Reaction

Anorectal Discomfort reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,279 reports · 74 co-occurring drugs

As of the last recalculation, Anorectal Discomfort appears in 5,279 FAERS reports alongside 74 co-occurring drug terms. The strongest observed disproportionality signal is PEGINTERFERON ALFA-2A (PRR 206.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Peginterferon Alfa-2A	1,845	206.3	213.6
Ribavirin	1,651	146.9	150.7
Infliximab-Dyyb	82	11.2	11.2
Mesalamine	139	10.0	10.0
Vedolizumab	172	8.1	8.1
Cholestyramine	22	7.2	7.2
Dabigatran Etexilate Mesylate	107	5.9	5.9
Linaclotide	38	5.6	5.7
Rabeprazole	31	5.5	5.5
Dabigatran Etexilate	104	5.4	5.4
Psyllium Husk	13	5.2	5.2
Loperamide Hydrochloride And Dimethicone	42	5.2	5.2
Regorafenib	15	5.1	5.1
Miconazole Nitrate	11	5.0	5.0
Octreotide Acetate	36	4.7	4.7
Sunitinib Malate	46	4.6	4.6
Loperamide Hydrochloride	52	4.6	4.6
Lubiprostone	11	4.6	4.6
Orlistat	30	4.6	4.6
Doxepin Hydrochloride	14	4.4	4.4
Irbesartan	49	4.4	4.4
Nirmatrelvir And Ritonavir	54	4.0	4.0
Polyethylene Glycol 3350	93	3.9	3.9
Erythropoietin	20	3.8	3.9
Polyethylene Glycol	10	3.6	3.6
Lisinopril And Hydrochlorothiazide Tablets	7	3.5	3.5
Doxepin	9	3.5	3.5
Loperamide Hydrochloride Oral	9	3.5	3.5
Ciprofolxacin	62	3.4	3.4
Ciprofloxacin Tablets	62	3.4	3.4
Hyoscyamine Sulfate	8	3.4	3.4
Hydrocortisone Acetate	62	3.4	3.4
Loperamide Hcl	11	3.4	3.4
Ciprofloxacin	77	3.3	3.3
Ciprofloxacin Hydrochloride	81	3.3	3.3
Instalax Polyethylene Glycol 3350	10	3.2	3.2
Diphenoxylate Hydrochloride And Atropine Sulfate	11	3.2	3.2
Polyethylene Glycol 400	10	3.1	3.1
Cabozantinib	37	3.1	3.1
Dicyclomine Hydrochloride	11	3.0	3.1
Lanreotide Acetate	6	3.0	3.0
Multivitamin	38	3.0	3.0
Rifampin	11	3.0	3.0
Abemaciclib	15	3.0	3.0
Trifluridine And Tipiracil	8	2.9	2.9
Teduglutide	10	2.9	2.9
Pirfenidone	30	2.9	2.9
Ciprofloxacin Hydrochloride And Hydrocortisone	15	2.8	2.9
Dronedarone	7	2.7	2.7
Lisinopril And Hydrochlorothiazide	7	2.7	2.7
Adalimumab-Adaz	36	2.7	2.7
Relugolix	16	2.7	2.7
Dexlansoprazole	28	2.7	2.7
Prochlorperazine Maleate	6	2.6	2.6
Panitumumab	10	2.5	2.5
Infliximab	131	2.4	2.4
Valsartan And Hydrochlorothiazide	8	2.3	2.3
Lapatinib	9	2.3	2.3
Lisinopril	170	2.2	2.2
Anakinra	9	2.1	2.1
Sorafenib	11	2.1	2.1
Iron Sucrose	5	2.1	2.1
Patiromer	7	2.0	2.0
Niraparib	11	2.0	2.0
Dutasteride	4	1.9	1.9
Metformin Hcl	26	1.9	1.9
Dofetilide	4	1.5	1.5
Naproxen Sodium Tablet	18	1.3	1.3
Lenvatinib	11	1.3	1.3
Rifaximin	7	1.3	1.3
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	6	1.3	1.3
Axitinib	6	1.2	1.2
Enzalutamide	15	1.0	1.0
Levonorgestrel	22	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.