Reaction

Ligament Rupture reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,372 reports · 97 co-occurring drugs

As of the last recalculation, Ligament Rupture appears in 4,372 FAERS reports alongside 97 co-occurring drug terms. The strongest observed disproportionality signal is CIPROFLOXACIN HYDROCHLORIDE AND HYDROCORTISONE (PRR 7.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Ciprofloxacin Hydrochloride And Hydrocortisone	32	7.4	7.4
Ciclesonide	19	6.7	6.7
Tizanidine Hydrochloride	24	6.4	6.4
Etonogestrel And Ethinyl Estradiol	29	6.3	6.3
Adalimumab	788	6.2	6.3
Infliximab-Dyyb	38	6.2	6.2
Modafinil	40	5.9	5.9
Ciprofloxacin Hydrochloride	117	5.9	5.9
Ciprofloxacin	110	5.8	5.8
Sodium Oxybate	79	5.8	5.8
Diphenhydramine Hydrochloride Capsule, Liquid Filled	25	5.6	5.6
Omalizumab	94	5.3	5.3
Ciprofolxacin	78	5.3	5.3
Ciprofloxacin Tablets	78	5.3	5.3
Upadacitinib	86	5.1	5.1
Calcium, Magnesium, Potassium, And Sodium Oxybates	9	5.0	5.0
Liothyronine Sodium	9	4.9	4.9
Asfotase Alfa	10	4.8	4.8
Buprenorphine Hydrochloride, Naloxone Hydrochloride	23	4.6	4.6
Indapamide	17	4.5	4.5
Mometasone Furoate	39	4.5	4.5
Risankizumab-Rzaa	76	4.5	4.5
Estradiol Gel 0.1%	40	4.2	4.2
Estradiol Transdermal	40	4.2	4.2
Interferon Beta-1A	167	4.2	4.2
Zinc Gluconate	22	4.0	4.0
Meloxicam	48	4.0	4.0
Cyclobenzaprine	41	3.9	3.9
Zinc	20	3.9	3.9
Zinc Chloride	20	3.8	3.8
Candesartan Cilexetil	21	3.8	3.8
Folic Acid	193	3.8	3.8
Fluticasone Propionate And Salmeterol Xinafoate	47	3.8	3.8
Tolterodine Tartrate	7	3.7	3.7
Ocrelizumab	48	3.7	3.7
Celecoxib	99	3.6	3.6
Armodafinil	16	3.6	3.6
Thyroid, Porcine	8	3.6	3.6
Isotretinoin	36	3.5	3.5
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	25	3.4	3.4
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	29	3.3	3.3
Adrenalinum	29	3.3	3.3
Mesalamine	39	3.3	3.3
Peginterferon Beta-1A	9	3.3	3.3
Biotin	21	3.2	3.2
Fish Oil	60	3.2	3.2
Estradiol	56	3.1	3.1
Emicizumab	8	3.1	3.1
Natalizumab	115	3.1	3.1
Testosterone	15	3.1	3.1
Oxycodone Hydrochloride And Acetaminophen	62	3.0	3.0
Epinephrine	41	3.0	3.0
Diclofenac Sodium	93	3.0	3.0
Dalfampridine	44	2.9	2.9
Cetirizine Hydrochloride Allergy	18	2.8	2.8
Cetirizine Hydrochloride Tablets	18	2.8	2.8
Eszopiclone	15	2.8	2.8
Diroximel Fumarate	7	2.8	2.8
Multivitamin	28	2.7	2.7
Dexlansoprazole	20	2.3	2.3
Mirabegron	18	2.2	2.2
Teriflunomide	21	2.2	2.2
Tofacitinib	84	2.2	2.2
Fingolimod Hcl	39	2.2	2.2
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate	4	2.1	2.1
Vedolizumab	38	2.1	2.1
Eptinezumab-Jjmr	4	2.1	2.1
Glatiramer Acetate	26	2.1	2.1
Etanercept	252	2.1	2.1
Fluticasone Propionate And Salmeterol	18	2.1	2.1
Certolizumab Pegol	49	2.0	2.0
Interferon Beta-1B	8	2.0	2.0
Teriparatide	45	1.9	1.9
Ofatumumab	13	1.9	1.9
Naltrexone	12	1.9	1.9
Naproxen Sodium Tablet	20	1.8	1.8
Golimumab	32	1.8	1.8
Ravulizumab	5	1.8	1.8
Pegvaliase-Pqpz	3	1.7	1.7
Naltrexone Hydrochloride And Bupropion Hydrochloride	3	1.7	1.7
Ruxolitinib	25	1.7	1.7
Lurasidone Hydrochloride	7	1.6	1.6
Cariprazine	3	1.5	1.5
Elexacaftor, Tezacaftor, And Ivacaftor	4	1.5	1.5
Hydrocodone Bitartrate And Acetaminophen	18	1.5	1.5
Medroxyprogesterone Acetate	15	1.4	1.4
Dimethyl Fumarate	33	1.3	1.3
Exenatide	13	1.2	1.2
Lifitegrast	4	1.2	1.2
Somatropin	16	1.0	1.0
Ixekizumab	8	1.0	1.0
Orlistat	5	0.9	0.9
Etonogestrel	9	0.9	0.9
Apremilast	25	0.8	0.8
Esketamine Hydrochloride	3	0.8	0.8
Galcanezumab-Gnlm	5	0.8	0.8
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	4	0.6	0.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.