Reaction

Infusion Site Extravasation reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,139 reports · 261 co-occurring drugs

As of the last recalculation, Infusion Site Extravasation appears in 6,139 FAERS reports alongside 261 co-occurring drug terms. The strongest observed disproportionality signal is INFLIXIMAB-DYYB (PRR 41.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Infliximab-Dyyb	335	41.0	41.5
Remdesivir	136	35.4	35.7
Adrenalinum	404	35.3	35.6
Human Immunoglobulin G	188	31.8	32.1
Diphenhydramine	517	30.2	30.4
Diphenhydramine Hydrochloride Capsule, Liquid Filled	169	27.5	27.8
Epinephrine	467	26.1	26.3
Agalsidase Beta	65	24.1	24.3
Iron Sucrose	58	20.8	20.9
Bendamustine Hydrochloride	71	20.3	20.4
Lidocaine	326	20.0	20.1
Lidicaine	245	17.6	17.7
Burn Relief	245	17.6	17.7
Lidocaine Hydrochloride And Epinephrine	245	17.6	17.7
Lidocaine, Menthol	245	17.4	17.5
Diphenhydramine Hydrochloride	721	16.6	16.6
Lidocaine Hydrochloride And Epinephrine Bitartrate	248	16.4	16.4
Iohexol	39	16.0	16.1
Lidocaine 4%	246	15.9	16.0
Eptinezumab-Jjmr	42	15.7	15.8
Dimenhydrinate	49	15.7	15.8
Lidocaine Hydrochloride	256	15.0	15.0
Sodium Chloride Tablet	304	14.7	14.7
Sodium Chloride Tablets	304	14.7	14.7
Sodium Chloride	321	14.5	14.5
Dextrose	41	10.6	10.7
Dextrose Monohydrate	41	10.5	10.5
Alemtuzumab	58	10.3	10.3
Hydrocortisone Sodium Succinate	26	9.4	9.4
Acetaminophen Tablet Extended Release	609	8.9	8.9
Pain Reliever	609	8.9	8.9
Acetaminophen 500Mg	609	8.9	8.9
Infliximab	521	8.7	8.8
Vedolizumab	211	8.6	8.6
Treprostinil	271	7.6	7.6
Azelastine	38	7.2	7.2
Carfilzomib	56	6.8	6.8
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	40	6.6	6.6
Naproxen Sodium, Pseudoephedrine Hydrochloride	40	6.6	6.6
Hydrocortisone Acetate	137	6.5	6.5
Cholestyramine	23	6.5	6.5
Hydrocortisone Cream	126	6.5	6.5
Anti-Itch	124	6.4	6.4
Anti-Pruritic	124	6.4	6.4
Antipruritic (Anti-Itch)	124	6.4	6.4
Cool Relief Gel With Aloe	124	6.4	6.4
Drs. Hydrocortisone	124	6.4	6.4
Hydrocortisone Continuous Spray	124	6.4	6.4
Hydrocortisone Spray	124	6.4	6.4
Anti-Itch Cream	124	6.4	6.4
Hydrocortisone Lotion	124	6.4	6.4
Hydrocortisone Cream 1%	124	6.4	6.4
Hydrocortisone Cream 1/2%	124	6.4	6.4
Hydrocortisone 1%	124	6.4	6.4
Methylprednisolone Sodium Succinate	85	6.3	6.3
Acetaminophen	734	6.2	6.2
Hydrocortisone	155	6.0	6.0
Rabeprazole	39	6.0	6.0
Fluticasone Propionate Nasal	52	5.9	5.9
Butalbital, Acetaminophen, And Caffeine	18	5.7	5.7
Fosaprepitant Dimeglumine	23	5.7	5.7
Cyclobenzaprine Hydrochloride	15	5.7	5.7
Guaifenesin	49	5.5	5.5
Hydroxyzine Hydrochloride	21	5.4	5.4
Hydroxyzine Hydrochloride Oral	21	5.4	5.4
Doxyclycline Hyclate	27	5.4	5.4
Pantoprazole Sodium In 0.9% Sodium Chloride	95	5.3	5.3
Pantoprazole Sodium Injection	95	5.3	5.3
Mesalamine	85	5.2	5.2
Tiotropium Bromide Inhalation Spray	17	5.2	5.2
Azathioprine	122	4.8	4.8
Alteplase	21	4.8	4.8
Nystatin Ointment	34	4.4	4.4
Nystatin Cream	34	4.4	4.4
