Reaction

Inhibitory Drug Interaction reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,570 reports · 59 co-occurring drugs

As of the last recalculation, Inhibitory Drug Interaction appears in 1,570 FAERS reports alongside 59 co-occurring drug terms. The strongest observed disproportionality signal is CIMETIDINE (PRR 79.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Cimetidine	56	79.9	80.4
Acetylcysteine	44	63.7	63.9
Diltiazem Hydrochloride Extended-Release Tablets	45	53.9	54.2
Memantine	53	53.1	53.3
Memantine Hydrochloride	53	53.1	53.3
Lithium Carbonate	55	44.5	44.6
Anakinra	52	42.9	43.1
Amitriptyline Hydrochloride	41	31.8	31.9
Bumetanide	53	27.5	27.6
Goserelin	21	21.0	21.0
Phenytoin	31	20.1	20.1
Diltiazem Hydrochloride	48	18.9	19.0
Rifampicin	14	18.5	18.5
Clonidine	59	15.8	15.8
Trimethoprim	12	13.6	13.6
Gentamicin	13	13.3	13.3
Primidone	10	13.1	13.1
Clarithromycin	32	12.6	12.6
Patiromer	13	12.5	12.6
Voriconazole Injection	20	12.4	12.4
Lidocaine Hydrochloride	54	12.3	12.3
Guanfacine	7	11.8	11.9
Cefuroxime	10	11.7	11.7
Gentamicin Sulfate	13	11.0	11.0
Rasagiline Mesylate	9	10.8	10.8
Liothyronine Sodium	7	10.7	10.7
Fluoxetine	51	10.4	10.5
Rocuronium Bromide	9	10.2	10.2
Montelukast	62	10.2	10.2
Phenobarbital	11	10.1	10.1
Voriconazole	22	9.7	9.7
Carbamazepine	47	9.6	9.6
Aripiprazole Oral	28	9.1	9.1
Aripiprazole Orally Disintegrating	28	9.1	9.1
Posaconazole	11	9.0	9.0
Extended Phenytoin Sodium	11	8.8	8.8
Valproic Acid	20	8.5	8.5
Metoroprolol Tartrate	41	8.4	8.4
Cefepime	9	8.4	8.4
Ezetimibe	46	8.3	8.4
Ritonavir 100 Mg	9	8.0	8.0
Sumatriptan Succinate	15	7.9	7.9
Levodopa	7	7.7	7.7
Mirabegron	22	7.6	7.6
Norepinephrine	6	7.5	7.5
Cefepime Hydrochloride	9	7.4	7.4
Rotigotine	7	6.4	6.4
Ranolazine	5	6.4	6.4
Tenofovir Disoproxil Fumarate Tablets	4	6.2	6.2
Naltrexone	14	6.1	6.1
Diroximel Fumarate	5	5.6	5.6
Rimegepant Sulfate	5	5.2	5.2
Apremilast	56	5.2	5.2
Sevoflurane	3	4.8	4.8
Vortioxetine	6	4.7	4.7
Pazopanib Hydrochloride	8	3.9	3.9
Varenicline Tartrate	21	3.5	3.5
Velpatasvir And Sofosbuvir	3	3.1	3.1
Erenumab-Aooe	11	2.7	2.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.