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Which drugs are most reported with Crohn's disease?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,861 reports · 91 co-occurring drugs

As of the last recalculation, Crohn's Disease appears in 6,861 FAERS reports alongside 91 co-occurring drug terms. The strongest observed disproportionality signal is ISOTRETINOIN (PRR 83.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Isotretinoin	1,140	83.7	85.6
Mercaptopurine	232	42.0	42.5
Mesalamine	602	35.6	35.9
Infliximab	1,267	21.4	21.5
Certolizumab Pegol	675	19.3	19.4
Azathioprine	469	17.3	17.3
Adalimumab	2,390	15.2	15.2
Diphenoxylate Hydrochloride And Atropine Sulfate	49	10.9	11.0
Metronidazole	214	10.5	10.5
Hyoscyamine Sulfate	30	10.0	10.0
Hydrocortisone Sodium Succinate	30	9.7	9.7
Cholestyramine	35	8.8	8.8
Tretinoin	21	7.9	7.9
Ciprofloxacin Hydrochloride And Hydrocortisone	52	7.6	7.7
Loperamide Hydrochloride And Dimethicone	79	7.6	7.6
Loperamide Hydrochloride	88	6.0	6.0
Metronidazole Topical	91	5.9	5.9
Budesonide	104	5.4	5.4
Iron	110	5.1	5.1
Promethazine Hydrochloride	30	4.9	4.9
Loperamide Hcl	20	4.7	4.7
Cortisone Acetate	19	4.7	4.7
Diphenhydramine Hcl	15	4.1	4.1
Rabeprazole Sodium	35	3.9	3.9
Ciprofloxacin	116	3.9	3.9
Prednisone	594	3.8	3.8
Ciprofloxacin Hydrochloride	120	3.8	3.8
Desloratadine	13	3.7	3.7
Meperidine Hydrochloride	11	3.6	3.6
Rizatriptan Benzoate	12	3.6	3.6
Esomeprazole Magnesium Capsule, Delayed Release	17	3.6	3.6
Esomeprazole Magnesium Delayed Release Capsules	17	3.6	3.6
Esomeprazole Magnesium Dihydrate	17	3.5	3.5
Antacid	50	3.2	3.2
Dicyclomine Hydrochloride	15	3.2	3.2
Hydrocortisone Acetate	74	3.1	3.1
Rifaximin	21	3.0	3.0
Esomeprazole Magnesium	227	3.0	3.0
Ascorbic Acid	23	3.0	3.0
Natalizumab	175	3.0	3.0
Erythromycin	18	2.9	2.9
Anti-Itch	62	2.8	2.8
Anti-Pruritic	62	2.8	2.8
Antipruritic (Anti-Itch)	62	2.8	2.8
Cool Relief Gel With Aloe	62	2.8	2.8
Drs. Hydrocortisone	62	2.8	2.8
Hydrocortisone Continuous Spray	62	2.8	2.8
Hydrocortisone Spray	62	2.8	2.8
Anti-Itch Cream	62	2.8	2.8
Hydrocortisone Lotion	62	2.8	2.8
Hydrocortisone Cream 1%	62	2.8	2.8
Hydrocortisone Cream 1/2%	62	2.8	2.8
Hydrocortisone 1%	62	2.8	2.8
Hydrocortisone Cream	62	2.8	2.8
Ciprofolxacin	64	2.7	2.7
Ciprofloxacin Tablets	64	2.7	2.7
Lansoprazole	155	2.7	2.7
Folic Acid	215	2.7	2.7
Sucralfate	21	2.7	2.7
Clobetasol Propionate Ointment Usp, 0.05%	9	2.7	2.7
Clobetasol Propionate	9	2.6	2.6
Etonogestrel And Ethinyl Estradiol	19	2.6	2.6
Gemfibrozil	13	2.6	2.6
Calcium Carbonate	57	2.6	2.6
Pantoprazole Sodium	119	2.5	2.5
Calcium	115	2.4	2.4
Tolterodine Tartrate	7	2.4	2.4
Sulfasalazine	60	2.3	2.3
Carisoprodol	14	2.2	2.2
Ibuprofen And Diphenhydramine Citrate	17	2.2	2.2
Drospirenone And Ethinyl Estradiol	30	2.1	2.1
Lisinopril And Hydrochlorothiazide Tablets	5	1.9	1.9
Metformin Hcl	35	1.9	1.9
Oxycodone Hydrochloride And Acetaminophen	60	1.8	1.8
Sumatriptan	23	1.8	1.8
Interferon Beta-1A	108	1.7	1.7
Iron Sucrose	5	1.6	1.6
Loratadine Tablet	28	1.6	1.6
Interferon Beta-1B	10	1.6	1.6
Loratadine And Pseudoephedrine Sulfate	4	1.5	1.5
Atomoxetine Hydrochloride	10	1.3	1.3
Hydrocodone Bitartrate	18	1.3	1.3
Acetaminophen, Aspirin (Nsaid) And Caffeine	7	1.2	1.2
Teriparatide	39	1.0	1.0
Conjugated Estrogens And Medroxyprogesterone Acetate	8	1.0	1.0
Acetaminophen, Aspirin, And Caffeine	7	1.0	1.0
Exenatide	17	1.0	1.0
Varenicline Tartrate	19	0.7	0.7
Orlistat	6	0.7	0.7
Adapalene	13	0.2	0.2
Salicylic Acid	3	0.2	0.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.