Reaction

Drug Level Above Therapeutic reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,488 reports · 188 co-occurring drugs

As of the last recalculation, Drug Level Above Therapeutic appears in 4,488 FAERS reports alongside 188 co-occurring drug terms. The strongest observed disproportionality signal is INFLIXIMAB-DYYB (PRR 131.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Infliximab-Dyyb	698	131.0	134.2
Voriconazole Injection	111	24.3	24.4
Voriconazole	129	20.2	20.3
Mesalamine	224	19.4	19.5
Infliximab	659	16.2	16.3
Hydrocortisone Sodium Succinate	32	15.9	15.9
Theophylline	39	15.9	15.9
Phenytoin	69	15.6	15.6
Theophylline Anhydrous	39	14.7	14.8
Azathioprine	264	14.7	14.7
Dronabinol	24	13.9	14.0
Cholestyramine	36	13.9	14.0
Sirolimus	40	13.9	13.9
Lithium Carbonate	48	13.2	13.3
Anti-Itch	170	12.2	12.2
Anti-Pruritic	170	12.2	12.2
Antipruritic (Anti-Itch)	170	12.2	12.2
Cool Relief Gel With Aloe	170	12.2	12.2
Drs. Hydrocortisone	170	12.2	12.2
Hydrocortisone Continuous Spray	170	12.2	12.2
Hydrocortisone Spray	170	12.2	12.2
Anti-Itch Cream	170	12.2	12.2
Hydrocortisone Lotion	170	12.2	12.2
Hydrocortisone Cream 1%	170	12.2	12.2
Hydrocortisone Cream 1/2%	170	12.2	12.2
Hydrocortisone 1%	170	12.2	12.2
Hydrocortisone Cream	170	12.1	12.1
Tacrolimus Ointment 0.1%	298	11.8	11.8
Hydrocortisone Acetate	178	11.8	11.8
Tacrolimus Extended-Release Capsules	298	11.8	11.8
Vancomycin Hydrochloride	160	11.6	11.7
Dimenhydrinate	26	11.4	11.4
Extended Phenytoin Sodium	39	10.9	10.9
Tacrolimus	340	10.8	10.8
Hydrocortisone	198	10.7	10.7
Vancomycin	129	10.6	10.6
Mycophenilic Acid	46	10.4	10.4
Oxazepam	46	10.0	10.0
Valganciclovir Hydrochloride Powder,	25	9.6	9.6
Diphenhydramine	121	9.1	9.1
Posaconazole Delayed-Release	21	8.9	8.9
Itraconazole	21	8.4	8.4
Lithium	45	8.4	8.4
Lithium Bromatum	45	8.4	8.4
Posaconazole	29	8.3	8.3
Valganciclovir	33	8.2	8.2
Valganciclovir Hydrochloride	33	8.2	8.2
Mercaptopurine	30	8.1	8.1
Ritonavir 100 Mg	25	7.8	7.8
Mycophenolic Acid	52	7.6	7.6
Efavirenz	18	7.5	7.5
Cefepime	23	7.5	7.5
Valproate Sodium	33	7.5	7.5
Piperacillin And Tazobactam	20	7.3	7.3
Cefepime Hydrochloride	25	7.2	7.2
Aripiprazole Oral	63	7.2	7.2
Aripiprazole Orally Disintegrating	63	7.2	7.2
Basiliximab	18	7.1	7.1
Anti-Thymocyte Globulin (Rabbit)	12	6.9	6.9
Prednisone	640	6.7	6.7
Amphotericin B	18	6.7	6.7
Desoximetasone	27	6.6	6.6
Valproic Acid	44	6.5	6.5
Indapamide	25	6.5	6.5
Guanfacine	11	6.5	6.5
Metronidazole	87	6.4	6.4
Metformin	452	6.4	6.4
Gentamicin	18	6.4	6.4
Metformin Er 500 Mg	381	6.3	6.3
Metformin Er 750 Mg	381	6.3	6.3
Piperacillin Sodium And Tazobactam Sodium	26	6.2	6.2
Budesonide	77	6.1	6.2
Midazolam Hydrochloride	35	6.1	6.1
Linezolid	38	6.0	6.0
Haloperidol	31	6.0	6.0
Gentamicin Sulfate	20	5.9	5.9
Metformin Hydrochloride	74	5.9	5.9
Haloperidol Lactate	31	5.8	5.8
Metformin Hydrochloride Tablets	71	5.8	5.8
Metformin Hydrochloride Extended-Release Tablets	71	5.8	5.8
Metformin Hydrochloride Tablet	71	5.8	5.8
Piperacillin Sodium,Tazobactam Sodium	33	5.8	5.8
Captopril	12	5.8	5.8
Midazolam	29	5.4	5.4
Carbamazepine	76	5.3	5.3
Daspone	11	5.2	5.3