Nystatin	35	4.4	4.4
Eculizumab	68	4.3	4.3
Norepinephrine Bitartrate	18	4.2	4.3
Iron	82	4.2	4.2
Tizanidine Hydrochloride	22	4.1	4.1
Dicyclomine Hydrochloride	17	4.1	4.1
Methylprednisolone	161	4.0	4.0
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	182	3.9	3.9
Fluticasone Furoate	14	3.9	3.9
Prednisone	541	3.9	3.9
Liothyronine Sodium	10	3.9	3.9
Oxybutynin Chloride	10	3.9	3.9
Aprepitant	21	3.9	3.9
Methocarbamol Tablets	19	3.9	3.9
Sucralfate	27	3.8	3.8
Mupirocin	15	3.8	3.8
Sildenafil	64	3.8	3.8
Magnesium	90	3.8	3.8
Desoximetasone	21	3.7	3.7
Cetirizine Hydrochloride Allergy	33	3.7	3.7
Cetirizine Hydrochloride Tablets	33	3.7	3.7
Mupirocin Calcium	15	3.7	3.7
Cetirizine Hcl	10	3.7	3.7
0Xygen	53	3.7	3.7
Oxygen	53	3.7	3.7
Clotrimazole	13	3.6	3.6
Sucralfate Oral	15	3.6	3.6
Sucralfate Oral Suspension	15	3.6	3.6
Macitentan	72	3.6	3.6
Sildenafil Powder,	37	3.5	3.5
Levocetirizine Dihydrochloride	25	3.5	3.5
Drs. Clotrimazole	12	3.5	3.5
Family Wellness Clotrimazole	12	3.5	3.5
Clotrimazole Topical	12	3.5	3.5
Cyanocobalamin	34	3.5	3.5
Melatonin	56	3.5	3.5
Amoxicillin And Clavulanate Potassium	28	3.5	3.5
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	31	3.5	3.5
Methocarbamol	23	3.4	3.4
Buspirone Hydrochloride	11	3.4	3.4
Fluticasone Propionate	126	3.3	3.3
Hyoscyamine Sulfate	9	3.3	3.3
Daratumumab	39	3.3	3.3
Vitamin C	89	3.3	3.3
Natalizumab	174	3.3	3.3
Zoledronic Acid	39	3.3	3.3
Ampicillin	8	3.3	3.3
Ampicillin Sodium	8	3.3	3.3
Tadalafil	95	3.3	3.3
Budesonide	56	3.2	3.2
Standardized Senna Concentrate	12	3.2	3.2
Cetirizine Hydrochloride	154	3.2	3.2
Ketoconazole Foam	14	3.2	3.2
Montelukast Sodium	114	3.2	3.2
Heparin Sodium	13	3.2	3.2
Ketoconazole Cream, 2%	14	3.2	3.2
Calcium	138	3.2	3.2
Pantoprazole Sodium	137	3.2	3.2
Propofol	34	3.2	3.2
Cyclobenzaprine	46	3.1	3.1
Polyethylene Glycol	10	3.1	3.1
Oxycodone And Acetaminophen Tablets	11	3.1	3.1
Ketoprofen	12	3.1	3.1
Ciprofloxacin Hydrochloride And Hydrocortisone	19	3.1	3.1
Psyllium Husk	9	3.1	3.1
Cetirizine	70	3.1	3.1
Hydroxyzine	43	3.1	3.1
Ergocalciferol	334	3.1	3.1
Umeclidinium	8	3.0	3.0
Fam-Trastuzumab Deruxtecan-Nxki	9	3.0	3.0
Azithromycin Dihydrate	52	3.0	3.0
Anti-Thymocyte Globulin (Rabbit)	7	2.9	2.9
Blinatumomab	9	2.9	2.9
Tretinoin	7	2.9	2.9
Chlorthalidone	10	2.9	2.9
Zinc	21	2.9	2.9
Dalteparin Sodium	9	2.9	2.9
Rocuronium Bromide	10	2.9	2.9
Azithromycin	34	2.9	2.9
Zinc Chloride	21	2.9	2.9
Zinc Gluconate	22	2.9	2.9
Mometasone Furoate And Formoterol Fumarate Dihydrate	13	2.8	2.8
Azithromycin Monohydrate	34	2.8	2.8
Ravulizumab	11	2.8	2.8
Clindamycin Phosphate	27	2.7	2.8
Ketoconazole	14	2.7	2.7
Fluticasone Furoate And Vilanterol Trifenatate	29	2.7	2.7
Vancomycin Hydrochloride	53	2.7	2.7
Biotin	25	2.7	2.7
Cetuximab	25	2.7	2.7
Cetiirizine	33	2.7	2.7
Doxycycline	53	2.6	2.6
Loratadine Oral	38	2.6	2.6
Doxycycline Hyclate	52	2.6	2.6
Dexlansoprazole	32	2.6	2.6
Fluticasone Propionate And Salmeterol Xinafoate	46	2.6	2.6
