Reaction

Prescription Drug Used Without A Prescription reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,025 reports · 104 co-occurring drugs

As of the last recalculation, Prescription Drug Used Without A Prescription appears in 6,025 FAERS reports alongside 104 co-occurring drug terms. The strongest observed disproportionality signal is FENTANYL (PRR 24.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Fentanyl	629	24.5	24.7
Amphetamine	37	15.5	15.6
Ethyl Alcohol	115	14.9	14.9
Isopropyl Alcohol	115	12.0	12.0
Methadone	142	11.7	11.8
Alcohol	116	10.5	10.5
Quinine	21	8.5	8.5
Lidocaine 4%	130	8.4	8.4
Nirmatrelvir And Ritonavir	127	8.3	8.3
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	97	8.2	8.2
Lidocaine	132	8.0	8.0
Captopril	22	7.9	7.9
Umeclidinium Bromide And Vilanterol Trifenatate	38	7.9	7.9
Tramadol Hydrochloride	85	7.9	7.9
Fluticasone Furoate And Vilanterol Trifenatate	79	7.7	7.7
Sildenafil Powder,	69	6.8	6.8
Diazepam Oral Solution (Concentrate)	169	6.7	6.7
Diazepam Oral	169	6.7	6.7
Methadone Hydrochloride	20	6.4	6.4
Diclofenac Sodium	265	6.3	6.3
Umeclidinium	16	6.2	6.2
Pregabalin	433	5.8	5.9
Fluticasone Propionate And Salmeterol	67	5.6	5.6
Sildenafil	90	5.4	5.4
Diazepam	184	5.4	5.4
Oxazepam	33	5.3	5.3
Oral Semaglutide	110	5.3	5.3
Testosterone	34	5.0	5.1
Icosapent Ethyl	12	4.9	4.9
Telmisartan	25	4.9	4.9
Sildenafil Citrate	172	4.8	4.8
Crisaborole	12	4.3	4.3
Albuterol Sulfate	351	4.3	4.3
Bisacodyl Suppositories	15	4.0	4.0
Lisdexamfetamine Dimesylate	38	4.0	4.0
Biscodyl	15	4.0	4.0
Clobetasol Propionate Ointment Usp, 0.05%	11	3.7	3.7
Bisacodyl	15	3.7	3.7
Fentanyl Citrate	19	3.7	3.7
Clobetasol Propionate	11	3.7	3.7
Guanfacine	8	3.5	3.5
Alprazolam	204	3.5	3.5
Vibegron	8	3.5	3.5
Dronabinol	8	3.4	3.4
Fluticasone Furoate	12	3.4	3.4
Suvorexant	12	3.2	3.2
Paroxetine Hydrochloride Hemihydrate	30	3.1	3.1
Insulin Degludec	21	3.1	3.1
Trazodone Hydrochloride	14	3.1	3.1
Testosterone Cypionate	8	3.1	3.1
Desoximetasone	17	3.1	3.1
Paroxetine	30	3.1	3.1
Mometasone	15	2.8	2.8
Nebivolol	13	2.8	2.8
Mupirocin	11	2.8	2.8
Mupirocin Calcium	11	2.8	2.8
Buprenorphine	71	2.7	2.7
Oxycodone And Acetaminophen Tablets	9	2.6	2.6
Oxycodone	138	2.6	2.6
Sitagliptin And Metformin Hydrochloride	16	2.6	2.6
Bimatoprost	21	2.5	2.5
Bupropion	32	2.5	2.5
Citalopram Hydrobromide	73	2.4	2.4
Somatropin	50	2.4	2.4
Fluoxetine	45	2.3	2.3
Linaclotide	18	2.3	2.3
Lifitegrast	11	2.3	2.3
Guaifenesin	20	2.3	2.3
Human Insulin	8	2.2	2.2
Methylphenidate Hydrochloride	37	2.2	2.2
Sertraline	73	2.2	2.2
Buprenorphine Hydrochloride, Naloxone Hydrochloride	15	2.2	2.2
Phenobarbital	9	2.1	2.1
Gabapentin	221	2.1	2.1
Levonorgestrel	120	2.1	2.1
Donepezil Hydrochloride	22	2.1	2.1
Tadalafil	59	2.0	2.0
Insulin Glulisine	6	2.0	2.0
Diclofenac Potassium	6	1.9	1.9
Oxybutynin	16	1.9	1.9
Oxycodone Hydrochloride	115	1.8	1.8
Nicotine	21	1.8	1.8
Oseltamivir	4	1.7	1.7
Varenicline Tartrate	38	1.6	1.6
Oxycodone And Acetaminophen	11	1.6	1.6
Miconazole Nitrate	4	1.6	1.6
Mometasone Furoate And Formoterol Fumarate Dihydrate	7	1.6	1.6
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	8	1.5	1.5
Brexpiprazole	7	1.5	1.5
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	4	1.4	1.4
Morphine Sulfate	48	1.4	1.4
Rimegepant Sulfate	5	1.4	1.4
Ranolazine	4	1.3	1.3
Naltrexone Hydrochloride And Bupropion Hydrochloride	3	1.2	1.2
Hydrocodone Bitartrate	15	1.2	1.2
Vigabatrin	5	1.2	1.2
Cannabidiol	8	1.2	1.2
Emtricitabine And Tenofovir Disoproxil Fumarate	15	1.1	1.1
Liraglutide	16	1.1	1.1
Hydrocodone Bitartrate And Acetaminophen	17	1.0	1.0
Esketamine Hydrochloride	5	1.0	1.0
Tapentadol Hydrochloride	9	0.9	0.9
Velpatasvir And Sofosbuvir	3	0.8	0.8
Droxidopa	5	0.8	0.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.