Reaction

Homicidal Ideation reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,020 reports · 120 co-occurring drugs

As of the last recalculation, Homicidal Ideation appears in 4,020 FAERS reports alongside 120 co-occurring drug terms. The strongest observed disproportionality signal is VARENICLINE TARTRATE (PRR 41.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Varenicline Tartrate	558	41.8	42.1
Ziprasidone	95	28.6	28.7
Ziprasidone Mesylate	63	23.2	23.3
Guanfacine	29	19.2	19.3
Atomoxetine Hydrochloride	73	16.2	16.2
Lithium	73	15.3	15.3
Lithium Bromatum	73	15.3	15.3
Lithium Carbonate	45	13.9	13.9
Paroxetine Hydrochloride	212	12.7	12.7
Olanzapine Pamoate	95	12.3	12.3
Lurasidone Hydrochloride	48	12.0	12.0
Divalproex Sodium	101	11.5	11.5
Aripiprazole Oral	87	11.1	11.1
Aripiprazole Orally Disintegrating	87	11.1	11.1
Sertraline Hydrochloride	226	10.4	10.4
Temazepam	74	10.3	10.4
Methylphenidate Hydrochloride	113	10.1	10.1
Risperidone	239	9.8	9.8
Venlafaxine Hydrochloride	235	9.7	9.7
Carisoprodol	35	9.6	9.6
Aripiprazole	215	9.5	9.6
Amphetamine	15	9.4	9.4
Quetiapine	322	9.3	9.3
Paliperidone Palmitate	56	9.1	9.1
Valproic Acid	53	8.8	8.8
Clonidine	83	8.5	8.6
Nevirapine	14	8.1	8.1
Fluoxetine Hydrochloride	183	7.7	7.7
Nicotine Polacrilex Mini	22	7.6	7.6
Nicotine Polarilex	22	7.6	7.6
Zidovudine	19	7.4	7.4
Vortioxetine	24	7.3	7.4
Methylphenidate	38	6.9	6.9
Peginterferon Alfa-2A	70	6.8	6.8
Mirtazapine	116	6.7	6.7
Buspirone Hydrochloride	14	6.6	6.6
Asenapine Maleate	11	6.6	6.6
Bupropion Hydrochloride	122	6.6	6.6
Olanzapine	128	6.3	6.3
Clonazepam	188	6.3	6.3
Sertraline	139	6.3	6.3
Oxcarbazepine	38	6.1	6.1
Buprenorphine Hydrochloride, Naloxone Hydrochloride	28	6.0	6.1
Lisdexamfetamine Dimesylate	38	6.0	6.0
Desvenlafaxine Succinate	31	6.0	6.0
Ribavirin	73	6.0	6.0
Ethyl Alcohol	31	5.9	6.0
Extended Phenytoin Sodium	19	5.9	5.9
Citalopram	149	5.8	5.8
Trazodone Hydrochloride	17	5.6	5.7
Diazepam	124	5.4	5.4
Haloperidol Lactate	25	5.3	5.3
Carbamazepine	67	5.2	5.3
Isopropyl Alcohol	34	5.2	5.2
Brivaracetam	9	5.2	5.2
Haloperidol	24	5.1	5.1
Montelukast Sodium	118	5.1	5.1
Paliperidone	23	5.1	5.1
Duloxetine Hydrochloride	179	5.1	5.1
Lacosamide	36	5.0	5.0
Brexpiprazole	16	5.0	5.0
Citalopram Hydrobromide	101	5.0	5.0
Escitalopram	130	4.9	4.9
Zonisamide	14	4.9	4.9
Lorazepam	164	4.9	4.9
Butalbital, Acetaminophen, And Caffeine	10	4.9	4.9
Paroxetine Hydrochloride Hemihydrate	31	4.8	4.9
Paroxetine	31	4.8	4.8
Naltrexone	28	4.7	4.7
Lamotrigine	114	4.6	4.6
Alcohol	34	4.6	4.6
Topiramate	79	4.5	4.5
Diazepam Oral Solution (Concentrate)	75	4.4	4.4
Diazepam Oral	75	4.4	4.4
Tizanidine	20	4.4	4.4
Escitslopram	48	4.3	4.3
Alprazolam	165	4.3	4.3
Venlafaxine	58	4.2	4.2
Nicotine	31	4.0	4.0
Escitalopram Oxalate	55	3.9	3.9
Vilazodone Hydrochloride	7	3.9	3.9
Zolpidem Tartrate	97	3.8	3.8
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	30	3.8	3.8
Quetiapine Fumarate	21	3.7	3.7
Fluoxetine	46	3.6	3.6
Hydroxyzine Hydrochloride	9	3.5	3.6
Hydroxyzine Hydrochloride Oral	9	3.5	3.6
Nicotine Polacrilex	26	3.5	3.5
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	23	3.4	3.4
Modafinil	21	3.4	3.4
Oxazepam	14	3.4	3.4
Lamotirigine	46	3.4	3.4
Lamotrigine Extended-Release	46	3.4	3.4
Lamotrigine Chewable Dispersible	46	3.4	3.4
Cariprazine	6	3.3	3.3
Testosterone	15	3.3	3.3
Sofosbuvir	12	3.2	3.2
Eszopiclone	15	3.1	3.1
Amantadine	9	3.0	3.0
Bupropion	25	2.9	2.9
Clozapine	66	2.8	2.8
Levetiracetam	70	2.7	2.7
Donepezil Hydrochloride	19	2.7	2.7
Calcium, Magnesium, Potassium, And Sodium Oxybates	4	2.4	2.4
Methadone Hydrochloride	5	2.4	2.4
Elexacaftor, Tezacaftor, And Ivacaftor	5	2.1	2.1
Esketamine Hydrochloride	7	2.0	2.0
Hydrocodone Bitartrate	17	2.0	2.0
Interferon Beta-1A	70	1.9	1.9
Isotretinoin	18	1.9	1.9
Sodium Oxybate	23	1.8	1.8
Conjugated Estrogens And Medroxyprogesterone Acetate	8	1.8	1.8
Suvorexant	4	1.6	1.6
Medroxyprogesterone Acetate	15	1.6	1.6
Glecaprevir And Pibrentasvir	3	1.4	1.4
Pseudoephedrine Hcl	3	1.4	1.4
Ledipasvir And Sofosbuvir	5	1.3	1.3
Valbenazine	6	1.2	1.2
Buprenorphine	22	1.2	1.2
Etonogestrel	6	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.