Reaction

Tongue Discolouration reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,350 reports · 89 co-occurring drugs

As of the last recalculation, Tongue Discolouration appears in 4,350 FAERS reports alongside 89 co-occurring drug terms. The strongest observed disproportionality signal is CHLORHEXIDINE GLUCONATE (PRR 22.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Chlorhexidine Gluconate	42	22.2	22.3
Linezolid	89	14.6	14.6
Nicotine Polacrilex	104	13.3	13.3
Clarithromycin	92	13.1	13.1
Liothyronine Sodium	18	9.9	9.9
Nicotine	80	9.6	9.6
Bisacodyl	24	8.2	8.2
Bisacodyl Suppositories	21	7.8	7.8
Biscodyl	21	7.7	7.7
Acetylcysteine	14	7.1	7.1
Metronidazole Topical	69	7.0	7.0
Fexofenadine Hcl	13	6.7	6.8
Metronidazole	87	6.6	6.6
Amikacin	23	6.5	6.5
Nystatin Ointment	35	6.4	6.4
Nystatin Cream	35	6.4	6.4
Nystatin	35	6.2	6.2
Fluticasone Propionate And Salmeterol	53	6.1	6.2
Tolterodine Tartrate	11	5.9	5.9
Peginterferon Alfa-2A	65	5.8	5.8
Buprenorphine Hydrochloride, Naloxone Hydrochloride	29	5.8	5.8
Doxepin	11	5.2	5.2
Niraparib	24	5.2	5.2
Asenapine Maleate	9	5.0	5.0
Sunitinib Malate	40	4.9	4.9
Amoxicillin	77	4.9	4.9
Rucaparib	9	4.9	4.9
Clindamycin Phosphate	33	4.8	4.8
Fluticasone Furoate And Vilanterol Trifenatate	35	4.7	4.7
Tiotropium Bromide	128	4.6	4.6
Drs. Clotrimazole	11	4.6	4.6
Family Wellness Clotrimazole	11	4.6	4.6
Clotrimazole Topical	11	4.6	4.6
Azithromycin Dihydrate	55	4.5	4.5
Budesonide And Formoterol Fumarate Dihydrate	88	4.4	4.4
Clindamycin	26	4.4	4.4
Fluticasone Furoate	11	4.4	4.4
Clotrimazole	11	4.3	4.3
Umeclidinium	8	4.3	4.3
Nirmatrelvir And Ritonavir	47	4.2	4.2
Doxepin Hydrochloride	11	4.2	4.2
Ciprofloxacin Hydrochloride And Hydrocortisone	18	4.2	4.2
Azithromycin	33	3.9	3.9
Salmeterol Xinafoate	7	3.9	3.9
Azithromycin Monohydrate	33	3.8	3.8
Extended Phenytoin Sodium	13	3.7	3.7
Losartan Potassium And Hydrochlorothiazide	9	3.7	3.7
Ribavirin	49	3.7	3.7
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	23	3.6	3.6
Thyroid, Porcine	8	3.6	3.6
Timolol	9	3.6	3.6
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	15	3.5	3.5
Naproxen Sodium, Pseudoephedrine Hydrochloride	15	3.5	3.5
Umeclidinium Bromide And Vilanterol Trifenatate	12	3.4	3.4
Lapatinib	11	3.4	3.4
Cetirizine Hydrochloride Allergy	21	3.3	3.3
Cetirizine Hydrochloride Tablets	21	3.3	3.3
Capecitabine	63	3.3	3.3
Testosterone	16	3.3	3.3
Oxybutynin	20	3.3	3.3
Fexofenadine	11	3.2	3.2
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	27	3.1	3.1
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	32	3.1	3.1
Amlodipine Besylate And Valsartan	7	3.0	3.0
Guaifenesin	19	3.0	3.0
Fish Oil	54	2.9	2.9
Sorafenib	12	2.8	2.8
Desoximetasone	11	2.8	2.8
Mometasone Furoate And Formoterol Fumarate Dihydrate	9	2.8	2.8
Ticagrelor	18	2.7	2.7
Naproxen Sodium Tablet	26	2.4	2.4
Dronedarone	5	2.3	2.3
Naltrexone	15	2.3	2.3
Alpelisib	4	2.2	2.2
Omalizumab	38	2.1	2.1
Panitumumab	7	2.1	2.1
Rifaximin	9	2.1	2.1
Prasugrel Hydrochloride	4	1.9	1.9
Olaparib	8	1.8	1.8
Secukinumab	61	1.8	1.8
Cabozantinib	18	1.8	1.8
Inclisiran	3	1.8	1.8
Alirocumab	9	1.7	1.7
Cetuximab	11	1.7	1.7
Varenicline Tartrate	27	1.6	1.6
Pazopanib Hydrochloride	9	1.6	1.6
Dimethyl Fumarate	31	1.2	1.2
Sarilumab	6	1.1	1.1
Voxelotor	4	0.9	0.9

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.