Reaction

Leg Amputation reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,081 reports · 72 co-occurring drugs

As of the last recalculation, Leg Amputation appears in 4,081 FAERS reports alongside 72 co-occurring drug terms. The strongest observed disproportionality signal is CANAGLIFLOZIN (PRR 167.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Canagliflozin	792	167.3	171.8
Insulin Human	113	14.9	14.9
Human Insulin	34	14.0	14.0
Quinine	20	11.9	12.0
Epoetin Alfa	25	10.8	10.8
Heparin Sodium	28	10.4	10.5
Insulin Aspart	116	9.2	9.2
Paricalcitol	24	8.7	8.7
Insulin	86	8.0	8.0
Insulin Glulisine	15	7.5	7.6
Insulin Glargine	331	7.4	7.4
Acetylcysteine	13	7.1	7.1
Patiromer	19	7.0	7.0
Sevelamer Carbonate	15	6.7	6.7
Ketoconazole Foam	19	6.6	6.6
Ketoconazole Cream, 2%	19	6.6	6.6
Darbepoetin Alfa	66	6.3	6.3
Empagliflozin	79	6.1	6.1
Insulin Glargine-Yfgn	24	5.6	5.6
Ketoconazole	19	5.6	5.6
Bosentan	54	5.5	5.5
Ranolazine	11	5.4	5.4
Alteplase	15	5.1	5.1
Agalsidase Beta	9	5.0	5.0
Cinacalcet Hydrochloride	44	4.9	4.9
Dalteparin Sodium	10	4.8	4.8
Insulin Degludec	21	4.6	4.6
Dolutegravir Sodium	8	4.5	4.5
Sitagliptin	63	4.5	4.5
Insulin Lispro	110	4.1	4.1
Lactulose	29	3.9	3.9
Warfarin Sodium	33	3.6	3.7
Amikacin	12	3.6	3.6
Norepinephrine Bitartrate	10	3.5	3.6
Glipizide	42	3.5	3.5
Clopidogrel	133	3.5	3.5
Metformin Hcl	36	3.3	3.3
Bumetanide	17	3.3	3.3
Atovaquone	5	3.2	3.2
Hydromorphone Hydrochloride	56	3.1	3.1
Linezolid	18	3.1	3.1
Dapagliflozin	19	3.1	3.1
Clopidogrel Bisulfate	61	3.1	3.1
Sildenafil Powder,	20	2.9	2.9
Norepinephrine	6	2.9	2.9
Oxycodone And Acetaminophen	13	2.9	2.9
Pioglitazone	24	2.8	2.8
Methoxy Polyethylene Glycol-Epoetin Beta	6	2.8	2.8
Glimepiride	21	2.8	2.8
Dofetilide	5	2.4	2.4
Selexipag	12	2.4	2.4
Abiraterone	6	2.2	2.3
Rivaroxaban	88	2.2	2.2
Risankizumab-Rzaa	33	2.1	2.1
Prasugrel Hydrochloride	4	2.0	2.0
Brentuximab Vedotin	4	2.0	2.0
Oxycodone Hydrochloride	82	1.9	1.9
Hydrocodone Bitartrate And Acetaminophen	21	1.9	1.9
Buprenorphine Hydrochloride, Naloxone Hydrochloride	9	1.9	1.9
Oxymorphone Hydrochloride	4	1.7	1.8
Cetuximab	10	1.6	1.6
Emtricitabine And Tenofovir Disoproxil Fumarate	14	1.6	1.6
Ambrisentan	38	1.6	1.6
Encorafenib	3	1.5	1.5
Ranibizumab	8	1.5	1.5
Emtricitabine And Tenofovir Alafenamide	3	1.3	1.3
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	8	1.3	1.3
Alirocumab	6	1.2	1.2
Aflibercept	7	1.1	1.1
Abiraterone Acetate	9	1.1	1.1
Guselkumab	7	1.0	1.0
Salicylic Acid	4	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.