Reaction

Drug Effect Increased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,167 reports · 38 co-occurring drugs

As of the last recalculation, Drug Effect Increased appears in 3,167 FAERS reports alongside 38 co-occurring drug terms. The strongest observed disproportionality signal is LISDEXAMFETAMINE DIMESYLATE (PRR 38.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Lisdexamfetamine Dimesylate	181	38.2	38.4
Buprenorphine	453	37.4	37.6
Methylphenidate	100	23.4	23.5
Armodafinil	69	22.0	22.0
Guanfacine	16	13.4	13.5
Nicotine Polacrilex Mini	25	11.0	11.0
Nicotine Polarilex	25	11.0	11.0
Fentanyl Citrate	22	8.1	8.2
Hydrocodone Bitartrate	52	8.0	8.0
Fentanyl	112	7.7	7.7
Vilazodone Hydrochloride	9	6.4	6.4
Rocuronium Bromide	11	6.2	6.2
Loratadine And Pseudoephedrine Sulfate	7	5.8	5.8
Carisoprodol	16	5.5	5.5
Nicotine	32	5.2	5.2
Doxepin	8	5.2	5.2
Nicotine Polacrilex	30	5.2	5.2
Polyethylene Glycol 3350	74	5.2	5.2
Estradiol	66	5.1	5.1
Liothyronine Sodium	6	4.5	4.5
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	27	4.3	4.3
Progesterone	14	4.0	4.0
Linaclotide	15	3.7	3.7
Efavirenz	6	3.5	3.5
Ziprasidone Mesylate	7	3.2	3.2
Insulin Human	19	3.2	3.2
Fesoterodine Fumarate	5	3.0	3.0
Lurasidone Hydrochloride	9	2.8	2.8
Oxycodone Hydrochloride	83	2.6	2.6
Suvorexant	5	2.5	2.5
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	3	2.4	2.4
Sevoflurane	3	2.4	2.4
Botulinum Toxin Type A	4	2.1	2.1
Paliperidone	6	1.7	1.7
Exenatide	13	1.6	1.6
Tapentadol Hydrochloride	8	1.6	1.6
Lifitegrast	3	1.2	1.2
Droxidopa	3	0.9	0.9

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.