Reaction

Secondary Adrenocortical Insufficiency reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,477 reports · 68 co-occurring drugs

As of the last recalculation, Secondary Adrenocortical Insufficiency appears in 1,477 FAERS reports alongside 68 co-occurring drug terms. The strongest observed disproportionality signal is IPILIMUMAB (PRR 86.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Ipilimumab	225	86.5	86.9
Ritonavir 100 Mg	75	74.5	74.9
Nivolumab	339	63.8	64.1
Canakinumab	42	56.3	56.5
Ritonavir	77	39.1	39.2
Anti-Itch	124	28.4	28.4
Anti-Pruritic	124	28.4	28.4
Antipruritic (Anti-Itch)	124	28.4	28.4
Cool Relief Gel With Aloe	124	28.4	28.4
Drs. Hydrocortisone	124	28.4	28.4
Hydrocortisone Continuous Spray	124	28.4	28.4
Hydrocortisone Spray	124	28.4	28.4
Anti-Itch Cream	124	28.4	28.4
Pembrolizumab	186	28.4	28.4
Hydrocortisone Lotion	124	28.4	28.4
Hydrocortisone Cream 1%	124	28.3	28.4
Hydrocortisone Cream 1/2%	124	28.3	28.4
Hydrocortisone 1%	124	28.3	28.4
Hydrocortisone Cream	124	28.2	28.3
Hydrocortisone Acetate	126	26.6	26.7
Hydrocortisone	134	23.2	23.2
Cimetidine	15	22.2	22.2
Atazanavir	21	20.9	20.9
Pemetrexed	29	19.4	19.4
Indomethacin	18	19.4	19.4
Triamcinolone Acetonide Ointment Usp, 0.05%	31	19.0	19.1
Posaconazole Delayed-Release	14	18.1	18.1
Clobetasol Propionate Ointment Usp, 0.05%	13	17.9	18.0
Clobetasol Propionate	13	17.9	17.9
Itraconazole	14	17.0	17.1
Pemetrexed Disodium	44	16.7	16.8
Atezolizumab	42	15.7	15.7
Triamcinolone Acetonide	32	14.9	14.9
Colchicine	27	14.7	14.7
Posaconazole	16	14.0	14.0
Anakinra	16	13.7	13.7
Busulfan	15	13.6	13.6
Fluticasone Propionate Nasal	28	13.3	13.3
Trimethoprim	11	13.2	13.3
Efavirenz	10	12.7	12.7
Abiraterone	12	12.5	12.5
Sumatriptan Succinate	22	12.4	12.4
Darunavir	13	12.2	12.2
Abacavir Sulfate	8	11.6	11.6
Ganciclovir	8	11.1	11.1
Aprepitant	14	10.8	10.8
Lamivudine Oral	19	10.7	10.7
Ganciclovir Sodium	8	10.7	10.7
Budesonide	42	10.3	10.3
Mesalamine	40	10.3	10.3
Carboplatin	84	9.8	9.8
Lamivudine	21	9.7	9.7
Loperamide Hydrochloride Oral	7	9.7	9.7
Pitavastatin Calcium	7	9.7	9.7
Metoclopramide	35	9.2	9.2
Paclitaxel (Aibumin-Bound)	50	8.8	8.8
Sumatriptan	22	8.2	8.2
Axitinib	11	8.0	8.0
Paclitaxel	53	7.8	7.8
Thiotepa	5	7.4	7.4
Fludarabine Phosphate	20	7.3	7.3
Lenvatinib	16	6.9	6.9
Durvalumab	9	6.3	6.3
Cisplatin	33	6.1	6.1
Vedolizumab	34	5.7	5.7
Oxaliplatin	29	5.6	5.6
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	3	4.2	4.2
Abiraterone Acetate	12	4.1	4.1

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.