Reaction

Therapeutic Response Changed reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,141 reports · 46 co-occurring drugs

As of the last recalculation, Therapeutic Response Changed appears in 6,141 FAERS reports alongside 46 co-occurring drug terms. The strongest observed disproportionality signal is TIRZEPATIDE (PRR 72.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Tirzepatide	2,231	72.9	73.9
Calcium, Magnesium, Potassium, And Sodium Oxybates	55	21.8	22.0
Lisdexamfetamine Dimesylate	132	13.8	13.9
Methylphenidate Hydrochloride	104	6.0	6.0
Guanfacine	13	5.6	5.6
Infliximab-Dyyb	40	4.7	4.7
Naproxen Sodium Tablet	71	4.6	4.6
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	43	4.1	4.2
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	48	3.9	3.9
Lamotirigine	81	3.9	3.9
Lamotrigine Extended-Release	81	3.9	3.9
Lamotrigine Chewable Dispersible	81	3.9	3.9
Acetaminophen, Aspirin, And Caffeine	22	3.5	3.6
Orlistat	27	3.5	3.5
Liothyronine Sodium	9	3.5	3.5
Zonisamide	15	3.4	3.4
Loratadine And Pseudoephedrine Sulfate	8	3.4	3.4
Armodafinil	20	3.2	3.2
Methylphenidate	27	3.2	3.2
Bupropion Hydrochloride	88	3.1	3.1
Lamotrigine	116	3.0	3.0
Niacin	10	2.9	2.9
Bupropion	33	2.5	2.5
Acetaminophen, Aspirin (Nsaid) And Caffeine	12	2.4	2.4
Rifampicin	7	2.3	2.3
Rizatriptan Benzoate	7	2.3	2.3
Duloxetine	46	2.2	2.2
Ibuprofen Tablets, Coated	25	2.0	2.0
Ibuprofen Sodium	25	2.0	2.0
Oxybutynin	17	2.0	2.0
Loratadine Tablet	29	1.8	1.8
Fluticasone Propionate And Salmeterol	22	1.8	1.8
Multivitamin	26	1.8	1.8
Amphetamine	4	1.6	1.6
Desvenlafaxine Succinate	13	1.6	1.6
Lurasidone Hydrochloride	10	1.6	1.6
Linaclotide	12	1.5	1.5
Eptinezumab-Jjmr	4	1.5	1.5
Varenicline Tartrate	35	1.5	1.5
Vilazodone Hydrochloride	4	1.5	1.5
Dalfampridine	31	1.5	1.5
Cariprazine	4	1.5	1.5
Sodium Oxybate	23	1.2	1.2
Asenapine Maleate	3	1.2	1.2
Paliperidone	7	1.0	1.0
Teriflunomide	13	1.0	1.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.