Reaction

Multiple Drug Overdose reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,969 reports · 114 co-occurring drugs

As of the last recalculation, Multiple Drug Overdose appears in 4,969 FAERS reports alongside 114 co-occurring drug terms. The strongest observed disproportionality signal is DERMA FOAM EXCEL HAND SANITIZER (PRR 86.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Derma Foam Excel Hand Sanitizer	159	86.0	87.8
Ethanol	159	85.7	87.5
Carisoprodol	217	49.8	50.3
Diphenhydramine Hcl	123	47.4	47.9
Alcohol	263	29.9	30.1
Methadone Hydrochloride	65	25.5	25.6
Nicotine Polacrilex Mini	80	22.7	22.8
Nicotine Polarilex	80	22.7	22.8
Diazepam Oral Solution (Concentrate)	409	20.9	21.0
Diazepam Oral	409	20.9	21.0
Diazepam	462	17.4	17.5
Ethyl Alcohol	102	16.0	16.1
Temazepam	128	14.6	14.6
Oxazepam	72	14.2	14.3
Morphine Sulfate	377	14.0	14.0
Theophylline	38	13.9	14.0
Isopropyl Alcohol	109	13.8	13.8
Hydrocodone Bitartrate	136	13.5	13.5
Quetiapine Fumarate	93	13.4	13.5
Theophylline Anhydrous	38	12.9	13.0
Valproic Acid	86	11.6	11.6
Alprazolam	480	10.7	10.7
Amphetamine	21	10.7	10.7
Citalopram Hydrobromide	259	10.6	10.6
Lithium Carbonate	41	10.2	10.2
Citalopram	295	9.5	9.6
Acetaminophen Tablet Extended Release	518	9.4	9.4
Pain Reliever	518	9.4	9.4
Acetaminophen 500Mg	518	9.4	9.4
Oxycodone Hydrochloride	432	9.0	9.0
Nicotine Polacrilex	80	8.9	8.9
Nicotine	82	8.6	8.6
Fluoxetine	128	8.2	8.2
Olanzapine Pamoate	77	8.0	8.0
Diltiazem Hydrochloride Extended-Release Tablets	21	7.8	7.8
Methadone	78	7.7	7.8
Pseudoephedrine Hcl	20	7.6	7.6
Morphine	129	7.4	7.4
Mirtazapine	153	7.2	7.2
Phenytoin	34	6.9	6.9
Buspirone Hydrochloride	18	6.9	6.9
Ziprasidone	28	6.7	6.7
Olanzapine	166	6.7	6.7
Quetiapine	290	6.6	6.6
Clonazepam	225	6.1	6.1
Doxepin	14	5.8	5.8
Acetaminophen	556	5.7	5.7
Zolpidem Tartrate	178	5.7	5.7
Clonidine	68	5.6	5.6
Fluoxetine Hydrochloride	164	5.5	5.5
Oxymorphone Hydrochloride	15	5.4	5.4
Tizanidine Hydrochloride	21	4.9	4.9
Carbamazepine	77	4.9	4.9
Lorazepam	201	4.8	4.8
Methocarbamol Tablets	19	4.8	4.8
Sertraline Hydrochloride	132	4.8	4.8
Doxepin Hydrochloride	14	4.7	4.7
Risperidone	144	4.6	4.6
Escitalopram Oxalate	79	4.6	4.6
Primidone	11	4.5	4.5
Divalproex Sodium	49	4.4	4.4
Haloperidol Lactate	26	4.4	4.4
Fentanyl	101	4.4	4.4
Haloperidol	25	4.3	4.3
Eszopiclone	26	4.3	4.3
Propranolol Hydrochloride	73	4.3	4.3
Ibuprofen 200 Mg	196	4.2	4.2
Ibuprofen Capsule	195	4.2	4.2
Ibuprofen Tablet, Film Coated	195	4.2	4.2
Ibupfrofen	195	4.2	4.2
Ibuprofen Tablets Usp, 200Mg	195	4.2	4.2
Ibuprofen Oral	195	4.2	4.2
Ibuprofen Capsules 200 Mg	195	4.2	4.2
Ibuprofen 200Mg	195	4.2	4.2
Escitalopram	136	4.1	4.1
Amitriptyline Hydrochloride	17	4.1	4.1
Cyclobenzaprine	48	4.1	4.1
Methocarbamol	21	3.9	3.9
Valproate Sodium	19	3.9	3.9
Ziprasidone Mesylate	13	3.8	3.8
Diphenhydramine Hydrochloride	148	3.8	3.8
Venlafaxine Hydrochloride	117	3.8	3.8
Cyclobenzaprine Hydrochloride	8	3.7	3.7
Cetirizine Hcl	8	3.7	3.7
Isosorbide Mononitrate	18	3.6	3.6
Oxycodone And Acetaminophen Tablets	10	3.5	3.5
Oxcarbazepine	27	3.5	3.5
Ibuprofen	219	3.5	3.5
Metformin Hcl	45	3.4	3.4
Quinine	7	3.4	3.4
Paroxetine Hydrochloride	71	3.3	3.3
Atenolol	102	3.3	3.3
Nifedipine	36	3.2	3.2
Lithium	18	3.0	3.0
Lithium Bromatum	18	3.0	3.0
Trazodone Hydrochloride	11	3.0	3.0
Diclofenac Sodium 1%	25	2.9	2.9
Diclofenac Sodium Topical	25	2.9	2.9
Diclofenac Sodium Topical Gel, 1%	25	2.9	2.9
Rizatriptan Benzoate	7	2.9	2.9
Venlafaxine	47	2.8	2.8
Topiramate	61	2.8	2.8
Clozapine	78	2.6	2.6
Oxycodone Hydrochloride And Acetaminophen	61	2.6	2.6
Fentanyl Citrate	11	2.6	2.6
Methylphenidate Hydrochloride	36	2.6	2.6
Zonisamide	9	2.6	2.6
Sertraline	70	2.5	2.5
Oxycodone And Acetaminophen	14	2.5	2.5
Hydrocodone Bitartrate And Acetaminophen	25	1.9	1.9
Atomoxetine Hydrochloride	10	1.8	1.8
Methylphenidate	12	1.7	1.7
Paliperidone	9	1.6	1.6
Tapentadol Hydrochloride	10	1.3	1.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.