Reaction

Mast Cell Activation Syndrome reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,307 reports · 65 co-occurring drugs

As of the last recalculation, Mast Cell Activation Syndrome appears in 1,307 FAERS reports alongside 65 co-occurring drug terms. The strongest observed disproportionality signal is OMALIZUMAB (PRR 84.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Omalizumab	338	84.8	85.2
Calcium, Magnesium, Potassium, And Sodium Oxybates	36	68.4	68.7
Esomeprazole Magnesium Capsule, Delayed Release	28	31.4	31.4
Esomeprazole Magnesium Delayed Release Capsules	28	31.4	31.4
Esomeprazole Magnesium Dihydrate	28	31.2	31.3
Human Immunoglobulin G	38	30.2	30.2
Famotidine	189	29.8	29.8
Promethazine Hydrochloride	33	29.0	29.0
Montelukast	130	27.3	27.3
Fexofenadine	24	23.5	23.6
Anastrozole Tablets	31	23.5	23.6
Hydroxyzine Hydrochloride	19	23.3	23.4
Hydroxyzine Hydrochloride Oral	19	23.3	23.4
Insulin Glargine-Yfgn	31	23.1	23.1
Avapritinib	17	22.6	22.7
Epinephrine	86	22.3	22.3
Adrenalinum	52	20.7	20.8
Loratadine Oral	61	20.7	20.7
Cetiirizine	50	19.5	19.5
Cetirizine	88	19.3	19.3
Anastrozole	42	18.8	18.8
Levocetirizine Dihydrochloride	27	18.3	18.3
Mometasone	20	17.6	17.6
Cetirizine Hcl	10	17.5	17.5
Doxepin	11	17.4	17.4
Montelukast Sodium	119	17.0	17.0
Cetirizine Hydrochloride	154	16.7	16.7
Hydroxyzine	47	16.2	16.3
Sodium Oxybate	64	16.2	16.2
Cetirizine Hydrochloride Allergy	30	16.1	16.1
Cetirizine Hydrochloride Tablets	30	16.1	16.1
Rosuvastatin Calcium	27	15.6	15.6
Doxepin Hydrochloride	12	15.3	15.3
Asfotase Alfa	9	14.4	14.4
Rimegepant Sulfate	11	13.9	13.9
Fexofenadine Hcl	8	13.9	13.9
Loratadine	86	13.6	13.6
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	29	13.4	13.4
Apixaban	52	12.8	12.9
Esomeprazole	47	12.5	12.5
Eptinezumab-Jjmr	7	12.3	12.3
Rifampin	11	12.1	12.1
Thyroid, Porcine	8	12.0	12.0
Fexofenadine Hydrochloride	16	11.9	11.9
Naltrexone	22	11.5	11.6
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	29	11.4	11.4
Lisdexamfetamine Dimesylate	22	10.8	10.8
Guanfacine	5	10.2	10.2
Buspirone Hydrochloride	7	10.2	10.2
Rocuronium Bromide	7	9.5	9.5
Azelastine	10	8.9	8.9
Tiotropium Bromide Inhalation Spray	6	8.6	8.6
Naproxen Sodium Tablet, Coated	7	8.3	8.3
Naproxen Sodium, Coated Tablets	7	8.3	8.3
Naproxen Sodium 220Mg	7	8.3	8.3
Imatinib	9	8.2	8.2
Galcanezumab-Gnlm	14	7.1	7.1
Lifitegrast	6	5.9	5.9
Benralizumab	7	5.6	5.6
Fremanezumab-Vfrm	4	5.6	5.6
Erenumab-Aooe	14	4.1	4.1
Onabotulinumtoxina	19	4.0	4.0
Nirmatrelvir And Ritonavir	8	2.4	2.4
Dupilumab	66	2.2	2.2
Droxidopa	3	2.2	2.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.