Reaction

Communication Disorder reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,785 reports · 118 co-occurring drugs

As of the last recalculation, Communication Disorder appears in 3,785 FAERS reports alongside 118 co-occurring drug terms. The strongest observed disproportionality signal is VALPROATE SODIUM (PRR 28.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Valproate Sodium	104	28.4	28.6
Rivastigmine	45	13.3	13.3
Pimavanserin Tartrate	118	12.1	12.1
Thiamine Hydrochloride	27	12.0	12.0
Cenobamate	14	9.3	9.3
Haloperidol	40	9.1	9.2
Haloperidol Lactate	40	9.0	9.0
Donepezil Hydrochloride	57	8.7	8.7
Carbidopa And Levodopa	66	7.8	7.8
Risperidone	170	7.3	7.3
Olanzapine Pamoate	53	7.2	7.2
Atomoxetine Hydrochloride	30	7.0	7.0
Olanzapine	131	6.9	6.9
Phenytoin	26	6.9	6.9
Memantine	17	6.9	6.9
Memantine Hydrochloride	17	6.9	6.9
Brivaracetam	11	6.7	6.8
Trimethoprim	14	6.6	6.6
Valproic Acid	37	6.5	6.5
Ketoprofen	15	6.3	6.3
Zidovudine	15	6.2	6.2
Lithium Carbonate	19	6.2	6.2
Topiramate	100	6.0	6.0
Divalproex Sodium	50	6.0	6.0
Primidone	11	6.0	6.0
Clobazam	26	5.9	5.9
Quetiapine	197	5.9	5.9
Indomethacin	14	5.8	5.8
Ziprasidone	18	5.6	5.6
Extended Phenytoin Sodium	17	5.6	5.6
Rasagiline Mesylate	11	5.4	5.5
Nitrofurantoin	16	5.4	5.4
Mirtazapine	87	5.3	5.3
Nitrofurantoin (Monohydrate/Macrocrystals)	16	5.3	5.3
Drs. Clotrimazole	11	5.2	5.2
Family Wellness Clotrimazole	11	5.2	5.2
Clotrimazole Topical	11	5.2	5.2
Rabeprazole	21	5.2	5.2
Paliperidone	22	5.2	5.2
Carbamazepine	62	5.2	5.2
Polyethylene Glycol	10	5.1	5.1
Lactulose	35	5.1	5.1
Ziprasidone Mesylate	13	5.0	5.0
Lurasidone Hydrochloride	19	5.0	5.0
Amantadine	14	5.0	5.0
Rotigotine	13	5.0	5.0
Clotrimazole	11	4.9	4.9
Lorazepam	152	4.8	4.8
Isosorbide Mononitrate	18	4.8	4.8
Phenobarbital	12	4.6	4.6
Levodopa	10	4.6	4.6
Paroxetine Hydrochloride	73	4.5	4.5
Amitriptyline Hydrochloride	14	4.4	4.4
Propranolol Hydrochloride	57	4.4	4.4
Diazepam Oral Solution (Concentrate)	69	4.3	4.3
Diazepam Oral	69	4.3	4.3
Quetiapine Fumarate	23	4.3	4.3
Levetiracetam	100	4.2	4.2
Clonazepam	119	4.2	4.2
Diazepam	90	4.1	4.1
Zonisamide	11	4.1	4.1
Droxidopa	16	4.1	4.1
Aripiprazole	88	4.0	4.0
Aripiprazole Oral	30	4.0	4.0
Aripiprazole Orally Disintegrating	30	4.0	4.0
Oxcarbazepine	23	3.9	3.9
Axicabtagene Ciloleucel	7	3.9	3.9
Fluoxetine Hydrochloride	88	3.9	3.9
Paliperidone Palmitate	22	3.8	3.8
Oxybutynin Chloride	6	3.8	3.8
Cefazolin Sodium	8	3.7	3.7
Brexpiprazole	11	3.7	3.7
Methylphenidate Hydrochloride	39	3.6	3.6
Methylphenidate	19	3.6	3.6
Vigabatrin	9	3.4	3.4
Fexofenadine	10	3.3	3.3
Mesna Injection	5	3.3	3.3
Sertraline	70	3.3	3.3
Mesna	5	3.3	3.3
Blinatumomab	6	3.2	3.2
Lacosamide	21	3.1	3.1
Levetiracetam In Sodium Chloride	42	3.0	3.0
Levetiracetam Oral	42	3.0	3.0
Levetiracetam Injection	42	3.0	3.0
Oseltamivir Phosphate	13	2.9	2.9
Mirabegron	19	2.7	2.7
Clozapine	60	2.7	2.7
Desvenlafaxine Succinate	13	2.7	2.7
Sevoflurane	4	2.6	2.6
Armodafinil	10	2.6	2.6
Natalizumab	84	2.6	2.6
Asenapine Maleate	4	2.5	2.5
Fesoterodine Fumarate	5	2.5	2.5
Peginterferon Beta-1A	6	2.5	2.5
Hydromorphone Hydrochloride	41	2.5	2.5
Agalsidase Beta	4	2.4	2.4
Esketamine Hydrochloride	7	2.2	2.2
Oseltamivir	3	2.1	2.1
Iohexol	3	2.0	2.0
Dimethyl Fumarate	44	2.0	2.0
Naltrexone Hydrochloride And Bupropion Hydrochloride	3	1.9	1.9
Erenumab-Aooe	19	1.9	1.9
Cannabidiol	8	1.9	1.9
Rucaparib	3	1.9	1.9
Hydrocodone Bitartrate And Acetaminophen	19	1.9	1.9
Fentanyl Citrate	6	1.8	1.8
Rifaximin	7	1.8	1.8
Buprenorphine	29	1.7	1.7
Varenicline Tartrate	23	1.6	1.6
Ranolazine	3	1.6	1.6
Drospirenone And Ethinyl Estradiol	12	1.5	1.5
Fremanezumab-Vfrm	3	1.4	1.4
Tafamidis	3	1.4	1.4
Relugolix	6	1.4	1.4
Diroximel Fumarate	3	1.4	1.4
Rimegepant Sulfate	3	1.3	1.3
Valbenazine	3	0.7	0.7
Cinacalcet Hydrochloride	5	0.6	0.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.