096 Dystonia 130 0.4 0.4 no signal
1097 Prostate Cancer 522 0.4 0.4 no signal
1098 Thrombotic Microangiopathy 62 0.4 0.4 no signal
1099 Device Dislocation 269 0.4 0.4 no signal
1100 Osteonecrosis 205 0.4 0.4 no signal
1101 Syringe Issue 108 0.4 0.4 no signal
1102 Device Breakage 240 0.4 0.4 no signal
1103 Product Preparation Error 126 0.4 0.4 no signal
1104 Ovarian Cancer 56 0.4 0.4 no signal
1105 Accidental Exposure To Product 591 0.3 0.3 no signal
1106 Dysmenorrhoea 77 0.3 0.3 no signal
1107 Abnormal Weight Gain 73 0.3 0.3 no signal
1108 Convulsion 339 0.3 0.3 no signal
1109 Breast Cancer Female 154 0.3 0.3 no signal
1110 Menorrhagia 109 0.3 0.3 no signal
1111 Application Site Irritation 68 0.3 0.3 no signal
1112 Exposure Via Skin Contact 122 0.3 0.3 no signal
1113 No Adverse Event 950 0.3 0.3 no signal
1114 Drug Toxicity 73 0.3 0.3 no signal
1115 Incorrect Route Of Drug Administration 191 0.3 0.3 no signal
1116 Rebound Effect 58 0.3 0.3 no signal
1117 Device Use Error 173 0.3 0.3 no signal
1118 Abortion Induced 47 0.3 0.3 no signal
1119 Drug Withdrawal Syndrome 434 0.3 0.3 no signal
1120 Gastric Cancer 122 0.3 0.3 no signal
1121 Renal Cancer 225 0.3 0.3 no signal
1122 Drug Dose Omission By Device 350 0.3 0.3 no signal
1123 Meningioma 67 0.3 0.3 no signal
1124 Haematotoxicity 41 0.3 0.3 no signal
1125 Product Complaint 110 0.3 0.3 no signal
1126 Cytomegalovirus Infection 72 0.3 0.3 no signal
1127 Grand Mal Convulsion 39 0.2 0.2 no signal
1128 Myelosuppression 138 0.2 0.2 no signal
1129 Metrorrhagia 70 0.2 0.2 no signal
1130 Menstruation Irregular 100 0.2 0.2 no signal
1131 Gynaecomastia 114 0.2 0.2 no signal
1132 Skeletal Injury 38 0.2 0.2 no signal
1133 Drug Effective For Unapproved Indication 102 0.2 0.2 no signal
1134 Genital Haemorrhage 45 0.2 0.2 no signal
1135 Pharmaceutical Product Complaint 91 0.2 0.2 no signal
1136 Peritonitis Bacterial 34 0.2 0.2 no signal
1137 Complication Of Device Insertion 62 0.2 0.2 no signal
1138 Menstruation Delayed 33 0.2 0.2 no signal
1139 Device Difficult To Use 206 0.2 0.2 no signal
1140 Unintended Pregnancy 31 0.2 0.2 no signal
1141 Drug Exposure During Pregnancy 102 0.2 0.2 no signal
1142 Drug Dependence 438 0.2 0.2 no signal
1143 Device Expulsion 157 0.1 0.1 no signal
1144 Oesophageal Carcinoma 71 0.1 0.1 no signal
1145 Device Deployment Issue 22 0.1 0.1 no signal
1146 Unintentional Medical Device Removal 21 0.1 0.1 no signal
1147 Colorectal Cancer 53 0.1 0.1 no signal
1148 Breast Cancer Stage I 8 0.0 0.0 no signal
1149 Device Adhesion Issue 10 0.0 0.0 no signal
1150 Dependence 34 0.0 0.0 no signal
1151 Intercepted Product Preparation Error 7 0.0 0.0 no signal
1152 Sickle Cell Anaemia With Crisis 9 0.0 0.0 no signal
1153 Drug Withdrawal Syndrome Neonatal 5 0.0 0.0 no signal