Reaction

On And Off Phenomenon reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,197 reports · 61 co-occurring drugs

As of the last recalculation, On And Off Phenomenon appears in 5,197 FAERS reports alongside 61 co-occurring drug terms. The strongest observed disproportionality signal is LEVODOPA (PRR 116.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Levodopa	328	116.0	119.2
Rotigotine	383	114.4	117.5
Carbidopa And Levodopa	1,053	111.2	113.7
Rasagiline Mesylate	267	101.2	103.7
Pramipexole	356	99.8	102.2
Amantadine	307	84.4	86.1
Rivastigmine	354	80.7	82.2
Ropinirole	243	66.5	67.5
Bisacodyl Suppositories	49	15.3	15.4
Biscodyl	49	15.2	15.2
Bisacodyl	50	14.4	14.4
Oxazepam	69	13.0	13.1
Clozapine	358	12.2	12.2
Instalax Polyethylene Glycol 3350	37	12.0	12.1
Polyethylene Glycol 400	37	11.8	11.8
Melatonin	143	10.8	10.8
Mirabegron	99	10.4	10.5
Memantine	29	8.5	8.5
Memantine Hydrochloride	29	8.5	8.5
Lactulose	80	8.5	8.5
Mirtazapine	179	8.1	8.1
Quetiapine	336	7.4	7.4
Standardized Senna Concentrate	21	6.7	6.7
Clonazepam	252	6.6	6.6
Lubiprostone	15	6.4	6.4
Donepezil Hydrochloride	55	6.1	6.1
Zonisamide	21	5.7	5.7
Sennosides 8.6 Mg Tablets	29	5.6	5.6
Senna	29	5.5	5.5
Pimavanserin Tartrate	75	5.5	5.5
Sennosides	38	5.1	5.1
Senna Leaf	29	5.1	5.1
Escitslopram	67	4.7	4.7
Cyanocobalamin	38	4.6	4.7
Pantoprazole Sodium In 0.9% Sodium Chloride	71	4.6	4.6
Pantoprazole Sodium Injection	71	4.6	4.6
Droxidopa	24	4.5	4.5
Dutasteride	9	4.4	4.4
Magnesium	89	4.4	4.4
Paroxetine Hydrochloride Hemihydrate	35	4.2	4.2
Paroxetine	35	4.1	4.1
Psyllium Husk	10	4.1	4.1
Escitalopram Oxalate	73	4.1	4.1
Rabeprazole	22	4.0	4.0
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	28	3.7	3.7
Magnesium Hydroxide	12	3.6	3.6
Polyethylene Glycol 3350	79	3.3	3.3
Trazodone Hydrochloride	13	3.3	3.3
Magnesium Oxide	34	3.3	3.3
Finasteride	47	3.1	3.1
Citalopram Hydrobromide	81	3.1	3.1
Midazolam	19	3.0	3.0
Midazolam Hydrochloride	19	2.8	2.8
Duloxetine	48	2.8	2.8
Venlafaxine	48	2.7	2.7
Fesoterodine Fumarate	7	2.6	2.6
Suvorexant	8	2.5	2.5
Linaclotide	15	2.3	2.3
Vibegron	4	2.0	2.0
Miconazole Nitrate	4	1.8	1.8
Onabotulinumtoxina	25	1.3	1.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.