Reaction

Respiratory Rate Decreased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,108 reports · 87 co-occurring drugs

As of the last recalculation, Respiratory Rate Decreased appears in 3,108 FAERS reports alongside 87 co-occurring drug terms. The strongest observed disproportionality signal is FENTANYL CITRATE (PRR 17.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Fentanyl Citrate	45	17.1	17.1
Morphine	142	13.3	13.3
Bupivacaine	17	12.2	12.3
Fentanyl	154	11.0	11.0
Dimenhydrinate	17	10.7	10.8
Midazolam Hydrochloride	41	10.3	10.3
Ciclesonide	20	9.9	9.9
Methadone Hydrochloride	15	9.3	9.3
Magnesium Sulfate Heptahydrate	18	9.3	9.3
Magnesium Sulfate	18	9.3	9.3
Sodium Oxybate	89	9.3	9.3
Morphine Sulfate	157	9.1	9.1
Sevoflurane	11	8.9	8.9
Midazolam	32	8.6	8.6
Omalizumab	101	8.2	8.2
Carisoprodol	23	8.1	8.1
Hydromorphone Hydrochloride	107	8.0	8.0
Fexofenadine Hcl	11	8.0	8.0
Erythromycin	22	7.9	7.9
Magnesium Sulfate In Water For	15	7.9	7.9
Propofol	42	7.8	7.8
Labetalol	15	7.6	7.6
Diazepam Oral Solution (Concentrate)	91	7.0	7.0
Diazepam Oral	91	7.0	7.0
Methadone	42	6.6	6.7
Diphenhydramine Hcl	11	6.6	6.6
Cefazolin	9	6.6	6.6
Amphetamine	8	6.5	6.5
Felodipine Extended-Release Tablets	11	6.5	6.5
Felodipine	11	6.5	6.5
Iohexol	8	6.5	6.5
Buprenorphine Hydrochloride, Naloxone Hydrochloride	23	6.4	6.4
Tizanidine Hydrochloride	17	6.3	6.3
Rocuronium Bromide	11	6.3	6.3
Calcium, Magnesium, Potassium, And Sodium Oxybates	8	6.2	6.2
Bisacodyl Suppositories	12	6.2	6.2
Biscodyl	12	6.2	6.2
Cefazolin Sodium	11	6.1	6.1
Armodafinil	19	6.1	6.1
Diazepam	107	6.1	6.1
Ethyl Alcohol	24	6.0	6.0
Rizatriptan Benzoate	9	5.9	5.9
Derma Foam Excel Hand Sanitizer	7	5.9	5.9
Ethanol	7	5.9	5.9
Bisacodyl	12	5.7	5.7
Quetiapine Fumarate	25	5.7	5.7
Docusate Sodium 100Mg	20	5.6	5.6
Isopropyl Alcohol	28	5.6	5.6
Dextrose Monohydrate	11	5.5	5.5
Oxycodone Hydrochloride	171	5.5	5.5
Clobazam	20	5.5	5.5
Acetaminophen And Codeine	10	5.5	5.5
Timolol Maleate	8	5.4	5.4
Alcohol	31	5.4	5.4
Baclofen	66	5.2	5.2
Clonazepam	120	5.2	5.2
Diphenhydramine	48	5.2	5.2
Norepinephrine Bitartrate	11	5.1	5.1
Alprazolam	149	5.0	5.0
Propranolol Hydrochloride	53	5.0	5.0
Teduglutide	10	5.0	5.0
Heparin Sodium	10	4.9	4.9
Infliximab-Dyyb	20	4.6	4.6
Valproic Acid	21	4.5	4.5
Tramadol Hydrochloride	25	4.5	4.5
Guanfacine	5	4.3	4.3
Tizanidine	15	4.2	4.2
Oxycodone	112	4.1	4.1
Budesonide And Formoterol Fumarate Dihydrate	57	4.0	4.0
Norepinephrine	6	3.8	3.8
Irinotecan Hydrochloride	7	3.7	3.7
Tobramycin	13	3.6	3.6
Rasagiline Mesylate	6	3.6	3.6
Ziprasidone Mesylate	7	3.3	3.3
Tapentadol Hydrochloride	16	3.2	3.2
Budesonide, Glycopyrrolate, And Formoterol Fumarate	5	3.2	3.2
Nintedanib	14	3.0	3.0
Fexofenadine Hydrochloride	9	2.8	2.8
Hydrocodone Bitartrate And Acetaminophen	22	2.6	2.6
Palivizumab	6	2.6	2.6
Buprenorphine	31	2.3	2.3
Dornase Alfa	6	2.1	2.1
Esketamine Hydrochloride	5	1.9	1.9
Vigabatrin	4	1.8	1.8
Pirfenidone	10	1.6	1.6
Pimavanserin Tartrate	8	1.0	1.0
Valbenazine	3	0.8	0.8

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.