Reaction

Rheumatoid Factor Positive reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,695 reports · 220 co-occurring drugs

As of the last recalculation, Rheumatoid Factor Positive appears in 5,695 FAERS reports alongside 220 co-occurring drug terms. The strongest observed disproportionality signal is CORTISONE ACETATE (PRR 1,636.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Cortisone Acetate	2,806	1,636.5	2,121.2
Pseudoephedrine Hydrochloride	2,506	1,591.1	2,108.0
Desoximetasone	3,349	1,558.0	1,892.5
Pseudoephedrine Hcl	2,540	1,520.0	1,978.6
Diclofenac Potassium, Film Coated	1,569	940.2	1,157.0
Diclofenac Potassium Tablets	1,569	939.5	1,156.0
Tofacitinib Citrate	2,033	880.8	1,043.4
Cetirizine Hydrochloride Allergy	3,007	767.7	852.8
Cetirizine Hydrochloride Tablets	3,007	767.6	852.7
Tocilizumab	4,595	757.8	789.8
Diclofenac Potassium	1,569	732.1	857.1
Sulfasalazine	4,138	704.3	743.9
Leflunomide	4,432	694.5	725.3
Diclofenac Sodium 1%	2,910	607.8	661.9
Diclofenac Sodium Topical	2,910	607.7	661.9
Diclofenac Sodium Topical Gel, 1%	2,910	606.5	660.5
Golimumab	3,792	481.6	504.0
Naproxen Sodium Tablet, Coated	1,332	469.0	520.4
Naproxen Sodium, Coated Tablets	1,332	469.0	520.4
Naproxen Sodium 220Mg	1,332	468.3	519.5
Abatacept	4,277	450.3	464.7
Sarilumab	1,944	407.9	440.4
Cetirizine	3,410	398.8	417.2
Hydroxychloroquine Sulfate	3,584	386.2	402.0
Diclofenac	3,470	375.3	391.1
Alendronate Sodium	3,539	336.9	349.2
Certolizumab Pegol	3,718	332.1	343.0
Calcium Gluconate	780	274.0	293.0
Rituximab	4,177	268.2	273.6
Adalimumab-Fkjp	2,122	266.3	279.1
Adalimumab-Adaz	2,291	264.8	276.8
Adalimumab-Aaty	2,121	260.4	272.6
Chlorhexidine Gluconate	574	255.2	272.4
Hydroxychloroquine	2,700	250.4	259.9
Tofacitinib	3,937	250.4	255.9
Infliximab	4,102	242.9	247.5
Methotrexate Sodium	4,842	237.4	239.8
Acetaminophen And Codeine	687	234.2	248.3
Diclofenac Sodium	3,503	219.4	224.7
Ustekinumab	2,939	215.8	222.2
Hydrocortisone Sodium Succinate	446	188.0	197.4
Cetirizine Hydrochloride	3,411	187.0	191.0
Methotrexate	4,503	183.1	185.1
Hydrocortisone Acetate	2,193	178.7	184.3
Quetiapine Fumarate	1,044	158.1	163.9
Folic Acid	3,719	155.2	157.6
Doxyclycline Hyclate	609	146.2	151.7
Cetiirizine	1,277	141.8	146.2
Risedronate Sodium	982	139.3	143.9
Adalimumab	4,659	127.8	128.6
Isopropyl Alcohol	980	127.8	131.6
Triamcinolone Acetonide Ointment Usp, 0.05%	707	125.9	129.8
Alcohol	980	111.2	114.1
Hydrocortisone	1,822	109.2	111.5
Antacid	1,131	108.3	111.0
Etanercept	4,306	104.7	105.4
Calcium Carbonate	1,406	101.3	103.4
Anti-Itch	1,359	97.0	99.0
Anti-Pruritic	1,359	97.0	99.0
Antipruritic (Anti-Itch)	1,359	97.0	99.0
Cool Relief Gel With Aloe	1,359	97.0	99.0
Drs. Hydrocortisone	1,359	97.0	99.0
