Reaction

Substance Use Disorder reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,036 reports · 50 co-occurring drugs

As of the last recalculation, Substance Use Disorder appears in 3,036 FAERS reports alongside 50 co-occurring drug terms. The strongest observed disproportionality signal is ETHYL ALCOHOL (PRR 122.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Ethyl Alcohol	418	122.2	124.1
Isopropyl Alcohol	418	98.2	99.4
Alcohol	418	85.5	86.4
Oxazepam	234	80.8	81.6
Diazepam Oral Solution (Concentrate)	664	65.2	65.7
Diazepam Oral	664	65.2	65.7
Diazepam	790	59.8	60.2
Methadone Hydrochloride	89	58.1	58.5
Oxycodone And Acetaminophen Tablets	83	49.1	49.4
Amphetamine	53	44.7	45.0
Methadone	238	41.3	41.5
Oxycodone And Acetaminophen	94	28.5	28.6
Tramadol Hydrochloride	131	24.9	25.0
Buprenorphine	297	24.3	24.4
Pregabalin	681	21.8	21.9
Hydromorphone Hydrochloride	247	19.9	20.0
Sildenafil Powder,	98	19.5	19.5
Oxycodone Hydrochloride	441	16.1	16.1
Morphine Sulfate	245	15.0	15.0
Buprenorphine Hydrochloride, Naloxone Hydrochloride	50	14.4	14.5
Clonazepam	301	14.2	14.2
Aripiprazole Oral	83	14.1	14.1
Aripiprazole Orally Disintegrating	83	14.1	14.1
Morphine	146	14.0	14.1
Hydrocodone Bitartrate And Acetaminophen	107	13.5	13.5
Sildenafil	102	12.5	12.5
Oxycodone	288	11.6	11.6
Alprazolam	283	10.3	10.3
Methylphenidate	41	9.8	9.8
Fentanyl	133	9.6	9.6
Naltrexone	40	9.0	9.0
Oxycodone Hydrochloride And Acetaminophen	125	9.0	9.0
Methylphenidate Hydrochloride	69	8.1	8.2
Paroxetine Hydrochloride Hemihydrate	39	8.1	8.1
Paroxetine	39	8.0	8.0
Quetiapine	208	7.9	7.9
Olanzapine	111	7.3	7.3
Venlafaxine	72	7.0	7.0
Amitriptyline Hydrochloride	17	6.7	6.7
Fentanyl Citrate	17	6.6	6.6
Hydrocodone Bitartrate	38	6.1	6.1
Sildenafil Citrate	108	6.0	6.0
Nicotine Polacrilex Mini	13	6.0	6.0
Nicotine Polarilex	13	6.0	6.0
Mirtazapine	74	5.7	5.7
Acetaminophen And Codeine	10	5.6	5.6
Zolpidem Tartrate	107	5.6	5.6
Aripiprazole	91	5.2	5.2
Cannabidiol	8	2.3	2.3
Esketamine Hydrochloride	4	1.5	1.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.