Reaction

Hyperammonaemic Encephalopathy reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,691 reports · 61 co-occurring drugs

As of the last recalculation, Hyperammonaemic Encephalopathy appears in 1,691 FAERS reports alongside 61 co-occurring drug terms. The strongest observed disproportionality signal is VALPROIC ACID (PRR 254.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Valproic Acid	471	254.6	258.5
Valproate Sodium	104	65.9	66.3
Phenobarbital	53	46.4	46.6
Zonisamide	48	41.1	41.2
Phenytoin	58	35.4	35.5
Brivaracetam	23	31.9	32.0
Oxaliplatin	159	29.0	29.1
Clobazam	55	28.6	28.7
Fluorouracil Cream, 0.5%	161	28.6	28.7
Levetiracetam In Sodium Chloride	163	28.6	28.6
Levetiracetam Oral	163	28.6	28.6
Levetiracetam Injection	163	28.5	28.6
Fluorouracil	161	28.2	28.3
Oxcarbazepine	62	24.3	24.4
Haloperidol	46	23.9	24.0
Divalproex Sodium	86	23.9	24.0
Haloperidol Lactate	46	23.5	23.5
Topiramate	157	22.8	22.8
Rifaximin	33	19.8	19.8
Midazolam	39	19.5	19.5
Lacosamide	56	19.1	19.2
Midazolam Hydrochloride	39	18.2	18.3
Carbamazepine	89	17.2	17.2
Levetiracetam	168	17.1	17.1
Lactulose	51	16.9	16.9
Leucovorin Calcium	24	15.7	15.7
Risperidone	148	14.9	14.9
Lithium	29	14.4	14.4
Lithium Bromatum	29	14.4	14.4
Olanzapine	113	13.8	13.8
Regorafenib	12	12.8	12.8
Aprepitant	19	12.8	12.8
Fosaprepitant Dimeglumine	14	12.6	12.6
Posaconazole Delayed-Release	11	12.4	12.4
Amlodipine Besylate And Valsartan	11	12.3	12.3
Primidone	10	12.1	12.2
Amantadine	15	12.0	12.0
Melphalan	21	11.5	11.5
Propofol	33	11.3	11.3
Thiamine Hydrochloride	11	10.9	11.0
Quetiapine	156	10.9	10.9
Bupivacaine	8	10.6	10.6
Basiliximab	10	10.5	10.5
Melphalan Hydrochloride	21	10.4	10.4
Panitumumab	13	10.3	10.3
Lithium Carbonate	14	10.2	10.2
Capecitabine	68	9.5	9.5
Deferasirox	20	9.4	9.4
Gemcitabine	28	8.9	8.9
Nebivolol	11	8.5	8.6
Paliperidone	16	8.5	8.5
Posaconazole	11	8.4	8.4
Gemcitabine Hydrochloride	33	7.8	7.8
Cisplatin	48	7.8	7.8
Oxazepam	13	7.5	7.5
Bleomycin Sulfate	6	7.2	7.2
Meropenem	18	7.0	7.0
Paliperidone Palmitate	15	5.8	5.8
Bevacizumab	55	5.6	5.6
Obinutuzumab	5	3.7	3.8
Vigabatrin	3	2.5	2.5

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.