Reaction

Product Physical Consistency Issue reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,397 reports · 66 co-occurring drugs

As of the last recalculation, Product Physical Consistency Issue appears in 5,397 FAERS reports alongside 66 co-occurring drug terms. The strongest observed disproportionality signal is LEUPROLIDE ACETATE (PRR 57.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Leuprolide Acetate	951	57.2	57.9
Cholestyramine	131	42.8	43.3
Tretinoin	37	17.7	17.8
Clobetasol Propionate	45	16.9	17.0
Clobetasol Propionate Ointment Usp, 0.05%	44	16.6	16.7
Testosterone	98	16.4	16.5
Patiromer	43	12.1	12.1
Dapsone	32	11.6	11.7
Naltrexone	86	10.9	10.9
Daspone	21	8.3	8.4
Dapsone Gel, 5%	21	8.3	8.4
Buprenorphine	192	8.3	8.3
Naproxen Sodium Tablet	104	7.7	7.7
Minoxidil	87	7.6	7.6
Crisaborole	18	7.3	7.3
Ruxolitinib	123	6.8	6.8
Testosterone Cypionate	15	6.5	6.5
Mupirocin	22	6.3	6.3
Mupirocin Calcium	22	6.2	6.2
Prednisolone Acetate	15	5.6	5.6
Docosanol	19	5.0	5.0
Brinzolamide	11	4.9	4.9
Triamcinolone Acetonide Ointment Usp, 0.05%	29	4.8	4.8
Ketoconazole Foam	18	4.7	4.7
Carboxymethylcellulose Sodium	11	4.5	4.5
Lanreotide Acetate	9	4.4	4.4
Ketoconazole Cream, 2%	17	4.4	4.4
Ketoconazole	19	4.2	4.2
Timolol	13	4.2	4.2
Triamcinolone Acetonide	32	4.0	4.0
Estradiol Gel 0.1%	42	3.6	3.6
Estradiol Transdermal	42	3.6	3.6
Polyethylene Glycol 3350	88	3.6	3.6
Travoprost	8	3.6	3.6
Lifitegrast	15	3.5	3.6
Bimatoprost	26	3.5	3.5
Glycerin, Lidocaine	12	3.3	3.3
Bicalutamide	13	3.3	3.3
Diclofenac Sodium 1%	30	3.3	3.3
Diclofenac Sodium Topical	30	3.3	3.3
Diclofenac Sodium Topical Gel, 1%	30	3.2	3.2
Naproxen Sodium	116	3.2	3.2
Liothyronine Sodium	7	3.1	3.1
Estradiol	68	3.1	3.1
Minocycline	9	3.0	3.0
Nicotine Polacrilex	28	2.8	2.8
Lisdexamfetamine Dimesylate	24	2.8	2.8
Cabotegravir	5	2.4	2.4
Timolol Maleate	6	2.3	2.3
Asfotase Alfa	6	2.3	2.3
Miconazole Nitrate	5	2.2	2.2
Nicotine	20	1.9	1.9
Latanoprost	24	1.8	1.8
Icosapent Ethyl	4	1.8	1.8
Somatropin	34	1.8	1.8
Brimonidine Tartrate	8	1.7	1.7
Inclisiran	3	1.4	1.4
Diclofenac Potassium	4	1.4	1.4
Paliperidone Palmitate	11	1.3	1.3
Medroxyprogesterone Acetate	15	1.2	1.2
Esketamine Hydrochloride	4	0.9	0.9
Cinacalcet Hydrochloride	9	0.7	0.7
Voxelotor	4	0.7	0.7
Nirmatrelvir And Ritonavir	6	0.4	0.4
Salicylic Acid	3	0.2	0.2
Adapalene	4	0.1	0.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.