Reaction

Product Leakage reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,263 reports · 80 co-occurring drugs

As of the last recalculation, Product Leakage appears in 5,263 FAERS reports alongside 80 co-occurring drug terms. The strongest observed disproportionality signal is GUSELKUMAB (PRR 115.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Guselkumab	875	115.8	118.7
Icosapent Ethyl	96	45.4	45.9
Leuprolide Acetate	332	18.0	18.1
Bimekizumab	83	15.6	15.7
Ustekinumab	370	15.3	15.4
Azelastine	60	13.4	13.4
Paliperidone Palmitate	89	11.1	11.1
Ketoprofen	34	10.3	10.3
0Xygen	101	8.2	8.3
Oxygen	101	8.2	8.3
Treprostinil	232	7.6	7.6
Amitriptyline Hydrochloride	32	7.3	7.3
Human Immunoglobulin G	34	6.6	6.6
Teduglutide	21	6.2	6.2
Blinatumomab	16	6.1	6.1
Cetirizine Hcl	12	5.2	5.2
Sodium Chloride Tablet	92	5.0	5.0
Sodium Chloride Tablets	92	5.0	5.0
Macitentan	86	5.0	5.0
Octreotide Acetate	38	4.9	4.9
Sildenafil Powder,	42	4.7	4.7
Sodium Chloride	92	4.7	4.7
Clobetasol Propionate Ointment Usp, 0.05%	12	4.6	4.6
Clobetasol Propionate	12	4.6	4.6
Sildenafil	66	4.6	4.6
Lanreotide Acetate	9	4.5	4.5
Golimumab	95	4.4	4.4
Mometasone Furoate	44	4.2	4.2
Insulin Degludec	24	4.1	4.1
Lidocaine Hydrochloride	59	3.9	3.9
Somatropin	71	3.9	3.9
Prednisolone Acetate	10	3.8	3.8
Bumetanide	25	3.8	3.8
Secukinumab	150	3.8	3.8
Naltrexone	29	3.7	3.7
Ofatumumab	31	3.7	3.7
Travoprost	8	3.7	3.7
Abatacept	125	3.6	3.6
Cyclobenzaprine Hydrochloride	8	3.5	3.5
Metolazone	10	3.5	3.5
Tretinoin	7	3.4	3.4
Riociguat	27	3.3	3.3
Polatuzumab Vedotin	8	3.2	3.2
Torsemide	27	3.2	3.2
Brinzolamide	7	3.2	3.2
Tadalafil	78	3.1	3.1
Methocarbamol Tablets	13	3.1	3.1
Adrenalinum	32	3.1	3.1
Testosterone	18	3.1	3.1
Hydroxyzine Hydrochloride	10	3.0	3.0
Hydroxyzine Hydrochloride Oral	10	3.0	3.0
Clonidine	38	2.9	2.9
Canakinumab	8	2.9	2.9
Buspirone Hydrochloride	8	2.9	2.9
Timolol Maleate	7	2.8	2.8
Testosterone Cypionate	6	2.7	2.7
Naproxen Sodium Tablet	34	2.5	2.5
Sildenafil Citrate	79	2.5	2.5
Epinephrine	40	2.4	2.4
Sumatriptan Succinate	15	2.4	2.4
Estradiol Gel 0.1%	26	2.3	2.3
Estradiol Transdermal	26	2.3	2.3
Alteplase	8	2.1	2.1
Mometasone Furoate And Formoterol Fumarate Dihydrate	8	2.0	2.0
Brimonidine Tartrate	9	2.0	2.0
Cenegermin-Bkbj	6	2.0	2.0
Benralizumab	9	1.8	1.8
Risperidone	59	1.8	1.8
Cariprazine	4	1.7	1.7
Ambrisentan	51	1.6	1.6
Esketamine Hydrochloride	7	1.6	1.6
Bimatoprost	11	1.5	1.5
Lifitegrast	6	1.5	1.5
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	15	1.4	1.4
Oral Semaglutide	26	1.4	1.4
Fremanezumab-Vfrm	4	1.4	1.4
Fam-Trastuzumab Deruxtecan-Nxki	3	1.2	1.2
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	9	1.1	1.1
Patiromer	4	1.1	1.1
Glatiramer Acetate	15	1.0	1.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.