Reaction

Premature Rupture Of Membranes reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,390 reports · 47 co-occurring drugs

As of the last recalculation, Premature Rupture Of Membranes appears in 2,390 FAERS reports alongside 47 co-occurring drug terms. The strongest observed disproportionality signal is ZIDOVUDINE (PRR 73.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Zidovudine	108	73.6	74.2
Lopinavir And Ritonavir	62	40.9	41.1
Ampicillin	36	38.4	38.6
Ampicillin Sodium	36	38.4	38.6
Nevirapine	35	34.3	34.4
Atazanavir	52	32.2	32.3
Ritonavir	100	31.1	31.2
Darunavir	48	28.2	28.3
Cefuroxime	36	27.8	27.9
Ritonavir 100 Mg	45	26.7	26.8
Raltegravir	38	20.4	20.4
Progesterone	45	17.4	17.5
Misoprostol	18	16.2	16.2
Efavirenz	20	15.7	15.8
Iron Sucrose	17	15.6	15.7
Lamivudine	54	15.5	15.6
Tenofovir Disoproxil Fumarate Tablets	15	15.2	15.2
Dalteparin Sodium	17	14.1	14.1
Lamivudine Oral	36	12.6	12.6
Magnesium Sulfate In Water For	17	11.7	11.7
Magnesium Sulfate Heptahydrate	17	11.4	11.5
Magnesium Sulfate	17	11.4	11.4
Erythromycin	24	11.2	11.3
Emtricitabine And Tenofovir Disoproxil Fumarate	54	10.5	10.5
Indomethacin	15	9.9	9.9
Oseltamivir	9	9.9	9.9
Human Immunoglobulin G	20	8.5	8.5
Bupivacaine	9	8.4	8.4
Labetalol	12	7.9	7.9
Azathioprine	73	7.4	7.4
Gentamicin Sulfate	13	7.2	7.2
Tenofovir Disoproxil Fumarate	27	7.2	7.2
Dolutegravir Sodium	7	6.8	6.8
Cefazolin	7	6.7	6.7
Nifedipine	32	6.0	6.0
Bleomycin Sulfate	7	5.9	5.9
Oseltamivir Phosphate	16	5.7	5.7
Fondaparinux Sodium	5	5.4	5.4
Rocuronium Bromide	7	5.2	5.2
Belimumab	14	3.9	3.9
Certolizumab Pegol	46	3.5	3.5
Ivacaftor	3	3.3	3.3
Buprenorphine Hydrochloride, Naloxone Hydrochloride	9	3.3	3.3
Benralizumab	7	3.1	3.1
Lurasidone Hydrochloride	7	2.9	2.9
Levonorgestrel	45	2.0	2.0
Copper	8	1.6	1.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.