OpenPV Signal Explorer
FAERS disproportionality dashboard
Reaction

Joint Destruction reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,544 reports · 82 co-occurring drugs

As of the last recalculation, Joint Destruction appears in 1,544 FAERS reports alongside 82 co-occurring drug terms. The strongest observed disproportionality signal is ANAKINRA (PRR 246.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.
DrugCo-reportsPRRROR
Anakinra254246.9250.7
Cortisone Acetate191237.9241.6
Calcium Gluconate142174.8176.9
Desoximetasone201163.3165.1
Naproxen Sodium Tablet, Coated134146.0147.4
Naproxen Sodium, Coated Tablets134146.0147.4
Naproxen Sodium 220Mg134145.8147.2
Triamcinolone Acetonide Ointment Usp, 0.05%203134.4135.6
Diclofenac Potassium, Film Coated74124.5125.6
Diclofenac Potassium Tablets74124.4125.5
Pseudoephedrine Hydrochloride85118.0118.9
Adalimumab-Adaz351115.8116.5
Adalimumab-Fkjp311113.1113.8
Adalimumab-Aaty311110.7111.4
Pseudoephedrine Hcl85110.0110.8
Human Immunoglobulin G144103.7104.4
Triamcinolone Acetonide203101.8102.5
Diclofenac Potassium7496.997.6
Sulfasalazine40995.596.0
Risedronate Sodium18591.091.6
Cetirizine Hydrochloride Allergy17487.287.7
Cetirizine Hydrochloride Tablets17487.287.7
Tocilizumab46177.277.5
Leflunomide41873.573.8
Diclofenac Sodium 1%14761.261.5
Diclofenac Sodium Topical14761.261.5
Diclofenac Sodium Topical Gel, 1%14761.161.3
Naproxen28559.860.0
Hydroxychloroquine26758.158.3
Abatacept39551.351.5
Hydroxychloroquine Sulfate27348.949.0
Tofacitinib Citrate4345.545.6
Quetiapine Fumarate9144.144.2
Cetirizine21443.043.1
Golimumab22140.440.5
Etanercept81137.437.4
Naproxen Sodium31637.237.3
Cetiirizine10435.435.5
Methotrexate Sodium68433.333.3
Infliximab37730.530.5
Methotrexate58929.929.9
Certolizumab Pegol21929.229.2
Alendronate Sodium19028.828.9
Diclofenac16428.628.6
Rituximab34528.028.1
Celecoxib22626.927.0
Tofacitinib28725.525.6
Folic Acid36225.325.3
Diphenhydramine Hydrochloride Capsule, Liquid Filled3321.321.3
Cetirizine Hydrochloride21520.320.3
Hydrocortisone Sodium Succinate1420.320.3
Secukinumab21020.120.2
Sarilumab3819.919.9
Pantoprazole Sodium In 0.9% Sodium Chloride8519.519.5
Pantoprazole Sodium Injection8519.519.5
Diltiazem Hydrochloride Extended-Release Tablets1619.119.2
Diclofenac Sodium18819.019.1
Acetaminophen And Codeine1617.917.9
Bupropion Hydrochloride12117.817.9
Ramipril14717.617.6
Botulinum Toxin Type A1516.416.5
Chlorhexidine Gluconate1116.316.4
Adalimumab52914.814.8
Doxyclycline Hyclate1713.613.6
Dexamethasone Sodium Phosphate912.012.0
Quetiapine15111.611.6
Tretinoin610.010.0
Icosapent Ethyl69.59.5
Meloxicam409.59.5
Quinapril Hydrochloride58.68.6
Linagliptin107.47.4
Erenumab-Aooe276.76.7
Levocetirizine Dihydrochloride116.26.2
Desvenlafaxine Succinate126.06.0
Atomoxetine Hydrochloride105.75.7
Ustekinumab395.25.2
Emicizumab44.44.4
Apremilast464.34.3
Alcohol124.24.2
Diroximel Fumarate33.43.4
Guselkumab62.32.3
Salicylic Acid41.01.0

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.