Reaction

Inadequate Analgesia reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,466 reports · 78 co-occurring drugs

As of the last recalculation, Inadequate Analgesia appears in 8,466 FAERS reports alongside 78 co-occurring drug terms. The strongest observed disproportionality signal is BUPRENORPHINE (PRR 126.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Buprenorphine	3,050	126.1	130.4
Fentanyl	657	17.7	17.8
Hydrocodone Bitartrate	278	16.2	16.3
Oxycodone Hydrochloride	1,142	14.8	14.9
Naltrexone	181	14.7	14.8
Fentanyl Citrate	86	11.9	12.0
Bupivacaine	44	11.6	11.7
Carisoprodol	84	10.9	11.0
Tizanidine Hydrochloride	46	6.3	6.3
Oxycodone	435	6.0	6.0
Morphine Sulfate	263	5.5	5.5
Oxycodone And Acetaminophen Tablets	25	5.2	5.2
Oxycodone Hydrochloride And Acetaminophen	201	5.1	5.1
Morphine	148	4.9	5.0
Hydromorphone Hydrochloride	167	4.5	4.5
Doxepin	15	3.6	3.6
Doxepin Hydrochloride	18	3.5	3.5
Methocarbamol	31	3.4	3.4
Methadone	56	3.2	3.2
Oxycodone And Acetaminophen	30	3.2	3.2
Lidocaine 4%	68	3.1	3.1
Hydrocodone Bitartrate And Acetaminophen	67	2.9	2.9
Lidocaine, Menthol	59	2.9	2.9
Lidicaine	58	2.9	2.9
Burn Relief	58	2.9	2.9
Lidocaine Hydrochloride And Epinephrine	58	2.9	2.9
Lidocaine	68	2.9	2.9
Clonidine	59	2.8	2.8
Lidocaine Hydrochloride And Epinephrine Bitartrate	59	2.7	2.7
Pregabalin	290	2.7	2.7
Diazepam	130	2.7	2.7
Tapentadol Hydrochloride	36	2.7	2.7
Lidocaine Hydrochloride	64	2.6	2.6
Lubiprostone	10	2.6	2.6
Gemfibrozil	16	2.6	2.6
Gabapentin	359	2.5	2.5
Biscodyl	13	2.5	2.5
Buprenorphine Hydrochloride, Naloxone Hydrochloride	24	2.4	2.5
Baclofen	82	2.4	2.4
Methocarbamol Tablets	16	2.4	2.4
Ibuprofen And Diphenhydramine Citrate	22	2.3	2.3
Butalbital, Acetaminophen, And Caffeine	10	2.3	2.3
Alprazolam	185	2.2	2.2
Naproxen Sodium Tablet, Coated	12	2.2	2.2
Naproxen Sodium, Coated Tablets	12	2.2	2.2
Naproxen Sodium 220Mg	12	2.2	2.2
Pitavastatin Calcium	9	2.2	2.2
Meperidine Hydrochloride	8	2.1	2.1
Celecoxib	113	2.1	2.1
Pramipexole	13	2.1	2.1
Ketoprofen	11	2.1	2.1
Bupropion Hydrochloride	81	2.0	2.0
Diphenhydramine Hcl	9	2.0	2.0
Methadone Hydrochloride	8	1.8	1.8
Clonazepam	116	1.8	1.8
Duloxetine Hydrochloride	133	1.8	1.8
Ibuprofen Capsule	138	1.7	1.7
Ibuprofen Tablet, Film Coated	138	1.7	1.7
Ibupfrofen	138	1.7	1.7
Ibuprofen Tablets Usp, 200Mg	138	1.7	1.7
Ibuprofen Oral	138	1.7	1.7
Ibuprofen Capsules 200 Mg	138	1.7	1.7
Ibuprofen 200 Mg	138	1.7	1.7
Rizatriptan Benzoate	7	1.7	1.7
Modafinil	22	1.7	1.7
Memantine	9	1.6	1.6
Memantine Hydrochloride	9	1.6	1.6
Tizanidine	15	1.5	1.5
Nebivolol	10	1.5	1.5
Tramadol Hydrochloride	23	1.5	1.5
Eszopiclone	14	1.4	1.4
Sevoflurane	4	1.2	1.2
Miconazole Nitrate	4	1.1	1.1
Vortioxetine	7	1.0	1.0
Isopropyl Alcohol	13	0.9	0.9
Cortisone Acetate	4	0.8	0.8
Cetuximab	10	0.8	0.8
Oxymorphone Hydrochloride	3	0.6	0.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.