Reaction

Extremity Necrosis reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,733 reports · 46 co-occurring drugs

As of the last recalculation, Extremity Necrosis appears in 1,733 FAERS reports alongside 46 co-occurring drug terms. The strongest observed disproportionality signal is NOREPINEPHRINE BITARTRATE (PRR 51.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Norepinephrine Bitartrate	60	51.8	52.0
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	31	46.2	46.4
Norepinephrine	40	46.0	46.2
Canagliflozin	95	40.3	40.4
Basiliximab	19	19.6	19.6
Pemetrexed Disodium	59	19.2	19.2
Pemetrexed	30	17.1	17.1
Hydroxyurea	27	15.6	15.6
Gemcitabine Hydrochloride	66	15.5	15.5
Posaconazole Delayed-Release	14	15.4	15.4
Gemcitabine	44	13.7	13.8
Adrenalinum	45	13.3	13.4
Salmeterol Xinafoate	9	12.6	12.6
Dapagliflozin	31	12.0	12.0
Felodipine Extended-Release Tablets	11	11.7	11.7
Felodipine	11	11.7	11.7
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	27	10.6	10.6
Heparin Sodium	12	10.5	10.6
Posaconazole	14	10.4	10.4
Midazolam	20	9.6	9.6
Insulin Glulisine	8	9.5	9.5
Midazolam Hydrochloride	21	9.5	9.5
Piperacillin And Tazobactam	10	9.4	9.4
Erythropoietin	16	9.4	9.4
Paricalcitol	11	9.4	9.4
Bosentan	38	9.2	9.2
Atovaquone	6	9.0	9.0
Cisplatin	56	8.9	8.9
Epinephrine	46	8.6	8.6
Meropenem	22	8.3	8.3
Anakinra	11	8.0	8.0
Piperacillin Sodium,Tazobactam Sodium	16	7.3	7.3
Insulin Glargine-Yfgn	13	7.2	7.2
Carboplatin	73	7.2	7.2
Micafungin Sodium	5	7.1	7.1
Bleomycin Sulfate	6	7.0	7.0
Methoxy Polyethylene Glycol-Epoetin Beta	6	6.5	6.6
Alteplase	8	6.4	6.4
Cetuximab	15	5.8	5.8
Durvalumab	9	5.3	5.3
Sorafenib	9	5.2	5.2
Pembrolizumab	44	5.1	5.1
Ticagrelor	13	4.9	4.9
Velpatasvir And Sofosbuvir	5	4.7	4.7
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	4	2.7	2.7
Cinacalcet Hydrochloride	5	1.3	1.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.