Hydrocortisone Continuous Spray	1,359	97.0	99.0
Hydrocortisone Spray	1,359	97.0	99.0
Anti-Itch Cream	1,359	97.0	99.0
Hydrocortisone Lotion	1,359	97.0	99.0
Hydrocortisone Cream 1%	1,359	96.9	98.9
Hydrocortisone Cream 1/2%	1,359	96.9	98.9
Hydrocortisone 1%	1,359	96.9	98.9
Hydrocortisone Cream	1,359	96.5	98.5
Triamcinolone Acetonide	707	95.3	97.6
Aprepitant	435	93.2	95.4
Anakinra	389	91.9	94.1
Prednisone	3,930	89.9	90.6
Pantoprazole Sodium In 0.9% Sodium Chloride	1,197	89.1	90.8
Pantoprazole Sodium Injection	1,197	89.1	90.8
Secukinumab	2,232	82.5	83.6
Doxycycline Hyclate	1,183	80.6	82.0
Doxycycline	1,183	79.7	81.1
Diltiazem Hydrochloride Extended-Release Tablets	232	77.6	79.2
Fosaprepitant Dimeglumine	278	77.6	79.2
Tramadol Hydrochloride	697	77.0	78.4
Acetaminophen Tablet Extended Release	2,748	75.2	76.0
Pain Reliever	2,748	75.1	75.9
Acetaminophen 500Mg	2,748	75.1	75.9
Methylprednisolone Sodium Succinate	802	73.3	74.6
Diphenhydramine Hydrochloride Capsule, Liquid Filled	388	71.2	72.5
Oxycodone And Acetaminophen Tablets	221	70.5	71.8
Naproxen Sodium	1,845	69.3	70.2
Apremilast	1,750	62.7	63.4
Celecoxib	1,608	61.8	62.6
Vitamin C	1,194	59.8	60.6
Ramipril	1,450	57.1	57.7
Naproxen	900	49.5	50.1
Acetaminophen	2,920	47.9	48.2
Ascorbic Acid	289	47.8	48.4
Erythromycin	222	45.0	45.5
Minocycline	134	43.0	43.5
Pantoprazole	1,949	42.3	42.6
Oxycodone	1,576	42.2	42.6
Cyanocobalamin	353	41.7	42.1
Mycophenolate Mofetil Hydrochloride	1,207	40.9	41.2
Mycophenolate Mofetil	1,190	40.2	40.6
Meloxicam	554	38.5	38.9
Quetiapine	1,495	38.1	38.4
Azathioprine	790	37.9	38.2
Pantoprazole Sodium	1,199	37.2	37.5
Oxycodone And Acetaminophen	222	36.2	36.5
Botulinum Toxin Type A	120	36.1	36.4
Moxifloxacin Hydrochloride	188	35.0	35.3
Ibuprofen Capsule	1,431	34.7	34.9
Ibuprofen Tablet, Film Coated	1,431	34.7	34.9
Ibupfrofen	1,431	34.7	34.9
Ibuprofen Tablets Usp, 200Mg	1,431	34.7	34.9
Ibuprofen Oral	1,431	34.7	34.9
Ibuprofen Capsules 200 Mg	1,431	34.7	34.9
Ibuprofen 200 Mg	1,431	34.7	34.9
Ibuprofen 200Mg	1,431	34.7	34.9
Moxifloxacin	127	33.7	34.0
Thiamine Hydrochloride	110	32.9	33.2
Magnesium	647	32.3	32.6
Trimethoprim	102	32.2	32.5
Fish Oil	639	29.0	29.2
Indomethacin	100	28.1	28.3
Ibuprofen	1,512	27.3	27.5
Alendronate Sodium Tablet	133	26.8	27.0
Ergocalciferol	1,907	26.7	26.9
Lorazepam	1,048	25.9	26.0
Diltiazem Hydrochloride	232	25.5	25.7
Lansoprazole	1,015	25.1	25.3
Calcium	860	24.7	24.9
Sulfamethoxazole And Trimethoprim	494	23.3	23.5
Tretinoin	48	21.8	21.9
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	782	20.5	20.6
Pregabalin	1,217	20.5	20.6
Telmisartan	97	20.2	20.3
Vedolizumab	419	19.1	19.2
Bupropion	220	18.7	18.8
Human Immunoglobulin G	103	18.6	18.7
