OpenPV Signal Explorer
FAERS disproportionality dashboard
Reaction

Megacolon reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,545 reports · 65 co-occurring drugs

As of the last recalculation, Megacolon appears in 1,545 FAERS reports alongside 65 co-occurring drug terms. The strongest observed disproportionality signal is METRONIDAZOLE TOPICAL (PRR 33.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.
DrugCo-reportsPRRROR
Metronidazole Topical11033.433.5
Piperacillin And Tazobactam3133.333.4
Metronidazole12127.627.7
Piperacillin Sodium,Tazobactam Sodium4825.125.2
Piperacillin Sodium And Tazobactam Sodium3524.624.6
Vancomycin9824.324.4
Vancomycin Hydrochloride10322.522.5
Rifaximin2717.717.7
Aripiprazole Oral5217.517.5
Aripiprazole Orally Disintegrating5217.517.5
Clindamycin3617.517.5
Clindamycin Phosphate4217.417.4
Abacavir Sulfate1216.716.7
Meropenem3816.316.3
Trimethoprim1416.116.2
Micafungin Sodium1016.016.0
Clozapine13615.915.9
Haloperidol Lactate2714.915.0
Loperamide Hcl1414.814.8
Haloperidol2614.614.7
Olanzapine10714.314.4
Cefuroxime1113.013.1
Ciprofolxacin6512.712.7
Ciprofloxacin Tablets6512.712.7
Cladribine912.712.7
Norepinephrine1012.712.7
Valproate Sodium1912.512.5
Oxazepam1912.012.0
Levofloxacin5111.711.8
Levofloxacin In 5% Dextrose5111.711.8
Ampicillin711.411.4
Ampicillin Sodium711.411.4
Ritonavir 100 Mg1210.910.9
Ciprofloxacin7010.710.7
Umeclidinium710.610.6
Cefazolin710.410.4
Cefazolin Sodium910.110.1
Linezolid2210.110.1
Ceftriaxone239.69.6
Calcitriol Capsules 0.25 Mcg149.59.5
Calcitriol Capsules 0.5 Mcg149.59.5
Norepinephrine Bitartrate109.49.4
Calcitriol149.49.4
Ganciclovir79.39.3
Brentuximab Vedotin79.29.2
Clarithromycin239.19.2
Olanzapine Pamoate279.09.0
Pertuzumab189.09.0
Darunavir109.09.0
Ganciclovir Sodium78.99.0
Valganciclovir Hydrochloride Powder,88.98.9
Ceftriaxone Sodium248.58.6
Cytarabine368.28.2
Loperamide Hydrochloride Oral67.97.9
Aripiprazole637.27.2
Amikacin97.17.1
Granisetron56.46.4
Obinutuzumab75.85.8
Ipilimumab185.75.7
Isotretinoin174.74.7
Docetaxel Anhydrous234.74.7
Docetaxel234.74.7
Paliperidone Palmitate104.24.2
Remdesivir44.14.1
Guselkumab72.62.6

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.