Reaction

Vitamin B12 Decreased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,838 reports · 109 co-occurring drugs

As of the last recalculation, Vitamin B12 Decreased appears in 2,838 FAERS reports alongside 109 co-occurring drug terms. The strongest observed disproportionality signal is DIMENHYDRINATE (PRR 33.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Dimenhydrinate	48	33.6	33.7
Timolol	32	19.6	19.7
Cyanocobalamin	78	17.8	17.9
Indomethacin	30	16.8	16.8
Risedronate Sodium	69	16.7	16.7
Doxepin	20	14.6	14.6
Doxepin Hydrochloride	24	14.0	14.1
Pseudoephedrine Hydrochloride	17	12.2	12.2
Pseudoephedrine Hcl	17	11.4	11.4
Nebivolol	23	10.7	10.7
Timolol Maleate	14	10.4	10.4
Teduglutide	19	10.4	10.4
Telmisartan	25	10.4	10.4
Carboxymethylcellulose Sodium	13	10.2	10.2
Diphenhydramine Hydrochloride Capsule, Liquid Filled	29	10.0	10.1
Linagliptin	24	9.7	9.7
Diclofenac	109	9.6	9.6
Rucaparib	11	9.2	9.2
Octreotide Acetate	36	8.7	8.7
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	35	8.6	8.6
Avapritinib	14	8.5	8.5
Pantoprazole Sodium In 0.9% Sodium Chloride	69	8.3	8.3
Pantoprazole Sodium Injection	69	8.3	8.3
Duloxetine	75	8.1	8.1
Diclofenac Sodium 1%	37	7.7	7.7
Diclofenac Sodium Topical	37	7.7	7.7
Diclofenac Sodium Topical Gel, 1%	37	7.7	7.7
Cladribine	10	7.7	7.7
Diphenoxylate Hydrochloride And Atropine Sulfate	14	7.5	7.5
Metformin Hydrochloride	57	7.2	7.2
Metformin Hydrochloride Tablets	55	7.2	7.2
Metformin Hydrochloride Extended-Release Tablets	55	7.2	7.2
Metformin Hydrochloride Tablet	55	7.2	7.2
Rosuvastatin Calcium	27	7.1	7.1
Niraparib	21	7.0	7.0
Metoclopramide	51	6.9	6.9
Cetiirizine	39	6.8	6.8
Calcium, Magnesium, Potassium, And Sodium Oxybates	8	6.8	6.8
Candesartan Cilexetil	24	6.7	6.7
Pantoprazole	213	6.6	6.6
Mirtazapine	80	6.6	6.6
Lanreotide Acetate	7	6.6	6.6
Ixazomib	24	6.2	6.2
Diclofenac Sodium	121	6.1	6.1
Posaconazole Delayed-Release	9	6.0	6.0
Mometasone	15	6.0	6.0
Zinc	20	6.0	6.0
Valsartan And Hydrochlorothiazide	11	6.0	6.0
Zinc Chloride	20	5.9	5.9
Zinc Gluconate	21	5.9	5.9
Cetirizine Hydrochloride Allergy	24	5.9	5.9
Cetirizine Hydrochloride Tablets	24	5.9	5.9
Extended Phenytoin Sodium	13	5.7	5.7
Iron	51	5.7	5.7
Ergocalciferol	274	5.7	5.7
Trazodone Hydrochloride	12	5.6	5.7
Ibuprofen Tablets, Coated	32	5.6	5.6
Ibuprofen Sodium	32	5.5	5.5
Metoclopramide Hydrochloride	57	5.5	5.5
Nebivolol Hydrochloride	25	5.5	5.5
Ranitidine Hydrochloride	40	5.5	5.5
Cetirizine	56	5.4	5.4
Celecoxib	93	5.3	5.3
Carbidopa And Levodopa	34	5.3	5.3
Loperamide Hydrochloride And Dimethicone	23	5.3	5.3
Aripiprazole Oral	29	5.2	5.2
Aripiprazole Orally Disintegrating	29	5.2	5.2
Metformin	232	5.1	5.1
Duloxetine Hydrochloride	126	5.1	5.1
Bisoprolol Fumarate	91	5.0	5.0
Empagliflozin	45	5.0	5.0
Mesalamine	37	4.9	4.9
Metformin Er 500 Mg	178	4.6	4.6
Metformin Er 750 Mg	178	4.6	4.6
Sulfasalazine	47	4.5	4.5
Ocrelizumab	37	4.4	4.4
Vedolizumab	51	4.4	4.4
Posaconazole	9	4.1	4.1
Acyclovir	62	4.0	4.0
Sitagliptin	39	4.0	4.0
Armodafinil	11	3.8	3.8
Interferon Beta-1B	10	3.8	3.8
Canagliflozin	15	3.7	3.7
Dofetilide	5	3.5	3.5
Lenalidomide	191	3.5	3.5
Naltrexone Hydrochloride And Bupropion Hydrochloride	4	3.4	3.4
Teriflunomide	21	3.4	3.4
Palbociclib	43	3.3	3.3
Abemaciclib	9	3.3	3.3
Ravulizumab	6	3.3	3.3
Cannabidiol	10	3.1	3.1
Ofatumumab	14	3.1	3.1
Natalizumab	75	3.1	3.1
Interferon Beta-1A	79	3.1	3.1
Sodium Oxybate	27	3.0	3.0
Fingolimod Hcl	34	2.9	2.9
Olaparib	8	2.8	2.8
Cabozantinib	18	2.8	2.8
Oral Semaglutide	27	2.7	2.7
Diclofenac Potassium, Film Coated	3	2.6	2.6
Diclofenac Potassium Tablets	3	2.6	2.6
Fremanezumab-Vfrm	4	2.6	2.6
Relugolix	8	2.5	2.5
Siponimod	3	2.5	2.5
Dimethyl Fumarate	41	2.5	2.5
Dalfampridine	22	2.3	2.3
Sofosbuvir	6	2.2	2.2
Pimavanserin Tartrate	10	1.3	1.3
Tirzepatide	20	0.9	0.9

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.