Reaction

Autism Spectrum Disorder reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,397 reports · 91 co-occurring drugs

As of the last recalculation, Autism Spectrum Disorder appears in 5,397 FAERS reports alongside 91 co-occurring drug terms. The strongest observed disproportionality signal is VALPROATE SODIUM (PRR 50.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Valproate Sodium	256	50.1	50.7
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	1,122	33.9	34.1
Acetaminophen	2,018	27.2	27.3
Guanfacine	53	26.2	26.4
Lisdexamfetamine Dimesylate	131	15.7	15.7
Valproic Acid	84	10.4	10.5
Aripiprazole Oral	93	8.8	8.8
Aripiprazole Orally Disintegrating	93	8.8	8.8
Methylphenidate Hydrochloride	127	8.4	8.5
Acetaminophen Tablet Extended Release	506	8.3	8.4
Pain Reliever	506	8.3	8.3
Acetaminophen 500Mg	506	8.3	8.3
Tramadol Hydrochloride	77	8.0	8.0
Oxymorphone Hydrochloride	24	8.0	8.0
Fentanyl Citrate	35	7.6	7.6
Lamotirigine	129	7.1	7.1
Lamotrigine Extended-Release	129	7.1	7.1
Lamotrigine Chewable Dispersible	129	7.1	7.1
Carbamazepine	116	6.8	6.8
Misoprostol	17	6.8	6.8
Calcium, Magnesium, Potassium, And Sodium Oxybates	15	6.7	6.7
Phenobarbital	24	6.4	6.4
Phytonadione	14	6.4	6.4
Clobazam	37	5.9	5.9
Divalproex Sodium	69	5.8	5.8
Lurasidone Hydrochloride	31	5.7	5.7
Oxcarbazepine	45	5.4	5.4
Aripiprazole	157	5.1	5.1
Methylphenidate	37	5.0	5.0
Lamotrigine	164	4.9	4.9
Oxycodone Hydrochloride And Acetaminophen	119	4.7	4.7
Elexacaftor, Tezacaftor, And Ivacaftor	15	4.6	4.7
Cannabidiol	28	4.6	4.6
Topiramate	110	4.6	4.6
Human Immunoglobulin G	24	4.5	4.5
Brivaracetam	10	4.3	4.3
Asfotase Alfa	11	4.2	4.2
Zonisamide	16	4.2	4.2
Fluoxetine Hydrochloride	131	4.0	4.0
Fluticasone Furoate	12	3.8	3.8
Somatropin	72	3.8	3.8
Risperidone	127	3.7	3.8
Hydroxyzine Hydrochloride	12	3.5	3.5
Hydroxyzine Hydrochloride Oral	12	3.5	3.5
Folic Acid	207	3.3	3.3
Levetiracetam In Sodium Chloride	65	3.3	3.3
Levetiracetam Oral	65	3.3	3.3
Levetiracetam Injection	65	3.3	3.3
Canakinumab	9	3.2	3.2
Vigabatrin	12	3.2	3.2
Rifampin	12	3.2	3.2
Phenytoin	17	3.1	3.2
Fluoxetine	54	3.1	3.1
Melatonin	43	3.1	3.1
Levetiracetam	104	3.0	3.0
Hydroxyzine	37	3.0	3.0
Atomoxetine Hydrochloride	18	2.9	2.9
Paroxetine Hydrochloride	66	2.8	2.8
Oxycodone And Acetaminophen	17	2.8	2.8
Esketamine Hydrochloride	12	2.6	2.6
Zidovudine	8	2.3	2.3
Clozapine	73	2.3	2.3
Tobramycin Solution	7	2.2	2.2
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	24	2.2	2.2
Tobramycin Sulfate	7	2.2	2.2
Ziprasidone Mesylate	8	2.2	2.2
Vedolizumab	48	2.2	2.2
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	19	2.1	2.1
Morphine Sulfate	63	2.0	2.0
Paliperidone	12	2.0	2.0
Ziprasidone	9	2.0	2.0
Tobramycin	12	1.9	1.9
Paliperidone Palmitate	16	1.9	1.9
Emicizumab	6	1.9	1.9
Cenobamate	4	1.8	1.8
Hydrocodone Bitartrate And Acetaminophen	26	1.8	1.8
Teduglutide	6	1.7	1.7
Diroximel Fumarate	5	1.6	1.6
Lacosamide	15	1.6	1.6
Sodium Oxybate	24	1.4	1.4
Botulinum Toxin Type A	4	1.2	1.2
Crisaborole	3	1.2	1.2
Dornase Alfa	6	1.2	1.2
Peginterferon Beta-1A	4	1.2	1.2
Brexpiprazole	5	1.2	1.2
Fremanezumab-Vfrm	3	1.0	1.0
Rimegepant Sulfate	3	0.9	0.9
Valbenazine	5	0.8	0.8
Lifitegrast	3	0.7	0.7
Galcanezumab-Gnlm	4	0.5	0.5
Dupilumab	60	0.5	0.5

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.