Reaction

Bipolar I Disorder reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,161 reports · 73 co-occurring drugs

As of the last recalculation, Bipolar I Disorder appears in 2,161 FAERS reports alongside 73 co-occurring drug terms. The strongest observed disproportionality signal is LITHIUM (PRR 48.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Lithium	119	48.1	48.3
Lithium Bromatum	119	48.1	48.3
Lithium Carbonate	59	34.4	34.5
Lurasidone Hydrochloride	63	29.8	29.9
Asenapine Maleate	26	29.2	29.3
Ziprasidone Mesylate	37	25.4	25.5
Divalproex Sodium	116	25.3	25.4
Ziprasidone	40	22.3	22.3
Valproate Sodium	44	20.9	21.0
Quetiapine	321	18.7	18.7
Cariprazine	16	16.7	16.7
Olanzapine Pamoate	68	16.5	16.5
Atropine Sulfate	18	16.2	16.2
Aripiprazole Oral	65	15.6	15.6
Aripiprazole Orally Disintegrating	65	15.6	15.6
Aripiprazole	182	15.5	15.6
Atropine	13	15.2	15.2
Atomoxetine Hydrochloride	36	14.8	14.8
Olanzapine	153	14.7	14.7
Lamotrigine	184	14.6	14.6
Temazepam	48	12.5	12.5
Oxcarbazepine	39	11.7	11.8
Naltrexone	36	11.4	11.4
Buspirone Hydrochloride	13	11.4	11.4
Pramipexole	18	11.4	11.4
Lamotirigine	79	11.0	11.0
Lamotrigine Extended-Release	79	11.0	11.0
Lamotrigine Chewable Dispersible	79	11.0	11.0
Valproic Acid	34	10.5	10.6
Guanfacine	8	9.8	9.8
Clonazepam	149	9.5	9.6
Clarithromycin	33	9.4	9.4
Risperidone	115	8.7	8.7
Trazodone Hydrochloride	13	8.0	8.1
Lisdexamfetamine Dimesylate	27	8.0	8.0
Quetiapine Fumarate	24	7.9	7.9
Bupropion Hydrochloride	78	7.9	7.9
Calcium, Magnesium, Potassium, And Sodium Oxybates	7	7.9	7.9
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	28	7.7	7.7
Sertraline Hydrochloride	90	7.6	7.6
Meperidine Hydrochloride	7	7.3	7.3
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	31	7.3	7.3
Modafinil	24	7.2	7.2
Fluoxetine Hydrochloride	91	7.1	7.1
Venlafaxine Hydrochloride	93	7.0	7.0
Varenicline Tartrate	56	6.9	6.9
Oxazepam	15	6.8	6.8
Haloperidol Lactate	17	6.7	6.7
Liothyronine Sodium	6	6.7	6.7
Haloperidol	16	6.4	6.4
Topiramate	60	6.3	6.4
Buprenorphine Hydrochloride, Naloxone Hydrochloride	15	6.0	6.0
Paliperidone	14	5.8	5.8
Methylphenidate Hydrochloride	34	5.6	5.6
Paliperidone Palmitate	18	5.4	5.4
Eszopiclone	14	5.3	5.3
Sodium Oxybate	35	5.2	5.2
Armodafinil	10	4.6	4.6
Vortioxetine	8	4.5	4.5
Isotretinoin	23	4.5	4.5
Desvenlafaxine Succinate	12	4.3	4.3
Vilazodone Hydrochloride	4	4.2	4.2
Clozapine	49	3.8	3.8
Mometasone Furoate And Formoterol Fumarate Dihydrate	6	3.7	3.7
Cabotegravir	3	3.6	3.6
Methadone Hydrochloride	4	3.6	3.6
Hydrocodone Bitartrate And Acetaminophen	19	3.3	3.3
Esketamine Hydrochloride	6	3.2	3.2
Brexpiprazole	5	2.9	2.9
Valbenazine	7	2.7	2.7
Elexacaftor, Tezacaftor, And Ivacaftor	3	2.3	2.3
Etonogestrel	6	1.2	1.2
Copper	5	1.1	1.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.