Reaction

Multiple Drug Therapy reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 689 reports · 83 co-occurring drugs

As of the last recalculation, Multiple Drug Therapy appears in 689 FAERS reports alongside 83 co-occurring drug terms. The strongest observed disproportionality signal is QUINAPRIL HYDROCHLORIDE (PRR 322.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Quinapril Hydrochloride	75	322.2	325.3
Bisacodyl Suppositories	79	208.2	209.5
Biscodyl	79	206.3	207.6
Bisacodyl	79	191.4	192.5
Diltiazem Hydrochloride Extended-Release Tablets	61	177.6	178.5
Magnesium Hydroxide	68	169.0	169.9
Quinine	43	161.5	162.3
Atropine	36	138.4	139.0
Cyclobenzaprine Hydrochloride	37	131.4	131.9
Oxazepam	82	130.6	131.1
Labetalol	50	122.1	122.6
Amitriptyline Hydrochloride	63	119.3	119.7
Calcium Gluconate	43	114.9	115.3
Atropine Sulfate	36	106.2	106.5
Phenobarbital	38	83.8	84.0
Zinc	61	81.9	82.1
Lactulose	90	81.4	81.6
Zinc Chloride	61	81.3	81.5
Zinc Gluconate	61	77.2	77.4
Isosorbide Mononitrate	48	75.1	75.3
Acetaminophen And Codeine	29	75.0	75.2
Methocarbamol Tablets	39	74.5	74.7
Antacid	97	71.6	71.8
Rosuvastatin Calcium	57	66.6	66.7
Vortioxetine	34	63.4	63.6
Cyclobenzaprine	90	62.5	62.6
Methocarbamol	43	61.0	61.1
Diltiazem Hydrochloride	63	60.4	60.6
Nitroglycerin	91	58.9	59.0
Tramadol Hydrochloride	65	57.5	57.6
Oxcarbazepine	55	55.5	55.5
Docusate Sodium 100Mg	40	53.6	53.7
Albuterol	162	53.0	53.1
Calcium Carbonate	98	51.2	51.3
Risedronate Sodium	49	51.2	51.3
Donepezil Hydrochloride	56	50.1	50.2
Dextrose	21	49.7	49.7
Torsemide	50	49.1	49.2
Dextrose Monohydrate	21	48.9	49.0
Cyanocobalamin	48	47.2	47.3
Psyllium Husk	15	46.9	46.9
Levothyroxine Sodium Anhydrous	124	45.4	45.4
Carbamazepine	87	44.7	44.8
Fluticasone Propionate Nasal	41	43.4	43.4
Pramipexole	20	40.6	40.6
Hydroxyzine	57	39.3	39.3
Diazepam Oral Solution (Concentrate)	96	37.7	37.7
Diazepam Oral	96	37.7	37.7
Levofloxacin	68	37.7	37.7
Levofloxacin In 5% Dextrose	68	37.7	37.7
Doxepin Hydrochloride	15	36.7	36.7
Hydroxyzine Hydrochloride	15	35.2	35.2
Hydroxyzine Hydrochloride Oral	15	35.2	35.2
Metoclopramide	57	34.1	34.1
Sennosides	32	33.9	33.9
Valsartan Oral	55	33.2	33.2
Quetiapine Fumarate	30	32.1	32.1
Quetiapine	155	31.1	31.1
Diazepam	96	27.5	27.6
Allopurinol	118	27.3	27.3
Doxepin	9	27.2	27.2
Haloperidol	21	26.9	26.9
Haloperidol Lactate	21	26.4	26.4
Telmisartan	15	25.9	26.0
Amlodipine Besylate	107	25.9	25.9
Theophylline Anhydrous	10	24.7	24.7
Metoclopramide Hydrochloride	58	24.7	24.7
Sitagliptin	54	24.5	24.5
Felodipine Extended-Release Tablets	9	24.2	24.2
Felodipine	9	24.2	24.2
Dabigatran Etexilate	57	24.1	24.1
Oxymorphone Hydrochloride	9	23.6	23.6
Rotigotine	11	23.3	23.4
Methadone	29	21.3	21.3
Febuxostat Tablets 40 Mg	7	21.0	21.0
Febuxostat Tablets 80 Mg	7	21.0	21.0
Morphine Sulfate	73	20.2	20.2
Apixaban	41	19.6	19.6
Tiotropium Bromide	75	18.4	18.4
Vigabatrin	7	14.6	14.7
Dapagliflozin	14	13.7	13.7
Valbenazine	4	4.8	4.8
Pimavanserin Tartrate	6	3.3	3.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.