Reaction

Therapeutic Product Effect Variable reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,768 reports · 95 co-occurring drugs

As of the last recalculation, Therapeutic Product Effect Variable appears in 3,768 FAERS reports alongside 95 co-occurring drug terms. The strongest observed disproportionality signal is LEVODOPA (PRR 163.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Levodopa	327	163.6	168.1
Asenapine Maleate	143	94.7	96.3
Rimegepant Sulfate	178	81.4	82.5
Lithium Carbonate	140	47.2	47.6
Carbidopa And Levodopa	282	35.4	35.6
Vibegron	49	34.2	34.4
Valproate Sodium	112	30.8	31.0
Haloperidol	124	29.1	29.3
Haloperidol Lactate	124	28.6	28.7
Calcium, Magnesium, Potassium, And Sodium Oxybates	41	26.6	26.7
Lisdexamfetamine Dimesylate	151	26.3	26.4
Rasagiline Mesylate	50	25.1	25.2
Ziprasidone	75	24.0	24.1
Amantadine	66	24.0	24.1
Pramipexole	65	23.8	23.9
Rotigotine	60	23.3	23.4
Acetaminophen, Aspirin (Nsaid) And Caffeine	70	23.1	23.2
Instalax Polyethylene Glycol 3350	51	23.0	23.1
Polyethylene Glycol 400	51	22.5	22.6
Ropinirole	55	20.1	20.1
Acetaminophen, Aspirin, And Caffeine	73	19.5	19.6
Quetiapine Fumarate	96	18.4	18.5
Aripiprazole Oral	127	17.5	17.6
Aripiprazole Orally Disintegrating	127	17.5	17.6
Rivastigmine	55	16.4	16.4
Lithium	62	13.8	13.8
Lithium Bromatum	62	13.8	13.8
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	95	12.9	13.0
Bupivacaine	21	12.5	12.5
Fremanezumab-Vfrm	24	11.6	11.6
Ziprasidone Mesylate	26	10.1	10.2
Linaclotide	47	9.8	9.9
Loperamide Hydrochloride Oral	18	9.8	9.8
Clozapine	192	8.8	8.9
Fluoxetine	100	8.5	8.5
Citalopram Hydrobromide	157	8.4	8.4
Olanzapine	153	8.2	8.2
Docosanol	21	8.0	8.0
Loperamide Hcl	18	7.8	7.8
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	49	7.8	7.8
Fluoxetine Hydrochloride	171	7.7	7.7
Polyethylene Glycol 3350	128	7.6	7.6
Ibuprofen Tablets, Coated	57	7.5	7.5
Ibuprofen Sodium	57	7.4	7.5
Aripiprazole	158	7.4	7.4
Sumatriptan Succinate	33	7.3	7.3
Glycerin, Lidocaine	17	6.7	6.7
Citalopram	158	6.6	6.6
Diclofenac Sodium	170	6.5	6.5
Risperidone	147	6.3	6.3
Orlistat	29	6.2	6.2
Psyllium Husk	11	6.2	6.2
Quetiapine	205	6.2	6.2
Methylphenidate Hydrochloride	62	5.9	5.9
Methylphenidate	27	5.2	5.2
Guanfacine	7	4.9	4.9
Selexipag	22	4.7	4.7
Amphetamine	7	4.7	4.7
Loperamide Hydrochloride	35	4.4	4.4
Sodium Oxybate	50	4.2	4.2
Sumatriptan	29	4.2	4.2
Thyroid, Porcine	8	4.2	4.2
Naltrexone Hydrochloride And Bupropion Hydrochloride	6	3.9	3.9
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	110	3.9	3.9
Gabapentin	244	3.9	3.9
Rizatriptan Benzoate	7	3.8	3.8
Cetirizine Hydrochloride Allergy	20	3.7	3.7
Cetirizine Hydrochloride Tablets	20	3.7	3.7
Onabotulinumtoxina	50	3.6	3.6
Fexofenadine Hydrochloride	14	3.6	3.6
Levocetirizine Dihydrochloride	15	3.5	3.5
Baricitinib	6	3.4	3.4
Oxazepam	13	3.3	3.3
Pimavanserin Tartrate	33	3.3	3.3
Vortioxetine	10	3.3	3.3
Mirabegron	21	3.0	3.0
Cariprazine	5	3.0	3.0
Armodafinil	11	2.9	2.9
Memantine	7	2.8	2.8
Memantine Hydrochloride	7	2.8	2.8
Budesonide, Glycopyrrolate, And Formoterol Fumarate	5	2.6	2.6
Suvorexant	6	2.6	2.6
Naproxen Sodium Tablet	24	2.5	2.5
Eptinezumab-Jjmr	4	2.4	2.4
Vilazodone Hydrochloride	4	2.4	2.4
Ranolazine	4	2.1	2.1
Lurasidone Hydrochloride	8	2.1	2.1
Galcanezumab-Gnlm	11	1.9	1.9
Voclosporin	3	1.9	1.9
Treprostinil	37	1.6	1.6
Erenumab-Aooe	16	1.6	1.6
Bimekizumab	6	1.6	1.6
Esketamine Hydrochloride	4	1.2	1.2
Valbenazine	5	1.1	1.1
Droxidopa	4	1.0	1.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.