Reaction

Substance Use reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,521 reports · 49 co-occurring drugs

As of the last recalculation, Substance Use appears in 1,521 FAERS reports alongside 49 co-occurring drug terms. The strongest observed disproportionality signal is METHADONE HYDROCHLORIDE (PRR 84.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Methadone Hydrochloride	64	84.5	85.0
Amphetamine	28	47.2	47.3
Calcium, Magnesium, Potassium, And Sodium Oxybates	29	47.0	47.1
Insulin Glulisine	34	46.8	46.9
Cabotegravir	27	46.6	46.7
Naltrexone	92	43.4	43.5
Doxepin Hydrochloride	38	42.2	42.3
Sodium Oxybate	140	31.9	32.0
Methadone	93	31.6	31.7
Fentanyl Citrate	39	30.6	30.7
Armodafinil	42	28.0	28.1
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	61	24.6	24.6
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	66	22.7	22.7
Trazodone Hydrochloride	22	19.5	19.5
Modafinil	38	16.5	16.5
Doxepin	12	16.3	16.3
Lisdexamfetamine Dimesylate	35	14.8	14.8
Divalproex Sodium	48	14.5	14.6
Elexacaftor, Tezacaftor, And Ivacaftor	13	14.4	14.4
Amitriptyline Hydrochloride	18	14.2	14.2
Ethyl Alcohol	27	13.8	13.8
Dronabinol	8	13.7	13.7
Aripiprazole	112	13.4	13.4
Aripiprazole Oral	37	12.5	12.5
Aripiprazole Orally Disintegrating	37	12.5	12.5
Esketamine Hydrochloride	16	12.4	12.4
Valproic Acid	28	12.4	12.4
Methylphenidate Hydrochloride	50	11.9	11.9
Fentanyl	81	11.8	11.8
Paliperidone Palmitate	27	11.7	11.7
Etonogestrel And Ethinyl Estradiol	18	11.2	11.2
Nicotine Polacrilex Mini	12	11.0	11.0
Nicotine Polarilex	12	11.0	11.0
Alcohol	30	10.8	10.8
Isopropyl Alcohol	26	10.7	10.7
Sildenafil Powder,	23	9.0	9.0
Darunavir	9	8.2	8.2
Bupropion	26	8.1	8.1
Glecaprevir And Pibrentasvir	6	7.5	7.5
Buprenorphine Hydrochloride, Naloxone Hydrochloride	13	7.4	7.4
Buprenorphine	47	7.1	7.1
Empagliflozin	34	7.0	7.0
Methylphenidate	14	6.7	6.7
Vortioxetine	7	5.7	5.7
Derma Foam Excel Hand Sanitizer	3	5.1	5.1
Clozapine	46	5.1	5.1
Ethanol	3	5.1	5.1
Paliperidone	8	4.7	4.7
Cannabidiol	8	4.7	4.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.