Reaction

Which drugs are most reported with Uterine perforation?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,442 reports · 43 co-occurring drugs

As of the last recalculation, Uterine Perforation appears in 8,442 FAERS reports alongside 43 co-occurring drug terms. The strongest observed disproportionality signal is LEVONORGESTREL (PRR 759.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Levonorgestrel	7,439	759.1	788.4
Copper	674	41.8	42.5
Ibuprofen And Diphenhydramine Citrate	154	16.6	16.7
Misoprostol	62	15.8	15.9
Etonogestrel And Ethinyl Estradiol	53	5.9	5.9
Promethazine Hydrochloride	38	5.1	5.1
Medroxyprogesterone Acetate	101	5.0	5.1
Metronidazole	128	5.0	5.0
Ciprofloxacin Hydrochloride And Hydrocortisone	37	4.4	4.4
Ibuprofen	428	4.0	4.0
Doxycycline Hyclate	100	3.7	3.7
Doxycycline	100	3.6	3.6
Ibuprofen Capsule	275	3.5	3.5
Ibuprofen Tablet, Film Coated	275	3.5	3.5
Ibupfrofen	275	3.5	3.5
Ibuprofen Tablets Usp, 200Mg	275	3.5	3.5
Ibuprofen Oral	275	3.5	3.5
Ibuprofen Capsules 200 Mg	275	3.5	3.5
Ibuprofen 200 Mg	275	3.5	3.5
Ibuprofen 200Mg	275	3.5	3.5
Docusate Sodium - Sennosides	44	3.4	3.4
Butalbital, Acetaminophen, And Caffeine	14	3.2	3.2
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	46	3.2	3.2
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	50	3.0	3.0
Sertraline Hydrochloride	137	2.9	2.9
Oxycodone Hydrochloride And Acetaminophen	113	2.8	2.8
Fluconazole	76	2.7	2.7
Rizatriptan Benzoate	11	2.7	2.7
Labetalol	14	2.6	2.6
Azithromycin Dihydrate	60	2.5	2.5
Sumatriptan	39	2.5	2.5
Docusate Sodium	55	2.4	2.4
Doxyclycline Hyclate	16	2.3	2.3
Metronidazole Topical	43	2.2	2.2
Ferrous Sulfate	44	2.2	2.2
Bupropion Hydrochloride	75	1.9	1.9
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	35	1.7	1.7
Miconazole Nitrate	5	1.4	1.4
Multivitamin	28	1.4	1.4
Naproxen Sodium Tablet	19	0.9	0.9
Acetaminophen, Aspirin (Nsaid) And Caffeine	6	0.9	0.9
Acetaminophen, Aspirin, And Caffeine	7	0.8	0.8
Drospirenone And Ethinyl Estradiol	13	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.