Dapsone Gel, 5%	11	5.2	5.3
Norepinephrine	12	5.2	5.2
Ritonavir	32	5.1	5.1
Quetiapine Fumarate	32	5.1	5.1
Divalproex Sodium	50	5.0	5.0
Diphenhydramine Hydrochloride	173	5.0	5.0
Olanzapine	113	5.0	5.0
Ciprofloxacin Hydrochloride And Hydrocortisone	22	4.9	4.9
Diazepam Oral Solution (Concentrate)	91	4.8	4.8
Diazepam Oral	91	4.8	4.8
Dapsone	11	4.8	4.8
Cyanocobalamin	33	4.7	4.7
Venlafaxine	70	4.6	4.6
Lamotirigine	69	4.5	4.5
Lamotrigine Extended-Release	69	4.5	4.5
Lamotrigine Chewable Dispersible	69	4.5	4.5
Phenobarbital	14	4.5	4.5
Amphetamine	8	4.5	4.5
Everolimus Tablets	16	4.4	4.4
Loperamide Hcl	12	4.3	4.3
Quinine	8	4.3	4.3
Ethyl Alcohol	25	4.3	4.3
Nystatin Ointment	24	4.3	4.3
Nystatin	25	4.3	4.3
Nystatin Cream	24	4.3	4.3
Mycophenolate Mofetil	121	4.2	4.2
Mycophenolate Mofetil Hydrochloride	121	4.2	4.2
Iron	60	4.2	4.2
Sodium Bicarbonate	21	4.2	4.2
Sodium Bicarbonate Injection,	21	4.2	4.2
Norepinephrine Bitartrate	13	4.2	4.2
Ciprofloxacin	81	4.1	4.2
Rifampicin	9	4.1	4.1
Warfarin Sodium	41	4.1	4.1
Ciprofloxacin Hydrochloride	85	4.1	4.1
Loperamide Hydrochloride Oral	9	4.1	4.1
Fluconazole	61	4.1	4.1
Ceftriaxone	28	4.0	4.0
Acetaminophen Tablet Extended Release	211	4.0	4.0
Pain Reliever	211	4.0	4.0
Acetaminophen 500Mg	211	4.0	4.0
Diazepam	102	4.0	4.0
Ciprofolxacin	60	3.9	3.9
Ciprofloxacin Tablets	60	3.9	3.9
Ketoprofen	11	3.9	3.9
Rifampin	12	3.8	3.8
Meropenem	26	3.8	3.8
Clonazepam	127	3.8	3.8
Diphenhydramine Hcl	9	3.8	3.8
Metronidazole Topical	38	3.7	3.7
Digoxin	57	3.7	3.7
Metoclopramide	43	3.7	3.7
Citalopram Hydrobromide	83	3.6	3.6
Alcohol	30	3.6	3.6
Ramipril	94	3.6	3.6
Loperamide Hydrochloride	34	3.5	3.5
Colchicine	20	3.5	3.5
Clarithromycin	26	3.5	3.5
Ceftriaxone Sodium	29	3.5	3.5
Nebivolol	12	3.5	3.5
Loperamide Hydrochloride And Dimethicone	24	3.5	3.5
Isopropyl Alcohol	25	3.4	3.4
Methadone Hydrochloride	8	3.4	3.4
Paroxetine Hydrochloride Hemihydrate	24	3.4	3.4
Paroxetine	24	3.3	3.3
Micafungin Sodium	6	3.3	3.3
Valsartan Oral	38	3.3	3.3
Clobazam	17	3.2	3.2
Aripiprazole	84	3.2	3.2
Methadone	29	3.2	3.2
Oxycodone And Acetaminophen Tablets	8	3.1	3.1
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate	6	3.1	3.1
Tramadol Hydrochloride	25	3.1	3.1
Tamsulosin Hydrochloride	13	3.0	3.0
Lamotrigine	83	3.0	3.0
Lisinopril And Hydrochlorothiazide Tablets	5	3.0	3.0
Metformin Hcl	35	2.9	2.9
Atazanavir	9	2.9	2.9
Derma Foam Excel Hand Sanitizer	5	2.9	2.9
Ethanol	5	2.9	2.9
Buprenorphine Hydrochloride, Naloxone Hydrochloride	15	2.9	2.9
Fentanyl	60	2.9	2.9
Sitagliptin	44	2.8	2.9
Clozapine	75	2.8	2.8
Chlorthalidone	7	2.8	2.8
Nirmatrelvir And Ritonavir	32	2.8	2.8
Olanzapine Pamoate	24	2.7	2.7
Oxcarbazepine	19	2.7	2.7
Lacosamide	21	2.6	2.6
Sitagliptin And Metformin Hydrochloride	12	2.6	2.6
Valacyclovir	23	2.6	2.6
Everolimus	28	2.6	2.6
Daptomycin	5	2.5	2.5
Liraglutide	25	2.4	2.4
Acetaminophen And Codeine	6	2.3	2.3
Levetiracetam In Sodium Chloride	36	2.2	2.2
Levetiracetam Oral	36	2.2	2.2
Levetiracetam Injection	36	2.2	2.2
Cortisone Acetate	4	1.5	1.5
Canagliflozin	9	1.4	1.4
Remdesivir	4	1.4	1.4
Pseudoephedrine Hcl	3	1.3	1.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.