Lisinopril	1,235	18.6	18.6
Methylprednisolone	626	18.5	18.6
Mesalamine	261	17.8	17.8
Atomoxetine Hydrochloride	113	17.7	17.8
Iron Sucrose	44	17.0	17.1
Levothyroxine Sodium Anhydrous	432	17.0	17.0
Pramipexole	70	16.9	17.0
Morphine	320	16.6	16.6
Bupropion Hydrochloride	415	16.5	16.6
Candesartan	152	16.0	16.0
Methylprednisolone Acetate	32	14.7	14.7
Prednisolone	634	14.3	14.4
Prednisolone Oral	634	14.3	14.4
Prednisolone Oral Solution	634	14.3	14.4
Erenumab-Aooe	208	14.3	14.3
Oxycodone Hydrochloride	745	14.3	14.3
Icosapent Ethyl	30	12.9	13.0
Morphine Sulfate	398	12.8	12.9
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	103	12.6	12.7
Magnesium Oxide	137	12.2	12.3
Diphenhydramine Hydrochloride	498	11.9	12.0
Mirabegron	120	11.6	11.6
Fluticasone Furoate	38	11.5	11.6
Oxycodone Hydrochloride And Acetaminophen	275	10.6	10.7
Rosuvastatin Calcium	77	10.1	10.1
Esomeprazole Magnesium Capsule, Delayed Release	39	9.9	9.9
Esomeprazole Magnesium Delayed Release Capsules	39	9.9	9.9
Esomeprazole Magnesium Dihydrate	39	9.8	9.9
Cyclobenzaprine Hydrochloride	24	9.8	9.8
Mepolizumab	129	9.7	9.7
Hydromorphone Hydrochloride	218	9.0	9.0
Budesonide	136	8.6	8.6
Iron	133	7.4	7.4
Propranolol Hydrochloride	142	7.4	7.4
Ibuprofen Sodium	84	7.3	7.3
Topiramate	180	7.3	7.3
Ibuprofen Tablets, Coated	81	7.0	7.1
Salicylic Acid	98	6.9	6.9
Paroxetine Hydrochloride Hemihydrate	60	6.6	6.7
Paroxetine	60	6.5	6.5
Diphenhydramine	110	6.5	6.5
Albuterol	203	6.4	6.4
Cyclobenzaprine	84	6.2	6.2
Levothyroxine Sodium	480	6.0	6.0
Magnesium Hydroxide	22	6.0	6.0
Trazodone Hydrochloride	25	5.9	5.9
Cyclosporine	172	5.8	5.8
Meperidine Hydrochloride	14	5.6	5.6
Ranitidine Hydrochloride	78	5.3	5.3
Upadacitinib	115	5.2	5.2
Bendamustine Hydrochloride	17	5.2	5.2
Metronidazole Topical	66	5.1	5.1
Dexamethasone Sodium Phosphate	14	5.0	5.1
Dexamethasone 1.5 Mg	381	5.0	5.0
Dexamethasone	381	5.0	5.0
Buprenorphine	119	4.8	4.8
Candesartan Cilexetil	34	4.7	4.8
Bendamustine Hcl	19	4.5	4.5
Paroxetine Hydrochloride	110	4.5	4.5
Esomeprazole	74	4.4	4.4
Atenolol	143	4.0	4.0
Metronidazole	67	3.9	3.9
Lamotrigine	134	3.8	3.8
Lamotirigine	71	3.7	3.7
Lamotrigine Extended-Release	71	3.7	3.7
Lamotrigine Chewable Dispersible	71	3.7	3.7
Fluticasone Propionate Nasal	30	3.6	3.6
Infliximab-Dyyb	27	3.4	3.4
Ixekizumab	34	3.4	3.4
Prednisolone Acetate	9	3.2	3.2
Bupivacaine	8	3.1	3.1
Albuterol Sulfate	246	3.1	3.1
Sertraline Hydrochloride	98	3.1	3.1
Amlodipine Besylate	112	2.8	2.8
Sertraline	81	2.5	2.5
Rizatriptan Benzoate	7	2.5	2.5
Leucovorin Calcium	13	2.5	2.5
Rifampin	8	2.0	2.0
Levocetirizine Dihydrochloride	13	2.0	2.0
Onabotulinumtoxina	29	1.4	1.4
Bortezomib	33	1.4	1.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.