Reaction

Flat Affect reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,246 reports · 66 co-occurring drugs

As of the last recalculation, Flat Affect appears in 2,246 FAERS reports alongside 66 co-occurring drug terms. The strongest observed disproportionality signal is LURASIDONE HYDROCHLORIDE (PRR 21.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Lurasidone Hydrochloride	48	21.7	21.7
Paliperidone Palmitate	71	21.1	21.1
Atomoxetine Hydrochloride	49	19.5	19.5
Lisdexamfetamine Dimesylate	57	16.4	16.4
Paroxetine Hydrochloride	145	15.7	15.7
Brexpiprazole	27	15.2	15.3
Paroxetine Hydrochloride Hemihydrate	51	14.5	14.5
Ziprasidone Mesylate	22	14.4	14.5
Paroxetine	51	14.2	14.2
Cariprazine	14	14.0	14.0
Ziprasidone	24	12.8	12.8
Diphenhydramine Hcl	15	12.6	12.6
Aripiprazole Oral	52	11.9	11.9
Aripiprazole Orally Disintegrating	52	11.9	11.9
Olanzapine Pamoate	51	11.8	11.8
Butalbital, Acetaminophen, And Caffeine	13	11.4	11.4
Olanzapine	122	11.1	11.1
Fluoxetine Hydrochloride	138	10.6	10.6
Lithium Carbonate	19	10.4	10.5
Lithium	28	10.4	10.4
Lithium Bromatum	28	10.4	10.4
Aripiprazole	126	10.0	10.1
Sertraline	113	9.3	9.4
Sertraline Hydrochloride	108	8.8	8.8
Zonisamide	14	8.8	8.8
Risperidone	118	8.6	8.6
Vortioxetine	14	7.7	7.7
Venlafaxine Hydrochloride	103	7.5	7.5
Guanfacine	6	7.1	7.1
Vilazodone Hydrochloride	7	7.1	7.1
Bupropion Hydrochloride	72	6.9	7.0
Fluoxetine	49	6.9	6.9
Escitalopram	101	6.9	6.9
Desvenlafaxine Succinate	20	6.9	6.9
Citalopram	97	6.8	6.8
Finasteride	43	6.7	6.7
Daspone	7	6.7	6.7
Valbenazine	18	6.7	6.7
Dapsone Gel, 5%	7	6.7	6.7
Asenapine Maleate	6	6.4	6.4
Lamotrigine	88	6.4	6.4
Duloxetine Hydrochloride	122	6.3	6.3
Methylphenidate Hydrochloride	39	6.2	6.2
Dapsone	7	6.1	6.1
Lamotirigine	46	6.1	6.1
Lamotrigine Extended-Release	46	6.1	6.1
Lamotrigine Chewable Dispersible	46	6.1	6.1
Haloperidol	15	5.8	5.8
Dutasteride	5	5.7	5.7
Haloperidol Lactate	15	5.6	5.6
Paliperidone	14	5.6	5.6
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	21	4.7	4.7
Loratadine And Pseudoephedrine Sulfate	4	4.7	4.7
Naltrexone	15	4.5	4.5
Varenicline Tartrate	37	4.3	4.3
Esketamine Hydrochloride	8	4.2	4.2
Ethyl Alcohol	11	3.8	3.8
Elexacaftor, Tezacaftor, And Ivacaftor	5	3.7	3.7
Isopropyl Alcohol	13	3.6	3.6
Clozapine	45	3.4	3.4
Cenobamate	3	3.3	3.3
Naltrexone Hydrochloride And Bupropion Hydrochloride	3	3.3	3.3
Pimavanserin Tartrate	17	2.9	2.9
Isotretinoin	15	2.8	2.8
Axicabtagene Ciloleucel	3	2.8	2.8
Alcohol	11	2.6	2.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.