Reaction

Which drugs are most reported with Drug use disorder?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,171 reports · 116 co-occurring drugs

As of the last recalculation, Drug Use Disorder appears in 8,171 FAERS reports alongside 116 co-occurring drug terms. The strongest observed disproportionality signal is OXAZEPAM (PRR 49.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Oxazepam	397	49.4	50.3
Ethyl Alcohol	469	46.6	47.4
Isopropyl Alcohol	460	36.7	37.2
Alcohol	469	32.6	33.0
Diazepam Oral Solution (Concentrate)	917	29.4	29.7
Diazepam Oral	917	29.4	29.7
Diazepam	1,142	27.6	27.9
Desoximetasone	189	25.8	26.1
Methadone Hydrochloride	100	23.8	24.0
Naltrexone	277	23.7	23.9
Methadone	350	21.7	21.9
Amphetamine	60	18.6	18.7
Tramadol Hydrochloride	250	17.4	17.5
Pregabalin	1,284	14.1	14.1
Alprazolam	951	13.2	13.2
Fentanyl	458	12.5	12.5
Cetirizine Hydrochloride Allergy	142	12.1	12.2
Cetirizine Hydrochloride Tablets	142	12.1	12.2
Buprenorphine	410	11.8	11.9
Zolpidem Tartrate	555	11.2	11.2
Fentanyl Citrate	65	9.3	9.4
Oxycodone	628	9.2	9.2
Nicotine Polacrilex Mini	49	8.4	8.4
Nicotine Polarilex	49	8.4	8.4
Clonazepam	477	8.0	8.0
Anakinra	51	7.9	7.9
Paroxetine Hydrochloride Hemihydrate	101	7.8	7.8
Morphine	223	7.8	7.8
Paroxetine	101	7.6	7.7
Oxycodone Hydrochloride	592	7.4	7.4
Buprenorphine Hydrochloride, Naloxone Hydrochloride	66	7.0	7.0
Loperamide Hydrochloride Oral	26	6.5	6.5
Buspirone Hydrochloride	26	6.0	6.0
Hydroxychloroquine Sulfate	210	6.0	6.0
Hydroxychloroquine	172	6.0	6.0
Venlafaxine	163	5.9	5.9
Loperamide Hcl	27	5.4	5.4
Tocilizumab	234	5.3	5.4
Cetirizine	158	5.3	5.3
Golimumab	169	5.1	5.1
Methylphenidate Hydrochloride	109	4.7	4.7
Olanzapine	195	4.7	4.7
Acetaminophen Tablet Extended Release	434	4.5	4.5
Pain Reliever	434	4.5	4.5
Acetaminophen 500Mg	434	4.5	4.5
Methylphenidate	51	4.5	4.5
Leflunomide	182	4.5	4.5
Abatacept	238	4.5	4.5
Propofol	63	4.4	4.4
Morphine Sulfate	194	4.1	4.2
Quetiapine	290	3.9	3.9
Tofacitinib Citrate	20	3.9	3.9
Paroxetine Hydrochloride	137	3.9	3.9
Midazolam	36	3.6	3.7
Mirtazapine	128	3.6	3.6
Aripiprazole Oral	58	3.6	3.6
Aripiprazole Orally Disintegrating	58	3.6	3.6
Nicotine Polacrilex	53	3.5	3.5
Fluoxetine	92	3.5	3.5
Venlafaxine Hydrochloride	179	3.5	3.5
Midazolam Hydrochloride	36	3.4	3.4
Paliperidone	31	3.4	3.4
Amitriptyline Hydrochloride	23	3.3	3.3
Fluoxetine Hydrochloride	164	3.3	3.3
Infliximab	272	3.2	3.3
Nicotine	51	3.2	3.2
Oxycodone And Acetaminophen Tablets	15	3.2	3.2
Gabapentin	418	3.0	3.0
Lorazepam	202	2.9	2.9
Acetaminophen	453	2.7	2.7
Tofacitinib	187	2.6	2.6
Cetirizine Hydrochloride	166	2.6	2.6
Hydroxyzine Hydrochloride	13	2.5	2.5
Hydroxyzine Hydrochloride Oral	13	2.5	2.5
Moxifloxacin Hydrochloride	20	2.5	2.5
Hydrocodone Bitartrate And Acetaminophen	55	2.5	2.5
Valproate Sodium	20	2.5	2.5
Escitslopram	56	2.5	2.5
Desloratadine	10	2.4	2.4
Hydroxyzine	44	2.4	2.4
Olanzapine Pamoate	37	2.3	2.3
Oxycodone And Acetaminophen	21	2.3	2.3
Doxepin	9	2.3	2.3
Exemestane	19	2.3	2.3
Doxepin Hydrochloride	11	2.2	2.2
Rituximab	177	2.2	2.2
Escitalopram Oxalate	60	2.1	2.1
Citalopram Hydrobromide	88	2.1	2.1
Sertraline	94	2.1	2.1
Hydromorphone Hydrochloride	72	2.0	2.0
Duloxetine	52	1.9	1.9
Tapentadol Hydrochloride	25	1.9	1.9
Modafinil	24	1.9	1.9
Clonidine	38	1.9	1.9
Loperamide Hydrochloride	33	1.9	1.9
Clobazam	17	1.8	1.8
Risperidone	90	1.7	1.7
Sulfasalazine	53	1.7	1.7
Lamotirigine	47	1.7	1.7
Lamotrigine Extended-Release	47	1.7	1.7
Lamotrigine Chewable Dispersible	47	1.7	1.7
Aripiprazole	79	1.6	1.7
Sildenafil Powder,	23	1.6	1.6
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	26	1.6	1.6
Lurasidone Hydrochloride	13	1.6	1.6
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	21	1.5	1.5
Rocuronium Bromide	7	1.5	1.5
Vortioxetine	10	1.5	1.5
Acetaminophen And Codeine	7	1.5	1.5
Oxycodone Hydrochloride And Acetaminophen	50	1.3	1.3
Hydrocodone Bitartrate	19	1.1	1.1
Etanercept	255	1.1	1.1
Cannabidiol	8	0.9	0.9
Cariprazine	3	0.8	0.8
Paliperidone Palmitate	9	0.7	0.7
Salicylic Acid	3	0.1	0.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.