Reaction

Labelled Drug-Drug Interaction Issue reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,386 reports · 61 co-occurring drugs

As of the last recalculation, Labelled Drug-Drug Interaction Issue appears in 1,386 FAERS reports alongside 61 co-occurring drug terms. The strongest observed disproportionality signal is NALTREXONE HYDROCHLORIDE AND BUPROPION HYDROCHLORIDE (PRR 165.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Naltrexone Hydrochloride And Bupropion Hydrochloride	88	165.4	167.2
Posaconazole	87	85.7	86.2
Posaconazole Delayed-Release	49	69.4	69.7
Rifampin	24	25.1	25.1
Asenapine Maleate	14	24.5	24.5
Quetiapine Fumarate	40	20.9	21.0
Clobazam	33	20.8	20.8
Tramadol Hydrochloride	48	19.8	19.8
Paroxetine Hydrochloride Hemihydrate	41	19.0	19.0
Paroxetine	41	18.6	18.7
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	49	18.4	18.4
Vortioxetine	20	17.9	17.9
Oxazepam	24	17.0	17.1
Cefazolin	9	14.9	14.9
Torsemide	32	14.8	14.8
Clarithromycin	32	14.3	14.3
Itraconazole	11	14.2	14.3
Voriconazole Injection	20	14.0	14.0
Valproate Sodium	18	13.2	13.2
Ritonavir 100 Mg	13	13.2	13.2
Cabotegravir	7	13.1	13.1
Isoniazid	13	12.2	12.2
Bupropion	34	11.7	11.7
Mycophenilic Acid	16	11.7	11.7
Isosorbide Mononitrate	16	11.7	11.7
Colchicine	20	11.6	11.6
Cefazolin Sodium	9	11.3	11.3
Methadone Hydrochloride	8	11.2	11.2
Donepezil Hydrochloride	26	10.8	10.8
Nirmatrelvir And Ritonavir	38	10.8	10.8
Voriconazole	21	10.5	10.5
Ticagrelor	22	10.5	10.5
Voclosporin	6	10.4	10.4
Oxymorphone Hydrochloride	8	10.4	10.4
Hydroxyzine Hydrochloride	9	10.3	10.3
Hydroxyzine Hydrochloride Oral	9	10.3	10.3
Dextrose	9	10.3	10.3
Dextrose Monohydrate	9	10.2	10.2
Sirolimus	9	10.1	10.1
Darunavir	10	10.0	10.0
Dapagliflozin	20	9.7	9.7
Amphotericin B	8	9.6	9.6
Pyrazinamide	6	9.6	9.6
Efavirenz	7	9.5	9.5
Cenobamate	5	9.0	9.0
Sumatriptan Succinate	15	9.0	9.0
Micafungin Sodium	5	8.9	8.9
Tenofovir Disoproxil Fumarate Tablets	5	8.7	8.7
Suvorexant	7	8.1	8.1
Apixaban	32	7.3	7.3
Ozanimod Hydrochloride	4	7.3	7.3
Valbenazine	12	7.2	7.2
Rucaparib	4	6.8	6.8
Ethyl Alcohol	12	6.7	6.7
Abiraterone	6	6.6	6.6
Azacitidine For	8	6.6	6.6
Sevoflurane	3	5.4	5.4
Umeclidinium Bromide And Vilanterol Trifenatate	6	5.4	5.4
Alcohol	12	4.7	4.7
Buprenorphine	22	3.6	3.6
Etonogestrel	8	2.5	2.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.