Montelukast	64	2.6	2.6
Epoprostenol	10	2.6	2.6
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	38	2.6	2.6
Fexofenadine Hcl	7	2.6	2.6
Budesonide And Formoterol Fumarate Dihydrate	73	2.6	2.6
Linaclotide	20	2.5	2.5
Labetalol	10	2.5	2.5
Tobramycin Solution	9	2.5	2.5
Sildenafil Citrate	94	2.5	2.5
Progesterone	17	2.5	2.5
Diclofenac Potassium	8	2.5	2.5
Canakinumab	8	2.5	2.5
Famotidine	86	2.5	2.5
Obinutuzumab	12	2.5	2.5
Tobramycin Sulfate	9	2.5	2.5
Benzonatate	12	2.5	2.5
Sevoflurane	6	2.4	2.5
Ambrisentan	89	2.4	2.4
Polatuzumab Vedotin	7	2.4	2.4
Atorvastatin Calcium, Film Coated	50	2.4	2.4
Ondansetron Hydrochloride	86	2.4	2.4
Alendronate Sodium Tablet	13	2.4	2.4
Acyclovir	79	2.4	2.4
Ocrelizumab	43	2.4	2.4
Albuterol Sulfate	202	2.4	2.4
Rifampin	10	2.3	2.3
Itraconazole	8	2.3	2.3
Sumatriptan	26	2.3	2.3
Clobetasol Propionate Ointment Usp, 0.05%	7	2.3	2.3
Clobetasol Propionate	7	2.3	2.3
Belimumab	21	2.3	2.3
Loperamide Hydrochloride And Dimethicone	21	2.2	2.2
Norepinephrine	7	2.2	2.2
Pegaspargase	8	2.2	2.2
Loperamide Hydrochloride	29	2.2	2.2
Mirabegron	25	2.2	2.2
Triamcinolone Acetonide Ointment Usp, 0.05%	15	2.2	2.2
Tamsulosin Hydrochloride	13	2.2	2.2
Loratadine	68	2.2	2.2
Duloxetine	44	2.1	2.1
Bupropion Hydrochloride	62	2.1	2.1
Tizanidine	15	2.1	2.1
Metoprolol Succinate Er Tablets	39	2.1	2.1
Vancomycin	36	2.1	2.1
Valacyclovir	26	2.1	2.1
Ondansetron	67	2.1	2.1
Ondansetron Tablets	67	2.1	2.1
Triamcinolone Acetonide	19	2.1	2.1
Riociguat	20	2.1	2.1
Oxycodone And Acetaminophen	14	2.0	2.0
Fexofenadine Hydrochloride	13	2.0	2.0
Diclofenac Potassium, Film Coated	5	2.0	2.0
Diclofenac Potassium Tablets	5	2.0	2.0
Ado-Trastuzumab Emtansine	5	2.0	2.0
Pembrolizumab	62	2.0	2.0
Etonogestrel And Ethinyl Estradiol	13	2.0	2.0
Brentuximab Vedotin	6	2.0	2.0
Memantine	8	2.0	2.0
Memantine Hydrochloride	8	2.0	2.0
Acetaminophen And Codeine	7	1.9	1.9
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	20	1.9	1.9
Cannabidiol	13	1.9	1.9
Rimegepant Sulfate	7	1.9	1.9
Abatacept	75	1.8	1.8
Selexipag	14	1.8	1.8
Umeclidinium Bromide And Vilanterol Trifenatate	9	1.8	1.8
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	22	1.8	1.8
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	22	1.8	1.8
Loratadine Tablet	28	1.8	1.8
Polyethylene Glycol 3350	47	1.7	1.7
Docetaxel Anhydrous	32	1.6	1.6
Docetaxel	32	1.6	1.6
Fluorouracil Cream, 0.5%	36	1.6	1.6
Fluorouracil	36	1.6	1.6
Doxorubicin Hydrochloride	15	1.6	1.6
Panitumumab	7	1.5	1.5
Fremanezumab-Vfrm	5	1.5	1.5
Tafamidis	5	1.4	1.4
Durvalumab	8	1.3	1.3
Lutetium Lu 177 Vipivotide Tetraxetan	5	1.3	1.3
Bosentan	19	1.3	1.3
Lifitegrast	6	1.2	1.2
Travoprost	3	1.2	1.2
Ranitidine	67	1.1	1.1
Naltrexone	10	1.1	1.1
Crisaborole	3	1.1	1.1
Nivolumab	30	1.1	1.1
Budesonide, Glycopyrrolate, And Formoterol Fumarate	3	1.0	1.0
Dornase Alfa	4	0.7	0.7
Galcanezumab-Gnlm	5	0.5	0.5
Erenumab-Aooe	8	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.